{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T06:03:49Z","timestamp":1789625029752,"version":"build-2803163510"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T00:00:00Z","timestamp":1789603200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Subthalamic nucleus deep brain stimulation (DBS-STN) is a recognized treatment for advanced Parkinson\u2019s disease. While it improves some clinical symptoms, especially bradykinesia and rigidity, it has limited application for late motor symptoms. Moreover stimulation-related motor adverse effects can increase the motor burden. There is a clear need to develop additional therapies that complement deep brain stimulation in controlling late motor symptoms. Physical activity is a commonly used and recommended form of therapy for patients with Parkinson\u2019s disease, supplementary to pharmacological therapy. However, there are no clear recommendations including patients after implantation of DBS-STN stimulators in the group undergoing physiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study is to systematically review the literature on physiotherapy interventions for patients who have undergone DBS-STN implantation and their influence on motor outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 guidelines, and a total of 10 studies were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Despite heterogeneous physiotherapy protocols, the main outcomes (balance, postural stability, gait speed, functional mobility) improved consistently, while motor severity scores and cognitive or neurophysiological effects remain underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Current evidence supports the use of physiotheruapy as a potentially effective and safe addition to the management of motor symptoms in patients after DBS-STN. Future trials with standardized physiotherapy protocols and uniform outcome measures are needed to create overall recommendations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1916520","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T05:32:58Z","timestamp":1789623178000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["The effect of physical activity on Parkinson\u2019s disease outcomes in patients with bilateral subthalamic nucleus deep brain stimulation: a systematic review"],"prefix":"10.3389","volume":"17","author":[{"given":"Marta","family":"Betka","sequence":"first","affiliation":[{"name":"Department of Neurology, Faculty of Health Sciences, Medical University of Warsaw","place":["Warsaw, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanis\u0142aw","family":"Szlufik","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Health Sciences, Medical University of Warsaw","place":["Warsaw, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Koziorowski","sequence":"additional","affiliation":[{"name":"Department of Neurology, Faculty of Health Sciences, Medical University of Warsaw","place":["Warsaw, Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"905","DOI":"10.4103\/1673-5374.297089","article-title":"Effects of bilateral subthalamic nucleus deep brain stimulation on motor symptoms in Parkinson's disease: a retrospective cohort study","volume":"16","author":"Cheng","year":"2021","journal-title":"Neural Regen 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