{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:04:57Z","timestamp":1790229897029,"version":"4.1.0"},"reference-count":29,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Small unruptured aneurysms are usually considered low-risk lesions and are typically managed conservatively. However, recent evidence indicates that small aneurysms account for a substantial proportion of ruptured intracranial aneurysms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To determine which morphology- and hemodynamics-related parameters are associated with the rupture status of small (&amp;lt;7\u202fmm) anterior communicating artery (ACoA) aneurysms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed 332 consecutive patients with ACoA aneurysms who were treated at our institute. Clinical data, imaging data, and intraoperative video recordings were reviewed and analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 317 patients with small (&amp;lt;7\u202fmm) ACoA aneurysms were included in the study, among whom 220 (69.4%) presented with ruptured aneurysms and 97 (30.6%) with unruptured aneurysms. The ruptured aneurysms showed a significantly higher height-to-width ratio, aspect ratio, and size ratio than the unruptured aneurysms (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.05), and were more often irregular in shape or accompanied by a daughter sac. Among the 317 aneurysms, 53 aneurysms were analyzed for intracranial atherosclerosis and 47 aneurysms were evaluated to assess the hemodynamic parameters. Moderate-to-severe parent-artery atherosclerosis was also more significantly found in the ruptured aneurysms group (\n                      <jats:italic>p<\/jats:italic>\n                      &amp;lt;\u202f0.01). Fluid\u2013structure interaction analysis showed that, compared with the unruptured aneurysms, the ruptured aneurysms were associated with a lower time-averaged wall shear stress, higher oscillatory shear index, and higher von Mises stress in the parent artery.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study demonstrated that the rupture of small (&amp;lt;7\u202fmm) ACoA aneurysms may be associated with the parent artery and aneurysmal neck atherosclerosis, the hemodynamic environment, and adverse morphological characteristics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1930043","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:44:24Z","timestamp":1790228664000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Atherosclerotic changes of the parent artery associated with ruptures in small (&lt;7\u202fmm) anterior communicating artery aneurysms"],"prefix":"10.3389","volume":"17","author":[{"given":"Nanhao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Zhongnan Hospital, Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjun","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zhongnan Hospital, Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yutang","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zhongnan Hospital, Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zhongnan Hospital, Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zhongnan Hospital, Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen Yun","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zhongnan Hospital, Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zhongnan Hospital, Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihui","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Zhongnan Hospital, Wuhan University","place":["Wuhan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"111542","DOI":"10.1016\/j.jocn.2025.111542","article-title":"Prevalence and independent predictors of unruptured intracranial aneurysms: a systematic review and meta-analysis","volume":"140","author":"Quan","year":"2025","journal-title":"J Clin Neurosci"},{"key":"ref2","first-page":"1397","article-title":"Impact of smoking on the detection of brain 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