{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T05:03:16Z","timestamp":1789966996121,"version":"4.0.1"},"reference-count":28,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurol."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dizziness, vertigo, and related autonomic symptoms are common in migraine, but whether their combined symptom-frequency burden is associated with hypothalamic subregional structure remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This exploratory cross-sectional secondary analysis included 39 women with ICHD-3-defined migraine. All source T1-weighted images were processed uniformly with FreeSurfer 7.4.1 and automated hypothalamic subunit segmentation. Blinded quality control was performed without clinical data and independently confirmed by a neuroradiologist. The exposure was VSS-C total score, a composite of vertigo-balance and autonomic-anxiety symptom frequency. Models for five bilateral subunits and whole-hypothalamus volume adjusted for age, estimated total intracranial volume, and baseline monthly migraine days; Benjamini-Hochberg false-discovery-rate correction was applied across the six outcomes. Outcome-specific quality-control denominators were 37 or 39.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Anterior-superior hypothalamic volume was associated with VSS-C total score (n\u202f=\u202f39; \u03b2\u202f=\u202f0.165\u202fmm\n                      <jats:sup>3<\/jats:sup>\n                      per point, 95% confidence interval 0.064 to 0.266,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.0021; BH-FDR-adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.0127). The association remained after restricting all six outcomes to the same 37 participants (BH-FDR-adjusted\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.0334). Across the observed 20-point VSS-C interquartile range, the coefficient corresponded to 3.31\u202fmm\n                      <jats:sup>3<\/jats:sup>\n                      , or 8.54% of mean anterior-superior volume. DHI identified the same subregion in a separately corrected supporting analysis, but mutual adjustment attenuated both coefficients.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Higher VSS-C total symptom burden was associated with larger anterior-superior hypothalamic volume in women with migraine. This result identifies a subregional target for prospective replication with component-level symptom assessment and formal vestibular phenotyping.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fneur.2026.1931533","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T04:27:59Z","timestamp":1789964879000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypothalamic subregional volume in relation to VSS-C total symptom burden in women with migraine: an exploratory cross-sectional MRI study"],"prefix":"10.3389","volume":"17","author":[{"given":"Linyi","family":"Che","sequence":"first","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanqun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, Chongqing Jiulongpo District Science City People's Hospital","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoping","family":"Fan","sequence":"additional","affiliation":[{"name":"Phase I Clinical Research Center, The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinlian","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruonan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Key Laboratory of Physical Medicine and Precision Rehabilitation of Chongqing Municipal Health Commission, The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiying","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Chongqing Medical University","place":["Chongqing, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1177\/0333102417738202","article-title":"The international classification of headache disorders, 3rd edition","volume":"38","year":"2018","journal-title":"Cephalalgia"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/VES-201644","article-title":"Vestibular migraine: diagnostic criteria","volume":"32","author":"Lempert","year":"2022","journal-title":"J Vestib Res"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1097\/WCO.0000000000001024","article-title":"Vestibular and auditory 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