{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:58:34Z","timestamp":1789664314418,"version":"4.0.1"},"reference-count":72,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T00:00:00Z","timestamp":1556150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003810","name":"Hospital de Cl\u00ednicas de Porto Alegre","doi-asserted-by":"publisher","award":["0000921"],"award-info":[{"award-number":["0000921"]}],"id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["PGI 011\/29"],"award-info":[{"award-number":["PGI 011\/29"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004809","name":"Financiadora de Estudos e Projetos","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302345\/2011-6"],"award-info":[{"award-number":["302345\/2011-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["301256\/2013-6"],"award-info":[{"award-number":["301256\/2013-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"DOI":"10.3389\/fnhum.2019.00138","type":"journal-article","created":{"date-parts":[[2019,4,25]],"date-time":"2019-04-25T04:25:46Z","timestamp":1556166346000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":42,"title":["Differential Neuroplastic Changes in Fibromyalgia and Depression Indexed by Up-Regulation of Motor Cortex Inhibition and Disinhibition of the Descending Pain System: An Exploratory Study"],"prefix":"10.3389","volume":"13","author":[{"given":"Tiago Madeira","family":"Cardinal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Concei\u00e7\u00e3o","family":"Antunes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aline Patricia","family":"Brietzke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane Schulz","family":"Parizotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Carvalho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andressa","family":"De Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iraci Lucena","family":"da Silva Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Fregni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolnei","family":"Caumo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,4,25]]},"reference":[{"key":"B1","year":"2013","journal-title":"Diagnostic and Statistical Manual of Mental Disorders"},{"key":"B2","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.jpainsymman.2009.09.023","article-title":"Anodal transcranial direct current stimulation of the motor cortex ameliorates chronic pain and reduces short intracortical inhibition.","volume":"39","author":"Antal","year":"2010","journal-title":"J. Pain Symptom. Manage."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/j.1532-2149.2012.00129.x","article-title":"Effects of dexmedetomidine on conditioned pain modulation in humans.","volume":"16","author":"Baba","year":"2012","journal-title":"Eur. J. Pain"},{"key":"B4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.apergo.2004.01.002","article-title":"Understanding statistical power in the context of applied research.","volume":"35","author":"Baguley","year":"2004","journal-title":"Appl. Ergon."},{"key":"B5","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0304-3959(79)90050-2","article-title":"Diffuse noxious inhibitory controls (DNIC). II. Lack of effect on non-convergent neurones, supraspinal involvement and theoretical implications.","volume":"6","author":"Bars","year":"1979","journal-title":"Pain"},{"key":"B6","author":"Beck","year":"1996","journal-title":"Beck Depression Inventory-II."},{"key":"B7","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.sleep.2010.04.020","article-title":"Validation of the Brazilian Portuguese version of the pittsburgh sleep quality index.","volume":"12","author":"Bertolazi","year":"2011","journal-title":"Sleep Med."},{"key":"B8","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2016.00308","article-title":"A framework for understanding the relationship between descending pain modulation, motor corticospinal, and neuroplasticity regulation systems in chronic myofascial pain.","volume":"10","author":"Botelho","year":"2016","journal-title":"Front. Hum. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.cct.2010.09.007","article-title":"Sertraline vs. electrical current therapy for treating depression clinical trial - SELECT TDCS: design, rationale and objectives.","volume":"32","author":"Brunoni","year":"2011","journal-title":"Contemp. Clin. Trials"},{"key":"B10","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1007\/978-3-211-79280-3_374","article-title":"The fibromyalgia impact questionnaire: development and validation.","volume":"18","author":"Burckhardt","year":"1991","journal-title":"J. Rheumatol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The pittsburgh sleep quality index: a new instrument for psychiatric practice and research.","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res."},{"key":"B12","doi-asserted-by":"publisher","DOI":"10.1177\/1759091417711512","article-title":"Cortical plasticity in depression.","volume":"9","author":"Cantone","year":"2017","journal-title":"ASN Neuro"},{"key":"B13","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1038\/npp.2016.133","article-title":"Characterization of glutamatergic and GABAA-Mediated neurotransmission in motor and dorsolateral prefrontal cortex using paired-pulse TMS-EEG.","volume":"42","author":"Cash","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1016\/j.jpain.2015.09.009","article-title":"Clinically effective treatment of fibromyalgia pain with high-definition transcranial direct current stimulation: phase II open-label dose optimization.","volume":"17","author":"Castillo-Saavedra","year":"2016","journal-title":"J. Pain"},{"key":"B15","doi-asserted-by":"publisher","first-page":"2109","DOI":"10.2147\/JPR.S131479","article-title":"The central sensitization inventory validated and adapted for a Brazilian population: psychometric properties and its relationship with brain-derived neurotrophic factor.","volume":"10","author":"Caumo","year":"2017","journal-title":"J. Pain Res."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fnhum.2016.00357","article-title":"Motor cortex excitability and BDNF levels in chronic musculoskeletal pain according to structural pathology.","volume":"10","author":"Caumo","year":"2016","journal-title":"Front. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1111\/j.1468-2982.2007.01337.x","article-title":"Transcranial direct current stimulation reveals inhibitory deficiency in migraine.","volume":"27","author":"Chadaide","year":"2007","journal-title":"Cephalalgia"},{"key":"B18","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/pcn.12812","article-title":"Analgesic effects of repetitive transcranial magnetic stimulation on modified 2010 criteria‐diagnosed fibromyalgia: a pilot study.","volume":"73","author":"Cheng","year":"2010","journal-title":"Psychiatry Clin. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1111\/pcn.12812","article-title":"Analgesic effects of repetitive transcranial magnetic stimulation on modified 2010 criteria-diagnosed fibromyalgia: pilot study.","volume":"73","author":"Cheng","year":"2018","journal-title":"Psychiatry Clin. Neurosci."},{"key":"B20","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1093\/ije\/31.1.163","article-title":"Fallibility in estimating direct effects.","volume":"31","author":"Cole","year":"2002","journal-title":"Int. J. Epidemiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s10194-011-0379-4","article-title":"Increased variability of motor cortical excitability to transcranial magnetic stimulation in migraine: a new clue to an old enigma.","volume":"13","author":"Conforto","year":"2012","journal-title":"J. Headache Pain"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-016-0934-0","article-title":"Changes in resting state functional connectivity after repetitive transcranial direct current stimulation applied to motor cortex in fibromyalgia patients.","volume":"18","author":"Cummiford","year":"2016","journal-title":"Arthr. Res. Ther."},{"key":"B23","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1016\/j.jpain.2014.05.001","article-title":"Repetitive transcranial magnetic stimulation increases the corticospinal inhibition and the brain-derived neurotrophic factor in chronic myofascial pain syndrome: an explanatory double-blinded, randomized, sham-controlled trial.","volume":"15","author":"Dall\u2019Agnol","year":"2014","journal-title":"J. Pain"},{"key":"B24","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1097\/AJP.0000000000000194","article-title":"Clinical value of serum neuroplasticity mediators in identifying the central sensitivity syndrome in patients with chronic pain with and without structural pathology.","volume":"31","author":"Deitos","year":"2015","journal-title":"Clin. J. Pain"},{"key":"B25","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1590\/S1516-44462001000300008","article-title":"Reliability of the structured clinical interview for DSM-IV\u2013 clinical version translated into Portuguese.","volume":"23","author":"Del-Ben","year":"2001","journal-title":"Rev. Bras. Psiquiatr."},{"key":"B26","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1113\/jphysiol.2006.114694","article-title":"GABAA receptor subtype specific enhancement of inhibition in human motor cortex.","volume":"575","author":"Di Lazzaro","year":"2006","journal-title":"J. Physiol."},{"key":"B27","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s002210050919","article-title":"Intracortical origin of the short latency facilitation produced by pairs of threshold magnetic stimuli applied to human motor cortex.","volume":"129","author":"Di Lazzaro","year":"1999","journal-title":"Exp. Brain Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"1578","DOI":"10.1093\/pm\/pnx297","article-title":"Higher cortical facilitation and serum BDNF are associated with increased sensitivity to heat pain and reduced endogenous pain inhibition in healthy males.","volume":"19","author":"Duss\u00e1n-Sarria","year":"2018","journal-title":"Pain Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1016\/j.pain.0000000000000006","article-title":"Transcranial direct current stimulation as a treatment for patients with fibromyalgia: a randomized controlled trial.","volume":"156","author":"Fagerlund","year":"2015","journal-title":"Pain"},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/429815","article-title":"Microglia control neuronal network excitability via BDNF signalling.","volume":"2013","author":"Ferrini","year":"2013","journal-title":"Neural Plast."},{"key":"B31","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1097\/YCT.0b013e31828b34d8","article-title":"Biological markers in noninvasive brain stimulation trials in major depressive disorder: a systematic review.","volume":"30","author":"Fidalgo","year":"2014","journal-title":"J. ECT"},{"key":"B32","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.rbp.2012.03.005","article-title":"Validation of the Brazilian Portuguese version of the beck depression inventory-II in a community sample.","volume":"34","author":"Gomes-Oliveira","year":"2012","journal-title":"Rev. Bras. Psiquiatr."},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078889","article-title":"Polymorphism in serotonin receptor 3B is associated with pain catastrophizing.","volume":"8","author":"Horjales-Araujo","year":"2013","journal-title":"PLoS One"},{"key":"B34","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1037\/0033-2909.105.2.302","article-title":"Multivariate analysis versus multiple univariate analyses.","volume":"105","author":"Huberty","year":"1989","journal-title":"Psychol. Bull."},{"key":"B35","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1113\/jphysiol.2002.030122","article-title":"Short-interval paired-pulse inhibition and facilitation of human motor cortex: the dimension of stimulus intensity.","volume":"545","author":"Ili\u0107","year":"2002","journal-title":"J. Physiol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.jpsychores.2009.09.013","article-title":"Evaluation of the structure of Brazilian state-trait anxiety inventory using a Rasch psychometric approach.","volume":"68","author":"Kaipper","year":"2010","journal-title":"J. Psychosom. Res."},{"key":"B37","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1016\/S0165-1781(02)00005-7","article-title":"Decreased serum brain-derived neurotrophic factor levels in major depressed patients.","volume":"109","author":"Karege","year":"2002","journal-title":"Psychiatry Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1001\/archgenpsychiatry.2010.189","article-title":"The serotonin transporter promoter variant (5-HTTLPR), stress, and depression meta-analysis revisited: evidence of genetic moderation.","volume":"68","author":"Karg","year":"2011","journal-title":"Arch. Gen. Psychiatry"},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.1097\/pr9.0000000000000692","article-title":"Latin American and Caribbean consensus on noninvasive central nervous system neuromodulation for chronic pain management (LAC2-NIN-CP).","volume":"4","author":"Karina do Monte-Silva","year":"2019","journal-title":"PAIN Rep."},{"key":"B40","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1002\/da.10144","article-title":"Slow right prefrontal transcranial magnetic stimulation as a treatment for medication-resistant depression: a double-blind, placebo-controlled study.","volume":"19","author":"Kauffmann","year":"2004","journal-title":"Depress. Anxiety"},{"key":"B41","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/S1474-4422(03)00321-1","article-title":"Transcranial magnetic stimulation in neurology.","volume":"2","author":"Kobayashi","year":"2003","journal-title":"Lancet Neurol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1113\/jphysiol.1993.sp019912","article-title":"Corticocortical inhibition in human motor cortex.","volume":"471","author":"Kujirai","year":"","journal-title":"J. Physiol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0168-5597(93)90100-4","article-title":"The effect of transcranial magnetic stimulation on median nerve somatosensory evoked potentials.","volume":"89","author":"Kujirai","year":"","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.jad.2015.10.020","article-title":"Cortical inhibitory and excitatory correlates of depression severity in children and adolescents.","volume":"190","author":"Lewis","year":"2016","journal-title":"J. Affect. Disord."},{"key":"B45","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1155\/2012\/610561","article-title":"Reliability of the conditioned pain modulation paradigm to assess endogenous inhibitory pain pathways.","volume":"17","author":"Lewis","year":"2012","journal-title":"Pain Res. Manag."},{"key":"B46","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018252","article-title":"Conditioned pain modulation is associated with common polymorphisms in the serotonin transporter gene.","volume":"6","author":"Lindstedt","year":"2011","journal-title":"PLoS One"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1111\/j.1526-4637.2011.01168.x","article-title":"An evolutionary stress-response hypothesis for chronic widespread pain (fibromyalgia syndrome).","volume":"12","author":"Lyon","year":"2011","journal-title":"Pain Med."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1111\/j.1742-1241.2007.01602.x","article-title":"Neurobiology of depression: an integrated view of key findings.","volume":"61","author":"Maletic","year":"2007","journal-title":"Int. J. Clin. Pract."},{"key":"B49","doi-asserted-by":"publisher","first-page":"2S","DOI":"10.1016\/j.biopsych.2014.03.014","article-title":"Translational use of tdcs in major depressive disorder: focus on neuroplasticity.","volume":"75","author":"Marie","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"B50","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1590\/S0482-50042006000100006","article-title":"Valida\u00e7\u00e3o da vers\u00e3o Brasileira do fibromyalgia impact questionnaire (FIQ).","volume":"46","author":"Marques","year":"2006","journal-title":"Rev. Bras. Reumatol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.pain.2010.03.009","article-title":"Alteration of cortical excitability in patients with fibromyalgia.","volume":"149","author":"Mhalla","year":"2010","journal-title":"Pain"},{"key":"B52","doi-asserted-by":"publisher","first-page":"6724","DOI":"10.1523\/jneurosci.22-15-06724.2002","article-title":"Partial peripheral nerve injury promotes a selective loss of GABAergic inhibition in the superficial dorsal horn of the spinal cord.","volume":"22","author":"Moore","year":"2002","journal-title":"J. Neurosci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"1295","DOI":"10.1016\/S1388-2457(02)00153-0","article-title":"Increased post-exercise facilitation of motor evoked potentials in multiple sclerosis.","volume":"113","author":"Nielsen","year":"2002","journal-title":"Clin. Neurophysiol."},{"key":"B54","doi-asserted-by":"crossref","first-page":"447","DOI":"10.36076\/ppj.2014\/17\/447","article-title":"Applying modern pain neuroscience in clinical practice: criteria for the classification of central sensitization pain.","volume":"17","author":"Nijs","year":"2014","journal-title":"Pain Phys."},{"key":"B55","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.brs.2016.03.020","article-title":"Is motor cortical excitability altered in people with chronic pain? A systematic review and meta-analysis.","volume":"9","author":"Parker","year":"2016","journal-title":"Brain Stimul."},{"key":"B56","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1093\/brain\/117.4.847","article-title":"Responses to rapid-rate transcranial magnetic stimulation of the human motor cortex.","author":"Pascual-leone","year":"1994","journal-title":"Brain"},{"key":"B57","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.pain.2011.11.025","article-title":"A systematic literature review of 10 years of research on sex\/gender and experimental pain perception \u2013 Part 1: are there really differences between women and men?","volume":"153","author":"Racine","year":"2012","journal-title":"Pain"},{"key":"B58","doi-asserted-by":"publisher","first-page":"943","DOI":"10.1590\/S0004-282X2011000700019","article-title":"Validation of a Brazilian quantitative sensory testing (QST) device for the diagnosis of small fiber neuropathies.","volume":"69","author":"Schestatsky","year":"2011","journal-title":"Arq. Neuropsiquiatr."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1425","DOI":"10.1111\/j.1526-4637.2012.01492.x","article-title":"Cross-cultural adaptation and validation of the Brazilian Portuguese version of the pain catastrophizing scale.","volume":"13","author":"Sehn","year":"2012","journal-title":"Pain Med."},{"key":"B60","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.jpain.2007.06.006","article-title":"Temporal summation of second pain and its maintenance are useful for characterizing widespread central sensitization of fibromyalgia patients.","volume":"8","author":"Staud","year":"2007","journal-title":"J. Pain"},{"key":"B61","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.neulet.2013.05.041","article-title":"The dopamine agonist apomorphine enhances conditioned pain modulation in healthy humans.","volume":"548","author":"Treister","year":"2013","journal-title":"Neurosci. Lett."},{"key":"B62","doi-asserted-by":"publisher","first-page":"393","DOI":"10.3171\/jns.1993.78.3.0393","article-title":"Chronic motor cortex stimulation in patients with thalamic pain.","volume":"78","author":"Tsubokawa","year":"1993","journal-title":"J. Neurosurg."},{"key":"B63","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1162\/jocn.2007.19.1.121","article-title":"Expectancy induces dynamic modulation of corticospinal excitability.","volume":"19","author":"van Elswijk","year":"2007","journal-title":"J. Cogn. Neurosci."},{"key":"B64","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-15-42","article-title":"Association of anxiety with intracortical inhibition and descending pain modulation in chronic myofascial pain syndrome.","volume":"15","author":"Vidor","year":"2014","journal-title":"BMC Neurosci."},{"key":"B65","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.semarthrit.2007.04.008","article-title":"Hypothesis: bipolar illness with complaints of chronic musculoskeletal pain is a form of pseudofibromyalgia.","volume":"37","author":"Wallace","year":"2008","journal-title":"Semin. Arthritis Rheum."},{"key":"B66","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1111\/j.1469-7793.1999.0591t.x","article-title":"Differential effects on motorcortical inhibition induced by blockade of GABA uptake in humans.","author":"Werhahn","year":"1999","journal-title":"J. Physiol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.pain.2010.09.030.Central","article-title":"Central sensitization: implications for the diagnosis and treatment of pain.","volume":"152","author":"Woolf","year":"2012","journal-title":"Pain"},{"key":"B68","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1097\/ACO.0b013e32833c348b","article-title":"Conditioned pain modulation (the diffuse noxious inhibitory control-like effect): its relevance for acute and chronic pain states.","volume":"23","author":"Yarnitsky","year":"2010","journal-title":"Curr. Opin. Anaesthesiol."},{"key":"B69","doi-asserted-by":"publisher","DOI":"10.1186\/1744-8069-10-46","article-title":"Higher serum S100B and BDNF levels are correlated with a lower pressure-pain threshold in fibromyalgia.","volume":"10","author":"Zanette","year":"2014","journal-title":"Mol. Pain"},{"key":"B70","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1124\/mol.113.086496","article-title":"Brain-Derived neurotrophic factor-mediated downregulation of brainstem K+-Cl- cotransporter and cell-type-specific GABA impairment for activation of descending pain facilitation.","volume":"84","author":"Zhang","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0172270","article-title":"Meta-analyses of comparative efficacy of antidepressant medications on peripheral BDNF concentration in patients with depression.","volume":"12","author":"Zhou","year":"2017","journal-title":"PLoS One"},{"key":"B72","doi-asserted-by":"publisher","first-page":"7000","DOI":"10.1523\/jneurosci.18-17-07000.1998","article-title":"Mechanisms of deafferentation-induced plasticity in human motor cortex.","volume":"18","author":"Ziemann","year":"1998","journal-title":"J. Neurosci."}],"container-title":["Frontiers in Human Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnhum.2019.00138\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:54:35Z","timestamp":1694825675000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnhum.2019.00138\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,25]]},"references-count":72,"alternative-id":["10.3389\/fnhum.2019.00138"],"URL":"https:\/\/doi.org\/10.3389\/fnhum.2019.00138","relation":{},"ISSN":["1662-5161"],"issn-type":[{"value":"1662-5161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,25]]},"article-number":"138"}}