{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:40:21Z","timestamp":1785523221230,"version":"3.56.0"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T00:00:00Z","timestamp":1612396800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:p><jats:bold>Objective:<\/jats:bold> To investigate the correlation between preoperative response to the L-dopa challenge test and efficacy of deep brain stimulation (DBS) on motor function in Parkinson\u2019s disease (PD).<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> We retrospectively reviewed the data of 38 patients with idiopathic PD who underwent DBS surgery with a median follow-up duration of 7 months. Twenty underwent bilateral globus pallidus interna (GPi) DBS, and 18 underwent bilateral subthalamic nucleus (STN) DBS. The Movement Disorder Society Unified Parkinson Disease Rating Scale-Motor Part (MDS UPDRS-III) was assessed before surgery and at the last follow-up in different medication and stimulation conditions, respectively.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Pearson\u2019s correlation analysis revealed a positive correlation between preoperative L-dopa challenge responsiveness and GPi-DBS responsiveness on the total score (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.283, <jats:italic>p<\/jats:italic> = 0.016) but not on the non-tremor total score (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.158, <jats:italic>p<\/jats:italic> = 0.083) of MDS UPDRS-III. Such correlation remained significant (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2032 = 0.332, <jats:italic>p<\/jats:italic> = 0.010) after controlling for age at the time of surgery as confounding factor by partial correlation analysis. The preoperative L-dopa challenge responsiveness was significantly correlated with the tremor-controlling outcome of GPi-DBS (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.390, <jats:italic>p<\/jats:italic> = 0.003). In contrast, we found a positive correlation between preoperative L-dopa challenge responsiveness and STN-DBS responsiveness on the non-tremor total score (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.290, <jats:italic>p<\/jats:italic> = 0.021), but not on the total score (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.130, <jats:italic>p<\/jats:italic> = 0.141) of MDS UPDRS-III. The partial correlation analysis further demonstrated that the predictive value of preoperative L-dopa challenge responsiveness on the non-tremor motor outcome of STN-DBS was eliminated (<jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup>\u2032 = 0.120, <jats:italic>p<\/jats:italic> = 0.174) after controlling for age at the time of surgery as confounding factor.<\/jats:p><jats:p><jats:bold>Interpretation:<\/jats:bold> The short-term predictive value of preoperative response to the L-dopa challenge test for the motor outcome of GPi-DBS in PD was systematically described. Our findings suggest: (1) a solid therapeutic effect of GPi-DBS in treating L-dopa-responsive tremors; (2) a negative effect of age at the time of surgery on motor outcomes of STN-DBS, (3) a possible preference of STN- to GPi-DBS in L-dopa-resistant tremor control, and (4) a possible preference of GPi- to STN-DBS in elderly PD patients who have a satisfactory dopamine response.<\/jats:p>","DOI":"10.3389\/fnhum.2021.604433","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T04:29:26Z","timestamp":1612412966000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":28,"title":["Revisiting the L-Dopa Response as a Predictor of Motor Outcomes After Deep Brain Stimulation in Parkinson\u2019s Disease"],"prefix":"10.3389","volume":"15","author":[{"given":"Zhengyu","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linbin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingfang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bomin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianyou","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,2,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1001\/jama.2019.22360","article-title":"Diagnosis and treatment of Parkinson disease: a review.","volume":"323","author":"Armstrong","year":"2020","journal-title":"JAMA"},{"key":"B2","doi-asserted-by":"publisher","first-page":"710","DOI":"10.1136\/jnnp-2017-317219","article-title":"Deep brain stimulation in the caudal zona incerta versus best medical treatment in patients with Parkinson\u2019s disease: a randomised blinded evaluation.","volume":"89","author":"Blomstedt","year":"2018","journal-title":"J. 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