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Hum. Neurosci."],"abstract":"<jats:p>Developmental stuttering (DS) is a disturbance of the normal rhythm of speech that may be interpreted as very debilitating in the most affected cases. Interventions for DS are historically based on the behavioral modifications of speech patterns (e.g., through speech therapy), which are useful to regain a better speech fluency. However, a great variability in intervention outcomes is normally observed, and no definitive evidence is currently available to resolve stuttering, especially in the case of its persistence in adulthood. In the last few decades, DS has been increasingly considered as a functional disturbance, affecting the correct programming of complex motor sequences such as speech. Compatibly, understanding of the neurophysiological bases of DS has dramatically improved, thanks to neuroimaging, and techniques able to interact with neural tissue functioning [e.g., non-invasive brain stimulation (NIBS)]. In this context, the dysfunctional activity of the cortico-basal-thalamo-cortical networks, as well as the defective patterns of connectivity, seems to play a key role, especially in sensorimotor networks. As a consequence, a direct action on the functionality of \u201cdefective\u201d or \u201cimpaired\u201d brain circuits may help people who stutter to manage dysfluencies in a better way. This may also \u201cpotentiate\u201d available interventions, thus favoring more stable outcomes of speech fluency. Attempts aiming at modulating (and improving) brain functioning of people who stutter, realized by using NIBS, are quickly increasing. Here, we will review these recent advancements being applied to the treatment of DS. Insights will be useful not only to assess whether the speech fluency of people who stutter may be ameliorated by acting directly on brain functioning but also will provide further suggestions about the complex and dynamic pathophysiology of DS, where causal effects and \u201cadaptive''\/\u2018\u2018maladaptive\u201d compensation mechanisms may be strongly overlapped. In conclusion, this review focuses future research toward more specific, targeted, and effective interventions for DS, based on neuromodulation of brain functioning.<\/jats:p>","DOI":"10.3389\/fnhum.2021.662016","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T04:48:39Z","timestamp":1628657319000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Speech Fluency Improvement in Developmental Stuttering Using Non-invasive Brain Stimulation: Insights From Available Evidence"],"prefix":"10.3389","volume":"15","author":[{"given":"Pierpaolo","family":"Busan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Moret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Masina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Del Ben","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Campana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"B1","first-page":"822","article-title":"On stuttering-like hesitation resulting from infarct in the midbrain and the mesial thalami","volume":"32","author":"Abe","year":"1992","journal-title":"Rinsho Shinkeigaku."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1024","DOI":"10.1136\/jnnp.56.9.1024","article-title":"Repetitive speech disorder resulting from infarcts in the paramedian thalami and midbrain","volume":"56","author":"Abe","year":"1993","journal-title":"J. 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