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Neurosci."],"abstract":"<jats:p>Research on light modulation has typically examined the wavelength, intensity, and exposure time of light, and measured rhythm, sleep, and cognitive ability to evaluate the regulatory effects of light variables on physiological and cognitive functions. Although the frequency of light is one of the main dimensions of light, few studies have attempted to manipulate it to test the effect on brain activation and performance. Recently, 40-Hz light stimulation has been proven to significantly alleviate deficits in gamma oscillation of the hippocampus caused by Alzheimer\u2019s disease. Although this oscillation is one of the key functional characteristics of performing memory tasks in healthy people, there is no evidence that 40-Hz blue light exposure can effectively regulate brain activities related to complex cognitive tasks. In the current study, we examined the difference in the effects of 40-Hz light or 0-Hz light exposure on brain activation and functional connectivity during a recognition memory task. Through joint augmentation of visual area activation, 40-Hz light enhanced brain areas mostly in the limbic system that are related to memory, such as the hippocampus and thalamus. Conversely, 0-Hz light enhanced brain areas mostly in the prefrontal cortex. Additionally, functional connection analysis, with the hippocampus as the seed point, showed that 40-Hz light enhanced connection with the superior parietal lobe and reduced the connection with the default network. These results indicate that light at a frequency of 40 Hz can change the activity and functional connection of memory-related core brain areas. They also indicate that in the use of light to regulate cognitive functions, its frequency characteristics merit attention.<\/jats:p>","DOI":"10.3389\/fnhum.2021.739333","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T09:12:18Z","timestamp":1639645938000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":34,"title":["40-Hz Blue Light Changes Hippocampal Activation and Functional Connectivity Underlying Recognition Memory"],"prefix":"10.3389","volume":"15","author":[{"given":"Zhenglong","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangqiang","family":"Hou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youli","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiqi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingwu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yatao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxian","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1016\/j.neuron.2019.04.011","article-title":"Gamma entrainment binds higher-order brain regions and offers neuroprotection.","volume":"102","author":"Adaikkan","year":"2019","journal-title":"Neuron"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.5665\/sleep.6090","article-title":"Exposure to blue light increases subsequent functional activation of the prefrontal cortex during performance of a working memory task.","volume":"39","author":"Alkozei","year":"2016","journal-title":"Sleep"},{"key":"B3","doi-asserted-by":"publisher","first-page":"19998","DOI":"10.1073\/pnas.0808312105","article-title":"Rods-cones and melanopsin detect light and dark to modulate sleep independent of image formation.","volume":"105","author":"Altimus","year":"2008","journal-title":"Proc. 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