{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T06:45:01Z","timestamp":1772693101409,"version":"3.50.1"},"reference-count":69,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T00:00:00Z","timestamp":1638230400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:p>Cortical network hyperexcitability is an inextricable feature of Alzheimer\u2019s disease (AD) that also might accelerate its progression. Seizures are reported in 10\u201322% of patients with AD, and subclinical epileptiform abnormalities have been identified in 21\u201342% of patients with AD without seizures. Accurate identification of hyperexcitability and appropriate intervention to slow the compromise of cognitive functions of AD might open up a new approach to treatment. Based on the results of several studies, epileptiform discharges, especially those with specific features (including high frequency, robust morphology, right temporal location, and occurrence during awake or rapid eye movement states), frequent small sharp spikes (SSSs), temporal intermittent rhythmic delta activities (TIRDAs), and paroxysmal slow wave events (PSWEs) recorded in long-term scalp electroencephalogram (EEG) provide sufficient sensitivity and specificity in detecting cortical network hyperexcitability and epileptogenicity of AD. In addition, magnetoencephalogram (MEG), foramen ovale (FO) electrodes, and computational approaches help to find subclinical seizures that are invisible on scalp EEGs. We performed a comprehensive analysis of the aforementioned electrophysiological biomarkers of AD-related seizures.<\/jats:p>","DOI":"10.3389\/fnhum.2021.747077","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T16:36:58Z","timestamp":1638376618000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":23,"title":["Electrophysiological Biomarkers of Epileptogenicity in Alzheimer\u2019s Disease"],"prefix":"10.3389","volume":"15","author":[{"given":"Tingting","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2021,11,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1016\/j.nicl.2015.03.002","article-title":"Co-localization between the BOLD response and epileptiform discharges recorded by simultaneous intracranial EEG-fMRI at 3 T.","volume":"7","author":"Aghakhani","year":"2015","journal-title":"Neuroimage Clin."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.514136","article-title":"Abnormalities of cortical sources of resting state delta electroencephalographic rhythms are related to epileptiform activity in patients with amnesic mild cognitive impairment not due to Alzheimer\u2019s disease.","volume":"11","author":"Babiloni","year":"2020","journal-title":"Front. 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