{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:28:06Z","timestamp":1787236086819,"version":"build-2736575974"},"reference-count":44,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T00:00:00Z","timestamp":1670284800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>\n                      Childhood trauma is known to have dramatic effects on the risks for developing psychiatric disorders and increased suicidality. We conducted a meta-analysis of whole brain voxel-based morphometry (VBM) correlates of childhood trauma in adolescents exposed to childhood maltreatment (\n                      <jats:italic>N<\/jats:italic>\n                      = 379) and unexposed controls (\n                      <jats:italic>N<\/jats:italic>\n                      = 348).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Anisotropic effect size-signed differential mapping (AES-SDM) was utilized to synthesize the studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We observed increased volume amongst adolescents with a history of childhood trauma in regions that are involved in motor functions and language production: left precentral gyrus, including part of the left inferior frontal gyrus, left fibers of the body of corpus callosum, and left postcentral gyrus. We observed decreased volume amongst adolescents with a history of childhood trauma in regions that are involved in language processing and\/or sensory processing: bilateral cerebellum, bilateral middle temporal gyrus, left rostrum of corpus callosum, and bilateral supramarginal gyrus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>We suggest that these morphometric differences may be reflective of impaired motor development and increased sensory sensitivity and hypervigilance in adolescents with experiences of childhood trauma. Our results differ from meta-analytical findings in adults with history of childhood trauma and may contribute to a better understanding of neural mechanisms of childhood trauma, prediction of neurodevelopmental outcomes, and development of more effective and personalized therapies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnhum.2022.1022791","type":"journal-article","created":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T02:25:00Z","timestamp":1670293500000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":13,"title":["A meta-analysis of brain morphometric aberrations in adolescents who experienced childhood trauma"],"prefix":"10.3389","volume":"16","author":[{"given":"Olga","family":"Tymofiyeva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roma","family":"Kidambi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ca","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey E.","family":"Max","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony T.","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,6]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1017\/S0033291718003823","article-title":"Childhood maltreatment and adult suicidality: a comprehensive systematic review with meta-analysis.","volume":"49","author":"Angelakis","year":"2019","journal-title":"Psychol. Med."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.4604","article-title":"Association of different types of childhood maltreatment with emotional responding and response control among youths.","volume":"2","author":"Blair","year":"2019","journal-title":"JAMA Netw. Open"},{"key":"B3","doi-asserted-by":"publisher","first-page":"324","DOI":"10.1097\/YCO.0b013e32833aa0aa","article-title":"Motor coordination and emotional\u2013behavioral problems in children.","volume":"23","author":"Cairney","year":"2010","journal-title":"Curr. Opin. Psychiatry"},{"key":"B4","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1016\/j.neuron.2014.08.050","article-title":"Unraveling the miswired connectome: a developmental perspective.","volume":"83","author":"Di Martino","year":"2014","journal-title":"Neuron"},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.807839","article-title":"Focusing on comorbidity\u2014a novel meta-analytic approach and protocol to disentangle the specific neuroanatomy of co-occurring mental disorders.","volume":"12","author":"Fortea","year":"2022","journal-title":"Front. Psychiatry"},{"key":"B6","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/j.nicl.2018.07.018","article-title":"Type and timing of childhood maltreatment and reduced visual cortex volume in children and adolescents with reactive attachment disorder.","volume":"20","author":"Fujisawa","year":"2018","journal-title":"NeuroImage Clin."},{"key":"B7","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1007\/s00787-020-01697-z","article-title":"Neuroanatomical changes associated with conduct disorder in boys: influence of childhood maltreatment.","volume":"31","author":"Gao","year":"2021","journal-title":"Eur. Child Adolesc. Psychiatry"},{"key":"B8","doi-asserted-by":"publisher","first-page":"8174","DOI":"10.1073\/pnas.0402680101","article-title":"Dynamic mapping of human cortical development during childhood through early adulthood.","volume":"101","author":"Gogtay","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.13354","article-title":"Structural brain differences predict early traumatic memory processing.","volume":"57","author":"Gvozdanovic","year":"2020","journal-title":"Psychophysiology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"3592","DOI":"10.1002\/hbm.23613","article-title":"Neural correlates of experimental trauma memory retrieval.","volume":"38","author":"Gvozdanovic","year":"2017","journal-title":"Hum. Brain Mapp."},{"key":"B11","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1080\/17450128.2019.1687963","article-title":"Sensory processing in children with a history of maltreatment: an occupational therapy perspective.","volume":"15","author":"Howard","year":"2020","journal-title":"Vulnerable Child. Youth Stud."},{"key":"B12","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.jad.2017.03.009","article-title":"Sexual trauma is more strongly associated with tonic immobility than other types of trauma \u2013 A population based study.","volume":"215","author":"Kalaf","year":"2017","journal-title":"J. Affect. Disord."},{"key":"B13","doi-asserted-by":"publisher","first-page":"1591","DOI":"10.1017\/S0954579415000966","article-title":"Sex differences in socioemotional functioning, attentional bias, and gray matter volume in maltreated children: a multilevel investigation.","volume":"27","author":"Kelly","year":"2015","journal-title":"Dev. Psychopathol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"842","DOI":"10.1016\/j.jaac.2019.10.011","article-title":"Meta-analysis: exposure to early life stress and risk for depression in childhood and adolescence.","volume":"59","author":"LeMoult","year":"2020","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0071898","article-title":"Childhood maltreatment is associated with larger left thalamic gray matter volume in adolescents with generalized anxiety disorder.","volume":"8","author":"Liao","year":"2013","journal-title":"PLoS One"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1034","DOI":"10.1017\/S0033291717002392","article-title":"Grey matter volume and thickness abnormalities in young people with a history of childhood abuse.","volume":"48","author":"Lim","year":"2018","journal-title":"Psychol. Med."},{"key":"B17","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1016\/j.neubiorev.2020.07.004","article-title":"Aberrant structural connectivity in childhood maltreatment: a meta-analysis.","volume":"116","author":"Lim","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B18","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1176\/appi.ajp.2014.13101427","article-title":"Gray matter abnormalities in childhood maltreatment: a voxel-wise meta-analysis.","volume":"171","author":"Lim","year":"2014","journal-title":"Am. J. Psychiatry"},{"key":"B19","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069350","article-title":"Reduced cingulate gyrus volume associated with enhanced cortisol awakening response in young healthy adults reporting childhood trauma.","volume":"8","author":"Lu","year":"2013","journal-title":"PLoS One"},{"key":"B20","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.nicl.2017.06.030","article-title":"General and emotion-specific alterations to cognitive control in women with a history of childhood abuse.","volume":"16","author":"Mackiewicz Seghete","year":"2017","journal-title":"NeuroImage Clin."},{"key":"B21","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1111\/acps.13268","article-title":"Childhood trauma and adult mental disorder: a systematic review and meta-analysis of longitudinal cohort studies.","volume":"143","author":"McKay","year":"2021","journal-title":"Acta Psychiatr. Scand."},{"key":"B22","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1146\/annurev-devpsych-121318-084950","article-title":"Childhood adversity and neural development: a systematic review.","volume":"1","author":"McLaughlin","year":"2019","journal-title":"Annu. Rev. Dev. Psychol."},{"key":"B23","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097","article-title":"Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement","volume":"6","author":"Moher","year":"2009","journal-title":"PLoS Med"},{"key":"B24","doi-asserted-by":"publisher","first-page":"20750","DOI":"10.1073\/pnas.1904931116","article-title":"Apparent thinning of human visual cortex during childhood is associated with myelination.","volume":"116","author":"Natu","year":"2019","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B25","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.jpsychires.2017.09.020","article-title":"Measuring childhood maltreatment to predict early-adult psychopathology: comparison of prospective informant-reports and retrospective self-reports.","volume":"96","author":"Newbury","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.neubiorev.2016.08.011","article-title":"Understanding heterogeneity in grey matter research of adults with childhood maltreatment-A meta-analysis and review.","volume":"69","author":"Paquola","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B27","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104589","article-title":"Neurostructural traces of early life adversities: a meta-analysis exploring age- and adversity-specific effects.","volume":"135","author":"Pollok","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B28","doi-asserted-by":"publisher","first-page":"605","DOI":"10.1016\/j.eurpsy.2011.04.001","article-title":"A new meta-analytic method for neuroimaging studies that combines reported peak coordinates and statistical parametric maps.","volume":"27","author":"Radua","year":"2012","journal-title":"Eur. Psychiatry J. Assoc. Eur. Psychiatr."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2014.00013","article-title":"Anisotropic kernels for coordinate-based meta-analyses of neuroimaging studies.","volume":"5","author":"Radua","year":"2014","journal-title":"Front. Psychiatry"},{"key":"B30","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1017\/S0954579415000127","article-title":"Beating the brain about abuse: empirical and meta-analytic studies of the association between maltreatment and hippocampal volume across childhood and adolescence.","volume":"27","author":"Riem","year":"2015","journal-title":"Dev. Psychopathol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/S2352-4642(18)30022-1","article-title":"The age of adolescence.","volume":"2","author":"Sawyer","year":"2018","journal-title":"Lancet Child Adolesc. Health"},{"key":"B32","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1136\/jnnp.56.4.329","article-title":"Penfield\u2019s homunculus: a note on cerebral cartography.","volume":"56","author":"Schott","year":"1993","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B33","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.neubiorev.2021.07.002","article-title":"Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: a voxel-based morphometry meta-analysis.","volume":"129","author":"Serra-Blasco","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B34","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1093\/cercor\/bhp118","article-title":"Brain maturation in adolescence and young adulthood: regional age-related changes in cortical thickness and white matter volume and microstructure.","volume":"1991","author":"Tamnes","year":"2010","journal-title":"Cereb. Cortex N.Y."},{"key":"B35","doi-asserted-by":"publisher","first-page":"642","DOI":"10.1016\/j.biopsych.2009.04.021","article-title":"Childhood sexual abuse is associated with reduced gray matter volume in visual cortex of young women.","volume":"66","author":"Tomoda","year":"","journal-title":"Biol. Psychiatry"},{"key":"B36","doi-asserted-by":"publisher","first-page":"T66","DOI":"10.1016\/j.neuroimage.2009.03.005","article-title":"Reduced prefrontal cortical gray matter volume in young adults exposed to harsh corporal punishment.","volume":"47","author":"Tomoda","year":"","journal-title":"NeuroImage"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0052528","article-title":"Reduced visual cortex gray matter volume and thickness in young adults who witnessed domestic violence during childhood.","volume":"7","author":"Tomoda","year":"2012","journal-title":"PLoS One"},{"key":"B38","doi-asserted-by":"publisher","first-page":"S280","DOI":"10.1016\/j.neuroimage.2010.05.027","article-title":"Exposure to parental verbal abuse is associated with increased gray matter volume in superior temporal gyrus.","volume":"54","author":"Tomoda","year":"2011","journal-title":"NeuroImage"},{"key":"B39","year":"2017","journal-title":"The Adolescent Brain: A Second Window of Opportunity."},{"key":"B40","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s40653-017-0186-4","article-title":"Child maltreatment and motor coordination deficits among preschool children.","volume":"11","author":"Wade","year":"2017","journal-title":"J. Child Adolesc. Trauma"},{"key":"B41","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1016\/j.nicl.2014.01.001","article-title":"General and specific effects of early-life psychosocial adversities on adolescent grey matter volume.","volume":"4","author":"Walsh","year":"2014","journal-title":"NeuroImage Clin."},{"key":"B42","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1037\/1040-3590.9.1.34","article-title":"Accuracy of adult recollections of childhood victimization, Part 2: childhood sexual abuse.","volume":"9","author":"Widom","year":"1997","journal-title":"Psychol. Assess."},{"key":"B43","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1037\/1040-3590.8.4.412","article-title":"Accuracy of adult recollections of childhood victimization: part 1. Childhood physical abuse.","volume":"8","author":"Widom","year":"1996","journal-title":"Psychol. Assess."},{"key":"B44","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1002\/hipo.20437","article-title":"Hippocampal and amygdala volumes in children and adults with childhood maltreatment-related posttraumatic stress disorder: a meta-analysis.","volume":"18","author":"Woon","year":"2008","journal-title":"Hippocampus"}],"container-title":["Frontiers in Human Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnhum.2022.1022791\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,12,6]],"date-time":"2022-12-06T02:25:03Z","timestamp":1670293503000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnhum.2022.1022791\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,6]]},"references-count":44,"alternative-id":["10.3389\/fnhum.2022.1022791"],"URL":"https:\/\/doi.org\/10.3389\/fnhum.2022.1022791","relation":{},"ISSN":["1662-5161"],"issn-type":[{"value":"1662-5161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,6]]},"article-number":"1022791"}}