{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T07:37:09Z","timestamp":1774424229982,"version":"3.50.1"},"reference-count":55,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T00:00:00Z","timestamp":1655164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>White matter hyperintensities (WMHs) and regional brain lobe atrophy coexist in the brain of patients with Alzheimer's disease (AD), but the association between them in patients with AD still lacks comprehensive investigation and solid imaging data support.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We explored whether WMHs can promote the pathological process of AD by aggravating atrophy in specific brain regions and tried to explain the regional specificity of these relationships.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A sample of 240 adults including 180 normal controls (NCs) and 80 cases with AD were drawn from the ADNI database. T1-weighted magnetic resonance imaging (MRI) and T2-weighted fluid-attenuated MRI of the participants were downloaded and were analyzed using AccuBrain<jats:sup>\u00ae<\/jats:sup> to generate the quantitative ratio of WMHs (WMHr, WMH volumes corrected by intracranial volume) and regional brain atrophy. We also divided WMHr into periventricular WMHr (PVWMHr) and deep WMHr (DWMHr) for the purpose of this study. The Cholinergic Pathways Hyperintensities Scale (CHIPS) scores were conducted by two evaluators. Independent <jats:italic>t<\/jats:italic>-test, Mann\u2013Whitney <jats:italic>U<\/jats:italic> test, or \u03c7<jats:sup>2<\/jats:sup> test were used to compare the demographic characteristics, and Spearman correlation coefficient values were used to determine the association between WMHs and different regions of brain atrophy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Positive association between WMHr and quantitative medial temporal lobe atrophy (QMTA) (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = 0.281, <jats:italic>p<\/jats:italic> = 0.011), temporal lobe atrophy (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = 0.285, <jats:italic>p<\/jats:italic> = 0.011), and insular atrophy (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = 0.406, <jats:italic>p<\/jats:italic> &amp;lt; 0.001) was found in the AD group before Bonferroni correction. PVWMHr contributed to these correlations. By separately analyzing the relationship between PVWMHr and brain atrophy, we found that there were still positive correlations after correction in QMTA (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = 0.325, <jats:italic>p<\/jats:italic> = 0.003), temporal lobe atrophy (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = 0.298, <jats:italic>p<\/jats:italic> = 0.007), and insular atrophy (<jats:italic>r<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub> = 0.429, <jats:italic>p<\/jats:italic> &amp;lt; 0.001) in AD group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>WMH severity tends to be associated with regional brain atrophy in patients with AD, especially with medial temporal lobe, temporal lobe, and insular lobe atrophy. PVWMHs were devoted to these correlations.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnhum.2022.760360","type":"journal-article","created":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T07:08:34Z","timestamp":1655190514000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["The Correlation Between White Matter Hyperintensity Burden and Regional Brain Volumetry in Patients With Alzheimer's Disease"],"prefix":"10.3389","volume":"16","author":[{"given":"Zhiyu","family":"Cao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingren","family":"Mai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenli","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yishan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wang","family":"Liao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuting","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Songhua","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent C. T.","family":"Mok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"The Alzheimer's Disease Neuroimaging Initiative","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2022,6,14]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1177\/0284185118795327","article-title":"Standardization of hippocampus volumetry using automated brain structure volumetry tool for an initial Alzheimer's disease imaging biomarker","volume":"60","author":"Abrigo","year":"2019","journal-title":"Acta Radiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1347","DOI":"10.3233\/JAD-180017","article-title":"A clinicopathological investigation of white matter hyperintensities and Alzheimer's disease neuropathology","volume":"63","author":"Alosco","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1870","DOI":"10.3174\/ajnr.A1693","article-title":"Association of white matter hyperintensity measurements on brain MR imaging with cognitive status, medial temporal atrophy, and cardiovascular risk factors","volume":"30","author":"Appel","year":"2009","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"2126","DOI":"10.1161\/01.STR.0000183615.07936.b6","article-title":"A new visual rating scale to assess strategic white matter hyperintensities within cholinergic pathways in dementia","volume":"36","author":"Bocti","year":"2005","journal-title":"Stroke"},{"key":"B5","doi-asserted-by":"publisher","first-page":"1482","DOI":"10.1016\/j.jalz.2018.04.007","article-title":"Cerebral small vessel disease and the risk of dementia: a systematic review and meta-analysis of population-based evidence","volume":"14","author":"Bos","year":"2018","journal-title":"Alzheimers Dement."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1508","DOI":"10.1093\/gerona\/glz279","article-title":"Cholinergic white matter lesions, AD-signature cortical thickness, and change in cognition: the northern manhattan study","volume":"75","author":"Caunca","year":"2020","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1016\/j.neuroimage.2007.10.031","article-title":"Spatial patterns of brain atrophy in MCI patients, identified via high-dimensional pattern classification, predict subsequent cognitive decline","volume":"39","author":"Fan","year":"2008","journal-title":"Neuroimage"},{"key":"B8","doi-asserted-by":"publisher","first-page":"351","DOI":"10.2214\/ajr.149.2.351","article-title":"MR signal abnormalities at 1.5 T in Alzheimer's dementia and normal aging","volume":"149","author":"Fazekas","year":"1987","journal-title":"AJR Am. J. Roentgenol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1683","DOI":"10.1212\/WNL.43.9.1683","article-title":"Pathologic correlates of incidental MRI white matter signal hyperintensities","volume":"43","author":"Fazekas","year":"1993","journal-title":"Neurology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1002\/hipo.22690","article-title":"White matter hyperintensities are associated with disproportionate progressive hippocampal atrophy","volume":"27","author":"Fiford","year":"2017","journal-title":"Hippocampus"},{"key":"B11","doi-asserted-by":"publisher","first-page":"576025","DOI":"10.3389\/fnagi.2020.576025","article-title":"Interaction of age and self-reported physical sports activity on white matter hyperintensity volume in healthy older adults","volume":"12","author":"Franchetti","year":"2020","journal-title":"Front. Aging Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1111\/psyg.12363","article-title":"Medial temporal lobe atrophy is independently associated with behavioural and psychological symptoms in Alzheimer's disease","volume":"19","author":"Garc\u00eda-Alberca","year":"2019","journal-title":"Psychogeriatrics"},{"key":"B13","doi-asserted-by":"publisher","first-page":"e1298","DOI":"10.1212\/WNL.0000000000007142","article-title":"WMH and long-term outcomes in ischemic stroke: a systematic review and meta-analysis","volume":"92","author":"Georgakis","year":"2019","journal-title":"Neurology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.nicl.2015.04.017","article-title":"The effects of white matter hyperintensities and amyloid deposition on Alzheimer dementia","volume":"8","author":"Gordon","year":"2015","journal-title":"Neuroimage Clin."},{"key":"B15","doi-asserted-by":"publisher","first-page":"679","DOI":"10.3389\/fnins.2019.00679","article-title":"Intra-scanner and inter-scanner reproducibility of automatic white matter hyperintensities quantification","volume":"13","author":"Guo","year":"2019","journal-title":"Front. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1093\/brain\/aww008","article-title":"White matter hyperintensities and imaging patterns of brain ageing in the general population","volume":"139","author":"Habes","year":"2016","journal-title":"Brain"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1001\/jamaneurol.2013.1878","article-title":"Dissociable effects of Alzheimer disease and white matter hyperintensities on brain metabolism","volume":"70","author":"Haight","year":"2013","journal-title":"JAMA Neurol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/s10571-015-0285-4","article-title":"Neurovascular and cognitive failure in Alzheimer's disease: benefits of cardiovascular therapy","volume":"36","author":"Hamel","year":"2016","journal-title":"Cell Mol. Neurobiol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1917","DOI":"10.1093\/brain\/awy132","article-title":"The cholinergic system in the pathophysiology and treatment of Alzheimer's disease","volume":"141","author":"Hampel","year":"2018","journal-title":"Brain"},{"key":"B20","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.neubiorev.2020.11.007","article-title":"White matter hyperintensities and risks of cognitive impairment and dementia: A systematic review and meta-analysis of 36 prospective studies","volume":"120","author":"Hu","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B21","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1159\/000345999","article-title":"Effect of white matter hyperintensity on medial temporal lobe atrophy in Alzheimer's disease","volume":"69","author":"Jang","year":"2013","journal-title":"Eur. Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1247","DOI":"10.3233\/JAD-180644","article-title":"Atherosclerosis, hypertension, and diabetes in alzheimer's disease, vascular dementia, and mixed dementia: prevalence and presentation","volume":"65","author":"Javanshiri","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"B23","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.cortex.2019.04.008","article-title":"Altered frontal and insular functional connectivity as pivotal mechanisms for apathy in Alzheimer's disease","volume":"119","author":"Jones","year":"2019","journal-title":"Cortex."},{"key":"B24","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.jns.2013.11.042","article-title":"Cerebral white matter disease is independently associated with BPSD in Alzheimer's disease","volume":"337","author":"Kandiah","year":"2014","journal-title":"J. Neurol. Sci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1111\/ene.12546","article-title":"Association between white matter hyperintensity and medial temporal atrophy at various stages of Alzheimer's disease","volume":"22","author":"Kandiah","year":"2015","journal-title":"Eur. J. Neurol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1001\/jamaneurol.2014.754","article-title":"Associations between cerebral small-vessel disease and Alzheimer disease pathology as measured by cerebrospinal fluid biomarkers","volume":"71","author":"Kester","year":"2014","journal-title":"JAMA Neurol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1111\/ene.14073","article-title":"Effect of cholinergic pathway disruption on cortical and subcortical volumes in subcortical vascular cognitive impairment","volume":"27","author":"Lim","year":"2020","journal-title":"Eur. J. Neurol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2673","DOI":"10.1016\/S0140-6736(17)31363-6","article-title":"Dementia prevention, intervention, and care","volume":"390","author":"Livingston","year":"2017","journal-title":"Lancet"},{"key":"B29","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","article-title":"Alzheimer disease: an update on pathobiology and treatment strategies","volume":"179","author":"Long","year":"2019","journal-title":"Cell"},{"key":"B30","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/j.arr.2016.01.003","article-title":"MRI morphometry in Alzheimer's disease","volume":"30","author":"Matsuda","year":"2016","journal-title":"Age. Res. Rev."},{"key":"B31","doi-asserted-by":"publisher","first-page":"785","DOI":"10.3233\/JAD-140588","article-title":"Cholinergic subcortical hyperintensities in Alzheimer's disease patients from the Sunnybrook Dementia Study: relationships with cognitive dysfunction and hippocampal atrophy","volume":"43","author":"McNeely","year":"2015","journal-title":"J. Alzheimers Dis."},{"key":"B32","doi-asserted-by":"publisher","first-page":"S393","DOI":"10.3233\/JAD-141473","article-title":"White matter hyperintensities as early and independent predictors of Alzheimer's disease risk","volume":"42","author":"Mortamais","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"B33","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/S1474-4422(10)70104-6","article-title":"Cerebral small vessel disease: from pathogenesis and clinical characteristics to therapeutic challenges","volume":"9","author":"Pantoni","year":"2010","journal-title":"Lancet Neurol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1159\/000330019","article-title":"White matter disease independently predicts progression from mild cognitive impairment to Alzheimer's disease in a clinic cohort","volume":"31","author":"Prasad","year":"2011","journal-title":"Dement Geriatr. Cogn. Disord."},{"key":"B35","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1001\/jamaneurol.2013.1321","article-title":"White matter hyperintensities and cerebral amyloidosis: necessary and sufficient for clinical expression of Alzheimer disease?","volume":"70","author":"Provenzano","year":"2013","journal-title":"JAMA Neurol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.neurobiolaging.2021.04.019","article-title":"Microvascular degeneration occurs before plaque onset and progresses with age in 3xTg AD mice","volume":"105","author":"Quintana","year":"2021","journal-title":"Neurobiol. Aging"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1124","DOI":"10.1001\/jamaneurol.2018.1123","article-title":"Interactive associations of vascular risk and \u03b2-amyloid burden with cognitive decline in clinically normal elderly individuals: findings from the harvard aging brain study","volume":"75","author":"Rabin","year":"2018","journal-title":"JAMA Neurol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.1212\/WNL.0b013e3181c3f293","article-title":"Age, Alzheimer disease, and brain structure","volume":"73","author":"Raji","year":"2009","journal-title":"Neurology"},{"key":"B39","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1038\/jcbfm.2015.172","article-title":"Consensus statement for diagnosis of subcortical small vessel disease","volume":"36","author":"Rosenberg","year":"2016","journal-title":"J. Cereb. Blood. Flow Metab."},{"key":"B40","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/S0140-6736(15)01124-1","article-title":"Alzheimer's disease","volume":"388","author":"Scheltens","year":"2016","journal-title":"Lancet"},{"key":"B41","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00401-011-0851-x","article-title":"Heterogeneity in age-related white matter changes","volume":"122","author":"Schmidt","year":"2011","journal-title":"Acta Neuropathol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"2249","DOI":"10.1093\/brain\/121.12.2249","article-title":"Trajectories of cholinergic pathways within the cerebral hemispheres of the human brain","volume":"121","author":"Selden","year":"1998","journal-title":"Brain"},{"key":"B43","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1016\/j.jneumeth.2012.12.014","article-title":"Automated quantification of white matter lesion in magnetic resonance imaging of patients with acute infarction","volume":"213","author":"Shi","year":"2013","journal-title":"J. Neurosci. Methods"},{"key":"B44","doi-asserted-by":"publisher","first-page":"e950","DOI":"10.1212\/WNL.0000000000008864","article-title":"White matter hyperintensities and CSF Alzheimer disease biomarkers in preclinical Alzheimer disease","volume":"94","author":"Soldan","year":"2020","journal-title":"Neurology"},{"key":"B45","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1055\/s-0037-1608808","article-title":"Neuroimaging in Dementia","volume":"37","author":"Staffaroni","year":"2017","journal-title":"Semin. Neurol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.3233\/JAD-210138","article-title":"Cortical thickness and its association with clinical cognitive and neuroimaging markers in cerebral amyloid angiopathy","volume":"81","author":"Subotic","year":"2021","journal-title":"J. Alzheimers Dis"},{"key":"B47","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1053\/jscd.2003.5","article-title":"Strategic involvement of cholinergic pathways and executive dysfunction: Does location of white matter signal hyperintensities matter?","volume":"12","author":"Swartz","year":"2003","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"B48","doi-asserted-by":"publisher","first-page":"515","DOI":"10.3233\/JAD-170573","article-title":"White matter hyperintensities and cognition in mild cognitive impairment and alzheimer's disease: a domain-specific meta-analysis","volume":"63","author":"van den Berg","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"B49","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1111\/j.1749-6632.2010.05786.x","article-title":"Aging and cerebrovascular dysfunction: contribution of hypertension, cerebral amyloid angiopathy, and immunotherapy","volume":"1207","author":"Vasileyko","year":"2010","journal-title":"Innate Inflam. Stroke."},{"key":"B50","doi-asserted-by":"publisher","first-page":"533","DOI":"10.3233\/JAD-180280","article-title":"Regional white matter hyperintensity influences grey matter atrophy in mild cognitive impairment","volume":"66","author":"Vipin","year":"2018","journal-title":"J. Alzheimers Dis."},{"key":"B51","doi-asserted-by":"publisher","first-page":"759","DOI":"10.3233\/JAD-191005","article-title":"Associations of white matter hyperintensities with cognitive decline: a longitudinal study","volume":"73","author":"Wang","year":"","journal-title":"J. Alzheimers Dis."},{"key":"B52","doi-asserted-by":"publisher","first-page":"612928","DOI":"10.3389\/fphys.2020.612928","article-title":"3D compressed convolutional neural network differentiates neuromyelitis optical spectrum disorders from multiple sclerosis using automated white matter hyperintensities segmentations","volume":"11","author":"Wang","year":"","journal-title":"Front. Physiol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1016\/S1474-4422(13)70124-8","article-title":"Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration","volume":"12","author":"Wardlaw","year":"2013","journal-title":"Lancet Neurol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.neuroimage.2005.08.057","article-title":"Gray matter reduction is correlated with white matter hyperintensity volume: a voxel-based morphometric study in a large epidemiological sample","volume":"29","author":"Wen","year":"2006","journal-title":"Neuroimage"},{"key":"B55","doi-asserted-by":"publisher","first-page":"6217","DOI":"10.18632\/aging.102184","article-title":"Risk estimation before progression to mild cognitive impairment and Alzheimer's disease: an AD resemblance atrophy index","volume":"11","author":"Zhao","year":"2019","journal-title":"Aging."}],"container-title":["Frontiers in Human Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnhum.2022.760360\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,14]],"date-time":"2022-06-14T07:08:38Z","timestamp":1655190518000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnhum.2022.760360\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,14]]},"references-count":55,"alternative-id":["10.3389\/fnhum.2022.760360"],"URL":"https:\/\/doi.org\/10.3389\/fnhum.2022.760360","relation":{},"ISSN":["1662-5161"],"issn-type":[{"value":"1662-5161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,14]]},"article-number":"760360"}}