{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T21:38:11Z","timestamp":1792705091826,"version":"4.5.0"},"reference-count":47,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:p>Loneliness has been reported to be associated with an increased risk of dementia; however, the extent of this relationship remains controversial. This study aimed to assess the strength of the relationship between loneliness and dementia using a meta-analysis approach. PubMed, EMBASE, and China National Knowledge Internet databases were systematically searched for potentially included studies from inception up to 17 February 2022. A meta-analysis was performed using a random-effects model to assess pooled relative risks (RRs) and 95% confidence intervals (CIs). A literature search identified 16 cohort studies (published in 15 articles), among which 4,625 dementia cases and 62,345 individuals were selected for further meta-analysis. Loneliness was associated with an increased risk of Alzheimer\u2019s disease (AD) (RR: 1.72, 95% CI: 1.32\u20132.23; <jats:italic>P<\/jats:italic> &amp;lt; 0.001) and dementia (RR: 1.23, 95% CI: 1.16\u20131.31; <jats:italic>P<\/jats:italic> &amp;lt; 0.00001). However, no significant association between loneliness and risk of mild cognitive impairment (MCI) (RR: 1.34, 95% CI: 0.97\u20131.87; <jats:italic>P<\/jats:italic> = 0.080) or vascular dementia (VaD) (RR: 1.01, 95% CI: 0.51\u20131.99; <jats:italic>P<\/jats:italic> = 0.973) was observed. Results revealed that loneliness might increase the risk of Alzheimer\u2019s disease and dementia. Early interventions that limit loneliness may reduce risk of dementia and Alzheimer\u2019s disease.<\/jats:p>","DOI":"10.3389\/fnhum.2022.899814","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T06:14:07Z","timestamp":1669875247000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":44,"title":["Association between loneliness and dementia risk: A systematic review and meta-analysis of cohort studies"],"prefix":"10.3389","volume":"16","author":[{"given":"Luyao","family":"Qiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gege","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.2307\/2533446","article-title":"Operating characteristics of a rank correlation test for publication bias.","volume":"50","author":"Begg","year":"1994","journal-title":"Biometrics"},{"key":"B2","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1177\/096228020101000303","article-title":"A review of adjusted estimators of attributable risk.","volume":"10","author":"Benichou","year":"2001","journal-title":"Stat. 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