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Neurosci."],"abstract":"<jats:p>High-frequency oscillations (HFO) are a promising biomarker for the identification of epileptogenic tissue. While HFO rates have been shown to predict seizure outcome, it is not yet clear whether their morphological features might improve this prediction. We validated HFO rates against seizure outcome and delineated the distribution of HFO morphological features. We collected stereo-EEG recordings from 20 patients (231 electrodes; 1,943 contacts). We computed HFO rates (the co-occurrence of ripples and fast ripples) through a validated automated detector during non-rapid eye movement sleep. Applying machine learning, we delineated HFO morphological features within and outside epileptogenic tissue across mesial temporal lobe (MTL) and Neocortex. HFO rates predicted seizure outcome with 85% accuracy, 79% specificity, 100% sensitivity, 100% negative predictive value, and 67% positive predictive value. The analysis of HFO features showed larger amplitude in the epileptogenic tissue, similar morphology for epileptogenic HFO in MTL and Neocortex, and larger amplitude for physiological HFO in MTL. We confirmed HFO rates as a reliable biomarker for epilepsy surgery and characterized the potential clinical relevance of HFO morphological features. Our results support the prospective use of HFO in epilepsy surgery and contribute to the anatomical mapping of HFO morphology.<\/jats:p>","DOI":"10.3389\/fnhum.2022.984306","type":"journal-article","created":{"date-parts":[[2022,9,29]],"date-time":"2022-09-29T08:00:30Z","timestamp":1664438430000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Epileptogenic high-frequency oscillations present larger amplitude both in mesial temporal and neocortical regions"],"prefix":"10.3389","volume":"16","author":[{"given":"Victor","family":"Karpychev","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Balatskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Utyashev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikita","family":"Pedyash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey","family":"Zuev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga","family":"Dragoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tommaso","family":"Fedele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2022,9,29]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1101\/765149","article-title":"Fast and slow cortical high frequency oscillations for cortico-cortical and cortico-hippocampal network consolidation during NonREM sleep.","author":"Aleman-Zapata","year":"2020","journal-title":"bioRxiv [Preprint]"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1986","DOI":"10.1111\/epi.12851","article-title":"The spatial and signal characteristics of physiologic high frequency oscillations.","volume":"55","author":"Alkawadri","year":"2014","journal-title":"Epilepsia"},{"key":"B3","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1111\/j.1528-1167.2008.01784.x","article-title":"Effect of sleep stage on interictal high-frequency oscillations recorded from depth macroelectrodes in patients with focal epilepsy.","volume":"50","author":"Bagshaw","year":"2009","journal-title":"Epilepsia"},{"key":"B4","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1145\/1007730.1007735","article-title":"A study of the behavior of several methods for balancing machine learning training data.","volume":"6","author":"Batista","year":"2004","journal-title":"SIGKDD Explor."},{"key":"B5","doi-asserted-by":"publisher","first-page":"204","DOI":"10.3978\/j.issn.2223-4292.2015.01.01","article-title":"Quantitative MRI in refractory temporal lobe epilepsy: relationship with surgical outcomes.","volume":"5","author":"Bonilha","year":"2015","journal-title":"Quant. 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