{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T01:13:38Z","timestamp":1785806018538,"version":"3.56.0"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Beta oscillations in sensorimotor structures contribute to the planning, sequencing, and stopping of movements, functions that are typically associated with the role of the basal ganglia. The presence of beta oscillations (13\u201330\u2009Hz) in the cerebellar zone of the thalamus (the ventral intermediate nucleus \u2013 Vim) indicates that this rhythm may also be involved in cerebellar functions such as motor learning and visuomotor adaptation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To investigate the possible role of Vim beta oscillations in visuomotor coordination, we recorded local field potential (LFP) and multiunit activity from the Vim of essential tremor (ET) patients during neurosurgery for the implantation of deep brain stimulation (DBS) electrodes. Using a computer, patients performed a visuomotor adaptation task that required coordinating center-out movements with incongruent visual feedback imposed by inversion of the computer display.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results show that, in ET, Vim beta oscillations of the LFP were lower during the incongruent center-out task than during the congruent orientation. Vim firing rates increased significantly during periods of low beta power, particularly on approach to the peripheral target. In contrast, beta power in the subthalamic nucleus of Parkinson\u2019s disease (PD) patients did not differ significantly between the incongruent and the congruent orientation of the center-out task.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The findings support the hypothesis that beta oscillations of the Vim are modulated by novel visuomotor tasks. The inverse relationship between the power of Vim-LFP beta oscillations and Vim firing rates suggest that the suppression of beta oscillations may facilitate information throughput to the thalamocortical circuit by modulation of Vim firing rates.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnhum.2023.1082196","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T06:11:30Z","timestamp":1682489490000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":11,"title":["Beta band oscillations in the motor thalamus are modulated by visuomotor coordination in essential tremor patients"],"prefix":"10.3389","volume":"17","author":[{"given":"Diellor","family":"Basha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suneil K.","family":"Kalia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojgan","family":"Hodaie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana L.","family":"Lopez Rios","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres M.","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Hutchison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.expneurol.2012.09.021","article-title":"Spatial extent of beta oscillatory activity in and between the subthalamic nucleus and substantia nigra pars reticulata of Parkinson\u2019s disease patients","volume":"245","author":"Alavi","year":"2013","journal-title":"Exp. Neurol."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.clinph.2007.10.017","article-title":"Oscillatory changes related to the forced termination of a movement","volume":"119","author":"Alegre","year":"2008","journal-title":"Clin. Neurophysiol."},{"key":"ref3","first-page":"S7","article-title":"Criteria for the diagnosis of essential tremor","volume":"54","author":"Bain","year":"2000","journal-title":"Neurology"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"782","DOI":"10.1016\/j.expneurol.2014.08.024","article-title":"Beta oscillatory neurons in the motor thalamus of movement disorder and pain patients","volume":"261","author":"Basha","year":"2014","journal-title":"Exp. Neurol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1634","DOI":"10.1152\/jn.2002.88.4.1634","article-title":"Long-range synchronization of gamma and beta oscillations and the plasticity of excitatory and inhibitory synapses: a network model","volume":"88","author":"Bibbig","year":"2002","journal-title":"J. Neurophysiol."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"8452","DOI":"10.1073\/pnas.1000496107","article-title":"The basal ganglia communicate with the cerebellum","volume":"107","author":"Bostan","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1146\/annurev-neuro-062111-150444","article-title":"Mechanisms of gamma oscillations","volume":"35","author":"Buzsaki","year":"2012","journal-title":"Annu. Rev. Neurosci."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1462","DOI":"10.1093\/cercor\/bhj087","article-title":"Effects of human cerebellar thalamus disruption on adaptive control of reaching","volume":"16","author":"Chen","year":"2006","journal-title":"Cereb. Cortex"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"tgaa017","DOI":"10.1093\/texcom\/tgaa017","article-title":"Is there an intrinsic relationship between LFP beta oscillation amplitude and firing rate of individual neurons in macaque motor cortex?","volume":"1","author":"Confais","year":"2020","journal-title":"Cereb. Cortex Commun."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1016\/j.neuron.2015.03.040","article-title":"A corticothalamic switch: controlling the thalamus with dynamic synapses","volume":"86","author":"Crandall","year":"2015","journal-title":"Neuron"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"2033","DOI":"10.1002\/mds.22755","article-title":"Essential tremor\u2013neurodegenerative or nondegenerative disease towards a working definition of ET","volume":"24","author":"Deuschl","year":"2009","journal-title":"Mov. Disord."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/s0028-3932(02)00158-6","article-title":"Distinct contribution of the cortico-striatal and cortico-cerebellar systems to motor skill learning","volume":"41","author":"Doyon","year":"2003","journal-title":"Neuropsychologia"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.conb.2010.02.015","article-title":"Beta-band oscillations\u2013signalling the status quo?","volume":"20","author":"Engel","year":"2010","journal-title":"Curr. Opin. Neurobiol."},{"key":"ref14","first-page":"153","article-title":"The unified parkinson\u2019s disease rating scale","volume-title":"Recent Developments in Parkinson\u2019s Disease, Vol. 2,","author":"Fahn","year":"1987"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"3635","DOI":"10.1093\/brain\/awq267","article-title":"Gait ataxia in essential tremor is differentially modulated by thalamic stimulation","volume":"133","author":"Fasano","year":"2010","journal-title":"Brain"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1550","DOI":"10.1002\/mds.23195","article-title":"Deep brain stimulation for essential tremor: a systematic review","volume":"25","author":"Flora","year":"2010","journal-title":"Mov. Disord."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2715","DOI":"10.1093\/brain\/awu191","article-title":"Encoding of sequence boundaries in the subthalamic nucleus of patients with Parkinson\u2019s disease","volume":"137","author":"Herrojo Ruiz","year":"2014","journal-title":"Brain"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1491","DOI":"10.1038\/nn1544","article-title":"The cerebellum communicates with the basal ganglia","volume":"8","author":"Hoshi","year":"2005","journal-title":"Nat. Neurosci."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1002\/ana.410440407","article-title":"Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson\u2019s disease","volume":"44","author":"Hutchison","year":"1998","journal-title":"Ann. Neurol."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.expneurol.2012.09.014","article-title":"The ups and downs of \u03b2 oscillations in sensorimotor cortex","volume":"245","author":"Kilavik","year":"2013","journal-title":"Exp. Neurol."},{"key":"ref21","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s12311-013-0511-x","article-title":"Consensus paper: the cerebellum\u2019s role in movement and cognition","volume":"13","author":"Koziol","year":"2014","journal-title":"Cerebellum"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"1196","DOI":"10.1093\/brain\/awf128","article-title":"Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson\u2019s disease","volume":"125","author":"Levy","year":"2002","journal-title":"Brain"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"3297","DOI":"10.1093\/brain\/awm266","article-title":"Neuropathological changes in essential tremor: 33 cases compared with 21 controls","volume":"130","author":"Louis","year":"2007","journal-title":"Brain"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1037\/a0031226","article-title":"Cortico-basal ganglia and cortico-cerebellar circuits in Parkinson\u2019s disease: pathophysiology or compensation?","volume":"127","author":"Martinu","year":"2013","journal-title":"Behav. Neurosci."},{"key":"ref25","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/0306-4522(90)90225-S","article-title":"Functional implications of burst firing and single spike activity in lateral geniculate relay neurons","volume":"39","author":"McCormick","year":"1990","journal-title":"Neuroscience"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"3094","DOI":"10.1152\/jn.00881.2004","article-title":"Differences in neuronal firing rates in pallidal and cerebellar receiving areas of thalamus in patients with Parkinson\u2019s disease, essential tremor, and pain","volume":"93","author":"Molnar","year":"2005","journal-title":"J. Neurophysiol."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/j.bandc.2012.12.001","article-title":"Impact of Parkinson\u2019s disease and dopaminergic medication on adaptation to explicit and implicit visuomotor perturbations","volume":"81","author":"Mongeon","year":"2013","journal-title":"Brain Cogn."},{"key":"ref28","doi-asserted-by":"publisher","first-page":"20160194","DOI":"10.1098\/rstb.2016.0194","article-title":"What stops a saccade?","volume":"372","author":"Optican","year":"2017","journal-title":"Phil. Trans. R. Soc. B"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.1152\/jn.1980.44.6.1058","article-title":"Cerebellar-dependent adaptive control of primate saccadic system","volume":"44","author":"Optican","year":"1980","journal-title":"J. Neurophysiol."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.cortex.2014.02.007","article-title":"Distinct spatio-temporal profiles of beta-oscillations within visual and sensorimotor areas during action recognition as revealed by MEG","volume":"54","author":"Pavlidou","year":"2014","journal-title":"Cortex"},{"key":"ref31","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.neuroscience.2010.08.068","article-title":"Parkinsonian impairment correlates with spatially extensive subthalamic oscillatory synchronization","volume":"171","author":"Pogosyan","year":"2010","journal-title":"Neuroscience"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.neuroscience.2014.06.008","article-title":"Changes of motor-cortical oscillations associated with motor learning","volume":"275","author":"Pollok","year":"2014","journal-title":"Neuroscience"},{"key":"ref33","author":"Schaltenbrand","year":"1977"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"988","DOI":"10.1002\/1531-8257(199911)14:6<988::aid-mds1012>3.0.co;2-m","article-title":"Visuomotor performance in patients with essential tremor","volume":"14","author":"Schwartz","year":"1999","journal-title":"Mov. Disord."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1007\/s00221-006-0571-y","article-title":"Bilateral basal ganglia activation associated with sensorimotor adaptation","volume":"175","author":"Seidler","year":"2006","journal-title":"Exp. Brain Res."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"3349","DOI":"10.1111\/ejn.14494","article-title":"Basal ganglia contributions during the learning of a visuomotor rotation: effect of dopamine, deep brain stimulation and reinforcement","volume":"50","author":"Singh","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2278","DOI":"10.1093\/brain\/124.11.2278","article-title":"The gait disorder of advanced essential tremor","volume":"124","author":"Stolze","year":"2001","journal-title":"Brain"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"5678","DOI":"10.1523\/jneurosci.4739-13.2014","article-title":"Dynamic neural correlates of motor error monitoring and adaptation during trial-to-trial learning","volume":"34","author":"Tan","year":"2014","journal-title":"J. Neurosci."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"1516","DOI":"10.1523\/JNEUROSCI.3204-15.2016","article-title":"Post-movement Beta activity in sensorimotor cortex indexes confidence in the estimations from internal models","volume":"36","author":"Tan","year":"2016","journal-title":"J. Neurosci."},{"key":"ref40","first-page":"883","author":"Tasker","year":"1997"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1002\/mds.20729","article-title":"Eye-hand coordination in essential tremor","volume":"21","author":"Trillenberg","year":"2006","journal-title":"Mov. Disord."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1152\/jn.00266.2007","article-title":"Sensory prediction errors drive cerebellum-dependent adaptation of reaching","volume":"98","author":"Tseng","year":"2007","journal-title":"J. Neurophysiol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1212\/wnl.33.6.766","article-title":"Adaptation to lateral displacement of vision in patients with lesions of the central nervous system","volume":"33","author":"Weiner","year":"1983","journal-title":"Neurology"}],"container-title":["Frontiers in Human Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnhum.2023.1082196\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T06:11:33Z","timestamp":1682489493000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnhum.2023.1082196\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,26]]},"references-count":43,"alternative-id":["10.3389\/fnhum.2023.1082196"],"URL":"https:\/\/doi.org\/10.3389\/fnhum.2023.1082196","relation":{},"ISSN":["1662-5161"],"issn-type":[{"value":"1662-5161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,26]]},"article-number":"1082196"}}