{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:10:27Z","timestamp":1753891827282,"version":"3.41.2"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T00:00:00Z","timestamp":1677110400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The Finger Tapping (F-T) test is useful for assessing motor function of the upper limbs in patients with idiopathic normal pressure hydrocephalus (iNPH). However, quantitative evaluation of F-T for iNPH has not yet been established. The purpose of this study was to investigate the usefulness of the quantitative F-T test and optimal measurement conditions as a motor evaluation and screening test for iNPH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen age-matched healthy controls (mean age 73 \u00b1 5 years; 7\/16 male) and fifteen participants with a diagnosis of definitive iNPH (mean age 76 \u00b1 5 years; 8\/15 male) completed the study (mean \u00b1 standard deviation). F-T performance of the index finger and thumb was quantified using a magnetic sensing device. The performance of repetitive F-T by participants was recorded in both not timing-regulated and timing-regulated conditions. The mean value of the maximum amplitude of F-T was defined as M-Amplitude, and the mean value of the maximum velocity of closure of F-T was defined as cl-Velocity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Finger Tapping in the iNPH group, with or without timing control, showed a decrease in M-Amplitude and cl-Velocity compared to the control group. We found the only paced F-T with 2.0 Hz auditory stimuli was found to improve both M-Amplitude and cl-Velocity after shunt surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The quantitative assessment of F-T with auditory stimuli at the rate of 2.0 Hz may be a useful and potentially supplemental screening method for motor assessment in patients with iNPH.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnhum.2023.1109670","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T11:11:49Z","timestamp":1677150709000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Clinical utility of paced finger tapping assessment in idiopathic normal pressure hydrocephalus"],"prefix":"10.3389","volume":"17","author":[{"given":"Yoko","family":"Shimizu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motoki","family":"Tanikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuya","family":"Horiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kento","family":"Sahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"Kawashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Kandori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoyasu","family":"Yamanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Nishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Matsukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshino","family":"Ueki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhito","family":"Mase","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,2,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1589\/jpts.29.1737","article-title":"Change in hand dexterity and habitual gait speed reflects cognitive decline over time in healthy older adults: a longitudinal study.","volume":"29","author":"Abe","year":"2017","journal-title":"J. Phys. Ther. Sci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1056\/NEJM196507152730301","article-title":"Symptomatic occult hydrocephalus with normal cerebrospinal-fluid pressure \u2014 a treatable syndrome.","volume":"273","author":"Adams","year":"1965","journal-title":"N. Engl. J. Med."},{"key":"B3","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1002\/mds.870130308","article-title":"Clinical impairment of sequential finger movements in Parkinson\u2019s disease.","volume":"13","author":"Agostino","year":"1998","journal-title":"Mov. Disord."},{"key":"B4","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.ijpsycho.2016.12.002","article-title":"Apathy and higher level of gait control in normal pressure hydrocephalus.","volume":"119","author":"Allali","year":"2017","journal-title":"Int. J. Psychophysiol."},{"key":"B5","doi-asserted-by":"publisher","DOI":"10.1186\/2045-8118-11-22","article-title":"A computerized neuropsychological test battery designed for idiopathic normal pressure hydrocephalus.","volume":"11","author":"Behrens","year":"2014","journal-title":"Fluids Barriers CNS."},{"key":"B6","doi-asserted-by":"publisher","first-page":"733","DOI":"10.3171\/2018.10.JNS18701","article-title":"The computerized general neuropsychological INPH Test revealed improvement in idiopathic normal pressure hydrocephalus after shunt surgery.","volume":"132","author":"Behrens","year":"2019","journal-title":"J. Neurosurg."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2129","DOI":"10.1002\/mds.22340","article-title":"Movement disorder society-sponsored revision of the unified Parkinson\u2019s disease rating scale (MDS-UPDRS): scale presentation and clinimetric testing results.","volume":"23","author":"Christopher","year":"2008","journal-title":"Mov. Disord."},{"key":"B8","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1007\/BF00201481","article-title":"A neural model of basal ganglia-thalamocortical relations in normal and parkinsonian movement.","volume":"73","author":"Contreras-Vidal","year":"1995","journal-title":"Biol Cybern."},{"key":"B9","doi-asserted-by":"publisher","first-page":"47","DOI":"10.14802\/jmd.19043","article-title":"Comparison of spontaneous motor tempo during finger tapping, toe tapping and stepping on the spot in people with and without Parkinson\u2019s disease.","volume":"13","author":"Dawn","year":"2020","journal-title":"J. Mov. Disord."},{"key":"B10","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1038\/ncpneuro0688","article-title":"Lower-body parkinsonism: reconsidering the threshold for external lumbar drainage.","volume":"4","author":"Espay","year":"2008","journal-title":"Nat. Clin. Pract. Neurol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"2095","DOI":"10.1093\/cercor\/bhw065","article-title":"The right dorsal premotor mosaic: organization, functions, and connectivity.","volume":"27","author":"Genon","year":"2017","journal-title":"Cereb. Cortex."},{"key":"B12","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.cortex.2008.01.005","article-title":"Impairment of beat-based rhythm discrimination in Parkinson\u2019s disease.","volume":"45","author":"Grahn","year":"2009","journal-title":"Cortex."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2932","DOI":"10.1093\/cercor\/bhn053","article-title":"Hemispheric asymmetry of frequency-dependent suppression in the ipsilateral primary motor cortex during finger movement: a functional magnetic resonance imaging study.","volume":"18","author":"Hayashi","year":"2008","journal-title":"Cereb Cortex."},{"key":"B14","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.clineuro.2011.09.014","article-title":"The neuropsychology of iNPH: findings and evaluation of tests in the European multicentre study.","volume":"114","author":"Hellstr\u00f6m","year":"2012","journal-title":"Clin. Neurol. Neurosurg."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2019.00602","article-title":"Impaired motor skill acquisition using mirror visual feedback improved by transcranial direct current stimulation (tDCS) in patients with Parkinson\u2019s disease.","volume":"13","author":"Horiba","year":"2019","journal-title":"Front. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1016\/s0959-4388(96)80037-7","article-title":"The representation of temporal information in perception and motor control.","volume":"6","author":"Ivry","year":"1996","journal-title":"Curr. Opin. Neurobiol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1016\/j.conb.2004.03.013","article-title":"The neural representation of time.","volume":"14","author":"Ivry","year":"2004","journal-title":"Curr. Opin. Neurobiol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"245","DOI":"10.4103\/0972-2327.160057","article-title":"Unusual idiopathic normal pressure hydrocephalus patient with marked asymmetric and upper body parkinsonism.","volume":"19","author":"Kang","year":"2016","journal-title":"Ann. Indian Acad. Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1126\/science.8342027","article-title":"Functional magnetic resonance imaging of motor cortex: hemispheric asymmetry and handedness.","volume":"261","author":"Kim","year":"1993","journal-title":"Science"},{"key":"B20","doi-asserted-by":"publisher","first-page":"165","DOI":"10.3233\/BEN-2009-0233","article-title":"Neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus.","volume":"21","author":"Kito","year":"2009","journal-title":"Behav. Neurol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/mds.870120110","article-title":"Movement disorders in adult hydrocephalus.","volume":"12","author":"Krauss","year":"1997","journal-title":"Mov. Disord."},{"key":"B22","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1159\/000111149","article-title":"Validation of grading scale for evaluating symptoms of idiopathic normal-pressure hydrocephalus.","volume":"25","author":"Kubo","year":"2008","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2904","DOI":"10.1093\/brain\/awn232","article-title":"Idiopathic normal pressure hydrocephalus: increased supplementary motor activity accounts for improvement after CSF drainage.","author":"Lenfeldt","year":"2008","journal-title":"Brain."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2301","DOI":"10.1007\/s00701-017-3301-2","article-title":"Finger tapping and verbal fluency post-tap test improvement in INPH: its value in differential diagnosis and shunt-treatment outcomes prognosis.","volume":"159","author":"Liouta","year":"2017","journal-title":"Acta Neurochir."},{"key":"B25","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1007\/s002210050805","article-title":"Spatiotemporal reorganization of electrical activity in the human brain associated with a timing transition in rhythmic auditory-motor coordination.","volume":"127","author":"Mayville","year":"1999","journal-title":"Exp. Brain Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1016\/j.expneurol.2005.11.003","article-title":"Broadening a classic clinical triad: the hypokinetic motor disorder of normal pressure hydrocephalus also affects the hand.","volume":"198","author":"Nowak","year":"2006","journal-title":"Exp. Neurol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1007\/s00415-006-0086-2","article-title":"CSF drainage ameliorates the motor deficit in normal pressure hydrocephalus: evidence from the analysis of grasping movements.","volume":"253","author":"Nowak","year":"2006","journal-title":"J. Neurol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"279","DOI":"10.3171\/jns.1969.31.3.0279","article-title":"Further experience with the syndrome of \u201cNormal\u201d pressure hydrocephalus.","volume":"31","author":"Ojemann","year":"1969","journal-title":"J. Neurosurg."},{"key":"B29","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1093\/brain\/115.3.875","article-title":"Performance of repetitive wrist movements in Parkinson\u2019s disease.","author":"Pastor","year":"1992","journal-title":"Brain"},{"key":"B30","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/j.1532-5415.1991.tb01616.x","article-title":"The timed \u201cUp & Go\u201d: a test of basic functional mobility for frail elderly persons.","volume":"39","author":"Podsiadlo","year":"1991","journal-title":"J. Am. Geriatr. Soc."},{"journal-title":"The Halstead-Reitan neuropsychological test battery: theory and clinical applications.","year":"1993","author":"Reitan","key":"B31"},{"key":"B32","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1152\/jn.1980.43.1.118","article-title":"Supplementary motor area and other cortical areas in organization of voluntary movements in man.","volume":"43","author":"Roland","year":"1980","journal-title":"J. Neurophysiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1001\/archneur.1986.00520010030016","article-title":"Motor disturbances in normal-pressure hydrocephalus. Special reference to stance and gait.","volume":"43","author":"S\u00f8rensen","year":"1986","journal-title":"Arch. Neurol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/j.bandc.2004.09.010","article-title":"Comparison of patients with Parkinson\u2019s disease or cerebellar lesions in the production of periodic movements involving event-based or emergent timing.","volume":"58","author":"Spencer","year":"2005","journal-title":"Brain Cogn."},{"key":"B35","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.bbr.2016.09.036","article-title":"Altered premotor cortical oscillations during repetitive movement in persons with Parkinson\u2019s disease.","volume":"317","author":"Stegem\u00f6ller","year":"2017","journal-title":"Behav. Brain Res."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1002\/mds.22535","article-title":"Effect of movement frequency on repetitive finger movements in patients with Parkinson\u2019s disease.","volume":"24","author":"Stegem\u00f6ller","year":"2009","journal-title":"Mov. Disord."},{"key":"B37","doi-asserted-by":"publisher","first-page":"3377","DOI":"10.1152\/jn.00281.2002","article-title":"Movement rate effect on activation and functional coupling of motor cortical areas.","volume":"88","author":"Toma","year":"2002","journal-title":"J. Neurophysiol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1016\/j.clineuro.2009.07.017","article-title":"Upper extremity motor measures of tap test response in normal pressure hydrocephalus.","volume":"111","author":"Tsakanikas","year":"2009","journal-title":"Clin. Neurol. Neurosurg."},{"key":"B39","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1097\/PHM.0b013e31815b6461","article-title":"Objective assessment of gait in normal-pressure hydrocephalus.","volume":"87","author":"Williams","year":"2008","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"B40","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.neuroimage.2008.04.025","article-title":"Functional neuroimaging correlates of finger-tapping task variations: an ALE meta-analysis.","volume":"42","author":"Witt","year":"2008","journal-title":"Neuroimage"}],"container-title":["Frontiers in Human Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnhum.2023.1109670\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T11:11:52Z","timestamp":1677150712000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnhum.2023.1109670\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,23]]},"references-count":40,"alternative-id":["10.3389\/fnhum.2023.1109670"],"URL":"https:\/\/doi.org\/10.3389\/fnhum.2023.1109670","relation":{},"ISSN":["1662-5161"],"issn-type":[{"type":"electronic","value":"1662-5161"}],"subject":[],"published":{"date-parts":[[2023,2,23]]},"article-number":"1109670"}}