{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:04:38Z","timestamp":1767373478202,"version":"3.41.2"},"reference-count":82,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Beetroot juice (BRJ) improves peripheral endothelial function and vascular compliance, likely due to increased nitric oxide bioavailability. It is unknown if BRJ alters cerebrovascular function and cardiovagal baroreflex control in healthy individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Purpose<\/jats:title><jats:p>We tested the hypotheses that BRJ consumption improves cerebral autoregulation (CA) and cardiovagal baroreflex sensitivity (cBRS) during lower-body negative pressure (LBNP).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirteen healthy adults (age: 26 \u00b1 4 years; 5 women) performed oscillatory (O-LBNP) and static LBNP (S-LBNP) before (PRE) and 3 h after consuming 500 mL of BRJ (POST). Participants inhaled 3% CO<jats:sub>2<\/jats:sub> (21% O<jats:sub>2<\/jats:sub>, 76% N<jats:sub>2<\/jats:sub>) during a 5 min baseline and throughout LBNP to attenuate reductions in end-tidal CO<jats:sub>2<\/jats:sub> tension (PETCO<jats:sub>2<\/jats:sub>). O-LBNP was conducted at \u223c0.02 Hz for six cycles (\u221270 mmHg), followed by a 3-min recovery before S-LBNP (\u221240 mmHg) for 7 min. Beat-to-beat middle cerebral artery blood velocity (MCAv) (transcranial Doppler) and blood pressure were continuously recorded. CA was assessed using transfer function analysis to calculate coherence, gain, and phase in the very-low-frequency (VLF; 0.020\u20130.070 Hz) and low-frequency bands (LF; 0.07\u20130.20 Hz). cBRS was calculated using the sequence method. Comparisons between POST vs. PRE are reported as mean \u00b1 SD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During O-LBNP, coherence<jats:sub><jats:italic>VLF<\/jats:italic><\/jats:sub> was greater at POST (0.55 \u00b1 0.06 vs. 0.46 \u00b1 0.08; <jats:italic>P<\/jats:italic> &amp;lt; 0.01), but phase<jats:sub><jats:italic>VLF<\/jats:italic><\/jats:sub> (<jats:italic>P<\/jats:italic> = 0.17) and gain<jats:sub><jats:italic>VLF<\/jats:italic><\/jats:sub> (<jats:italic>P<\/jats:italic> = 0.69) were not different. Coherence<jats:sub><jats:italic>LF<\/jats:italic><\/jats:sub> and phase<jats:sub><jats:italic>LF<\/jats:italic><\/jats:sub> were not different, but gain<jats:sub><jats:italic>LF<\/jats:italic><\/jats:sub> was lower at POST (1.03 \u00b1 0.20 vs. 1.12 \u00b1 0.30 cm\/s\/mmHg; <jats:italic>P<\/jats:italic> = 0.05). During S-LBNP, CA was not different in the VLF or LF bands (all <jats:italic>P<\/jats:italic> &amp;gt; 0.10). Up-cBRS and Down-cBRS were not different during both LBNP protocols.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These preliminary data indicate that CA and cBRS during LBNP in healthy, young adults is largely unaffected by an acute bolus of BRJ.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnhum.2023.1115355","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T07:12:41Z","timestamp":1674112361000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Acute beetroot juice consumption does not alter cerebral autoregulation or cardiovagal baroreflex sensitivity during lower-body negative pressure in healthy adults"],"prefix":"10.3389","volume":"17","author":[{"given":"Morgan L.","family":"Worley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emma L.","family":"Reed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher L.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Kueck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Seymour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Triniti","family":"Fitts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hannah","family":"Zazulak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zachary J.","family":"Schlader","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blair D.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1161\/01.str.20.1.45","article-title":"Cerebral autoregulation dynamics in humans.","volume":"20","author":"Aaslid","year":"1989","journal-title":"Stroke. 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