{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T04:24:30Z","timestamp":1790655870644,"version":"4.1.0"},"reference-count":32,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T00:00:00Z","timestamp":1681948800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013076","name":"National Major Science and Technology Projects of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Antisaccade is closely associated with cognitive ability in Alzheimer's disease (AD). However, studies regarding antisaccade in the early stages of AD are scarce. Considering that first-degree family history is a well-established risk factor for AD, we explored the influence of family history on the performance of antisaccade tasks in individuals with normal cognition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 44 participants (aged 50\u201366 years) with a family history of AD (FH+) and 44 age-, gender-, and educational level-matched controls (FH-) were enrolled in our study. After cognitive assessment using the Montreal Cognitive Assessment and Mini-mental State Examination, participants underwent antisaccade trials, and all parameters were recorded using an eye tracker.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>While the average velocity was relatively lower in FH+ individuals than in FH\u2212 individuals (107.9 \u00b1 14.3\u00b0\/s vs. 132.9 \u00b1 23.7\u00b0\/s, <jats:italic>p<\/jats:italic> &amp;lt; 0.001), FH+ individuals surprisingly showed relatively fewer uninhibited reflexive saccades (44.7 \u00b1 26.0% vs. 56.2 \u00b1 24.7%, <jats:italic>p<\/jats:italic> = 0.037) than the control group. They also required a relatively shorter time to detect and correct false saccades (121.6 \u00b1 40.7 ms vs. 143.9 \u00b1 37.0 ms, <jats:italic>p<\/jats:italic> = 0.023).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study showed that family history is associated with alterations in antisaccadic parameters, suggesting that eye tracking can be used to assess oculomotor control and executive function in individuals at risk of developing dementia.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnhum.2023.1143690","type":"journal-article","created":{"date-parts":[[2023,4,20]],"date-time":"2023-04-20T20:09:14Z","timestamp":1682021354000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Antisaccadic eye movements in middle-aged individuals with a family history of Alzheimer's disease"],"prefix":"10.3389","volume":"17","author":[{"given":"Anjiao","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanlin","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingda","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanfeng","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2023,4,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1037\/neu0000222","article-title":"diffusion model analysis of episodic recognition in preclinical individuals with a family history for Alzheimer's disease: The adult children study","volume":"30","author":"Aschenbrenner","year":"2016","journal-title":"Neuropsychology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1982","DOI":"10.1111\/j.1460-9568.2011.07700.x","article-title":"The role of the lateral intraparietal area in orienting attention and its implications for visual search","volume":"33","author":"Bisley","year":"2011","journal-title":"Eur. 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