{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T11:16:07Z","timestamp":1778152567755,"version":"3.51.4"},"reference-count":103,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T00:00:00Z","timestamp":1701302400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:sec><jats:title>Purpose<\/jats:title><jats:p>To explore the regions of aberrant spontaneous brain activity in asthma patients and their potential impacts using the Percent amplitude of fluctuation (PerAF) analysis method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>In this study, a total of 31 bronchial asthma (BA) patients were ultimately included, comprising 17 males and 14 females. Subsequently, 31 healthy control subjects (HCS) were recruited, consisting of 17 males and 14 females, and they were matched with the BA group based on age, sex, and educational status. The PerAF analysis technique was employed to study the differences in spontaneous brain activity between the two groups. The SPM12 toolkit was used to carry out a two sample <jats:italic>t<\/jats:italic>-test on the collected fMRI data, in order to examine the differences in PerAF values between the asthma patients and the healthy controls. We employed the Montreal Cognitive Assessment (MoCA) scale and the Hamilton Depression Scale (HAMD) to evaluate the cognitive and emotional states of the two groups. Pearson correlation analysis was utilized to ascertain the relationship between changes in the PerAF values within specific brain regions and cognitive as well as emotional conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the healthy control group, areas of the brain with reduced PerAF in asthma patients included the inferior cerebellum, fusiform gyrus, right inferior orbital frontal gyrus, left middle orbital frontal gyrus, left\/right middle frontal gyrus (MFG), dorsal lateral superior frontal gyrus (SFGdl), left superior temporal gyrus (STG), precuneus, right inferior parietal lobule (IPL), and left\/right angular gyrus. BA patients exhibit mild cognitive impairments and a propensity for emotional disturbances. Furthermore, the perAF values of the SFGdl region are significantly positively correlated with the results of the MoCA cognitive assessment, while negatively correlated with the HAMD evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Through the application of PerAF analysis methods, we discovered that several brain regions in asthma patients that control the amplitude of respiration, vision, memory, language, attention, and emotional control display abnormal changes in intrinsic brain activity. This helps characterize the neural mechanisms behind cognitive, sensory, and motor function impairments in asthma patients, providing valuable insights for potential therapeutic targets and disease management strategies.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnhum.2023.1228541","type":"journal-article","created":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T07:01:25Z","timestamp":1701327685000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":6,"title":["Investigation of altered spontaneous brain activity in patients with bronchial asthma using the percent amplitude of fluctuation method: a resting-state functional MRI study"],"prefix":"10.3389","volume":"17","author":[{"given":"Tao","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-xue","family":"Dai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kang-min","family":"Zhan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,30]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1007\/s00429-012-0440-3","article-title":"Superior temporal gyrus thickness correlates with cognitive performance in multiple sclerosis.","volume":"218","author":"Achiron","year":"2013","journal-title":"Brain Struct. 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CNS Disord."},{"key":"B6","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1017\/S1092852919001810","article-title":"Analysis of the superior temporal gyrus as a possible biomarker in schizophrenia using voxel-based morphometry of the brain magnetic resonance imaging: a comprehensive review.","volume":"26","author":"Bandeira","year":"2021","journal-title":"CNS Spectrums"},{"key":"B7","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.neuropsychologia.2016.10.003","article-title":"The role of the left inferior parietal lobule in second language learning: An intensive language training fMRI study.","volume":"98","author":"Barbeau","year":"2017","journal-title":"Neuropsychologia"},{"key":"B8","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/978-3-319-40764-7_16","article-title":"Prenatal Systemic Hypoxia-Ischemia and Oligodendroglia Loss in Cerebellum.","volume":"949","author":"Barradas","year":"2016","journal-title":"Adv. Exp. Med. 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Disord."},{"key":"B12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000336495","article-title":"The brain and asthma: what are the linkages?","volume":"98","author":"Busse","year":"2012","journal-title":"Chem. Immunol. Allergy"},{"key":"B13","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.jaip.2017.05.001","article-title":"Asthma Exacerbations: Pathogenesis, Prevention, and Treatment.","volume":"5","author":"Castillo","year":"2017","journal-title":"J. Allergy Clin. Immunol. Pract."},{"key":"B14","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: a review of its functional anatomy and behavioural correlates.","volume":"129","author":"Cavanna","year":"2006","journal-title":"Brain"},{"key":"B15","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s11682-015-9403-7","article-title":"Reduced cortical thickness, surface area in patients with chronic obstructive pulmonary disease: a surface-based morphometry and neuropsychological study.","volume":"10","author":"Chen","year":"2016","journal-title":"Brain Imaging Behav."},{"key":"B16","doi-asserted-by":"crossref","first-page":"e285","DOI":"10.1111\/jgs.14530","article-title":"Validation of the Chinese Version of Montreal Cognitive Assessment Basic for Screening Mild Cognitive Impairment.","volume":"64","author":"Chen","year":"2016","journal-title":"J. Am. Geriatr. 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A meta-analytic review.","volume":"39","author":"Irani","year":"2017","journal-title":"J. Clin. Exp. Neuropsychology"},{"key":"B35","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2015.00023","article-title":"A role of right middle frontal gyrus in reorienting of attention: a case study.","volume":"9","author":"Japee","year":"2015","journal-title":"Front. Syst. 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Asthma"},{"key":"B39","doi-asserted-by":"crossref","first-page":"8877","DOI":"10.1523\/JNEUROSCI.2063-07.2007","article-title":"Failure to regulate: counterproductive recruitment of top-down prefrontal-subcortical circuitry in major depression.","volume":"27","author":"Johnstone","year":"2007","journal-title":"J. Neurosci."},{"key":"B40","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.757","article-title":"Recruitment of orbitofrontal cortex during unpredictable threat among adults at risk for affective disorders.","volume":"7","author":"Kirlic","year":"2017","journal-title":"Brain Behav."},{"key":"B41","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1002\/aur.2558","article-title":"Association of adverse childhood experiences and precuneus volume with intrusive reexperiencing in autism spectrum disorder.","volume":"14","author":"Kitamura","year":"2021","journal-title":"Autism Res."},{"key":"B42","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.1002\/hbm.20791","article-title":"Contingency learning in human fear conditioning involves the ventral striatum.","volume":"30","author":"Klucken","year":"2009","journal-title":"Hum. Brain Mapp."},{"key":"B43","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1523\/JNEUROSCI.0433-03.2004","article-title":"Neural substrates mediating human delay and trace fear conditioning.","volume":"24","author":"Knight","year":"2004","journal-title":"J. Neurosci."},{"key":"B44","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/B978-0-444-63956-1.00008-4","article-title":"The neuropathology of the adult cerebellum.","volume":"154","author":"Koeppen","year":"2018","journal-title":"Handb. Clin. Neurol."},{"key":"B45","first-page":"186","article-title":"Right Fusiform Gyrus Infarct with Acute Prosopagnosia.","volume":"31","author":"Koh","year":"2022","journal-title":"Acta Neurol. Taiwan."},{"key":"B46","article-title":"Asthma, the central nervous system, and neurocognition: Current findings, potential mechanisms, and treatment implications.","volume":"146","author":"Kroll","year":"2023","journal-title":"Neurosci. Biobehav. Revi."},{"key":"B47","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.nicl.2018.04.012","article-title":"Hippocampal metabolites in asthma and their implications for cognitive function.","volume":"19","author":"Kroll","year":"2018","journal-title":"NeuroImage Clin."},{"key":"B48","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2020.110234","article-title":"Fronto-limbic neuroimaging biomarkers for diagnosis and prediction of treatment responses in major depressive disorder.","volume":"107","author":"Lai","year":"2021","journal-title":"Prog. Neuro-psychopharmacol. Biol. Psychiatry"},{"key":"B49","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.pnpbp.2007.06.030","article-title":"The neural substrates of affective processing toward positive and negative affective pictures in patients with major depressive disorder.","volume":"31","author":"Lee","year":"2007","journal-title":"Prog. Neuro-psychopharmacol. Biol. 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Immunol."},{"key":"B61","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1111\/bpa.12331","article-title":"Pathophysiology of Hypoperfusion of the Precuneus in Early Alzheimer\u2019s Disease.","volume":"26","author":"Miners","year":"2016","journal-title":"Brain Pathol."},{"key":"B62","article-title":"Asthma amplifies dementia risk: Evidence from CSF biomarkers and cognitive decline.","volume":"8","author":"Nair","year":"2022","journal-title":"Alzheimers Dement."},{"key":"B63","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/pcn.12195","article-title":"Neurobiological model of obsessive-compulsive disorder: evidence from recent neuropsychological and neuroimaging findings.","volume":"68","author":"Nakao","year":"2014","journal-title":"Psychiatry Clin. 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Pharmacol."},{"key":"B71","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.anai.2020.08.022","article-title":"Association between cognitive function and asthma in adults.","volume":"126","author":"Rhyou","year":"2021","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"B72","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1080\/14734220410017941","article-title":"Nitric oxide in the rat cerebellum after hypoxia\/ischemia.","volume":"3","author":"Rodrigo","year":"2004","journal-title":"Cerebellum"},{"key":"B73","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.neuropsychologia.2017.09.021","article-title":"The orbitofrontal cortex and emotion in health and disease, including depression.","volume":"128","author":"Rolls","year":"2019","journal-title":"Neuropsychologia"},{"key":"B74","doi-asserted-by":"crossref","DOI":"10.1016\/j.heares.2022.108595","article-title":"Neuroanatomical alterations in middle frontal gyrus and the precuneus related to tinnitus and tinnitus distress.","volume":"424","author":"Rosemann","year":"2022","journal-title":"Hear. Res."},{"key":"B75","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040921","article-title":"Are there neurophenotypes for asthma? 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