{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:07:09Z","timestamp":1753891629737,"version":"3.41.2"},"reference-count":79,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:p>Our understanding of the organization of the frontal cortex can be traced back to the experimental studies in the late 1800s by Fritsch and Hitzig on the frontal cortex of dogs and the frontal cortex of monkeys by Ferrier. These studies and many other studies that followed focused on motor functions, but halfway through the 20th century, very little was understood about the role of the frontal lobe in the control of other functions, and it was generally thought that the frontal lobe did not play a significant role in cognition. One result was that studies of cortical functions in cognition were carried out largely on parietal and temporal cortical regions with surprisingly little interest in the frontal lobe. The first systematic studies of the effects of prefrontal lesions on non-human primates began around 1950, especially by Rosvold and Mishkin in the Laboratory of Psychology at the National Institute of Mental Health (NIMH) in the United States. With her background in development, Pat Goldman joined this laboratory in 1965 and began an examination of the effects of prefrontal lobectomy on behavior in infant rhesus monkeys, both during development and later as the animals grew into adulthood. Her developmental studies were groundbreaking as they demonstrated that the effects of early prefrontal lesions varied with precise age (including prenatal), precise lesion location, behaviors measured, and age at assessment. She also began in parallel extensive studies of the role of the prefrontal cortex for a range of functions (especially working memory) in adult monkeys, which led to an examination of factors that influenced functional outcomes after injury or disease. This research was critical in helping to identify the significant role of the prefrontal cortex in cognition in both normal brains and neurological diseases such as schizophrenia. Her pioneering study demonstrating the role of the prefrontal cortex in cognition led to a remarkable increase in the number of researchers studying prefrontal functions in both non-human primates and rodents. This review will chronicle the key findings in her 35<jats:sup>+<\/jats:sup> years studying the prefrontal cortex and illustrate the course she set for generations to follow.<\/jats:p>","DOI":"10.3389\/fnhum.2023.1334264","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T11:07:31Z","timestamp":1706526451000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["Patricia Goldman-Rakic: a pioneer and leader in frontal lobe research"],"prefix":"10.3389","volume":"17","author":[{"given":"Bryan","family":"Kolb","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,1,29]]},"reference":[{"key":"ref1","unstructured":"Comparative anatomy of the frontal cortex and anatomical connections372396\n            AkertK.\n          \n            WarrenJ. M.\n            AkertK.\n          New YorkMcGraw-Hill1964"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1944","DOI":"10.1126\/science.132.3444.1944","article-title":"Learned behavior of rhesus monkeys following bilateral prefrontal lobotomy","volume":"132","author":"Akert","year":"1960","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1016\/0006-8993(78)90566-8","article-title":"Functional development of the dorsolateral prefrontal cortex: an analysis utilizing reversible cryogenic depression","volume":"143","author":"Alexander","year":"1978","journal-title":"Brain Res."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"2269","DOI":"10.1093\/cercor\/bht195","article-title":"The neurobiology of thought: the groundbreaking discoveries of Patricia Goldman-Rakic 1937\u20132003","volume":"23","author":"Arnsten","year":"2013","journal-title":"Cereb. Cortex"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"8089","DOI":"10.1093\/cercor\/bhad159","article-title":"Retrospective: Patricia S. Goldman-Rakic, pioneer in neuroscience and co-founder of the journal, cerebral cortex","volume":"33","author":"Arnsten","year":"2023","journal-title":"Cereb. Cortex"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1007\/BF02245056","article-title":"Dopamine D1 receptor mechanisms in the cognitive performance of young adult and aged monkeys","volume":"116","author":"Arnsten","year":"1994","journal-title":"Psychopharmacology"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1016\/j.neuroscience.2015.06.028","article-title":"The neuropathology of schizophrenia: a selective review of past studies and emerging themes in brain structure and cytoarchitecture","volume":"303","author":"Bakshshi","year":"2015","journal-title":"Neuroscience"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/0028-3932(90)90084-2","article-title":"The effects of developmental factors on IQ in hemiplegic children","volume":"28","author":"Banich","year":"1990","journal-title":"Neuropsychologia"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1002\/cne.902730109","article-title":"Regional and laminar distribution of the dopamine and serotonin innervation in the macaque cerebral cortex: a radioautographic study","volume":"273","author":"Berger","year":"1988","journal-title":"J. Comp. Neurol."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1037\/h0028160","article-title":"Posterior neodecortication in the rat: age at operation and experience","volume":"69","author":"Bland","year":"1969","journal-title":"J. Comp. Physiol. Psychol."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1126\/science.112679","article-title":"Cognitive deficit caused by regional depletion of dopamine in prefrontal cortex of rhesus monkey","volume":"205","author":"Brozoski","year":"1979","journal-title":"Science"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"1446","DOI":"10.1523\/JNEUROSCI.3987-03.2004","article-title":"Enhancement of working memory in aged monkeys by a sensitizing regimen of dopamine D1 receptor stimulation","volume":"24","author":"Castner","year":"2004","journal-title":"J. Neurosci."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"CD008016","DOI":"10.1002\/14651858.CD008016.pub3","article-title":"Maintenance treatment with antipsychotic drugs for schizophrenia","volume":"8","author":"Ceraso","year":"2020","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.ibneur.2023.03.008","article-title":"Investigating the symptomatic and morphological changes in the brain based on pre and post-treatment: a critical review from clinical to neuroimaging studies on schizophrenia","volume":"14","author":"Chatterjee","year":"2023","journal-title":"IBRO Neurosci. Rep."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/cne.901430306","article-title":"Survival of pattern vision after removal of the striate cortex in the adult cat","volume":"143","author":"Doty","year":"1971","journal-title":"J. Comp. Neurol."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1016\/j.biopsych.2008.07.029","article-title":"Impairment of working memory maintenance and response in schizophrenia: functional magnetic resonance imaging evidence","volume":"64","author":"Driesen","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1152\/jn.1989.61.2.331","article-title":"Mnemonic coding of visual space in the monkey\u2019s dorsolateral prefrontal cortex","volume":"61","author":"Funahashi","year":"1989","journal-title":"J. Neurophysiol."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1152\/jn.1990.63.4.814","article-title":"Visuo-spatial coding in primate prefrontal neurons revealed by oculomotor paradigms","volume":"63","author":"Funahashi","year":"1990","journal-title":"J. Neurophysiol."},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.1523\/JNEUROSCI.13-04-01479.1993","article-title":"Dorsolateral prefrontal lesions and oculomotor delayed-response performance: evidence for mnemonic \"scotomas\"","volume":"13","author":"Funahashi","year":"","journal-title":"J. Neurosci."},{"key":"ref20","doi-asserted-by":"publisher","first-page":"753","DOI":"10.1038\/365753a0","article-title":"Prefrontal neuronal activity in rhesus monkeys performing a delayed anti-saccade task","volume":"365","author":"Funahashi","year":"","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"652","DOI":"10.1126\/science.173.3997.652","article-title":"Neuron activity related to short-term memory","volume":"173","author":"Fuster","year":"1971","journal-title":"Science"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1002\/cne.902770204","article-title":"Mediodorsal nucleus: areal, laminar, and tangential distribution of afferents and efferents in the frontal lobe of rhesus monkeys","volume":"277","author":"Giguere","year":"1988","journal-title":"J. Comp. Neurol."},{"key":"ref23","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1001\/archpsyc.57.1.65","article-title":"Decreased dendritic spine density on prefrontal cortical pyramidal neurons in schizophrenia","volume":"57","author":"Glantz","year":"2000","journal-title":"Arch. Gen. Psychiatry"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1016\/0003-3472(65)90103-X","article-title":"Conditioned emotionality in the rat as a function of stress in infancy","volume":"13","author":"Goldman","year":"1965","journal-title":"Anim. Behav."},{"key":"ref25","first-page":"495","article-title":"Developmental determinants of cortical plasticity","volume":"32","author":"Goldman","year":"1972","journal-title":"Acta Neurobiol. Exp."},{"key":"ref26","first-page":"149","article-title":"An alternative to developmental plasticity: heterology of CNS structures in infants and adults","volume-title":"Plasticity and recovery of function in the central nervous system","author":"Goldman","year":"1974"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1038\/267613a0","article-title":"Maturation of prefrontal cortex in the monkey revealed by local reversible cryogenic depression","volume":"267","author":"Goldman","year":"1977","journal-title":"Nature"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1016\/0006-8993(78)91103-4","article-title":"Prenatal removal of frontal association cortex in the fetal rhesus monkey: anatomical and functional consequences in postnatal life","volume":"152","author":"Goldman","year":"1978","journal-title":"Brain Res."},{"key":"ref29","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/0006-8993(77)90453-X","article-title":"Columnar distribution of cortico-cortical fibers in the frontal association, limbic, and motor cortex of the developing rhesus monkey","volume":"122","author":"Goldman","year":"1977","journal-title":"Brain Res."},{"key":"ref30","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/0014-4886(70)90222-0","article-title":"Localization of function within the dorsolateral prefrontal cortex of the rhesus monkey","volume":"27","author":"Goldman","year":"1970","journal-title":"Exp. Neurol."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1037\/h0028701","article-title":"Evidence for behavioral impairment following prefrontal lobectomy in infant monkeys","volume":"70","author":"Goldman","year":"","journal-title":"J. Comp. Physiol. Psychol."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/0014-4886(70)90053-1","article-title":"Selective sparing of function following prefrontal lobectomy in infant monkeys","volume":"29","author":"Goldman","year":"","journal-title":"Exp. Neurol."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1037\/h0031649","article-title":"Analysis of the delayed-alternation deficit produced by dorsolateral prefrontal lesions in the rhesus monkey","volume":"77","author":"Goldman","year":"1971","journal-title":"J. Comp. Physiol. Psychol."},{"key":"ref34","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/0003-3472(67)90058-9","article-title":"Behaviour modification in infant rats","volume":"15","author":"Goldman","year":"1967","journal-title":"Anim. Behav."},{"key":"ref35","first-page":"373","article-title":"Circuitry of the primate prefrontal cortex and the regulation of behavior by representational memory","volume-title":"Handbook of physiology, the nervous system, higher functions of the brain","author":"Goldman-Rakic","year":"1987"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1176\/jnp.6.4.348","article-title":"Working memory dysfunction in schizophrenia","volume":"6","author":"Goldman-Rakic","year":"1994","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1016\/0896-6273(95)90304-6","article-title":"Cellular basis of working memory","volume":"14","author":"Goldman-Rakic","year":"1995","journal-title":"Neuron"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1002\/cne.902420406","article-title":"The primate mediodorsal (MD) nucleus and its projection to the frontal lobe","volume":"242","author":"Goldman-Rakic","year":"1985","journal-title":"J. Comp. Neurol."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1093\/schbul\/23.3.437","article-title":"Functional and anatomical aspects of prefrontal pathology in schizophrenia","volume":"23","author":"Goldman-Rakic","year":"1997","journal-title":"Schizophr. Bull."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"453","DOI":"10.1016\/0014-4886(62)90057-2","article-title":"Evidence for dissociation of impairment on auditory discrimination and delayed response following lateral frontal lesions in monkeys","volume":"5","author":"Gross","year":"1962","journal-title":"Exp. Neurol."},{"key":"ref42","first-page":"126","article-title":"The effects of bilateral lesions of prefrontal cortex on the learned behavior of neonatal, infant, and preadolescent monkeys","volume-title":"The frontal granular cortex and behavior","author":"Harlow","year":"1964"},{"key":"ref43","first-page":"79","volume-title":"The neuropsychology of development","author":"Harlow","year":"1968"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1001\/archneurpsyc.1945.02300070020002","article-title":"Man\u2019s frontal lobes: a critical review","volume":"54","author":"Hebb","year":"1945","journal-title":"Arch. Neurol. Psychiatr."},{"key":"ref9001","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/0014-4886(70)90069-5","article-title":"Motor-sensory and visual behavior after hemispherectomy in newborn and adult rats","volume":"29","author":"Hicks","year":"1970","journal-title":"Exp. Neurol."},{"key":"ref45","first-page":"1","article-title":"Studies of cerebral function in primates","volume":"13","author":"Jacobsen","year":"1935","journal-title":"Comp. Psychol. Monogr."},{"key":"ref46","first-page":"1","article-title":"Studies of cerebral function in primates. I. The functions of the frontal association areas in monkeys","volume":"13","author":"Jacobsen","year":"1936","journal-title":"Comp. Psychol. Monogr."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/S0140-6736(76)90890-4","article-title":"Cerebral ventricular size and cognitive impairment in chronic schizophrenia","volume":"2","author":"Johnstone","year":"1976","journal-title":"Lancet"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1001\/archneurpsyc.1942.02290080073002","article-title":"Cortical reorganization of motor function: studies on series of monkeys of various ages from infancy to maturity","volume":"48","author":"Kennard","year":"1942","journal-title":"Arch. Neurol. Psychiatr."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/0006-8993(67)90056-X","article-title":"The effects of combined lesions of frontal granular cortex and caudate nucleus in the neonatal monkey","volume":"6","author":"Kling","year":"1967","journal-title":"Brain Res."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1016\/0006-8993(94)91641-1","article-title":"Neonatal frontal cortical lesions in rats alter cortical structure and connectivity","volume":"645","author":"Kolb","year":"1994","journal-title":"Brain Res."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1126\/science.935872","article-title":"Functional development of the prefrontal cortex in rats continues into adolescence","volume":"193","author":"Kolb","year":"1976","journal-title":"Science"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/0006-8993(78)90956-3","article-title":"Sparing of function in rats with early prefrontal cortex lesions","volume":"151","author":"Kolb","year":"1978","journal-title":"Brain Res."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1037\/0735-7044.99.4.691","article-title":"Neonatal frontal lesions in hamsters impair species-typical behaviors and reduce brain weight and cortical thickness","volume":"99","author":"Kolb","year":"1985","journal-title":"Behav. Neurosci."},{"volume-title":"Fundamentals of human neuropsychology","year":"2020","author":"Kolb","key":"ref9002"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1152\/jn.1971.34.3.337","article-title":"Prefrontal cortical unit activity and delayed alternation performance in monkeys","volume":"34","author":"Kubota","year":"1971","journal-title":"J. Neurophysiol."},{"key":"ref55","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0006-8993(69)90003-1","article-title":"The prefrontal cortex of the rat. I. Cortical projection of the mediodorsal nucleus. II. Efferent connections","volume":"12","author":"Leonard","year":"1969","journal-title":"Brain Res."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"8690","DOI":"10.1073\/pnas.91.18.8690","article-title":"Functional magnetic resonance imaging of human prefreontal cortrex activation during a spatial working memory task","volume":"91","author":"McCarthy","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"600","DOI":"10.1093\/cercor\/6.4.600","article-title":"Activation of human prefrontal cortrex during spatial and nonspatial working memory tasks measured by functional MRI","volume":"6","author":"McCarthy","year":"1996","journal-title":"Cereb. Cortex"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1002\/wps.20693","article-title":"Dopamine and glutamate in schizophrenia: biology, symptoms, and treatment","volume":"19","author":"McCutcheon","year":"2020","journal-title":"World Psychiatry"},{"key":"ref59","first-page":"397","article-title":"Some efferent connections of the prefrontal cortex of the monkey","volume-title":"The frontal granular cortex and behavior","author":"Nauta","year":"1964"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1162\/jocn.1995.7.1.1","article-title":"Do rats have a prefrontal cortex? The Rose\u2013Woolsey\u2013Akert program reconsidered","volume":"7","author":"Preuss","year":"1995","journal-title":"J. Cogn. Neurosci."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"e1003","DOI":"10.1038\/tp.2016.257","article-title":"Putative presynaptic pr4synaptic dopamine dysregulation in schizophrenia is supported by molecular evidence from post-mortem human midbrain","volume":"7","author":"Purves-Tyson","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"ref9003","first-page":"210","article-title":"The orbitofrontal cortex and its connections with the mediodorsal nucleus in rabbit, sheep and cat","volume":"27","author":"Rose","year":"1948","journal-title":"Res. Publ. Assoc. Res. Nerv. Ment. Dis."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1037\/h0043331","article-title":"The effect of frontal lobe damage on delayed response performance in chimpanzees","volume":"54","author":"Rosvold","year":"1961","journal-title":"J. Comp. Physiol. Psychol."},{"key":"ref63","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1152\/jn.1994.71.2.515","article-title":"The role of D1-dopamine receptors in working memory: local injections of dopamine antagonists into the prefrontal cortex of rhesus monkeys performing an oculomotor delayed response task","volume":"71","author":"Sawaguchi","year":"1994","journal-title":"J. Neurophysiol."},{"key":"ref9004","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000124348","article-title":"Early lesions of superior colliculus: factors affecting the formation of abnormal retinal projections","volume":"8","author":"Schneider","year":"1973","journal-title":"Brain. Behav. Evol."},{"key":"ref9005","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/cne.903070113","article-title":"Prenatal specification of callosal connections in rhesus monkey","volume":"307","author":"Schwartz","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1523\/JNEUROSCI.05-03-00776.1985","article-title":"Longitudinal topography and interdigitation of corticostriatal projections in the rhesus monkey","volume":"5","author":"Selemon","year":"1985","journal-title":"J. Neurosci."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"4049","DOI":"10.1523\/JNEUROSCI.08-11-04049.1988","article-title":"Common cortical and subcortical targets of the dorsolateral prefrontal and posterior parietal cortices in the rhesus monkey: evidence for a distributed neural network subserving spatially guided behavior","volume":"8","author":"Selemon","year":"1988","journal-title":"J. Neurosci."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1016\/S0006-3223(98)00281-9","article-title":"The reduced neuropil hypothesis: a circuit based model of schizophrenia","volume":"45","author":"Selemon","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1002\/(SICI)1096-9861(19980316)392:3<402::AID-CNE9>3.0.CO;2-5","article-title":"Elevated neuronal density in prefrontal area 46 in brains from schizophrenic patients: application of a three-dimensional, stereologic counting method","volume":"392","author":"Selemon","year":"1998","journal-title":"J. Comp. Neurol."},{"key":"ref68","first-page":"410","article-title":"The riddle of frontal lobe function in man","volume-title":"The frontal granular cortex and behavior","author":"Teuber","year":"1964"},{"key":"ref69","article-title":"Recovery of function after brain damage in man","volume-title":"Outcome of severe damage to the nervous system","author":"Teuber","year":"1975"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.tics.2019.05.009","article-title":"Lesion studies in contemporary neuroscience","volume":"23","author":"Vaidya","year":"2019","journal-title":"Trends Cogn. Sci."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/0166-4328(93)90063-V","article-title":"Neurological and behavioral effects of a unilateral frontal cortical lesion in fetal kittens, II. Visual system tests and proposing a \u2018critical period\u2019 for lesion effects","volume":"57","author":"Villablanca","year":"1993","journal-title":"Behav. Brain Res."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1016\/0014-4886(78)90028-6","article-title":"Effects of caudate nuclei or frontal cortical ablations in kittens: neurology and gross behavior","volume":"61","author":"Villablanca","year":"1978","journal-title":"Exp. Neurol."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"633","DOI":"10.1038\/s44220-023-00110-3","article-title":"Neuroimaging and multiomics reveal cross-scale circuit abnormalities in schizophrenia","volume":"1","author":"Wang","year":"2023","journal-title":"Nat. Ment. 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