{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T07:46:18Z","timestamp":1771919178354,"version":"3.50.1"},"reference-count":54,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T00:00:00Z","timestamp":1713830400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aims to investigate the influence of the cerebellum on visual selective attention function and its neuromodulatory mechanism in patients with multiple lacunar cerebral infarction (MLCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis was conducted on 210 patients admitted with MLCI from January 2016 to May 2022. Analyzed the electrophysiological characteristics of the P3a and P3b components of vision in both groups, as well as source reconstruction simulations of dipole activation in the brains of the two groups, and analyzed the brain regions with differences in activation strength between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>This study found that there was no significant difference in peak amplitude between the two groups, but compared with the control group, the peak latency of the case group was significantly prolonged. Specifically, the P3a peak latency induced by the novel stimulus was longer than that induced by the target stimulus P3b peak latency. Source reconstruction results showed decreased and increased activation in several brain regions in the case group compared to the control group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study suggests that the impairment of distracted attention capture is more pronounced in patients with MLCI. The cerebellum indirectly influences the ventral and dorsal frontoparietal attention networks by modulating the levels of excitation and inhibition within the cerebral cortex of the attention network. This may represent a potential mechanism through which the cerebellum regulates visual selective attention information in MLCI patients.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnhum.2024.1380739","type":"journal-article","created":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T04:27:53Z","timestamp":1713846473000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":2,"title":["The influence of cerebellum on visual selective attention in patients with multiple lacunar cerebral infarction and its neuromodulatory mechanisms"],"prefix":"10.3389","volume":"18","author":[{"given":"Xiaodong","family":"Yuan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liqin","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qirong","family":"Ling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingyun","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongchun","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingshu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2024,4,23]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","DOI":"10.1186\/s40673-017-0071-9","article-title":"Cognitive impairment in cerebellar lesions: A logit model based on neuropsychological testing.","volume":"4","author":"Bolcekova","year":"2017","journal-title":"Cereb. Ataxias"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1723","DOI":"10.1111\/ejn.15975","article-title":"A frontoparietal network for volitional control of gaze following.","volume":"57","author":"Breu","year":"2023","journal-title":"Eur. J. Neurosci"},{"key":"B3","doi-asserted-by":"publisher","first-page":"14470","DOI":"10.16281\/j.cnki.jocml.2017.74.007","article-title":"Multiple lacunar cerebral infarction and cognitive function in early clinical correlation with P300.","volume":"4","author":"Cao","year":"2017","journal-title":"J. Clin. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"1740","DOI":"10.1001\/jama.288.14.1740","article-title":"Developmental trajectories of brain volume abnormalities in children and adolescents with attention-deficit\/hyperactivity disorder.","volume":"288","author":"Castellanos","year":"2002","journal-title":"J. Am. Med. Assoc"},{"key":"B5","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1093\/brain\/awl004","article-title":"The precuneus: A review of its functional anatomy and behavioural correlates.","volume":"129","author":"Cavanna","year":"2006","journal-title":"Brain"},{"key":"B6","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/1460-6984.12781","article-title":"Neuropsychological correlates of P300 parameters in individuals with aphasia.","volume":"58","author":"Choinski","year":"2023","journal-title":"Int. J. Lang. Comm. Dis"},{"key":"B7","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/nrn755","article-title":"Control of goal-directed and stimulus-driven attention in the brain.","volume":"3","author":"Corbetta","year":"2002","journal-title":"Nat. Rev. Neurosci"},{"key":"B8","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/s10548-020-00752-x","article-title":"Transcranial alternating current stimulation (tACS) as a tool to modulate P300 amplitude in attention deficit hyperactivity disorder (ADHD): Preliminary findings.","volume":"33","author":"Dallmer-Zerbe","year":"2020","journal-title":"Brain Topogr"},{"key":"B9","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.36781","article-title":"Cerebellar involvement in an evidence-accumulation decision-making task.","volume":"7","author":"Deverett","year":"2018","journal-title":"Elife"},{"key":"B10","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.nicl.2018.04.035","article-title":"Neural correlates of cognitive function and symptoms in attention-deficit\/hyperactivity disorder in adults.","volume":"19","author":"Duan","year":"2018","journal-title":"Neuroimage Clin"},{"key":"B11","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2021.136252","article-title":"The assessment of cognitive functions in patients with isolated cerebellar infarctions: A follow-up study.","volume":"765","author":"Erdal","year":"2021","journal-title":"Neurosci. Lett"},{"key":"B12","author":"Fogwe","year":"2023","journal-title":"Neuroanatomy, Hippocampus."},{"key":"B13","doi-asserted-by":"publisher","first-page":"702","DOI":"10.1016\/s1388-2457(02)00030-5","article-title":"A standardized boundary element, method volume conductor model.","volume":"113","author":"Fuchs","year":"2002","journal-title":"Clin. Neurophysiol"},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2021.106690","article-title":"Cognitive impairment and affective disorder: A rare presentation of cerebellar stroke.","volume":"206","author":"Gok-Dursun","year":"2021","journal-title":"Clin. Neurol Neurosur"},{"key":"B15","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1016\/j.neuropsychologia.2016.07.011","article-title":"The medial temporal lobe supports sensing-based visual working memory.","volume":"89","author":"Goodrich","year":"2016","journal-title":"Neuropsychologia"},{"key":"B16","author":"Gore","year":"2023","journal-title":"Lacunar Stroke."},{"key":"B17","doi-asserted-by":"publisher","first-page":"610","DOI":"10.3760\/cma.j.issn.0254-1424.2022.07.008","article-title":"The value of event-related potential P300 for diagnosing cognitive impairment after stroke.","volume":"44","author":"Guo","year":"2022","journal-title":"Chin. J. Phys. Med. Rehabil."},{"key":"B18","doi-asserted-by":"publisher","first-page":"543","DOI":"10.1016\/B978-0-444-64032-1.00036-9","article-title":"Cognitive neurophysiology: Event-related potentials.","volume":"160","author":"Helfrich","year":"2019","journal-title":"Handb. Clin. Neurol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"304","DOI":"10.1038\/nrn2332","article-title":"Control of mental activities by internal models in the cerebellum.","volume":"9","author":"Ito","year":"2008","journal-title":"Nat. Rev. Neurosci"},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2023.148635","article-title":"Effects of brain atrophy and altered functional connectivity on poststroke cognitive impairment.","volume":"1822","author":"Jia","year":"2024","journal-title":"Brain Res"},{"key":"B21","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.tins.2019.12.005","article-title":"Evolutionary expansion of human cerebellar germinal Zones.","volume":"43","author":"Keefe","year":"2020","journal-title":"Trends Neurosci"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2022.105252","article-title":"Gambling associated risk-taking decision in cerebellar ataxia.","volume":"107","author":"Lai","year":"2023","journal-title":"Parkinsonism Relat Disord"},{"key":"B23","doi-asserted-by":"publisher","first-page":"22","DOI":"10.12114\/j.issn.1008-5971.2022.00.001","article-title":"Influencing factors of cognitive impairment in patients with multiple lacunar infarction.","volume":"30","author":"Li","year":"2022","journal-title":"Pjccpvd"},{"key":"B24","doi-asserted-by":"publisher","first-page":"e656","DOI":"10.1016\/j.wneu.2020.08.058","article-title":"Anatomy and white matter connections of the inferior temporal gyrus.","volume":"143","author":"Lin","year":"2020","journal-title":"World Neurosurg"},{"key":"B25","first-page":"4","article-title":"Changes of intelligence and event-related potential P300in the elderly patients with asymptomatic cerebral infarction.","volume":"3","author":"Ma","year":"2004","journal-title":"Chin. J. Geriatr"},{"key":"B26","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1007\/s12311-019-01014-8","article-title":"The cerebellum modulates attention network functioning: Evidence from a cerebellar transcranial direct current stimulation and attention network teststudy.","volume":"18","author":"Mannarelli","year":"2019","journal-title":"Cerebellum"},{"key":"B27","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1080\/13554794.2014.977922","article-title":"Insights from ERPs into attention during recovery after cerebellar stroke: A case report.","volume":"21","author":"Mannarelli","year":"2015","journal-title":"Neurocase"},{"key":"B28","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.neuropsychologia.2016.02.002","article-title":"Effects of cerebellar transcranial direct current stimulation on attentional processing of the stimulus: Evidence from an event-related potentials study.","volume":"84","author":"Mannarelli","year":"2016","journal-title":"Neuropsychologia"},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63351-7","article-title":"The role of attention in the relationship between early life stress and depression.","volume":"10","author":"Mao","year":"2020","journal-title":"Sci. Rep."},{"key":"B30","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.neuroimage.2018.10.041","article-title":"Fronto-central P3a to distracting sounds: An index of their arousing properties.","volume":"185","author":"Masson","year":"2019","journal-title":"Neuroimage"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.12688\/wellcomeopenres.16183.2","article-title":"Case Report: Obsessive compulsive disorder in posterior cerebellar infarction - illustrating clinical and functional connectivity modulation using MRI-informed transcranial magnetic stimulation.","volume":"5","author":"Mehta","year":"2020","journal-title":"Wellcome Open Res"},{"key":"B32","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1007\/s12149-020-01436-z","article-title":"Relationship between decreased cerebral blood flow and amnesia after microsurgery for anterior communicating artery aneurysm.","volume":"34","author":"Mugikura","year":"2020","journal-title":"Ann. Nucl. Med"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21145007","article-title":"Serum tau proteins as potential biomarkers for the assessment of Alzheimer\u2019s Disease progression.","volume":"21","author":"Nam","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1007\/s12311-023-01570-0","article-title":"P300 wave alterations and cognitive impairment in cerebellum lesions.","author":"Nanda","year":"2023","journal-title":"Cerebellum"},{"key":"B35","doi-asserted-by":"publisher","first-page":"71","DOI":"10.3760\/cma.j.cn371468-20210713-00398","article-title":"Visual attention impairment in patients with cerebral small vessel disease: An event-related potential P3 study.","volume":"31","author":"Nei","year":"2022","journal-title":"Chin. J. Behav. Med. Brain Sci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"102","DOI":"10.1016\/j.jad.2023.10.003","article-title":"Altered brain regional homogeneity is associated with cognitive dysfunction in first-episode drug-naive major depressive disorder: A resting-state fMRI study.","volume":"343","author":"Ni","year":"2023","journal-title":"J. Affect. Disord"},{"key":"B37","doi-asserted-by":"publisher","DOI":"10.1111\/psyp.14395","article-title":"Cerebellar EEG source localization reveals age-related compensatory activity moderated by genetic risk for Alzheimer\u2019s disease.","volume":"60","author":"Paitel","year":"2023","journal-title":"Psychophysiology"},{"key":"B38","doi-asserted-by":"publisher","first-page":"674","DOI":"10.4103\/1793-5482.238077","article-title":"Microsurgical anatomy of medial temporal lobe in North-West Indian population: Cadaveric brain dissection.","volume":"13","author":"Patra","year":"2018","journal-title":"Asian J. Neurosurg"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1016\/j.clinph.2007.04.019","article-title":"Updating P300: An integrative theory of P3a and P3b.","volume":"118","author":"Polich","year":"2007","journal-title":"Clin. Neurophysiol"},{"key":"B40","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2020.116751","article-title":"The function of the hippocampus and middle temporal gyrus in forming new associations and concepts during the processing of novelty and usefulness features in creative designs.","volume":"214","author":"Ren","year":"2020","journal-title":"Neuroimage"},{"key":"B41","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0286113","article-title":"The impact of a rosemary containing drink on event-related potential neural markers of sustained attention.","volume":"18","author":"Riby","year":"2023","journal-title":"PLoS One"},{"key":"B42","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.ejpn.2018.01.009","article-title":"The neuropsychology of basal ganglia.","volume":"22","author":"Riva","year":"2018","journal-title":"Eur. J. Paediatr. Neurol"},{"key":"B43","doi-asserted-by":"publisher","DOI":"10.1186\/s40673-019-0097-2","article-title":"Insights into cognitive decline in spinocerebellar Ataxia type 2: A P300 event-related brain potential study.","volume":"6","author":"Rodriguez-Labrada","year":"2019","journal-title":"Cereb. Ataxias"},{"key":"B44","doi-asserted-by":"publisher","first-page":"530","DOI":"10.1007\/s11682-023-00783-5","article-title":"Functional abnormalities of the cerebellum in vascular mild cognitive impairment.","volume":"17","author":"Ruan","year":"2023","journal-title":"Brain Imaging Behav"},{"key":"B45","doi-asserted-by":"publisher","first-page":"19538","DOI":"10.1073\/pnas.2002896117","article-title":"The human cerebellum has almost 80% of the surface area of the neocortex.","volume":"117","author":"Sereno","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"B46","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.neuropsychologia.2018.03.027","article-title":"The role of the right superior temporal gyrus in stimulus-centered spatial processing.","volume":"113","author":"Shah-Basak","year":"2018","journal-title":"Neuropsychologia"},{"key":"B47","first-page":"1","article-title":"The limbic system. An overview of the anatomy and its development.","volume":"7","author":"Sitoh","year":"1997","journal-title":"Neuroimage Clin. N. Am"},{"key":"B48","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/0926-6410(93)90027-3","article-title":"Chronometrical analysis of event-related potentials and reaction time in patients with multiple lacunar infarcts.","volume":"1","author":"Tachibana","year":"1993","journal-title":"Brain Res. Cogn. Brain Res"},{"key":"B49","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1159\/000213349","article-title":"Event-related potentials in patients with multiple lacunar infarcts.","volume":"38","author":"Tachibana","year":"1992","journal-title":"Gerontology"},{"key":"B50","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2022.104917","article-title":"Attentional biases in human anxiety.","volume":"142","author":"Valadez","year":"2022","journal-title":"Neurosci. Biobehav. R"},{"key":"B51","doi-asserted-by":"publisher","DOI":"10.1016\/j.bandc.2023.106102","article-title":"The CODECS study: Cognitive deficits in cerebellar stroke.","volume":"173","author":"van der Giessen","year":"2023","journal-title":"Brain Cogn."},{"key":"B52","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1177\/1073858413494269","article-title":"Dorsal and ventral attention systems: Distinct neural circuits but collaborative roles.","volume":"20","author":"Vossel","year":"2014","journal-title":"Neuroscientist"},{"key":"B53","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci13081158","article-title":"Effects of repetitive transcranial magnetic stimulation at the cerebellum on working memory.","volume":"13","author":"Yao","year":"2023","journal-title":"Brain Sci."},{"key":"B54","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1007\/s10548-022-00916-x","article-title":"Visual selective attention P300 source in frontal-parietal lobe: ERP and fMRI Study.","volume":"35","author":"Zhang","year":"2022","journal-title":"Brain Topogr"}],"container-title":["Frontiers in Human Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnhum.2024.1380739\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,23]],"date-time":"2024-04-23T04:31:24Z","timestamp":1713846684000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnhum.2024.1380739\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":54,"alternative-id":["10.3389\/fnhum.2024.1380739"],"URL":"https:\/\/doi.org\/10.3389\/fnhum.2024.1380739","relation":{},"ISSN":["1662-5161"],"issn-type":[{"value":"1662-5161","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,4,23]]},"article-number":"1380739"}}