{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:15:42Z","timestamp":1769922942983,"version":"3.49.0"},"reference-count":78,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:p>Alexithymia denotes the \u201cabsence\u201d of \u201cwords\u201d for \u201cemotion\u201d and has its roots in the Greek words \u201ca,\u201d \u201clexis,\u201d and \u201cthymos.\u201d It is sometimes referred to as \u201cemotional blindness,\u201d \u201cblunted feeling,\u201d or \u201cdisrupted emotional awareness.\u201d The term \u201calexithymia\u201d first appeared in the 1970s in the works of Sifneos, Nemiah, and colleagues. It entails difficulties in identifying and expressing emotions and an externally oriented thinking style. It is not a psychiatric disorder but rather a multidimensional personality trait or construct, appearing to be normally distributed in the general population, with high levels of alexithymia in approximately 10% of individuals. Evidence suggests that alexithymia serves as a prognostic risk factor for health problems, a transdiagnostic risk factor for emotion-based psychopathologies, and a predictor of poor psychiatric treatment outcomes. It is frequently observed in neurological diseases. Nevertheless, its mechanisms, assessment, and management remain overlooked. In multiple sclerosis (MS), an autoimmune disease of the central nervous system, alexithymia seems to occur in up to 53% of patients. However, it remains understudied despite recent growing interest. In this mini review, we briefly reassess the prevalence, as well as the clinical, sociodemographic and neuropsychological correlates of alexithymia in MS (e.g., anxiety, depression, fatigue, socio-emotional outcomes). This is followed by an analysis of neurobiological underpinnings of alexithymia derived from neurophysiological and neuroimaging studies in this clinical population. Finally, we provide perspectives to guide future research exploring and managing alexithymia in MS.<\/jats:p>","DOI":"10.3389\/fnhum.2025.1552494","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T06:50:58Z","timestamp":1738911058000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["Alexithymia in multiple sclerosis: past, present and future"],"prefix":"10.3389","volume":"19","author":[{"given":"Samar S.","family":"Ayache","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moussa A.","family":"Chalah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"745","DOI":"10.31083\/j.jin2003079","article-title":"Neurofeedback therapy for the management of multiple sclerosis symptoms: current knowledge and future perspectives","volume":"20","author":"Ayache","year":"2021","journal-title":"J. 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