{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:07:10Z","timestamp":1753891630449,"version":"3.41.2"},"reference-count":116,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Lower sensitivity (LS) to acute alcohol promotes hazardous alcohol use, increasing risk for alcohol use disorder (AUD). Compared to peers with high sensitivity (HS), LS individuals exhibit amplified responses to alcohol cues and difficulty exerting inhibitory control (IC) over those cued responses. However, it is unclear whether LS and HS individuals differ in neural or behavioral responses when exerting IC over affectively neutral prepotent responses (i.e., domain-general IC). This fMRI pilot study examined domain-general IC and its neural correlates in young adult LS and HS individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Participants (<jats:italic>N<\/jats:italic> = 32, M<jats:sub><jats:italic>age<\/jats:italic><\/jats:sub> = 20.3) were recruited based on their Alcohol Sensitivity Questionnaire responses (HS: <jats:italic>n<\/jats:italic> = 16; LS: <jats:italic>n<\/jats:italic> = 16; 9 females\/group) to complete an event-related fMRI IC task in a sober state. Retrospective assessments of alcohol craving, consumption, and problems were taken outside the lab.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Although IC performance (accuracy) was numerically lower for the LS group (M[SD] = 0.527[0.125]) compared to the HS group (M[SD] = 0.595[0.124]), no significant difference was detected [<jats:italic>t<\/jats:italic>(30) = 1.55, <jats:italic>p<\/jats:italic> = 0.132]. Across groups, IC-related activity was observed in bilateral fronto-cortico-striatal circuitry, including dorsal striatum (DS) and dorsal\/supragenual anterior cingulate cortex (dACC). Within group HS, IC-related dACC activity was greater among individuals reporting less intense (b-95 CI = [\u22120.201, \u22120.041], <jats:italic>p<\/jats:italic> = 0.004) and less frequent alcohol craving experiences (b-95 CI = [\u22120.131, 0.005], <jats:italic>p<\/jats:italic> = 0.068), whereas in group LS, IC-related dACC activity was greater among individuals reporting more intense (b-95 CI = [0.009, 0.140], <jats:italic>p<\/jats:italic> = 0.028) and more frequent alcohol craving experiences (b-95 CI = [0.022, 0.128], <jats:italic>p<\/jats:italic> = 0.007).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In sum, while LS and HS individuals demonstrated similar domain-general IC performance and recruited similar neural resources to perform IC, findings suggest that compensatory over-activation of frontocortical nodes of the fronto-cortico-striatal IC circuitry may be related to affective-motivational aspects of AUD symptomatology (craving in daily life) among LS individuals. Based on these preliminary findings, future studies with larger samples are warranted to determine the extent to which domain-general IC performance associated with fronto-cortico-striatal IC circuit activation contributes to the alcohol use pathophysiology, and whether therapeutic interventions (e.g., non-invasive brain stimulation) targeting fronto-cortico-striatal IC circuitry may decrease AUD symptomatology.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnhum.2025.1557661","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T07:29:44Z","timestamp":1740727784000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Inhibitory control in the sober state as a function of alcohol sensitivity: a pilot functional magnetic resonance imaging (fMRI) study"],"prefix":"10.3389","volume":"19","author":[{"given":"Roberto U.","family":"Cofres\u00ed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Spencer","family":"Upton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devon","family":"Terry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander A.","family":"Brown","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"Piasecki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce D.","family":"Bartholow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brett","family":"Froeliger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,2,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1751","DOI":"10.1111\/psyp.12741","article-title":"Alcohol words elicit reactive cognitive control in low-sensitivity drinkers.","volume":"53","author":"Bailey","year":"2016","journal-title":"Psychophysiology"},{"key":"B2","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1037\/a0017705","article-title":"Specificity of P3 Event-related potential reactivity to alcohol cues in individuals low in alcohol sensitivity.","volume":"24","author":"Bartholow","year":"2010","journal-title":"Psychol. Addict. Behav."},{"key":"B3","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/S0301-0511(03)00108-X","article-title":"Effects of alcohol consumption and alcohol susceptibility on cognition: A psychophysiological examination.","volume":"64","author":"Bartholow","year":"2003","journal-title":"Biol. Psychol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"592443","DOI":"10.3389\/fpsyt.2021.592443","article-title":"Associations between smoking abstinence, inhibitory control, and smoking behavior: An fMRI study.","volume":"12","author":"Bell","year":"2021","journal-title":"Front. Psychiatry"},{"key":"B5","doi-asserted-by":"publisher","first-page":"423","DOI":"10.3922\/j.psns.2009.1.12","article-title":"The alcohol use disorders identification test (AUDIT): Validation of a screening instrument for use in medical settings.","volume":"56","author":"Bohn","year":"1995","journal-title":"J. Stud. Alcohol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.tics.2004.10.003","article-title":"Conflict monitoring and anterior cingulate cortex: An update.","volume":"8","author":"Botvinick","year":"2004","journal-title":"Trends Cogn. Sci."},{"key":"B7","article-title":"Region of interest analysis using an SPM toolbox","author":"Brett","year":"2002","journal-title":"in 8th International Conference on Functional Mapping of the Human Brain."},{"key":"B8","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/j.drugalcdep.2017.03.018","article-title":"Executive functions in alcohol-dependence: A theoretically grounded and integrative exploration.","volume":"177","author":"Brion","year":"2017","journal-title":"Drug Alcohol Dependence"},{"key":"B9","doi-asserted-by":"publisher","first-page":"109766","DOI":"10.1016\/j.drugalcdep.2023.109766","article-title":"Associations between right inferior frontal gyrus morphometry and inhibitory control in individuals with nicotine dependence.","volume":"244","author":"Brown","year":"2023","journal-title":"Drug Alcohol Dependence"},{"key":"B10","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1037\/hea0001353","article-title":"The adolescent brain cognitive development study.","volume":"42","author":"Brown","year":"2023","journal-title":"Health Psychol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"108799","DOI":"10.1016\/j.neuropsychologia.2024.108799","article-title":"Corticospinal excitability reductions during action preparation and action stopping in humans: Different sides of the same inhibitory coin?","volume":"195","author":"Bundt","year":"2024","journal-title":"Neuropsychologia"},{"key":"B12","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1093\/cercor\/bhn065","article-title":"Functional dissociation in right inferior frontal cortex during performance of go\/no-go task.","volume":"19","author":"Chikazoe","year":"2009","journal-title":"Cereb. Cortex"},{"key":"B13","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1111\/add.15728","article-title":"Behavioral response bias and event-related brain potentials implicate elevated incentive salience attribution to alcohol cues in emerging adults with lower sensitivity to alcohol.","volume":"117","author":"Cofres\u00ed","year":"","journal-title":"Addiction"},{"key":"B14","doi-asserted-by":"publisher","first-page":"100041","DOI":"10.1016\/j.addicn.2022.100041","article-title":"Acute sensitization of the P3 event-related potential response to beverage images and the risk for alcohol use disorder.","volume":"4","author":"Cofres\u00ed","year":"","journal-title":"Addict. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"100156","DOI":"10.1016\/j.addicn.2024.100156","article-title":"Mesocorticolimbic system reactivity to alcohol use-related visual cues as a function of alcohol sensitivity phenotype: A pilot fMRI study.","volume":"11","author":"Cofres\u00ed","year":"2024","journal-title":"Addict. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1111\/add.13477","article-title":"Alcohol consumption as a cause of cancer.","volume":"112","author":"Connor","year":"2017","journal-title":"Addiction"},{"key":"B17","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1016\/j.neubiorev.2012.11.003","article-title":"Have we been asking the right questions when assessing response inhibition in go\/no-go tasks with fMRI? A meta-analysis and critical review.","volume":"37","author":"Criaud","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B18","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1111\/adb.12229","article-title":"The impact of cognitive impairment and impulsivity on relapse of alcohol-dependent patients: Implications for psychotherapeutic treatment.","volume":"21","author":"Czapla","year":"2016","journal-title":"Addict. Biol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1111\/acer.14607","article-title":"Effects of alcohol sensitivity on alcohol- - Induced blackouts and passing out: An examination of the alcohol sensitivity questionnaire among underage drinkers.","volume":"45","author":"Davis","year":"2021","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.neulet.2011.03.074","article-title":"Transient alcohol craving suppression by rTMS of dorsal anterior cingulate: An fMRI and LORETA EEG study.","volume":"496","author":"De Ridder","year":"2011","journal-title":"Neurosci. Lett."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1961","DOI":"10.1111\/acer.13841","article-title":"A clinical trial with combined transcranial direct current stimulation and attentional bias modification in alcohol-dependent patients.","volume":"42","author":"den Uyl","year":"2018","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1632","DOI":"10.1111\/adb.12463","article-title":"A clinical trial with combined transcranial direct current stimulation and alcohol approach bias retraining.","volume":"22","author":"den Uyl","year":"2017","journal-title":"Addict. Biol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1037\/vio0000106","article-title":"Alcohol, drugs, and violence: A meta-meta-analysis.","volume":"8","author":"Duke","year":"2017","journal-title":"Psychol. Violence"},{"key":"B24","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/j.drugalcdep.2005.01.002","article-title":"The level of response to alcohol in daughters of alcoholics and controls.","volume":"79","author":"Eng","year":"2005","journal-title":"Drug Alcohol Dependence"},{"key":"B25","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.neubiorev.2010.04.008","article-title":"What are the specific vs. Generalized effects of drugs of abuse on neuropsychological performance?","volume":"35","author":"Fern\u00e1ndez-Serrano","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B26","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1037\/a0031565","article-title":"Alcohol cues, approach bias, and inhibitory control: Applying a dual process model of addiction to alcohol sensitivity.","volume":"28","author":"Fleming","year":"2014","journal-title":"Psychol. Addict. Behav."},{"key":"B27","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1111\/acer.13015","article-title":"The alcohol sensitivity questionnaire: Evidence for construct validity.","volume":"40","author":"Fleming","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B28","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1037\/0096-3445.133.1.101","article-title":"The relations among inhibition and interference control functions: A latent-variable analysis.","volume":"133","author":"Friedman","year":"2004","journal-title":"J. Exp. Psychol. General"},{"key":"B29","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.cortex.2016.04.023","article-title":"Unity and diversity of executive functions: Individual differences as a window on cognitive structure.","volume":"86","author":"Friedman","year":"2017","journal-title":"Cortex"},{"key":"B30","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1001\/jamapsychiatry.2017.0017","article-title":"Association between baseline corticothalamic-mediated inhibitory control and smoking relapse vulnerability.","volume":"74","author":"Froeliger","year":"2017","journal-title":"JAMA Psychiatry"},{"key":"B31","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1007\/s11682-020-00369-5","article-title":"Contiguity of proactive and reactive inhibitory brain areas: A cognitive model based on ALE meta-analyses.","volume":"15","author":"Gavazzi","year":"2021","journal-title":"Brain Imaging Behav."},{"key":"B32","doi-asserted-by":"publisher","first-page":"105285","DOI":"10.1016\/j.neubiorev.2023.105285","article-title":"Subregional prefrontal cortex recruitment as a function of inhibitory demand: An fMRI metanalysis.","volume":"152","author":"Gavazzi","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1642","DOI":"10.1176\/appi.ajp.159.10.1642","article-title":"Drug addiction and its underlying neurobiological basis: Neuroimaging evidence for the involvement of the frontal cortex.","volume":"159","author":"Goldstein","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"B34","doi-asserted-by":"publisher","first-page":"909992","DOI":"10.3389\/fpsyt.2022.909992","article-title":"Right inferior frontal activation during alcohol-specific inhibition increases with craving and predicts drinking outcome in alcohol use disorder.","volume":"13","author":"Grieder","year":"2022","journal-title":"Front. Psychiatry"},{"key":"B35","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1016\/S0140-6736(18)31310-2","article-title":"Alcohol use and burden for 195 countries and territories, 1990\u20132016: A systematic analysis for the Global Burden of Disease Study 2016.","volume":"392","author":"Griswold","year":"2018","journal-title":"Lancet"},{"key":"B36","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1038\/s41398-024-02987-9","article-title":"Factors underlying the neurofunctional domains of the Addictions Neuroclinical Assessment assessed by a standardized neurocognitive battery.","volume":"14","author":"Gunawan","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"B37","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1038\/s41583-021-00485-1","article-title":"Towards real-world generalizability of a circuit for action-stopping.","volume":"22","author":"Hannah","year":"2021","journal-title":"Nat. Rev. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.biopsych.2021.11.020","article-title":"Repetitive transcranial magnetic stimulation in alcohol dependence: A randomized, double-blind, sham-controlled proof-of-concept trial targeting the medial prefrontal and anterior cingulate cortices.","volume":"91","author":"Harel","year":"2022","journal-title":"Biol. Psychiatry"},{"key":"B39","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)-A metadata-driven methodology and workflow process for providing translational research informatics support.","volume":"42","author":"Harris","year":"2009","journal-title":"J. Biomed. Informatics"},{"key":"B40","first-page":"141","article-title":"The inheritance of alcohol sensitivity and of patterns of alcohol use.","volume":"1","author":"Heath","year":"1991","journal-title":"Alcohol Alcoholism"},{"key":"B41","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1017\/S0033291799008909","article-title":"Genetic differences in alcohol sensitivity and the inheritance of alcoholism risk.","volume":"29","author":"Heath","year":"1999","journal-title":"Psychol. Med."},{"key":"B42","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s40429-015-0048-9","article-title":"Neuroimaging risk markers for substance abuse: Recent findings on inhibitory control and reward system functioning.","volume":"2","author":"Heitzeg","year":"2015","journal-title":"Curr. Addict. Rep."},{"key":"B43","doi-asserted-by":"publisher","first-page":"287","DOI":"10.1016\/j.biopsych.2010.02.020","article-title":"Striatal dysfunction marks preexisting risk and medial prefrontal dysfunction is related to problem drinking in children of alcoholics.","volume":"68","author":"Heitzeg","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B44","doi-asserted-by":"publisher","first-page":"2297","DOI":"10.1111\/ejn.14108","article-title":"Binge drinking is associated with attenuated frontal and parietal activation during successful response inhibition in fearful context.","volume":"50","author":"Herman","year":"2019","journal-title":"Eur. J. Neurosci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neubiorev.2021.06.011","article-title":"Neural correlates of inhibitory control in relation to the degree of substance use and substance-related problems \u2013 A systematic review and perspective.","volume":"128","author":"Hildebrandt","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B46","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1093\/alcalc\/agad049","article-title":"Neuroanatomical predictors of problematic alcohol consumption in adolescents: A systematic review of longitudinal studies.","volume":"58","author":"Honarvar","year":"2023","journal-title":"Alcohol Alcohol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1630","DOI":"10.1111\/acer.13447","article-title":"Women\u2019s alcohol sensitivity predicts alcohol-related regretted sex.","volume":"41","author":"Hone","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B48","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1111\/acer.12964","article-title":"Association of drinking problems and duration of alcohol use to inhibitory control in nondependent young adult social drinkers.","volume":"40","author":"Hu","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B49","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1016\/j.neubiorev.2021.07.021","article-title":"Cortical and subcortical contributions to interference resolution and inhibition \u2013 An fMRI ALE meta-analysis.","volume":"129","author":"Isherwood","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B50","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1038\/nrn4038","article-title":"A fronto\u2013striato\u2013subthalamic\u2013pallidal network for goal-directed and habitual inhibition.","volume":"16","author":"Jahanshahi","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"B51","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1007\/s00213-011-2628-2","article-title":"Memantine, an NMDA receptor antagonist, differentially influences Go\/No-Go performance and fMRI activity in individuals with and without a family history of alcoholism.","volume":"222","author":"Jamadar","year":"2012","journal-title":"Psychopharmacology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"101294","DOI":"10.1016\/j.dcn.2023.101294","article-title":"Associations between alcohol use and sex-specific maturation of subcortical gray matter morphometry from adolescence to adulthood: Replication across two longitudinal samples.","volume":"63","author":"Jones","year":"2023","journal-title":"Dev. Cogn. Neurosci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1007\/s00213-013-3038-4","article-title":"Family history of alcoholism interacts with alcohol to affect brain regions involved in behavioral inhibition.","volume":"228","author":"Kareken","year":"2013","journal-title":"Psychopharmacology"},{"key":"B54","doi-asserted-by":"publisher","first-page":"e13439","DOI":"10.1111\/adb.13439","article-title":"Alcohol and brain structure across the lifespan: A systematic review of large-scale neuroimaging studies.","volume":"29","author":"Karoly","year":"2024","journal-title":"Addict. Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.bpsc.2018.03.016","article-title":"Transdiagnostic effects of ventromedial prefrontal cortex transcranial magnetic stimulation on cue reactivity.","volume":"3","author":"Kearney-Ramos","year":"2018","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"B56","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1176\/appi.ajp.2020.20030247","article-title":"Subjective responses to alcohol in the development and maintenance of alcohol use disorder.","volume":"178","author":"King","year":"2021","journal-title":"Am. J. Psychiatry"},{"key":"B57","doi-asserted-by":"publisher","first-page":"1892","DOI":"10.1038\/s41386-022-01340-2","article-title":"Haven\u2019t lost the positive feeling: A dose-response, oral alcohol challenge study in drinkers with alcohol use disorder.","volume":"47","author":"King","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"B58","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1037\/pha0000540","article-title":"Alcohol craving in the natural environment: Moderating roles of cue exposure, drinking, and alcohol sensitivity.","volume":"31","author":"Kohen","year":"2023","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"B59","doi-asserted-by":"publisher","first-page":"e13368","DOI":"10.1111\/adb.13368","article-title":"Predictive utility of the P3 event-related potential (ERP) response to alcohol cues for ecologically assessed alcohol craving and use.","volume":"29","author":"Kohen","year":"2024","journal-title":"Addict. Biol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1016\/j.neubiorev.2021.04.028","article-title":"Distinct patterns of prefrontal cortical disengagement during inhibitory control in addiction: A meta-analysis based on population characteristics.","volume":"127","author":"Le","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B61","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1177\/1073858405280524","article-title":"The P300: Where in the brain is it produced and what does it tell us?","volume":"11","author":"Linden","year":"2005","journal-title":"Neuroscientist"},{"key":"B62","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1093\/alcalc\/agt168","article-title":"Impact of alcohol use on inhibitory control (and vice versa) during adolescence and young adulthood: A review.","volume":"49","author":"L\u00f3pez-Caneda","year":"2014","journal-title":"Alcohol Alcohol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1503\/jpn.130052","article-title":"Systematic review of ERP and fMRI studies investigating inhibitory control and error processing in people with substance dependence and behavioural addictions.","volume":"39","author":"Luijten","year":"2014","journal-title":"J. Psychiatry Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1111\/add.12472","article-title":"The craving experience questionnaire: A brief, theory-based measure of consummatory desire and craving.","volume":"109","author":"May","year":"2014","journal-title":"Addiction"},{"key":"B65","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1038\/s41386-023-01776-0","article-title":"A systematic review and meta-analysis of neuromodulation therapies for substance use disorders.","volume":"49","author":"Mehta","year":"2024","journal-title":"Neuropsychopharmacology"},{"key":"B66","doi-asserted-by":"publisher","first-page":"e2452027","DOI":"10.1001\/jamanetworkopen.2024.52027","article-title":"Neuroanatomical variability and substance use initiation in late childhood and early adolescence.","volume":"7","author":"Miller","year":"2024","journal-title":"JAMA Netw. Open"},{"key":"B67","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1006\/cogp.1999.0734","article-title":"The unity and diversity of executive functions and their contributions to complex \u201cfrontal lobe\u201d tasks: A latent variable analysis.","volume":"41","author":"Miyake","year":"2000","journal-title":"Cogn. Psychol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/bs.pbr.2015.07.007.Neuroscience","article-title":"Neuroscience of inhibition for addiction medicine: From prediction of initiation to prediction of relapse.","volume":"223","author":"Moeller","year":"2016","journal-title":"Progr. Brain Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"101478","DOI":"10.1016\/j.dcn.2024.101478","article-title":"Associations between mesolimbic connectivity, and alcohol use from adolescence to adulthood.","volume":"70","author":"Morales","year":"2024","journal-title":"Dev. Cogn. Neurosci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1016\/j.brainres.2014.09.012","article-title":"Fronto-striatal circuits in response-inhibition: Relevance to addiction.","volume":"1628","author":"Morein-Zamir","year":"2015","journal-title":"Brain Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.addbeh.2011.05.012","article-title":"The role of executive function in bridging the intention-behaviour gap for binge-drinking in university students.","volume":"36","author":"Mullan","year":"2011","journal-title":"Addict. Behav."},{"key":"B72","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/j.drugalcdep.2010.10.011","article-title":"Cognitive predictors of problem drinking and AUDIT scores among college students.","volume":"115","author":"Murphy","year":"2011","journal-title":"Drug Alcohol Dependence"},{"key":"B73","doi-asserted-by":"publisher","first-page":"260","DOI":"10.3389\/fpsyt.2020.00260","article-title":"Dissociable effects of theta-burst repeated transcranial magnetic stimulation to the inferior frontal gyrus on inhibitory control in nicotine addiction.","volume":"11","author":"Newman-Norlund","year":"2020","journal-title":"Front. Psychiatry"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/adb.12729","article-title":"Inhibitory-control event-related potentials correlate with individual differences in alcohol use.","volume":"25","author":"O\u2019Halloran","year":"2020","journal-title":"Addict. Biol."},{"key":"B75","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3390\/brainsci10100725","article-title":"Alcohol sensitivity as an endophenotype of alcohol use disorder: Exploring its translational utility between rodents and humans.","volume":"10","author":"Parker","year":"2020","journal-title":"Brain Sci."},{"key":"B76","doi-asserted-by":"publisher","first-page":"848","DOI":"10.1016\/j.biopsych.2012.04.016","article-title":"High versus low level of response to alcohol: Evidence of differential reactivity to emotional stimuli.","volume":"72","author":"Paulus","year":"2012","journal-title":"Biol. Psychiatry"},{"key":"B77","doi-asserted-by":"publisher","first-page":"1363","DOI":"10.1111\/j.1530-0277.2006.00164.x","article-title":"Alcohol attenuates load-related activation during a working memory task: Relation to level of response to alcohol.","volume":"30","author":"Paulus","year":"2006","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.drugalcdep.2011.12.002","article-title":"Gender differences in the factor structure of the Alcohol Use Disorders Identification Test in multinational general population surveys.","volume":"124","author":"Peng","year":"2012","journal-title":"Drug Alcohol Dependence"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-372560-8.X5000-1","author":"Penny","year":"2007","journal-title":"Statistical Parametric Mapping: The Analysis of Functional Brain Images"},{"key":"B80","doi-asserted-by":"publisher","first-page":"104637","DOI":"10.1016\/j.neubiorev.2022.104637","article-title":"Effects of binge drinking during adolescence and emerging adulthood on the brain: A systematic review of neuroimaging studies.","volume":"137","author":"P\u00e9rez-Garc\u00eda","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B81","doi-asserted-by":"publisher","first-page":"925","DOI":"10.15288\/jsad.2012.73.925","article-title":"Low sensitivity to alcohol: Relations with hangover occurrence and susceptibility in an ecological momentary assessment investigation.","volume":"73","author":"Piasecki","year":"2012","journal-title":"J. Stud. Alcohol. Drugs"},{"key":"B82","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1016\/j.clinph.2007.04.019","article-title":"Updating P300: An integrative theory of P3a and P3b.","volume":"118","author":"Polich","year":"2007","journal-title":"Clin. Neurophysiol."},{"key":"B83","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1016\/j.drugalcdep.2013.04.008","article-title":"Prospective associations between brain activation to cocaine and no-go cues and cocaine relapse.","volume":"131","author":"Prisciandaro","year":"2013","journal-title":"Drug Alcohol Dependence"},{"key":"B84","doi-asserted-by":"publisher","first-page":"1742","DOI":"10.3109\/10826084.2010.482427","article-title":"Subjective responses to alcohol consumption as endophenotypes: Advancing behavioral genetics in etiological and treatment models of alcoholism.","volume":"45","author":"Ray","year":"2010","journal-title":"Substance Use Misuse"},{"key":"B85","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/acer.12924","article-title":"Impulsivity and alcohol dependence treatment completion: Is there a neurocognitive risk factor at treatment entry?","volume":"40","author":"Rupp","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B86","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1111\/j.1360-0443.1993.tb02093.x","article-title":"Development of the alcohol use disorders identification test (AUDIT): WHO collaborative project on early detection of persons with harmful alcohol consumption-II.","volume":"88","author":"Saunders","year":"1993","journal-title":"Addiction"},{"key":"B87","doi-asserted-by":"publisher","first-page":"242","DOI":"10.15288\/jsa.1980.41.242","article-title":"Self-rating of alcohol intoxication by young men with and without family histories of alcoholism.","volume":"41","author":"Schuckit","year":"1980","journal-title":"J. Stud. Alcohol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1111\/acer.13628","article-title":"A critical review of methods and results in the search for genetic contributors to alcohol sensitivity.","volume":"42","author":"Schuckit","year":"2018","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B89","doi-asserted-by":"publisher","first-page":"827","DOI":"10.15288\/jsa.2000.61.827","article-title":"The relationships of a family history of alcohol dependence, a low level of response to alcohol and six domains of life functioning to the development of alcohol use disorders.","volume":"61","author":"Schuckit","year":"2000","journal-title":"J. Stud. Alcohol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1046\/j.1360-0443.2001.96690311.x","article-title":"The clinical course of alcohol dependence associated with a low level of response to alcohol.","volume":"96","author":"Schuckit","year":"2001","journal-title":"Addiction"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/acer.14710","article-title":"Cross-sectional and prospective associations of drinking characteristics with scores from the Self-report of the effects of alcohol questionnaire and findings from alcohol challenges.","volume":"45","author":"Schuckit","year":"2021","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B92","doi-asserted-by":"publisher","first-page":"1329","DOI":"10.1111\/acer.13407","article-title":"A prospective comparison of how the level of response to alcohol and impulsivity relate to future DSM-IV alcohol problems in the COGA youth panel.","volume":"41","author":"Schuckit","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B93","doi-asserted-by":"publisher","first-page":"371","DOI":"10.15288\/jsad.2007.68.371","article-title":"The ability of the self-rating of the effects of alcohol (SRE) scale to predict alcohol-related outcomes five years later.","volume":"68","author":"Schuckit","year":"2007","journal-title":"J. Stud. Alcohol Drugs"},{"key":"B94","doi-asserted-by":"publisher","first-page":"1308","DOI":"10.1111\/j.1530-0277.2006.00158.x","article-title":"Relationships among the level of response to alcohol and the number of alcoholic relatives in predicting alcohol-related outcomes.","volume":"30","author":"Schuckit","year":"2006","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B95","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1111\/j.1530-0277.2011.01590.x","article-title":"fMRI differences between subjects with low and high responses to alcohol during a stop signal task.","volume":"36","author":"Schuckit","year":"2012","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B96","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1196\/annals.1308.050","article-title":"An fMRI study of response inhibition in youths with a family history of alcoholism.","volume":"1021","author":"Schweinsburg","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B97","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1038\/nn.4384","article-title":"Dorsal anterior cingulate cortex and the value of control.","volume":"19","author":"Shenhav","year":"2016","journal-title":"Nat. Neurosci."},{"key":"B98","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1016\/j.neuropsychologia.2007.07.015","article-title":"Meta-analysis of Go\/No-go tasks demonstrating that fMRI activation associated with response inhibition is task-dependent.","volume":"46","author":"Simmonds","year":"2008","journal-title":"Neuropsychologia"},{"key":"B99","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.drugalcdep.2014.08.009","article-title":"Deficits in behavioural inhibition in substance abuse and addiction: A meta-analysis.","volume":"145","author":"Smith","year":"2014","journal-title":"Drug Alcohol Dependence"},{"key":"B100","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4612-0357-5_3","article-title":"Timeline follow-back","author":"Sobell","year":"1992","journal-title":"Measuring alcohol consumption"},{"key":"B101","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.brs.2018.12.975","article-title":"Effects of single-session versus multi-session non-invasive brain stimulation on craving and consumption in individuals with drug addiction, eating disorders or obesity: A meta-analysis.","volume":"12","author":"Song","year":"2019","journal-title":"Brain Stimul."},{"key":"B102","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1111\/j.1360-0443.2011.03442.x","article-title":"Measuring alcohol craving: Development of the alcohol craving experience questionnaire.","volume":"106","author":"Statham","year":"2011","journal-title":"Addiction"},{"key":"B103","doi-asserted-by":"publisher","first-page":"112973","DOI":"10.1016\/j.bbr.2020.112973","article-title":"Alcohol-related context modulates neural correlates of inhibitory control in alcohol dependent patients: Preliminary data from an fMRI study using an alcohol-related Go\/NoGo-task.","volume":"398","author":"Stein","year":"2021","journal-title":"Behav. Brain Res."},{"key":"B104","doi-asserted-by":"publisher","first-page":"535","DOI":"10.3389\/fpsyt.2020.00535","article-title":"Response inhibition and binge drinking during transition to university: An fMRI study.","volume":"11","author":"Su\u00e1rez-Su\u00e1rez","year":"2020","journal-title":"Front. Psychiatry"},{"key":"B105","doi-asserted-by":"publisher","first-page":"692","DOI":"10.15288\/jsa.2004.65.692","article-title":"Level of response to alcohol and brain response during visual working memory.","volume":"65","author":"Tapert","year":"2004","journal-title":"J. Stud. Alcohol."},{"key":"B106","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1037\/pha0000206","article-title":"Moderation of alcohol craving reactivity to drinking-related contexts by individual differences in alcohol sensitivity: An ecological investigation.","volume":"26","author":"Trela","year":"2018","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"B107","doi-asserted-by":"publisher","first-page":"2185","DOI":"10.1007\/s00213-016-4270-5","article-title":"The natural expression of individual differences in self-reported level of response to alcohol during ecologically assessed drinking episodes.","volume":"233","author":"Trela","year":"2016","journal-title":"Psychopharmacology"},{"key":"B108","doi-asserted-by":"publisher","first-page":"1162","DOI":"10.1111\/j.1530-0277.2010.01193.x","article-title":"Acute Ethanol Effects on Brain Activation in Low- and High-Level Responders to Alcohol.","volume":"34","author":"Trim","year":"2010","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B109","doi-asserted-by":"publisher","first-page":"1166912","DOI":"10.3389\/fpsyt.2023.1166912\/abstract","article-title":"Right Inferior frontal gyrus theta-burst stimulation reduces smoking behaviors and strengthens fronto-striatal-limbic resting-state functional connectivity: A randomized crossover trial.","volume":"14","author":"Upton","year":"","journal-title":"Front. Psychiatry"},{"key":"B110","doi-asserted-by":"publisher","first-page":"1156","DOI":"10.1016\/j.bpsc.2023.07.014","article-title":"Effects of hyperdirect pathway theta burst transcranial magnetic stimulation on inhibitory control, craving, and smoking in adults with nicotine dependence: A double-blind, randomized crossover trial.","volume":"8","author":"Upton","year":"","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"B111","doi-asserted-by":"publisher","first-page":"105512","DOI":"10.1016\/j.bandc.2019.105512","article-title":"Bifrontal tDCS applied to the dorsolateral prefrontal cortex in heavy drinkers: Influence on reward-triggered approach bias and alcohol consumption.","volume":"138","author":"Vanderhasselt","year":"2020","journal-title":"Brain Cogn."},{"key":"B112","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1097\/01.ALC.0000067974.41160.95","article-title":"Subjective intoxication in response to alcohol challenge: Heritability and covariation with personality, breath alcohol level, and drinking history.","volume":"27","author":"Viken","year":"2003","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.tics.2023.09.008","article-title":"Neural mechanisms of domain-general inhibitory control.","volume":"28","author":"Wessel","year":"2024","journal-title":"Trends Cogn. Sci."},{"key":"B114","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1007\/s00702-016-1541-6","article-title":"Transcranial direct current stimulation of the prefrontal cortex reduces cue-reactivity in alcohol-dependent patients.","volume":"123","author":"Wietschorke","year":"2016","journal-title":"J. Neural Transmiss."},{"key":"B115","doi-asserted-by":"publisher","first-page":"3973","DOI":"10.1007\/s00429-017-1443-x","article-title":"Large-scale functional neural network correlates of response inhibition: An fMRI meta-analysis.","volume":"222","author":"Zhang","year":"2017","journal-title":"Brain Struct. Funct."},{"key":"B116","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1016\/j.neuron.2018.03.048","article-title":"Neuroimaging impaired response inhibition and salience attribution in human drug addiction: A systematic review.","volume":"98","author":"Zilverstand","year":"2018","journal-title":"Neuron"}],"container-title":["Frontiers in Human Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnhum.2025.1557661\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T07:29:51Z","timestamp":1740727791000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnhum.2025.1557661\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,28]]},"references-count":116,"alternative-id":["10.3389\/fnhum.2025.1557661"],"URL":"https:\/\/doi.org\/10.3389\/fnhum.2025.1557661","relation":{},"ISSN":["1662-5161"],"issn-type":[{"type":"electronic","value":"1662-5161"}],"subject":[],"published":{"date-parts":[[2025,2,28]]},"article-number":"1557661"}}