{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T16:07:11Z","timestamp":1753891631623,"version":"3.41.2"},"reference-count":65,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T00:00:00Z","timestamp":1750723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["R33MH107589","R01MH111794"],"award-info":[{"award-number":["R33MH107589","R01MH111794"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:p>Obsessive-compulsive disorder (OCD) is chronic and impairing. While OCD often involves fear of harm or bad events, many patients experience \u201csensory phenomena,\u201d which are aversive sensory experiences that drive repetitive behaviors regardless of specific fears. Standard treatments do not effectively address sensory phenomena, and novel approaches are needed. Transcranial magnetic stimulation (TMS) is a safe and non-invasive neuromodulation technique increasingly used in psychiatric disorders, including OCD. This work presents a data-driven approach to identifying TMS brain targets for modulating sensory urges in OCD incorporating both behavioral and clinical criteria (Study 1) for a proof-of-concept investigation (Study 2). Study 1 included 69 individuals with OCD and 23 controls who completed an urges-for-action fMRI task involving instructed eyeblink suppression as an experimental model for sensory-based urges. Data-driven conjunction analysis revealed several brain regions, including the right postcentral gyrus, that were associated with more blink suppression failure (behavioral), more severe sensory phenomena (clinical), and were hyperactivated in OCD patients compared to controls. Study 2 administered single-session inhibitory TMS on 4 returning OCD patients using individualized targets within the postcentral gyrus identified from Study 1. Compared to sham, inhibitory TMS delivered to individualized postcentral gyrus targets resulted in fewer blink suppression failures, reduced activation in the target (postcentral gyrus) and key urge-related areas (insula, mid-cingulate), and greater reduction in self-reported urge to engage in OCD-related compulsions, with medium to large effect sizes. These findings demonstrate the potential of utilizing data-driven approaches incorporating behavioral and clinical criteria to target hard-to-treat sensory phenomena in OCD.<\/jats:p>","DOI":"10.3389\/fnhum.2025.1587644","type":"journal-article","created":{"date-parts":[[2025,6,24]],"date-time":"2025-06-24T05:21:52Z","timestamp":1750742512000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Personalized non-invasive neuromodulation for sensory-based urge suppression in individuals with OCD: a proof-of-concept investigation"],"prefix":"10.3389","volume":"19","author":[{"given":"Goi Khia","family":"Eng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arielle","family":"Tambini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molly S.","family":"Hermiller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolette","family":"Recchia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeanmarie R.","family":"Harvey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan V.","family":"Iosifescu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell H.","family":"Tobe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily R.","family":"Stern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,6,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1037\/0022-006X.71.6.1049","article-title":"Symptom presentation and outcome of cognitive-behavioral therapy for obsessive-compulsive disorder","volume":"71","author":"Abramowitz","year":"2003","journal-title":"J. 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Psychiatry"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1016\/j.comppsych.2014.02.008","article-title":"Validation of the University of S\u00e3o Paulo\u2019s sensory phenomena scale\u2014English version","volume":"55","author":"Sampaio","year":"2014","journal-title":"Compr. Psychiatry"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1860","DOI":"10.3389\/fpsyg.2015.01860","article-title":"Involvement of sensory regions in affective experience: a meta-analysis","volume":"6","author":"Satpute","year":"2015","journal-title":"Front. Psychol."},{"key":"ref48","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-3-030-21293-3_1","article-title":"SimNIBS 2.1: a comprehensive pipeline for individualized electric field modelling for transcranial brain stimulation","volume-title":"Brain and human body modeling: computational human modeling at EMBC 2018","author":"Saturnino","year":"2019"},{"key":"ref49","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.jpsychires.2014.06.010","article-title":"Phenomenology of OCD: lessons from a large multicenter study and implications for ICD-11","volume":"57","author":"Shavitt","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"ref50","first-page":"22","article-title":"The mini-international neuropsychiatric interview (MINI): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatry"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"4583","DOI":"10.1038\/s41380-020-01007-8","article-title":"Toward a neurocircuit-based taxonomy to guide treatment of obsessive\u2013compulsive disorder","volume":"26","author":"Shephard","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"ref52","doi-asserted-by":"publisher","first-page":"2944","DOI":"10.1002\/hbm.22113","article-title":"Keeping the body in mind: insula functional organization and functional connectivity integrate interoceptive, exteroceptive, and emotional awareness","volume":"34","author":"Simmons","year":"2013","journal-title":"Hum. Brain Mapp."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"269","DOI":"10.4088\/jcp.v67n0214","article-title":"Response versus remission in obsessive-compulsive disorder","volume":"67","author":"Simpson","year":"2006","journal-title":"J. Clin. 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