{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:52:32Z","timestamp":1791571952930,"version":"4.3.4"},"reference-count":40,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T00:00:00Z","timestamp":1762992000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:p>\n                    Parkinson\u2019s disease (PD) is the second most common neurodegenerative disease in the world and involves impairment of both motor and cognitive functions, significantly affecting the quality of walking and consequently the quality of life of people affected by this disease. This study analyzed the relationship between gait alterations and cognitive deterioration, using validated clinical tests and an innovative indicator, the\n                    <jats:italic>\u03c6<\/jats:italic>\n                    -bonacci gait number, which quantifies gait harmonicity, symmetry, and consistency. Kinematic data collected during the 6-Minute Walk test on 19 people with PD (pwPD) and 15 healthy adults were analyzed. The results highlighted a significant negative correlation between gait harmonicity and cognitive performance (\n                    <jats:italic>\u03c6<\/jats:italic>\n                    -bonacci gait number\u2014Time Up and Go Dual Task;\n                    <jats:italic>r<\/jats:italic>\n                    \u202f=\u202f0.797,\n                    <jats:italic>p<\/jats:italic>\n                    \u202f&amp;lt;\u202f0.05). Finally, mediation analysis showed that global cognitive function (MoCA) indirectly influences gait harmonicity through TUG-DT. The results suggest that gait in pwPD is strongly modulated by executive-attentional functions, supporting its cognitive modulation rather than a purely automatic nature. This study allowed to explore the complex relationship between cognitive functions and the motor system, deepening how these interactions influence and refine motor behavior. Therefore, rehabilitation programs combining motor exercises and cognitive training could be more effective in improving gait quality, reducing the risk of falls, and improving person\u2019s quality of life.\n                  <\/jats:p>","DOI":"10.3389\/fnhum.2025.1636813","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:03:06Z","timestamp":1763017386000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":5,"title":["New gait performance indices and cognitive functions: a pilot study on correlation in people with Parkinson\u2019s disease"],"prefix":"10.3389","volume":"19","author":[{"given":"Elena Sofia","family":"Cocco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie-Louise","family":"Thouant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Pietrosanti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Infarinato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta Maria","family":"Manzia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Romano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raimondo Stefano Maria","family":"Torcisi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Franceschini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano Maria","family":"Verrelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanaz","family":"Pournajaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,11,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"662","DOI":"10.3390\/s24020662","article-title":"Characterization of walking in mild Parkinson\u2019s disease: reliability, validity and discriminant ability of the six-minute walk test instrumented with a single inertial sensor","volume":"24","author":"Bailo","year":"2024","journal-title":"Sensors"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"353","DOI":"10.3389\/fnhum.2017.00353","article-title":"Guidelines for assessment of gait and reference values for spatiotemporal gait parameters in older adults: the Biomathics and Canadian gait consortiums initiative","volume":"11","author":"Beauchet","year":"2017","journal-title":"Front. 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