{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T07:32:14Z","timestamp":1787643134438,"version":"build-2736575974"},"reference-count":179,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T00:00:00Z","timestamp":1759968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:p>Neuroaesthetics, an emerging field at the intersection of neuroscience, psychology, and the arts, offers new perspectives on the biological and cognitive mechanisms of aesthetic experience. This narrative review explores the convergence of neuroaesthetics and neurodegenerative disorders, focusing on Alzheimer\u2019s disease, Parkinson\u2019s disease, frontotemporal dementia, and Huntington\u2019s disease. Drawing on evidence from neuroimaging, neuropsychology, and clinical studies, we examine how neurodegenerative processes differentially disrupt the neural systems of the \u201caesthetic triad\u201d: sensory-motor, emotion-valuation, and meaning-knowledge. Such disruptions not only impair patients\u2019 ability to perceive and create art but may also reveal unexpected creative capacities. We discuss the therapeutic potential of arts-based interventions, highlighting the benefits of personalized and technology-driven approaches, including immersive virtual reality and digital art platforms, to enhance neurorehabilitation and psychological wellbeing. The \u201cMichelangelo effect,\u201d where engagement in meaningful aesthetic activities supports learning, motivation, and resilience, exemplifies this translational potential. Our synthesis underscores clinical, neuroscientific, and rehabilitative implications, while noting ongoing challenges such as the need for standardized outcomes and interdisciplinary collaboration. Integrating neuroaesthetic principles into neurorehabilitation may help preserve cognitive and motor functions and enrich quality of life and self-concept in people with neurodegenerative disease. Future research should optimize these approaches to ensure meaningful benefits for patients.<\/jats:p>","DOI":"10.3389\/fnhum.2025.1658617","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T05:27:40Z","timestamp":1759987660000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":4,"title":["Beauty in the shadow of neurodegenerative disease: a narrative review on aesthetic experience, neural mechanisms, and therapeutic frontiers"],"prefix":"10.3389","volume":"19","author":[{"given":"Andrea","family":"Calderone","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaria","family":"De Luca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalia","family":"Calapai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Mirabile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Quartarone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocco Salvatore","family":"Calabr\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/j.cortex.2011.04.012","article-title":"Neuroimaging findings in frontotemporal lobar degeneration spectrum of disorders","volume":"48","author":"Agosta","year":"2012","journal-title":"Cortex"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"2314","DOI":"10.3390\/electronics10182314","article-title":"A systematic review of the use of art in virtual reality","volume":"10","author":"Aldridge","year":"2021","journal-title":"Electronics"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"3677","DOI":"10.1016\/j.neuroimage.2011.11.019","article-title":"Large-scale brain networks emerge from dynamic processing of musical timbre, key and rhythm","volume":"59","author":"Alluri","year":"2012","journal-title":"NeuroImage"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"11732","DOI":"10.3390\/ijms241411732","article-title":"Frontotemporal dementia, where do we stand? 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