{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T07:21:21Z","timestamp":1761636081728,"version":"build-2065373602"},"reference-count":39,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T00:00:00Z","timestamp":1761609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hypertrophic olivary degeneration (HOD) is a rare transsynaptic neurodegenerative disorder arising from disruption of the Guillain-Mollaret triangle (GMT), a neural circuit critical for motor coordination. Classical clinical presentation includes palatal tremor. While cerebrovascular etiology dominates reported cases, HOD secondary to intracranial infections remains poorly characterized, posing diagnostic challenges.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case presentation<\/jats:title>\n                    <jats:p>\n                      A 72-year-old man with diabetes and hypertension presented with a 7-day history of fever, headache, and vomiting. Initial neuroimaging revealed right cerebellar hematoma with multiple brain abscesses. Antibacterial treatment achieved symptomatic improvement, but follow-up was lost. Seven months later, readmission occurred due to memory decline and personality changes. Magnetic resonance imaging (MRI) showed T\n                      <jats:sub>2<\/jats:sub>\n                      -weighted hyperintensity in the left anterior medulla oblongata and hemosiderosis in the right cerebellar hemisphere. Despite the absence of clinical manifestations of HOD, prior abscess-induced GMT involvement strongly supported the diagnosis. Symptomatic management stabilized the patient, with persistent lesions but no clinical progression at 5-month follow-up.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This case documents a rare case of HOD following bacterial brain abscess, presenting with atypical clinical features. It expands the etiological spectrum of HOD and underscores the need for heightened clinical suspicion in post-infectious neurological deterioration. Multimodal MRI facilitates early diagnosis and timely intervention, highlighting its critical role in managing this underrecognized entity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnhum.2025.1674100","type":"journal-article","created":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T07:15:29Z","timestamp":1761635729000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Hypertrophic olivary degeneration secondary to brain abscess: a case report and literature review"],"prefix":"10.3389","volume":"19","author":[{"given":"Shihan","family":"Tian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Biqiu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohe","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2025,10,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1007\/s11060-008-9523-7","article-title":"Hypertrophic olivary degeneration after resection of a cerebellar tumor","volume":"87","author":"Akar","year":"2008","journal-title":"J. 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