{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T20:03:23Z","timestamp":1769803403837,"version":"3.49.0"},"reference-count":30,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T00:00:00Z","timestamp":1769731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:p>Psychotherapeutic interventions following acquired brain injury often underestimate the influence of neural connectivity on emotional and cognitive recovery, contributing to treatment response variability. We present a single-case report of an adult with mild acquired brain injury, in whom diffusion tensor imaging (tractography) and neuropsychological assessment were integrated to guide individualized clinical planning. Baseline tractography revealed globally preserved white-matter organization with rightward asymmetries in the uncinate and superior longitudinal fasciculi\u2013pathways involved in cognitive\u2013emotional integration. This specific neuroanatomical profile informed a psychotherapeutic plan that prioritized attentional and experiential strategies, being functionally compatible with the preserved networks, over those requiring complex verbal-analytic processing. After 1 year of intervention (approximately 40 sessions), reassessment documented significant functional improvements, quantified by a reduction in anxiety to a non-clinical range (HADS-A: 11 \u2192 6) and a normalization in cognitive flexibility (TMT-B: 190 \u2192 128 s), without observable structural change. These findings validate the hypothesis that therapeutic change may arise from functional optimization within preserved networks rather than anatomical reorganization. This report proposes the functional compatibility framework as a transferable and theoretically grounded model for precision psychotherapy, bridging the gap between neuroscience and clinical practice.<\/jats:p>","DOI":"10.3389\/fnhum.2026.1738846","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T06:43:04Z","timestamp":1769755384000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroanatomically informed psychotherapy after mild brain injury: a single-case report of clinical improvement"],"prefix":"10.3389","volume":"20","author":[{"given":"Rosario","family":"Bord\u00f3n Guerra","sequence":"first","affiliation":[{"name":"Department of Psychiatry, Hospital Universitario de Gran Canaria Doctor Negr\u00edn","place":["Las Palmas de Gran Canaria, Spain"]},{"name":"Department of Medical and Surgical Sciences, Psychiatry and Medical Psychology Knowledge Area, University of Las Palmas de Gran Canaria","place":["Las Palmas de Gran Canaria, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenceslao","family":"Pe\u00f1ate Castro","sequence":"additional","affiliation":[{"name":"Department of Clinical Psychology, Psychobiology and Methodology, Faculty of Psychology, University of La Laguna","place":["San Crist\u00f3bal de La Laguna, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eilin","family":"Ferreiro D\u00edaz-V\u00e9lis","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Hospital Universitario de Gran Canaria Doctor Negr\u00edn","place":["Las Palmas de Gran Canaria, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Coralia","family":"Sosa P\u00e9rez","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital Universitario de Gran Canaria Doctor Negr\u00edn","place":["Las Palmas de Gran Canaria, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Luis","family":"Hern\u00e1ndez Fleta","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Psychiatry and Medical Psychology Knowledge Area, University of Las Palmas de Gran Canaria","place":["Las Palmas de Gran Canaria, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jes\u00fas","family":"Morera Molina","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital Universitario de Gran Canaria Doctor Negr\u00edn","place":["Las Palmas de Gran Canaria, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,1,30]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1080\/13554794.2024.2439568","article-title":"Knowing and not knowing: Practical reflections on video based feedback as part of neuro-rehabilitation in a case of persistent anosognosia for hemiplegia.","volume":"31","author":"Allum","year":"2025","journal-title":"Neurocase"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1278908","DOI":"10.3389\/fneur.2023.1278908","article-title":"The relationship between cognition and white matter tract damage after mild traumatic brain injury in a premorbidly healthy, hospitalised adult cohort during the post-acute period.","volume":"14","author":"Anderson","year":"2023","journal-title":"Front. 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