{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T08:18:30Z","timestamp":1772180310913,"version":"3.50.1"},"reference-count":86,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T00:00:00Z","timestamp":1772150400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Juvenile Idiopathic Arthritis (JIA) is a heterogeneous pediatric rheumatic disease characterized by persistent pain, functional limitations, and psychosocial difficulties that frequently persist despite optimized pharmacological treatment. Active Action Observation (AAO), which involves observing and then executing goal-directed movements, has been shown to engage mirror-neuron and visuomotor networks. This approach has shown promise in neurological and orthopedic rehabilitation, but has not been studied in adolescents with JIA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the feasibility, acceptability, and preliminary clinical effects of an eight-week home-based AAO telerehabilitation program in adolescents with JIA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A prospective exploratory case series included 10 adolescents with JIA (11\u201317\u202fyears). The participants completed an eight-week AAO protocol delivered via weekly pre-recorded YouTube videos and brief online follow-up sessions. Outcomes were assessed at baseline, week 4, and week 8 and included pain interference (PROMIS), stress (SSI-SM), self-efficacy (GSES), fear of pain (FOPQ-III), Timed Up and Go (TUG), hand-grip strength, 6-min walk test (6MWT), and cervical pressure pain thresholds (PPT). The analyses focused on descriptive statistics, change scores, percentage change, and robust estimators (Hodges\u2013Lehmann, Kendall\u2019s W).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>AAO was feasible and well accepted, with no participants withdrawing, and only mild and transient adverse effects reported. From baseline to week 8, the median changes were \u221242.1% for pain interference, \u221222.2% for stress, +18.8% for self-efficacy, and \u221225.7% for fear of pain\/movement. While functional mobility (TUG) showed improvement, handgrip strength and 6-min walk test responses were found to be heterogeneous, and cervical PPT exhibited a pattern of increased sensitivity. In line with AAO\u2019s neurocognitive framework, the observed reduction in fear of pain, coupled with increased self-efficacy and reduced stress, may indicate an update in threat-related motor representations. This update disrupts the previously formed \u201cmovement\u202f=\u202fdanger\u201d association, thereby enabling safer functional engagement and less pain interference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>AAO delivered at home via telerehabilitation appears to be a feasible, acceptable, and potentially beneficial adjunct for adolescents with JIA, particularly for pain-related and psychological outcomes. These preliminary findings support the feasibility of AAO and justify future controlled trials to establish its efficacy and elucidate the underlying mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnhum.2026.1766070","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T06:51:54Z","timestamp":1772175114000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of active action observation on cognitive, emotional, motor, and somatosensory outcomes in adolescents with juvenile idiopathic arthritis: a prospective exploratory case series"],"prefix":"10.3389","volume":"20","author":[{"given":"Enrique","family":"Carrasco-Gonz\u00e1lez","sequence":"first","affiliation":[{"name":"Physical Therapy Department, CSEU La Salle, Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]},{"name":"Motion in Brains Research Group, CSEU La Salle, Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]},{"name":"Grupo de Investigaci\u00f3n en Neuronciencias Aplicadas a la Rehabilitaci\u00f3n (GINARE)","place":["Alcorc\u00f3n, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillermo","family":"Ceniza-Bordallo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Center for Health Outcomes and Interdisciplinary Research, Massachusetts General Hospital, One Bowdoin Square","place":["Boston, MA, United States"]},{"name":"Department of Psychiatry, Harvard Medical School","place":["Boston, MA, United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Clemente Garulo","sequence":"additional","affiliation":[{"name":"Unidad de Reumatolog\u00eda Pedi\u00e1trica, Hospital Universitario Ni\u00f1o Jes\u00fas","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara","family":"Udaondo Gasc\u00f3n","sequence":"additional","affiliation":[{"name":"Unidad de Reumatolog\u00eda Pedi\u00e1trica, Hospital Universitario La Paz","place":["Madrid, Spain"]},{"name":"Ciberinfec, Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Infecciosas, Instituto de Salud Carlos III","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"Lerma-Lara","sequence":"additional","affiliation":[{"name":"Physical Therapy Department, CSEU La Salle, Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]},{"name":"Motion in Brains Research Group, CSEU La Salle, Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roy","family":"La Touche","sequence":"additional","affiliation":[{"name":"Physical Therapy Department, CSEU La Salle, Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]},{"name":"Motion in Brains Research Group, CSEU La Salle, Universidad Aut\u00f3noma de Madrid","place":["Madrid, Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2026,2,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1016\/j.jvb.2008.10.005","article-title":"The longitudinal impact of self-efficacy and career goals on objective and subjective career success","volume":"74","author":"Abele","year":"2009","journal-title":"J. Vocat. Behav."},{"key":"ref2","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1186\/s12891-023-07070-w","article-title":"A single session of action observation therapy versus observing a natural landscape in adults with chronic neck pain\u2014a randomized controlled trial","volume":"24","author":"Al Shrbaji","year":"2023","journal-title":"BMC Musculoskelet. Disord."},{"key":"ref3","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1111\/apa.14884","article-title":"Review of childhood pain highlights the role of negative stress","volume":"108","author":"Alfven","year":"2019","journal-title":"Acta Paediatrica"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1002\/acr.23100","article-title":"Internet program for physical activity and exercise capacity in children with juvenile idiopathic arthritis: a multicenter randomized controlled trial","volume":"69","author":"Armbrust","year":"2017","journal-title":"Arthritis Care Res."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1186\/s13075-020-02345-2","article-title":"Pain sensitivity in young adults with juvenile idiopathic arthritis: a quantitative sensory testing study","volume":"22","author":"Arnstad","year":"2020","journal-title":"Arthritis Res. Ther."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1164\/ajrccm.166.1.at1102","article-title":"ATS statement: guidelines for the six-minute walk test","volume":"166","year":"2002","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.redar.2020.01.006","article-title":"Test sensitivos cuantitativos (\u00abQuantitative Sensory Testing\u00bb) en el diagn\u00f3stico y tratamiento del dolor. Breve revisi\u00f3n y propuesta de protocolizaci\u00f3n de empleo","volume":"67","author":"Avellanal","year":"2020","journal-title":"Rev. Esp. Anestesiol. Reanim."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3389\/fneur.2020.00016","article-title":"Feasibility of a home-based action observation training for children with unilateral cerebral palsy: an explorative study","volume":"11","author":"Beani","year":"2020","journal-title":"Front. Neurol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"7621","DOI":"10.3390\/jcm14217621","article-title":"Resilience factors and physical activity engagement in adolescents with chronic musculoskeletal pain: a cross-sectional study","volume":"14","author":"Black","year":"2025","journal-title":"J. Clin. Med."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1186\/s12969-023-00828-5","article-title":"A systematic review of the psychosocial factors associated with pain in children with juvenile idiopathic arthritis","volume":"21","author":"Brandelli","year":"2023","journal-title":"Pediatr. Rheumatol. Online J."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"20130185","DOI":"10.1098\/rstb.2013.0185","article-title":"Action observation treatment: a novel tool in neurorehabilitation","volume":"369","author":"Buccino","year":"2014","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"ref12","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1111\/j.1460-9568.2001.01385.x","article-title":"Action observation activates premotor and parietal areas in a somatotopic manner: an fMRI study","volume":"13","author":"Buccino","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"e56816","DOI":"10.2196\/56816","article-title":"Development and delivery of an integrated digital health care approach for children with juvenile idiopathic arthritis: usability study","volume":"7","author":"Butler","year":"2024","journal-title":"JMIR Pediatrics Parenting"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jbtep.2015.06.003","article-title":"Learned, instructed and observed pathways to fear and avoidance","volume":"50","author":"Cameron","year":"2016","journal-title":"J. Behav. Ther. Exp. Psychiatry"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.pedn.2022.05.015","article-title":"Validity and reliability of Spanish PROMIS pediatric pain interference short form","volume":"66","author":"Ceniza-Bordallo","year":"2022","journal-title":"J. Pediatr. Nurs."},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1409","DOI":"10.1002\/acr.25377","article-title":"Relationship of fatigue, pain interference, and physical disability in children newly diagnosed with juvenile idiopathic arthritis","volume":"76","author":"Choong","year":"2024","journal-title":"Arthritis Care Res."},{"key":"ref17","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/1546-0096-12-39","article-title":"Pain hypersensitivity in juvenile idiopathic arthritis: a quantitative sensory testing study","volume":"12","author":"Cornelissen","year":"2014","journal-title":"Pediatr. Rheumatol. Online J."},{"key":"ref18","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1002\/ejp.1870","article-title":"Pain relief by movement representation strategies: an umbrella and mapping review with meta-meta-analysis of motor imagery, action observation and mirror therapy","volume":"26","author":"Cuenca-Mart\u00ednez","year":"2022","journal-title":"European J Pain"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"e70118","DOI":"10.1111\/jon.70118","article-title":"Disrupted sensorimotor network integration in women with fibromyalgia revealed by resting-state functional MRI","volume":"36","author":"De Oliveira","year":"2026","journal-title":"J Neuroimag"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"S69","DOI":"10.1097\/BRS.0b013e31822ef6de","article-title":"Evaluating the correlation and responsiveness of patient-reported pain with function and quality-of-life outcomes after spine surgery","volume":"36","author":"DeVine","year":"2011","journal-title":"Spine"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"1114","DOI":"10.1001\/jamapediatrics.2024.3039","article-title":"Anxiety and depression in youth with chronic pain: a systematic review and Meta-analysis","volume":"178","author":"Dudeney","year":"2024","journal-title":"JAMA Pediatr."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"643","DOI":"10.23736\/S1973-9087.24.08413-2","article-title":"Effectiveness of action observation treatment based on pathological model in hemiplegic children: a randomized-controlled trial","volume":"60","author":"Errante","year":"2024","journal-title":"Eur. J. Phys. Rehabil. Med."},{"key":"ref23","first-page":"475","article-title":"Adaptaci\u00f3n espa\u00f1ola de la escala de manifestaciones de estr\u00e9s del student stress inventory (SSI_SM)","volume":"23","author":"Espejo","year":"2011","journal-title":"Psicothema"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"237","DOI":"10.2147\/OARRR.S174408","article-title":"Depression and anxiety in patients with juvenile idiopathic arthritis: current insights and impact on quality of life, a systematic review","volume":"11","author":"Fair","year":"2019","journal-title":"Open Access Rheumatol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"810","DOI":"10.3390\/children12070810","article-title":"Action observation for children and adolescents with cerebral palsy: Hope or hype? A systematic review with meta-analysis","volume":"12","author":"Fierro-Marrero","year":"2025","journal-title":"Children"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1136\/bjsports-2015-095424","article-title":"Exercise for osteoarthritis of the knee: a Cochrane systematic review","volume":"49","author":"Fransen","year":"2015","journal-title":"Br. J. Sports Med."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1007\/BF03393102","article-title":"Understanding observational learning: an interbehavioral approach","volume":"27","author":"Fryling","year":"2011","journal-title":"Analysis Verbal Behavior"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1111\/head.12246","article-title":"The CARE guidelines: consensus-based clinical case reporting guideline development","volume":"53","author":"Gagnier","year":"2013","journal-title":"Headache"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"8026","DOI":"10.3390\/ijerph17218026","article-title":"Test-retest reliability of handgrip strength measurement in children and preadolescents","volume":"17","author":"G\u0105sior","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1519\/JPT.0000000000000113","article-title":"First-person perspective action observation training in individuals with Parkinson\u2019s disease: a consideration-of-concept controlled pilot trial","volume":"41","author":"Giorgi","year":"2018","journal-title":"J. Geriatr. Phys. Ther."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.pcl.2012.03.014","article-title":"Juvenile idiopathic arthritis","volume":"59","author":"Gowdie","year":"2012","journal-title":"Pediatr. Clin. N. Am."},{"key":"ref32","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1080\/01942638.2023.2299028","article-title":"Impact of musculoskeletal pain on functioning and disability in children with juvenile idiopathic arthritis in Iceland","volume":"44","author":"Gudjonsdottir","year":"2024","journal-title":"Phys. Occup. Ther. Pediatr."},{"key":"ref33","doi-asserted-by":"publisher","first-page":"1671","DOI":"10.1001\/jama.294.13.1671","article-title":"Medical treatment of juvenile idiopathic arthritis","volume":"294","author":"Hashkes","year":"2005","journal-title":"JAMA"},{"key":"ref34","doi-asserted-by":"publisher","first-page":"CD009790","DOI":"10.1002\/14651858.CD009790.pub2","article-title":"Exercise therapy for chronic low back pain","volume":"9","author":"Hayden","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1111\/jan.14574","article-title":"The effect of physical exercise on rheumatoid arthritis: an overview of systematic reviews and meta-analysis","volume":"77","author":"Hu","year":"2021","journal-title":"J. Adv. Nurs."},{"key":"ref36","doi-asserted-by":"publisher","first-page":"108352","DOI":"10.1016\/j.biopsycho.2022.108352","article-title":"The relationship between sleep quality and emotional modulation of spinal, supraspinal, and perceptual measures of pain","volume":"171","author":"Huber","year":"2022","journal-title":"Biol. Psychol."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1542\/peds.109.1.109","article-title":"Current treatment of juvenile rheumatoid arthritis","volume":"109","author":"Ilowite","year":"2002","journal-title":"Pediatrics"},{"key":"ref38","doi-asserted-by":"publisher","first-page":"112184","DOI":"10.1016\/j.jpsychores.2025.112184","article-title":"Telerehabilitation for functional neurological disorders: a scoping review","volume":"195","author":"Jiang","year":"2025","journal-title":"J. Psychosom. Res."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"e596","DOI":"10.1097\/j.pain.0000000000002431","article-title":"Neurobiological antecedents of multisite pain in children","volume":"163","author":"Kaplan","year":"2022","journal-title":"Pain"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.bbi.2016.04.001","article-title":"Why sickness hurts: a central mechanism for pain induced by peripheral inflammation","volume":"57","author":"Karshikoff","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"ref41","doi-asserted-by":"publisher","first-page":"22889","DOI":"10.1038\/s41598-024-73430-8","article-title":"Associations between pain-related fear and lumbar movement variability during activities of daily living in patients with chronic low back pain and healthy controls","volume":"14","author":"Kehl","year":"2024","journal-title":"Sci. Rep."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"e001141","DOI":"10.1136\/rmdopen-2019-001141","article-title":"The impact of upper limb exercise on function, daily activities and quality of life in systemic lupus erythematosus: a pilot randomised controlled trial","volume":"6","author":"Keramiotou","year":"2020","journal-title":"RMD Open"},{"key":"ref43","volume-title":"Therapeutic exercise: Foundations and techniques","author":"Kisner","year":"2017"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"1307","DOI":"10.1016\/j.jpain.2019.05.001","article-title":"Pain-induced reduction in corticomotor excitability is counteracted by combined action-observation and motor imagery","volume":"20","author":"Larsen","year":"2019","journal-title":"J. Pain"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.3899\/jrheum.120793","article-title":"Decreased pain threshold in juvenile idiopathic arthritis: a cross-sectional study","volume":"40","author":"Leegaard","year":"2013","journal-title":"J. Rheumatol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.3390\/biomedicines10051188","article-title":"Distress and sensitization as Main mediators of severity in women with fibromyalgia: a structural equation model","volume":"10","author":"Liew","year":"2022","journal-title":"Biomedicine"},{"key":"ref47","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1097\/AJP.0000000000000385","article-title":"Somatosensory test responses and physical and psychological functioning of children and adolescents with chronic non-neuropathic pain: an exploratory study","volume":"33","author":"Lim","year":"2017","journal-title":"Clin. J. Pain"},{"key":"ref48","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1016\/j.gerinurse.2024.10.013","article-title":"Association of kinesiophobia with pain, disability and functional limitation in adults with knee osteoarthritis: a systematic review and meta-analysis","volume":"60","author":"Lozano-Meca","year":"2024","journal-title":"Geriatr. Nurs."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1136\/bjsports-2017-098673","article-title":"Role of kinesiophobia on pain, disability and quality of life in people suffering from chronic musculoskeletal pain: a systematic review","volume":"53","author":"Luque-Suarez","year":"2019","journal-title":"Br. J. Sports Med."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1097\/PEP.0000000000000333","article-title":"Minimal detectable change for TUG and TUDS tests for children with down syndrome","volume":"29","author":"Martin","year":"2017","journal-title":"Pediatric Physical Therapy"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/j.semarthrit.2014.05.001","article-title":"The impact of rheumatoid arthritis on quality-of-life assessed using the SF-36: a systematic review and meta-analysis","volume":"44","author":"Matcham","year":"2014","journal-title":"Semin. Arthritis Rheum."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1023\/a:1018782831217","article-title":"Development of the fear of pain questionnaire\u2014III","volume":"21","author":"McNeil","year":"1998","journal-title":"J. Behav. Med."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"S53","DOI":"10.3233\/JPD-230219","article-title":"Action observation and motor imagery as a treatment in patients with Parkinson\u2019s disease","volume":"14","author":"Mezzarobba","year":"2024","journal-title":"J. Parkinsons Dis."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1016\/j.jpain.2022.12.007","article-title":"Chronic pain and high impact chronic pain in children and adolescents: a cross-sectional study","volume":"24","author":"Mir\u00f3","year":"2023","journal-title":"J. Pain"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1080\/17476348.2016.1258305","article-title":"Reference value for the 6-minute walk test in children and adolescents: a systematic review","volume":"10","author":"Mylius","year":"2016","journal-title":"Expert Rev. Respir. Med."},{"key":"ref56","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1590\/S0103-05822013000300016","article-title":"Timed \u201cup & go\u201d test in children and adolescents","volume":"31","author":"Nicolini-Panisson","year":"2013","journal-title":"Revista Paulista De Pediatria"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"1348","DOI":"10.1111\/jep.12795","article-title":"Smallest detectable change and test-retest reliability of a self-reported outcome measure: results of the Center for Epidemiologic Studies Depression Scale, general self-efficacy scale, and 12-item general health questionnaire","volume":"23","author":"Ohno","year":"2017","journal-title":"J. Eval. Clin. Pract."},{"key":"ref58","doi-asserted-by":"publisher","first-page":"1797","DOI":"10.3390\/healthcare11121797","article-title":"Feasibility of a home-based mirror therapy program in children with unilateral spastic cerebral palsy","volume":"11","author":"Ortega-Mart\u00ednez","year":"2023","journal-title":"Healthcare"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"168","DOI":"10.12965\/jer.140112","article-title":"The effect of action observation training on knee joint function and gait ability in total knee replacement patients","volume":"10","author":"Park","year":"2014","journal-title":"J Exercise Rehabil"},{"key":"ref60","volume-title":"Textbook of pediatric rheumatology","author":"Petty","year":"2015"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1111\/j.1532-5415.1991.tb01616.x","article-title":"The timed \u201cup & go\u201d: a test of basic functional mobility for frail elderly persons","volume":"39","author":"Podsiadlo","year":"1991","journal-title":"J. Am. Geriatr. Soc."},{"key":"ref62","doi-asserted-by":"publisher","first-page":"109535","DOI":"10.1016\/j.mehy.2019.109535","article-title":"Action observation as a treatment option for fear avoidance behavior in chronic spinal pain","volume":"137","author":"Raghava Neelapala","year":"2020","journal-title":"Med. Hypotheses"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"1119","DOI":"10.3899\/jrheum.2024-0254","article-title":"Pain interference in juvenile idiopathic arthritis","volume":"51","author":"Randell","year":"2024","journal-title":"J. Rheumatol."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/S0140-6736(07)60363-8","article-title":"Juvenile idiopathic arthritis","volume":"369","author":"Ravelli","year":"2007","journal-title":"Lancet"},{"key":"ref65","doi-asserted-by":"publisher","first-page":"e65826","DOI":"10.2196\/65826","article-title":"Digital interventions for patients with juvenile idiopathic arthritis: systematic review and Meta-analysis","volume":"8","author":"Ren","year":"2025","journal-title":"JMIR Pediatrics Parenting"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.bbr.2010.04.027","article-title":"Corticospinal excitability during observation and imagery of simple and complex hand tasks: implications for motor rehabilitation","volume":"213","author":"Roosink","year":"2010","journal-title":"Behav. Brain Res."},{"key":"ref67","author":"Sanju\u00e1n-Su\u00e1rez","year":"2000"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"pzab053","DOI":"10.1093\/ptj\/pzab053","article-title":"Effectiveness of telerehabilitation in physical therapy: a rapid overview","volume":"101","author":"Seron","year":"2021","journal-title":"Phys. Ther."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"e79028","DOI":"10.7759\/cureus.79028","article-title":"Cost-effectiveness of Telerehabilitation compared to traditional in-person rehabilitation: a systematic review and Meta-analysis","volume":"17","author":"Shambushankar","year":"2025","journal-title":"Cureus"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1177\/1359105316686669","article-title":"The reliability and validity of the Spanish version of the fear of pain questionnaire","volume":"24","author":"Sol\u00e9","year":"2019","journal-title":"J. Health Psychol."},{"key":"ref71","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1007\/s11916-012-0298-3","article-title":"The context of pain in arthritis: self-efficacy for managing pain and other symptoms","volume":"16","author":"Somers","year":"2012","journal-title":"Curr. Pain Headache Rep."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"2356346","DOI":"10.1155\/2017\/2356346","article-title":"Effectiveness of therapeutic exercise in fibromyalgia syndrome: a systematic review and meta-analysis of randomized clinical trials","volume":"2017","author":"Sosa-Reina","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"1399","DOI":"10.1002\/art.24115","article-title":"Feasibility and effectiveness of an aerobic exercise program in children with fibromyalgia: results of a randomized controlled pilot trial","volume":"59","author":"Stephens","year":"2008","journal-title":"Arthritis Rheum."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1546-0096-12-13","article-title":"Treatment of juvenile idiopathic arthritis: a revolution in care","volume":"12","author":"Stoll","year":"2014","journal-title":"Pediatr. Rheumatol. Online J."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"2794036","DOI":"10.1155\/2020\/2794036","article-title":"Minimum clinically important difference of Gross motor function and gait endurance in children with motor impairment: a comparison of distribution-based approaches","volume":"2020","author":"Storm","year":"2020","journal-title":"Biomed. Res. Int."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"101934","DOI":"10.1016\/j.berh.2024.101934","article-title":"Practical approaches for clinicians in chronic pain management: strategies and solutions","volume":"38","author":"Sturgeon","year":"2024","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"ref77","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780192632920.001.0001","volume-title":"Arthritis in children and adolescents: Juvenile idiopathic arthritis","author":"Szer","year":"2006"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jad.2024.12.025","article-title":"Exploring the associations between the presence, characteristics, and biopsychosocial covariates of pain and lifetime depression in adolescents: a cross-sectional ABCD study analysis","volume":"372","author":"Tagliaferri","year":"2025","journal-title":"J. Affect. Disord."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s11136-015-1058-8","article-title":"Estimating minimally important difference (MID) in PROMIS pediatric measures using the scale-judgment method","volume":"25","author":"Thissen","year":"2016","journal-title":"Quality Life Res"},{"key":"ref80","doi-asserted-by":"publisher","first-page":"2611","DOI":"10.1002\/art.27561","article-title":"Heterogeneity in juvenile idiopathic arthritis: impact of molecular profiling based on DNA polymorphism and gene expression patterns","volume":"62","author":"Thompson","year":"2010","journal-title":"Arthritis Rheum."},{"key":"ref81","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1177\/0269215516642605","article-title":"Effects of action observation treatment in recovery after total knee replacement: a prospective clinical trial","volume":"31","author":"Villafa\u00f1e","year":"2017","journal-title":"Clin. 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