{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:31:25Z","timestamp":1789173085862,"version":"build-2803163510"},"reference-count":41,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T00:00:00Z","timestamp":1773360000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mild traumatic brain injury (mTBI) often results in persistent cognitive and somatic deficits despite unremarkable routine neuroimaging. Evidence suggests mTBI affects large-scale neural systems rather than isolated regions, yet structural findings remain heterogeneous across studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>This study synthesized T1-weighted MRI data into a unified structural network fingerprint (SNF) of mTBI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We analyzed ten peer-reviewed studies identifying regional abnormalities in adult mTBI via voxel-based, volumetry, grey\/white-matter probability mapping or tensor-based morphometry. Thirty-five significant regions of interest (ROIs) were extracted and mapped to a standardized anatomical atlas. ROIs were categorized into canonical networks, and we applied co-alteration graph modeling, principal component analysis (PCA), and hierarchical clustering to evaluate network-level convergence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The SNF identified a core triad of vulnerability: the default mode network (DMN), the limbic\/memory system, and thalamic\u2013callosal relay structures. Graph modeling revealed robust clustering among DMN\u2013limbic\u2013thalamic regions. Furthermore, PCA and hierarchical clustering demonstrated that structural alterations strictly align with intrinsic network boundaries, rather than appearing as stochastic damage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>mTBI exhibits a reproducible structural signature characterized by DMN and thalamo-limbic involvement. This SNF framework establishes a basis for clinically interpretable biomarkers and computable decision-support tools in concussion care.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnhum.2026.1800956","type":"journal-article","created":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T06:47:51Z","timestamp":1773384471000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":1,"title":["A structural network fingerprint of mild traumatic brain injury: a multi-study synthesis of T1-weighted MRI abnormalities"],"prefix":"10.3389","volume":"20","author":[{"given":"Ioannis","family":"Mavroudis","sequence":"first","affiliation":[{"name":"Leeds Teaching Hospitals, NHS Trust","place":["Leeds, United Kingdom"]},{"name":"Romanian Academy of Scientists (Academia Oamenilor de \u0218tiin\u021b\u0103 din Rom\u00e2nia)","place":["Bucharest, Romania"]},{"name":"Third Department of Neurology, Aristotle University of Thessaloniki","place":["Thessaloniki, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Foivos","family":"Petridis","sequence":"additional","affiliation":[{"name":"Third Department of Neurology, Aristotle University of Thessaloniki","place":["Thessaloniki, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alin-Stelian","family":"Ciob\u00eec\u0103","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Biology, \u201cAlexandru Ioan Cuza\u201d University of Ia\u0219i","place":["Ia\u0219i, Romania"]},{"name":"\u201cIoan H\u0103ulic\u0103\u201d Institute, Apollonia\u201d University of Ia\u0219i","place":["Ia\u0219i, Romania"]},{"name":"Biomedical Research Group, \u201cOlga Necrasov\u201d Center, Romanian Academy","place":["Ia\u0219i, Romania"]},{"name":"CENEMED Platform for Interdisciplinary Research, University of Medicine and Pharmacy, \u201cGrigore T. Popa\u201d","place":["Ia\u0219i, Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roxana O.","family":"Cojocariu","sequence":"additional","affiliation":[{"name":"Department of Biological and Morphological Sciences, Faculty of Medicine and Biological Science, Stefan cel Mare University of Suceava","place":["Suceava, Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitrios","family":"Kazis","sequence":"additional","affiliation":[{"name":"Third Department of Neurology, Aristotle University of Thessaloniki","place":["Thessaloniki, Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Adel Mansour","family":"Kamar","sequence":"additional","affiliation":[{"name":"Medical Department, GUPCO, Cairo Office","place":["Cairo, Egypt"]},{"name":"Department of Orthopedics and Traumatology, Clinical Recovery Hospital (Recuperare)","place":["Ia\u0219i, Romania"]},{"name":"Doctoral School of Biology, Faculty of Biology, \u201cAlexandru Ioan Cuza\u201d University of Ia\u0219i","place":["Ia\u0219i, Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u0103t\u0103lina","family":"Ionescu","sequence":"additional","affiliation":[{"name":"\u201cIoan H\u0103ulic\u0103\u201d Institute, Apollonia\u201d University of Ia\u0219i","place":["Ia\u0219i, Romania"]},{"name":"Doctoral School of Biology, Faculty of Biology, \u201cAlexandru Ioan Cuza\u201d University of Ia\u0219i","place":["Ia\u0219i, Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Gheban","sequence":"additional","affiliation":[{"name":"\u201cIoan H\u0103ulic\u0103\u201d Institute, Apollonia\u201d University of Ia\u0219i","place":["Ia\u0219i, Romania"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalin","family":"Morosan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Grigore T. 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