{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T05:01:21Z","timestamp":1780290081539,"version":"3.54.0"},"reference-count":45,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To evaluate whether neurite orientation dispersion and density imaging (NODDI) can reflect cognitive impairment (CI) in nasopharyngeal carcinoma (NPC) patients with late-delayed radiation-induced temporal lobe injury (RTLI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective study, 90 NPC patients with RTLI underwent structural MRI, conventional diffusion-weighted imaging, and NODDI. Cognitive function was assessed using the Montreal Cognitive Assessment (MoCA; score &amp;lt; 26 indicated CI). NODDI-derived parameters\u2014intra-neurite volume fraction (ICVF), isotropic volume fraction (ISOVF), and orientation dispersion index (ODI)\u2014and apparent diffusion coefficient (ADC) were compared between patients with and without CI. Diagnostic performance and correlations with MoCA scores were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 90 patients, 66 had CI. CI patients exhibited significantly lower ICVF and ODI (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.047, respectively), while ISOVF and ADC did not differ (\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;gt;\u202f0.05). ICVF demonstrated superior discriminative performance (AUC\u202f=\u202f0.869) versus ODI (AUC\u202f=\u202f0.638). Correlation analyses demonstrated a strong positive association between ICVF and the MoCA scores (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u202f=\u202f0.781,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f&amp;lt;\u202f0.001), a weak negative correlation for ISOVF (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u202f=\u202f\u22120.310,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.003) and ADC (\n                      <jats:italic>\u03c1<\/jats:italic>\n                      \u202f=\u202f\u22120.215,\n                      <jats:italic>p<\/jats:italic>\n                      \u202f=\u202f0.041), and no significant correlations for ODI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>NODDI-derived ICVF is associated with CI and correlates with MoCA scores in NPC patients with RTLI.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnhum.2026.1809205","type":"journal-article","created":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T04:18:55Z","timestamp":1780287535000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Association of neurite orientation dispersion and density imaging with cognitive impairment in nasopharyngeal carcinoma patients with radiation-induced temporal lobe injury"],"prefix":"10.3389","volume":"20","author":[{"given":"Weike","family":"Zeng","sequence":"first","affiliation":[{"name":"Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Wen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingxia","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuoheng","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Yan","sequence":"additional","affiliation":[{"name":"MR Research Collaboration Team, Diagnostic Imaging, Siemens Healthineers Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"Qin","sequence":"additional","affiliation":[{"name":"MR Research Collaboration Team, Diagnostic Imaging, Siemens Healthineers Ltd.","place":["Shanghai, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaji","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Radiology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University","place":["Guangzhou, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"eadk1291","DOI":"10.1126\/science.adk1291","article-title":"SynGAP regulates synaptic plasticity and cognition independently of its catalytic activity","volume":"383","author":"Araki","year":"2024","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"6910","DOI":"10.1007\/s00330-022-08853-w","article-title":"A MRI-based radiomics model predicting radiation-induced temporal lobe injury in nasopharyngeal carcinoma","volume":"32","author":"Bao","year":"2022","journal-title":"Eur. 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