{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T13:14:19Z","timestamp":1788354859239,"version":"build-2803163510"},"reference-count":119,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:00:00Z","timestamp":1788307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:p>The neuro-endocrine-immune (NEI) network is a key regulatory network that maintains organismal homeostasis and participates in stress responses. Its function depends on the dynamic coupling among the nervous, endocrine, and immune systems. Astrocytes, as abundant and functionally diverse glial cells in the central nervous system, are increasingly recognized as important participants in the NEI network. Growing evidence indicates that astrocytes do not merely provide structural support in the traditional sense, but also exhibit marked regional heterogeneity and functional diversity. Through broad sensing of neural, endocrine, and immune signals, gliotransmitter release, metabolic regulation, extracellular vesicle-mediated communication, and interactions with neurons, glial cells, the glymphatic system, and endocrine axes, astrocytes actively participate in the integration of neural activity, the regulation of endocrine homeostasis, and immune responses. Under physiological conditions, astrocytes contribute to the dynamic balance of the NEI network by integrating multisource signals derived from neurons, endocrine factors, and immune molecules. Under pathological conditions, such as inflammation, ischemia, and neurodegenerative diseases, the phenotype and function of astrocytes undergo substantial remodeling, thereby contributing to NEI network dysregulation and disease progression. In this structured narrative review, literature published between 2016 and 2026 was retrieved from the PubMed and Web of Science databases using \u201castrocytes,\u201d \u201cnervous,\u201d \u201cendocrine,\u201d and \u201cimmune\u201d as search terms. It summarizes the structural and functional basis of astrocytes and the mechanisms by which they regulate the NEI network, with the aim of systematically elucidating the physiological and pathological significance of astrocytes in NEI network integration and providing a theoretical basis for mechanistic studies and targeted intervention strategies for related diseases.<\/jats:p>","DOI":"10.3389\/fnhum.2026.1865645","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:18:11Z","timestamp":1788351491000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Regulatory mechanisms and research progress of astrocytes in the neuro-endocrine-immune network"],"prefix":"10.3389","volume":"20","author":[{"given":"Xinhui","family":"Cheng","sequence":"first","affiliation":[{"name":"School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]},{"name":"Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Guo","sequence":"additional","affiliation":[{"name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]},{"name":"National Clinical Research Center for Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yupei","family":"Cheng","sequence":"additional","affiliation":[{"name":"School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]},{"name":"Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yu","sequence":"additional","affiliation":[{"name":"First Teaching Hospital of Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]},{"name":"National Clinical Research Center for Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Tranditional Chinese Medicine, Qinghai Unversity Medical College","place":["Xining, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenjun","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]},{"name":"Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Guo","sequence":"additional","affiliation":[{"name":"School of Acupuncture & Moxibustion and Tuina, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]},{"name":"Research Center of Experimental Acupuncture Science, Tianjin University of Traditional Chinese Medicine","place":["Tianjin, China"]},{"name":"National Clinical Research Center for Chinese Medicine","place":["Tianjin, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1126\/science.aat0473","article-title":"Glia as architects of central nervous system formation and function","volume":"362","author":"Allen","year":"2018","journal-title":"Science"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1727","DOI":"10.1126\/science.1206936","article-title":"The hedgehog pathway promotes blood-brain barrier integrity and CNS immune quiescence","volume":"334","author":"Alvarez","year":"2011","journal-title":"Science"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"e1632","DOI":"10.1002\/wsbm.1632","article-title":"Synaptic plasticity and the role of astrocytes in central metabolic circuits","volume":"16","author":"Ameroso","year":"2024","journal-title":"WIREs Mechanisms Dis."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"a041351","DOI":"10.1101\/cshperspect.a041351","article-title":"Generation of mammalian astrocyte functional heterogeneity","volume":"16","author":"Bartels","year":"2024","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"ref5","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1038\/nrn.2016.159","article-title":"Functional diversity of astrocytes in neural circuit regulation","volume":"18","author":"Ben Haim","year":"2016","journal-title":"Nat. Rev. Neurosci."},{"key":"ref6","doi-asserted-by":"publisher","first-page":"457","DOI":"10.1038\/s41593-025-01878-6","article-title":"Astrocyte heterogeneity reveals region-specific astrogenesis in the white matter","volume":"28","author":"Bocchi","year":"2025","journal-title":"Nat. Neurosci."},{"key":"ref7","doi-asserted-by":"publisher","first-page":"1546","DOI":"10.1016\/j.cmet.2021.07.006","article-title":"Astrocyte-neuron metabolic cooperation shapes brain activity","volume":"33","author":"Bonvento","year":"2021","journal-title":"Cell Metab."},{"key":"ref8","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1007\/s00401-021-02391-3","article-title":"Heterogeneity of white matter astrocytes in the human brain","volume":"143","author":"Bugiani","year":"2022","journal-title":"Acta Neuropathol."},{"key":"ref9","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1038\/jcbfm.2011.193","article-title":"White-matter astrocytes, axonal energy metabolism, and axonal degeneration in multiple sclerosis","volume":"32","author":"Cambron","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"ref10","doi-asserted-by":"publisher","first-page":"e13415","DOI":"10.1111\/jne.13415","article-title":"The influence of the prolactin\/vasoinhibin axis on post-stroke lesion volume, astrogliosis, and survival","volume":"36","author":"Castillo","year":"2024","journal-title":"J. Neuroendocrinol."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"531","DOI":"10.1016\/j.neuron.2017.06.029","article-title":"Neural circuit-specialized astrocytes: transcriptomic, proteomic, morphological, and functional evidence","volume":"95","author":"Chai","year":"2017","journal-title":"Neuron"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"102365","DOI":"10.1016\/j.pneurobio.2022.102365","article-title":"Mode of action of astrocytes in pain: from the spinal cord to the brain","volume":"219","author":"Chen","year":"2022","journal-title":"Prog. Neurobiol."},{"key":"ref13","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1038\/s41593-024-01680-w","article-title":"Spatiotemporally selective astrocytic ATP dynamics encode injury information sensed by microglia following brain injury in mice","volume":"27","author":"Chen","year":"2024","journal-title":"Nat. Neurosci."},{"key":"ref14","doi-asserted-by":"publisher","first-page":"1719532","DOI":"10.3389\/fncel.2025.1719532","article-title":"Advances in astrocytic calcium signaling research","volume":"19","author":"Chen","year":"2025","journal-title":"Front. Cell. Neurosci."},{"key":"ref15","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/nrendo.2017.124","article-title":"The special relationship: glia-neuron interactions in the neuroendocrine hypothalamus","volume":"14","author":"Clasadonte","year":"2018","journal-title":"Nat. Rev. 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Neurosci."},{"key":"ref24","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.neuroscience.2018.11.010","article-title":"Diversity and specificity of astrocyte-neuron communication","volume":"396","author":"Durkee","year":"2019","journal-title":"Neuroscience"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"eadc9020","DOI":"10.1126\/science.adc9020","article-title":"Molecular basis of astrocyte diversity and morphology across the CNS in health and disease","volume":"378","author":"Endo","year":"2022","journal-title":"Science"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s40478-020-00897-7","article-title":"Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer","volume":"8","author":"English","year":"2020","journal-title":"Acta Neuropathol. 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Rep."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/nature18928","article-title":"Transfer of mitochondria from astrocytes to neurons after stroke","volume":"535","author":"Hayakawa","year":"2016","journal-title":"Nature"},{"key":"ref36","doi-asserted-by":"publisher","first-page":"4203","DOI":"10.1038\/s44319-025-00529-y","article-title":"Astrocyte diversity and subtypes: aligning transcriptomics with multimodal perspectives","volume":"26","author":"Hennes","year":"2025","journal-title":"EMBO Rep."},{"key":"ref37","doi-asserted-by":"publisher","first-page":"1532","DOI":"10.1016\/j.cmet.2022.09.002","article-title":"Hypothalamic astrocytes control systemic glucose metabolism and energy balance","volume":"34","author":"Herrera Moro Chao","year":"2022","journal-title":"Cell Metab."},{"key":"ref38","doi-asserted-by":"publisher","first-page":"7231","DOI":"10.1523\/JNEUROSCI.1709-08.2008","article-title":"STAT3 is a critical regulator of astrogliosis and scar formation after spinal cord injury","volume":"28","author":"Herrmann","year":"2008","journal-title":"J. Neurosci."},{"key":"ref39","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.bbi.2022.09.002","article-title":"Transfer of neuron-derived \u03b1-synuclein to astrocytes induces neuroinflammation and blood-brain barrier damage after methamphetamine exposure: involving the regulation of nuclear receptor-associated protein 1","volume":"106","author":"Huang","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"ref40","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1016\/j.neuron.2019.02.017","article-title":"Therapeutic AAV gene transfer to the nervous system: a clinical reality","volume":"101","author":"Hudry","year":"2019","journal-title":"Neuron"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1026","DOI":"10.1007\/s11064-022-03699-6","article-title":"A\u03b2 pathology and neuron-glia interactions: a synaptocentric view","volume":"48","author":"Huffels","year":"2023","journal-title":"Neurochem. Res."},{"key":"ref42","doi-asserted-by":"publisher","first-page":"e01901","DOI":"10.1128\/JVI.01901-17","article-title":"Alpha\/beta interferon (IFN-\u03b1\/\u03b2) signaling in astrocytes mediates protection against viral encephalomyelitis and regulates IFN-\u03b3-dependent responses","volume":"92","author":"Hwang","year":"2018","journal-title":"J. Virol."},{"key":"ref43","doi-asserted-by":"publisher","first-page":"147ra111","DOI":"10.1126\/scitranslmed.3003748","article-title":"A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci. Transl. Med."},{"key":"ref44","doi-asserted-by":"publisher","first-page":"885","DOI":"10.1016\/j.tins.2019.09.006","article-title":"Astroglia-derived ATP modulates CNS neuronal circuits","volume":"42","author":"Illes","year":"2019","journal-title":"Trends Neurosci."},{"key":"ref45","doi-asserted-by":"publisher","first-page":"824","DOI":"10.1007\/s11481-013-9480-6","article-title":"Immune players in the CNS: the astrocyte","volume":"8","author":"Jensen","year":"2013","journal-title":"J. Neuroimmune Pharmacol."},{"key":"ref46","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1172\/JCI81950","article-title":"CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5","volume":"126","author":"Jiang","year":"2016","journal-title":"J. Clin. Invest."},{"key":"ref47","doi-asserted-by":"publisher","first-page":"1626","DOI":"10.1038\/s41593-022-01192-5","article-title":"Dentate gyrus astrocytes exhibit layer-specific molecular, morphological and physiological features","volume":"25","author":"Karpf","year":"2022","journal-title":"Nat. Neurosci."},{"key":"ref48","doi-asserted-by":"publisher","first-page":"e3002687","DOI":"10.1371\/journal.pbio.3002687","article-title":"Aberrant activation of hippocampal astrocytes causes neuroinflammation and cognitive decline in mice","volume":"22","author":"Kim","year":"2024","journal-title":"PLoS Biol."},{"key":"ref49","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.trsl.2017.06.010","article-title":"Mesencephalic astrocyte-derived neurotrophic factor (MANF), a new player in endoplasmic reticulum diseases: structure, biology, and therapeutic roles","volume":"188","author":"Kim","year":"2017","journal-title":"Transl. Res."},{"key":"ref50","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1016\/j.expneurol.2016.03.009","article-title":"The multifaceted role of astrocytes in regulating myelination","volume":"283","author":"K\u0131ray","year":"2016","journal-title":"Exp. Neurol."},{"key":"ref51","doi-asserted-by":"publisher","first-page":"691","DOI":"10.1016\/j.tins.2025.06.009","article-title":"A functional perspective on astrocyte heterogeneity","volume":"48","author":"Kwon","year":"2025","journal-title":"Trends Neurosci."},{"key":"ref52","doi-asserted-by":"publisher","first-page":"e23781","DOI":"10.1096\/fj.202301923RR","article-title":"Toll-like receptor 4-dependent innate immune responses are mediated by intracrine corticosteroids and activation of glycogen synthase kinase-3\u03b2 in astrocytes","volume":"38","author":"Lai","year":"2024","journal-title":"FASEB J."},{"key":"ref53","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s40478-023-01526-9","article-title":"Roles of neuropathology-associated reactive astrocytes: a systematic review","volume":"11","author":"Lawrence","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"key":"ref54","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1038\/s41420-025-02812-2","article-title":"Inhibition of astrocyte BMP signaling alleviates neuroinflammation in experimental models of Parkinson\u2019s disease","volume":"11","author":"Li","year":"2025","journal-title":"Cell Death Discov."},{"key":"ref55","doi-asserted-by":"publisher","first-page":"E396","DOI":"10.1073\/pnas.1612930114","article-title":"Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity","volume":"114","author":"Li","year":"2017","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"112676","DOI":"10.1016\/j.intimp.2024.112676","article-title":"Single-cell RNA-sequencing analysis reveals \u03b1-syn induced astrocyte-neuron crosstalk-mediated neurotoxicity","volume":"139","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"ref57","doi-asserted-by":"publisher","first-page":"3274","DOI":"10.1016\/j.cell.2025.04.008","article-title":"Neural-activity-regulated and glia-mediated control of brain lymphatic development","volume":"188","author":"Li","year":"2025","journal-title":"Cell"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1002\/glia.23734","article-title":"Neurochemical regulation of the expression and function of glial fibrillary acidic protein in astrocytes","volume":"68","author":"Li","year":"2020","journal-title":"Glia"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1038\/s41380-024-02851-8","article-title":"Astrocytes release ATP\/ADP and glutamate in flashes via vesicular exocytosis","volume":"30","author":"Li","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"850866","DOI":"10.3389\/fncel.2022.850866","article-title":"The specific role of reactive astrocytes in stroke","volume":"16","author":"Li","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"ref61","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","article-title":"Reactive astrocytes: production, function, and therapeutic potential","volume":"46","author":"Liddelow","year":"2017","journal-title":"Immunity"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s12950-023-00349-8","article-title":"Stem cell-derived brainstem mouse astrocytes obtain a neurotoxic phenotype in vitro upon neuroinflammation","volume":"20","author":"Lindblad","year":"2023","journal-title":"J. Inflamm."},{"key":"ref64","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.pneurobio.2015.09.008","article-title":"Astrocytes, therapeutic targets for neuroprotection and neurorestoration in ischemic stroke","volume":"144","author":"Liu","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"ref65","doi-asserted-by":"publisher","first-page":"892497","DOI":"10.3389\/fncel.2022.892497","article-title":"Astrocytes: GABAceptive and GABAergic cells in the brain","volume":"16","author":"Liu","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"ref66","doi-asserted-by":"publisher","first-page":"7355","DOI":"10.1523\/JNEUROSCI.0115-20.2020","article-title":"Neuron-derived estrogen is critical for astrocyte activation and neuroprotection of the ischemic brain","volume":"40","author":"Lu","year":"2020","journal-title":"J. Neurosci."},{"key":"ref67","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1038\/s41418-018-0150-3","article-title":"Glucocorticoid receptor in astrocytes regulates midbrain dopamine neurodegeneration through connexin hemichannel activity","volume":"26","author":"Maatouk","year":"2019","journal-title":"Cell Death Different."},{"key":"ref68","doi-asserted-by":"publisher","first-page":"e12726","DOI":"10.1111\/jne.12726","article-title":"Astrocytes in neuroendocrine systems: an overview","volume":"31","author":"MacDonald","year":"2019","journal-title":"J. Neuroendocrinol."},{"key":"ref69","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/nrn.2018.19","article-title":"Lactate in the brain: from metabolic end-product to signalling molecule","volume":"19","author":"Magistretti","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"ref70","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1159\/000527182","article-title":"Extracellular vesicles and the stress system","volume":"113","author":"Makrygianni","year":"2023","journal-title":"Neuroendocrinology"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"105568","DOI":"10.1016\/j.isci.2022.105568","article-title":"Astrocyte heterogeneity within white matter tracts and a unique subpopulation of optic nerve head astrocytes","volume":"25","author":"Mazumder","year":"2022","journal-title":"iScience."},{"key":"ref72","doi-asserted-by":"publisher","first-page":"45","DOI":"10.3389\/fnsyn.2018.00045","article-title":"Astrocyte-neuron networks: a multilane highway of signaling for homeostatic brain function","volume":"10","author":"Mederos","year":"2018","journal-title":"Front. Synaptic Neurosci."},{"key":"ref73","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1038\/s41593-020-00752-x","article-title":"GABAergic signaling to astrocytes in the prefrontal cortex sustains goal-directed behaviors","volume":"24","author":"Mederos","year":"2021","journal-title":"Nat. Neurosci."},{"key":"ref74","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/s42255-023-00756-4","article-title":"Loss of fatty acid degradation by astrocytic mitochondria triggers neuroinflammation and neurodegeneration","volume":"5","author":"Mi","year":"2023","journal-title":"Nat. Metab."},{"key":"ref75","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1002\/jnr.22482","article-title":"How factors secreted from astrocytes impact myelin repair","volume":"89","author":"Moore","year":"2011","journal-title":"J. Neurosci. Res."},{"key":"ref76","doi-asserted-by":"publisher","first-page":"1666","DOI":"10.1002\/glia.24188","article-title":"Orai2 channel regulates prostaglandin E2 production in TNF\u03b1\/IL1\u03b1-stimulated astrocytes","volume":"70","author":"Nakajima","year":"2022","journal-title":"Glia"},{"key":"ref77","doi-asserted-by":"publisher","first-page":"13028","DOI":"10.1523\/JNEUROSCI.1449-11.2011","article-title":"Functional duality of astrocytes in myelination","volume":"31","author":"Nash","year":"2011","journal-title":"J. Neurosci."},{"key":"ref78","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1146\/annurev-cellbio-100913-013101","article-title":"Myelination of the nervous system: mechanisms and functions","volume":"30","author":"Nave","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"ref79","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1126\/science.1240514","article-title":"Neuroscience. 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Pathol."},{"key":"ref90","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1002\/glia.24304","article-title":"Monitoring regional astrocyte diversity by cell type-specific proteomic labeling in vivo","volume":"71","author":"Prabhakar","year":"2023","journal-title":"Glia"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1083\/jcb.201010126","article-title":"REST\/NRSF governs the expression of dense-core vesicle gliosecretion in astrocytes","volume":"193","author":"Prada","year":"2011","journal-title":"J. Cell Biol."},{"key":"ref92","doi-asserted-by":"publisher","first-page":"dev166074","DOI":"10.1242\/dev.166074","article-title":"Brain organoids: advances, applications and challenges","volume":"146","author":"Qian","year":"2019","journal-title":"Development"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"1016","DOI":"10.1016\/S1474-4422(18)30318-1","article-title":"The glymphatic pathway in neurological disorders","volume":"17","author":"Rasmussen","year":"2018","journal-title":"Lancet Neurol."},{"key":"ref94","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1002\/glia.23573","article-title":"Astrocyte-targeted IL-10 production decreases proliferation and induces a downregulation of activated microglia\/macrophages after PPT","volume":"67","author":"Recasens","year":"2019","journal-title":"Glia"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1186\/s12974-021-02268-y","article-title":"Small extracellular vesicles encapsulating CCL2 from activated astrocytes induce microglial activation and neuronal apoptosis after traumatic spinal cord injury","volume":"18","author":"Rong","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1038\/s41586-018-0119-x","article-title":"Microglial control of astrocytes in response to microbial metabolites","volume":"557","author":"Rothhammer","year":"2018","journal-title":"Nature"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1038\/s41593-024-01612-8","article-title":"Centripetal integration of past events in hippocampal astrocytes regulated by locus coeruleus","volume":"27","author":"Rupprecht","year":"2024","journal-title":"Nat. Neurosci."},{"key":"ref98","doi-asserted-by":"publisher","first-page":"e20202715","DOI":"10.1084\/jem.20202715","article-title":"Functional immune cell-astrocyte interactions","volume":"218","author":"Sanmarco","year":"2021","journal-title":"J. Exp. 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Alzheimer's Dis"},{"key":"ref102","doi-asserted-by":"publisher","first-page":"755955","DOI":"10.3389\/fncel.2021.755955","article-title":"Activation and role of astrocytes in ischemic stroke","volume":"15","author":"Shen","year":"2021","journal-title":"Front. Cell. 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