{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:56:19Z","timestamp":1790571379806,"version":"4.1.0"},"reference-count":59,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Hum. Neurosci."],"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sleep disturbances affect nearly half of older adults and are linked to cognitive decline, yet the mechanistic pathways linking exercise to cognitive benefits remain poorly understood. We hypothesized that sleep quality mediates the exercise\u2013cognition relationship in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We systematically searched PubMed, Web of Science, Cochrane CENTRAL, Embase, and PsycINFO from inception to June 2026 for randomized controlled trials examining structured exercise interventions (\u22654 weeks) in adults aged \u226560 years that reported both cognitive and sleep outcomes. Random-effects meta-analyses and meta-analytic structural equation modeling (MASEM) were used to test the mediation hypothesis. Subgroup analyses examined baseline cognitive status and intervention duration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight studies (841 participants) were included. Exercise significantly improved cognitive function (SMD = 1.32, 95% CI: 0.70\u20131.94) and sleep quality (SMD = \u22121.13, 95% CI: \u22121.73 to \u22120.53). MASEM confirmed sleep quality as a significant partial mediator, with an indirect effect of \u03b2 = 0.300 (95% CI: 0.125\u20130.404), accounting for 50.8% of the total cognitive benefit. The mediation proportion was larger in individuals with mild cognitive impairment (67.6%) than in cognitively healthy older adults (31.9%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sleep quality significantly mediates the exercise\u2013cognition relationship in older adults, accounting for approximately half of the cognitive benefit. These findings identify sleep as a candidate mechanistic target for optimizing exercise interventions, though larger mediation-designed trials are needed to confirm these exploratory estimates.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3389\/fnhum.2026.1949679","type":"journal-article","created":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T04:29:20Z","timestamp":1790569760000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of exercise on cognitive function in older adults: a systematic review and meta-analysis of the mediating role of sleep"],"prefix":"10.3389","volume":"20","author":[{"given":"Wenhui","family":"Zheng","sequence":"first","affiliation":[{"name":"School of Sports Training, Guangzhou Sport University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mian","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Sports Science, South China Normal University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhe","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Physical Education, Zhuhai University of Science and Technology","place":["Zhuhai, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaolan","family":"Li","sequence":"additional","affiliation":[{"name":"School of Sports Training, Guangzhou Sport University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liying","family":"Huang","sequence":"additional","affiliation":[{"name":"School of Sports and Health, Guangzhou Sport University","place":["Guangzhou, Guangdong, China"]},{"name":"Guangdong Provincial Key Laboratory of Human Movement Science, Guangzhou Sport University","place":["Guangzhou, Guangdong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2026,9,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.gerinurse.2023.02.008","article-title":"Effects of aerobic exercise on global cognitive function and sleep in older adults with mild cognitive impairment: a systematic review and meta-analysis","volume":"51","author":"Ahn","year":"2023","journal-title":"Geriatr. 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