{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T11:56:38Z","timestamp":1768823798221,"version":"3.49.0"},"reference-count":38,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T00:00:00Z","timestamp":1699488000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neuroimaging"],"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>It is now understood that in focal epilepsy, impacted neural regions are not limited to the epileptogenic zone. As such, further investigation into the underlying functional connectivity (FC) patterns in those enduring Temporal Lobe Epilepsy (TLE) with Mesial Temporal Sclerosis (MTS) is imperative to understanding the intricacies of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The rsfMRIs of 17 healthy participants, 10 left-sided TLE-MTS patients with a pre-operative history of focal impaired awareness seizures (FIA), and 13 left-sided TLE-MTS patients with a pre-operative history of focal aware seizures (FA) were compared to determine the existence of distinct FC patterns with respect to seizure types. Similarly, the rsfMRIs of the above-mentioned healthy participants, 16 left-sided TLE-MTS individuals who were seizure-free (SF) 12 months postoperatively, and 16 left-sided TLE-MTS persons without seizure freedom (nSF) were interrogated. The ROI-to-ROI connectivity analysis included a total of 175 regions of interest (ROIs) and accounted for both age and duration of epileptic activity. Significant correlations were determined via two-sample <jats:italic>t-<\/jats:italic>tests and Bonferroni correction (\u03b1 = 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Comparisons of FA and FIA groups depicted significant correlations between the contralateral anterior cingulate gyrus, subgenual region, and the contralateral cerebellum, lobule III (<jats:italic>p<\/jats:italic>-value = 2.26e-4, mean z-score = \u22120.05 \u00b1 0.28, T = \u22124.23). Comparisons of SF with nSF depicted two significantly paired-ROIs; the contralateral amygdala and the contralateral precuneus (<jats:italic>p-<\/jats:italic>value = 2.9e-5, mean z-score = \u22120.12 \u00b1 0.19, T = 4.98), as well as the contralateral locus coeruleus and the ipsilateral intralaminar nucleus (<jats:italic>p<\/jats:italic>-value= 1.37e-4, mean z-score = 0.06 \u00b1 0.17, T = \u22124.41).<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>FC analysis proves to be a lucrative modality for exploring unique signatures with respect to seizure types and postoperative outcomes. By furthering our understanding of the differences between epileptic phenotypes, we can achieve improvement in future treatment modalities not limited to targeting advancements.<\/jats:p><\/jats:sec>","DOI":"10.3389\/fnimg.2023.1201682","type":"journal-article","created":{"date-parts":[[2023,11,13]],"date-time":"2023-11-13T02:46:56Z","timestamp":1699843616000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":3,"title":["Profiles of resting state functional connectivity in temporal lobe epilepsy associated with post-laser interstitial thermal therapy seizure outcomes and semiologies"],"prefix":"10.3389","volume":"2","author":[{"given":"Mashaal","family":"Syed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingya","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anish","family":"Sathe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kichang","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arichena","family":"Manmatharayan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Kogan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caio M.","family":"Matias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwini","family":"Sharan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi","family":"Alizadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2023,11,9]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"108122","DOI":"10.1016\/j.yebeh.2021.108122","article-title":"Temporal lobe epilepsy: a never-ending story","volume":"122","author":"Abarrategui","year":"2021","journal-title":"Epilepsy Behav."},{"key":"B2","doi-asserted-by":"publisher","first-page":"e77916","DOI":"10.1371\/journal.pone.0077916","article-title":"Functional connectivity estimated from intracranial EEG predicts surgical outcome in intractable temporal lobe epilepsy","volume":"8","author":"Antony","year":"2013","journal-title":"PLoS ONE"},{"key":"B3","doi-asserted-by":"publisher","first-page":"662","DOI":"10.1016\/j.wneu.2016.12.074","article-title":"Prevalence and incidence of drug-resistant mesial temporal lobe epilepsy in the United States","volume":"99","author":"Asadi-Pooya","year":"2017","journal-title":"World Neurosurg."},{"key":"B4","doi-asserted-by":"publisher","first-page":"48","DOI":"10.2214\/AJR.16.16144","article-title":"Journal club: longitudinal qualitative characterization of mri features after laser interstitial thermal therapy in drug-resistant epilepsy","volume":"208","author":"Atsina","year":"2017","journal-title":"Am. 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