{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T20:12:24Z","timestamp":1765483944035},"reference-count":47,"publisher":"Frontiers Media SA","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2014.00291","type":"journal-article","created":{"date-parts":[[2014,9,12]],"date-time":"2014-09-12T14:35:32Z","timestamp":1410532532000},"source":"Crossref","is-referenced-by-count":5,"title":["Enhanced sensitivity of laforin- and malin-deficient mice to the convulsant agent pentylenetetrazole"],"prefix":"10.3389","volume":"8","author":[{"given":"Ana M.","family":"Garc\u00c3\u00ada-Cabrero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gentzane","family":"S\u00c3\u00a1nchez-Elexpuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00c3\u00a9 M.","family":"Serratosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina P.","family":"S\u00c3\u00a1nchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2014,9,12]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1111\/j.1528-1157.1995.tb00482.x","article-title":"Familial progressive myoclonus epilepsy: clinical and electrophysiologic observations","volume":"36","author":"Acharya","year":"1995","journal-title":"Epilepsia"},{"key":"B2","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1093\/hmg\/ddq190","article-title":"Laforin, the most common protein mutated in Lafora disease, regulates autophagy","volume":"19","author":"Aguado","year":"2010","journal-title":"Hum. Mol. Genet"},{"key":"B3","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1056\/NEJM198607313150506","article-title":"Progressive myoclonus epilepsies: specific causes and diagnosis","volume":"315","author":"Berkovic","year":"1986","journal-title":"N. Engl. J. Med"},{"key":"B4","doi-asserted-by":"publisher","first-page":"261","DOI":"10.1097\/00004691-199107010-00003","article-title":"Progressive myoclonus epilepsies: clinical and neurophysiological diagnosis","volume":"8","author":"Berkovic","year":"1991","journal-title":"J. Clin. Neurophysiol"},{"key":"B5","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1002\/ana.410100116","article-title":"Ultrastructural findings in Lafora disease","volume":"10","author":"Carpenter","year":"1981","journal-title":"Ann. Neurol"},{"key":"B6","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1136\/jmg.40.9.671","article-title":"Genetic mapping of a new Lafora progressive myoclonus epilepsy locus (EPM2B) on 6p22","volume":"40","author":"Chan","year":"2003","journal-title":"J. Med. Genet"},{"key":"B7","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1212\/01.WNL.0000133215.65836.03","article-title":"Progressive myoclonus epilepsy with polyglucosans (Lafora disease): evidence for a third locus","volume":"63","author":"Chan","year":"2004","journal-title":"Neurology"},{"key":"B8","doi-asserted-by":"publisher","first-page":"841","DOI":"10.2174\/092986709787549316","article-title":"Epilepsy, regulation of brain energy metabolism and neurotransmission","volume":"16","author":"Cloix","year":"2009","journal-title":"Curr. Med. Chem"},{"key":"B9","doi-asserted-by":"publisher","first-page":"314","DOI":"10.1016\/S0006-8993(00)03103-6","article-title":"Post-ictal analgesia: involvement of opioid, serotoninergic and cholinergic mechanisms","volume":"888","author":"Coimbra","year":"2001a","journal-title":"Brain Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/S0006-8993(01)02366-6","article-title":"Opioid neurotransmission in the post-ictal analgesia: involvement of mu(1)-opioid receptor","volume":"903","author":"Coimbra","year":"2001b","journal-title":"Brain Res"},{"key":"B11","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1093\/hmg\/ddr590","article-title":"Lafora bodies and neurological defects in malin-deficient mice correlate with impaired autophagy","volume":"21","author":"Criado","year":"2012","journal-title":"Hum. Mol. Genet"},{"key":"B12","doi-asserted-by":"publisher","first-page":"25372","DOI":"10.1074\/jbc.M110.148668","article-title":"Genetic depletion of the malin E3 ubiquitin ligase in mice leads to lafora bodies and the accumulation of insoluble laforin","volume":"285","author":"Depaoli-Roach","year":"2010","journal-title":"J. Biol. Chem"},{"key":"B13","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/B978-012088554-1\/50036-0","article-title":"Kainate-induced status epilepticus: a chronic model of acquired epilepsy","volume-title":"Models of Seizures and Epilepsy","author":"Dudek","year":"2006"},{"key":"B14","doi-asserted-by":"publisher","first-page":"2061","DOI":"10.1093\/brain\/awn133","article-title":"Recurrent seizures and brain pathology after inhibition of glutamine synthetase in the hippocampus in rats","volume":"131","author":"Eid","year":"2008","journal-title":"Brain"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1200","DOI":"10.1046\/j.1471-4159.2003.01781.x","article-title":"Pentylenetetrazole decreases metabolic glutamate turnover in rat brain","volume":"85","author":"Eloqayli","year":"2003","journal-title":"J. Neurochem"},{"key":"B16","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S0920-1211(00)00197-2","article-title":"Altered activities of rat brain metabolic enzymes caused by pentylenetetrazol kindling and pentylenetetrazol\u00e2\u20ac\u201cinduced seizures","volume":"43","author":"Erakovic","year":"2001","journal-title":"Epilepsy Res"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1251","DOI":"10.1093\/hmg\/11.11.1251","article-title":"Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy and impaired behavioral response in mice","volume":"11","author":"Ganesh","year":"2002","journal-title":"Hum. Mol. Genet"},{"key":"B18","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1097\/NEN.0b013e318253350f","article-title":"Laforin and malin deletions in mice produce similar neurologic impairments","volume":"71","author":"Garcia-Cabrero","year":"2012","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"B19","doi-asserted-by":"publisher","first-page":"477","DOI":"10.1083\/jcb.200704094","article-title":"The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease","volume":"178","author":"Gentry","year":"2007","journal-title":"J. Cell Biol"},{"key":"B20","doi-asserted-by":"publisher","first-page":"8501","DOI":"10.1073\/pnas.0503285102","article-title":"Insights into Lafora disease: malin is an E3 ubiquitin ligase that ubiquitinates and promotes the degradation of laforin","volume":"102","author":"Gentry","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B21","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1212\/01.WNL.0000154519.10805.F7","article-title":"Lafora disease due to EPM2B mutations: a clinical and genetic study","volume":"64","author":"Gomez-Abad","year":"2005","journal-title":"Neurology"},{"key":"B22","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1093\/brain\/78.3.325","article-title":"Progressive familial myoclonic epilepsy in three families: its clinical features and pathological basis","volume":"78","author":"Harriman","year":"1955","journal-title":"Brain"},{"key":"B23","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/BF01989438","article-title":"\u00c3\u0153ber das Corkommen amyloider K\u00c3\u00b6rperchen im Innern der Ganglienzellen; zugliech Ein zum Studium der amyloiden Substanz im Nervensystem","volume":"205","author":"Lafora","year":"1911","journal-title":"Virchows Arch. Pathol. Anat"},{"key":"B24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF02863929","article-title":"Beitrag zur Histogpathologie der myoklonischen Epilepsie","volume":"6","author":"Lafora","year":"1911","journal-title":"Z. Gesamte Neurol. Psychiatr"},{"key":"B25","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1016\/S0301-0082(97)00035-X","article-title":"Animal models of intractable epilepsy","volume":"53","author":"L\u00c3\u00b6scher","year":"1997","journal-title":"Prog. Neurobiol"},{"key":"B26","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1038\/2470","article-title":"Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy","volume":"20","author":"Minassian","year":"1998","journal-title":"Nat. Genet"},{"key":"B27","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1007\/s004010051048","article-title":"Immunohistochemical, conventional and immunoelectron microscopical characteristics of periodic acid-Schiff-positive granules in the mouse brain","volume":"98","author":"Mitsuno","year":"1999","journal-title":"Acta Neuropathol"},{"key":"B28","first-page":"48","article-title":"Effect of the pentylenetetrazole (PTZ) induced seizures on the gabaergic system in the mouse brain","volume":"10","author":"Panagopoulos","year":"1998","journal-title":"Eur. J. Neurosci"},{"key":"B29","volume-title":"Models of Seizures and Epilepsy","author":"Pitkanen","year":"2006"},{"key":"B30","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/B978-0-12-721840-3.50009-X","article-title":"Experimental evaluation of anticonvulsants","volume-title":"Anticonvulsants","author":"Reinhard","year":"1977"},{"key":"B31","first-page":"381","article-title":"Progressive myoclonus epilepsies in childhood and adolescence","volume-title":"Epileptic Syndromes in Infancy, Childhood and Adolescence","author":"Roger","year":"1992"},{"key":"B32","doi-asserted-by":"publisher","first-page":"160","DOI":"10.1212\/WNL.20.2.160","article-title":"Studies in myoclonus epilepsy (Lafora body form). II. polyglucosans in the systemic deposits of myoclonus epilepsy and in corpora amylacea","volume":"20","author":"Sakai","year":"1970","journal-title":"Neurology"},{"key":"B33","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1093\/hmg\/8.2.345","article-title":"A novel protein tyrosine phosphatase gene is mutated in progressive myoclonus epilepsy of the Lafora type (EPM2)","volume":"8","author":"Serratosa","year":"1999","journal-title":"Hum. Mol. Genet"},{"key":"B34","first-page":"265","article-title":"Anti-seizure efficacy of nimodipine in pentylenetetrazole and kainic acid combined seizure models in mice","volume":"50","author":"Shitak","year":"2006","journal-title":"Indian J. Physiol. Pharmacol"},{"key":"B35","doi-asserted-by":"publisher","first-page":"e48","DOI":"10.1136\/jmg.2005.039479","article-title":"Novel NHLRC1 mutations and genotype-phenotype correlations in patients with Lafora's progressive myoclonic epilepsy","volume":"43","author":"Singh","year":"2006","journal-title":"J. Med. Genet"},{"key":"B36","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1007\/s10038-005-0263-7","article-title":"Mutations in the NHLRC1 gene are the common cause for Lafora disease in the Japanese population","volume":"50","author":"Singh","year":"2005","journal-title":"J. Hum. Genet"},{"key":"B37","doi-asserted-by":"crossref","first-page":"6218","DOI":"10.1523\/JNEUROSCI.20-16-06218.2000","article-title":"Modulation of absence seizures by the GABA(A) receptor: a critical rolefor metabotropic glutamate receptor 4 (mGluR4)","volume":"20","author":"Snead","year":"2000","journal-title":"J. Neurosci"},{"key":"B38","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1159\/000136093","article-title":"Convulsant actions of tetrazole derivatives","volume":"3","author":"Stone","year":"1970","journal-title":"Pharmacology"},{"key":"B39","first-page":"85","article-title":"Experimental selection, quantification, and evaluation of anticonvulsants","volume-title":"Antiepileptic drugs","author":"Swinyard","year":"1989"},{"key":"B40","doi-asserted-by":"publisher","first-page":"33816","DOI":"10.1074\/jbc.M807428200","article-title":"Abnormal metabolism of glycogen phosphate as a cause for Lafora disease","volume":"283","author":"Tagliabracci","year":"2008","journal-title":"J. Biol. Chem"},{"key":"B41","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1002\/ana.22156","article-title":"Glycogen hyperphosphorylation underlies lafora body formation","volume":"68","author":"Turnbull","year":"2010","journal-title":"Ann. Neurol"},{"key":"B42","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1002\/emmm.201100174","article-title":"Neurodegeneration and functional impairments associated with glycogen synthase accumulation in a mouse model of Lafora disease","volume":"3","author":"Valles-Ortega","year":"2011","journal-title":"EMBO Mol. Med"},{"key":"B43","first-page":"382","article-title":"Lafora disease, a form of progressive myoclonus epilepsy","volume-title":"The Epilepsies, Handbook of Clinical Neurology","author":"Van Heycop Ten Ham","year":"1974"},{"key":"B44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/B978-012088554-1\/50013-X","article-title":"Models of chemically-induced acute seizures","volume-title":"Models of Seizures and Epilepsy","author":"Velisek","year":"2006"},{"key":"B45","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1111\/j.1528-1157.1969.tb03841.x","article-title":"The developing animal as a model","volume":"10","author":"Vernadakis","year":"1969","journal-title":"Epilepsia"},{"key":"B46","first-page":"249","article-title":"Convulsant drugs: mechanism of action","volume-title":"Advances in Neurology","author":"Woodbury","year":"1980"},{"key":"B47","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1001\/archneur.1968.00480010033002","article-title":"Studies in myoclonus epilepsy (Lafora body form). I. isolation and preliminary characterization of Lafora bodies in two cases","volume":"19","author":"Yokoi","year":"1968","journal-title":"Arch. Neurol"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"deposited":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T23:11:12Z","timestamp":1565824272000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnins.2014.00291\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,12]]},"references-count":47,"URL":"https:\/\/doi.org\/10.3389\/fnins.2014.00291","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,12]]}}}