{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T04:56:33Z","timestamp":1779080193972,"version":"3.51.4"},"reference-count":66,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R37-AA015614"],"award-info":[{"award-number":["R37-AA015614"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K12-GM088021"],"award-info":[{"award-number":["K12-GM088021"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50-AA022534"],"award-info":[{"award-number":["P50-AA022534"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2016.00266","type":"journal-article","created":{"date-parts":[[2016,6,7]],"date-time":"2016-06-07T23:46:55Z","timestamp":1465343215000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":10,"title":["Third Trimester Equivalent Alcohol Exposure Reduces Modulation of Glutamatergic Synaptic Transmission by 5-HT1A Receptors in the Rat Hippocampal CA3 Region"],"prefix":"10.3389","volume":"10","author":[{"given":"Russell A.","family":"Morton","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Fernando","family":"Valenzuela","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2016,6,8]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1126\/science.1101678","article-title":"Early-life blockade of the 5-HT transporter alters emotional behavior in adult mice","volume":"306","author":"Ansorge","year":"2004","journal-title":"Science"},{"key":"B2","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1046\/j.1460-9568.2002.02072.x","article-title":"Differential modulation of I(h) by 5-HT receptors in mouse CA1 hippocampal neurons","volume":"16","author":"Bickmeyer","year":"2002","journal-title":"Eur. J. Neurosci."},{"key":"B3","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1016\/S0028-3908(97)00056-7","article-title":"Role of the 5-HT1A receptor in development of the neonatal rat brain: preliminary behavioral studies","volume":"36","author":"Borella","year":"1997","journal-title":"Neuropharmacology"},{"key":"B4","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/dev.21385","article-title":"Prenatal stress and early-life exposure to fluoxetine have enduring effects on anxiety and hippocampal BDNF gene expression in adult male offspring","volume":"58","author":"Boulle","year":"2015","journal-title":"Dev. Psychobiol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1038\/nn.3304","article-title":"Memory, navigation and theta rhythm in the hippocampal-entorhinal system","volume":"16","author":"Buzsaki","year":"2013","journal-title":"Nat. Neurosci."},{"key":"B6","doi-asserted-by":"publisher","first-page":"36553","DOI":"10.1074\/jbc.M203752200","article-title":"Serotonin 5-HT1A receptors regulate AMPA receptor channels through inhibiting Ca2+\/calmodulin-dependent kinase II in prefrontal cortical pyramidal neurons","volume":"277","author":"Cai","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B7","doi-asserted-by":"publisher","first-page":"2163","DOI":"10.1046\/j.1460-9568.1998.00229.x","article-title":"Serotonin depresses excitatory synaptic transmission and depolarization-evoked Ca2+ influx in rat basolateral amygdala via 5-HT1A receptors","volume":"10","author":"Cheng","year":"1998","journal-title":"Eur. J. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1097\/WNR.0b013e3283614cbf","article-title":"5-Hydroxytryptamine 1A receptors inhibit glutamate release in rat medullary dorsal horn neurons","volume":"24","author":"Choi","year":"2013","journal-title":"Neuroreport"},{"key":"B9","doi-asserted-by":"publisher","first-page":"790","DOI":"10.1002\/hipo.20940","article-title":"5-HT(1A) and 5-HT(7) receptors differently modulate AMPA receptor-mediated hippocampal synaptic transmission","volume":"22","author":"Costa","year":"2012","journal-title":"Hippocampus"},{"key":"B10","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.devbrainres.2004.02.009","article-title":"The serotonin-1A agonist ipsapirone prevents ethanol-associated death of total rhombencephalic neurons and prevents the reduction of fetal serotonin neurons","volume":"150","author":"Druse","year":"2004","journal-title":"Brain Res. Dev. Brain Res."},{"key":"B11","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.brainres.2006.02.065","article-title":"The effects of ethanol and the serotonin(1A) agonist ipsapirone on the expression of the serotonin(1A) receptor and several antiapoptotic proteins in fetal rhombencephalic neurons","volume":"1092","author":"Druse","year":"2006","journal-title":"Brain Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.devbrainres.2005.06.015","article-title":"Signaling pathways involved with serotonin1A agonist-mediated neuroprotection against ethanol-induced apoptosis of fetal rhombencephalic neurons","volume":"159","author":"Druse","year":"2005","journal-title":"Brain Res. Dev. Brain Res."},{"key":"B13","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1159\/000207490","article-title":"Drugs, biogenic amine targets and the developing brain","volume":"31","author":"Frederick","year":"2009","journal-title":"Dev. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.alcohol.2006.11.001","article-title":"Immature hippocampal neuronal networks do not develop tolerance to the excitatory actions of ethanol","volume":"40","author":"Galindo","year":"2006","journal-title":"Alcohol"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1500","DOI":"10.1111\/j.1471-4159.2005.03294.x","article-title":"Alcohol is a potent stimulant of immature neuronal networks: implications for fetal alcohol spectrum disorder","volume":"94","author":"Galindo","year":"2005","journal-title":"J. Neurochem."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1002","DOI":"10.1038\/nrn1256","article-title":"The developmental role of serotonin: news from mouse molecular genetics","volume":"4","author":"Gaspar","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"3093","DOI":"10.1046\/j.1460-9568.1999.00728.x","article-title":"Action of serotonin on the hyperpolarization-activated cation current (Ih) in rat CA1 hippocampal neurons","volume":"11","author":"Gasparini","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1038\/416396a","article-title":"Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult","volume":"416","author":"Gross","year":"2002","journal-title":"Nature"},{"key":"B19","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1002\/syn.890200109","article-title":"Pre- and post-synaptic effects of the 5-HT3 agonist 2-methyl-5-HT on the 5-HT system in the rat brain","volume":"20","author":"Haddjeri","year":"1995","journal-title":"Synapse"},{"key":"B20","doi-asserted-by":"publisher","first-page":"15049","DOI":"10.1073\/pnas.95.25.15049","article-title":"Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice","volume":"95","author":"Heisler","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B21","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1111\/j.1530-0277.2006.00316.x","article-title":"Hypothalamic-pituitary-adrenal responses to 5-HT1A and 5-HT2A\/C agonists are differentially altered in female and male rats prenatally exposed to ethanol","volume":"31","author":"Hofmann","year":"2007","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B22","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.pbb.2005.10.010","article-title":"Prenatal ethanol exposure: sex differences in anxiety and anxiolytic response to a 5-HT1A agonist","volume":"82","author":"Hofmann","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B23","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1007\/s00213-002-1048-8","article-title":"Prenatal ethanol exposure in rats alters serotonergic-mediated behavioral and physiological function","volume":"161","author":"Hofmann","year":"2002","journal-title":"Psychopharmacology (Berl)."},{"key":"B24","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/j.euroneuro.2008.09.002","article-title":"Long-lasting behavioural and molecular alterations induced by early postnatal fluoxetine exposure are restored by chronic fluoxetine treatment in adult mice","volume":"19","author":"Karpova","year":"2009","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1111\/j.1530-0277.1997.tb04434.x","article-title":"Effects of maternal ethanol consumption and buspirone treatment on 5-HT1A and 5-HT2A receptors in offspring","volume":"21","author":"Kim","year":"1997","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1093\/jnen\/62.11.1178","article-title":"Serotonergic brainstem abnormalities in Northern Plains Indians with the sudden infant death syndrome","volume":"62","author":"Kinney","year":"2003","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1016\/j.biopsych.2007.07.017","article-title":"Moderate level fetal alcohol exposure and serotonin transporter gene promoter polymorphism affect neonatal temperament and limbic-hypothalamic-pituitary-adrenal axis regulation in monkeys","volume":"63","author":"Kraemer","year":"2008","journal-title":"Biol. Psychiatry"},{"key":"B28","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/0361-9230(82)90077-6","article-title":"An immunohistochemical study of serotonin neuron development in the rat: ascending pathways and terminal fields","volume":"8","author":"Lidov","year":"1982","journal-title":"Brain Res. Bull."},{"key":"B29","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/S0892-0362(03)00030-8","article-title":"Fetal alcohol exposure and temporal vulnerability: effects of binge-like alcohol exposure on the developing rat hippocampus","volume":"25","author":"Livy","year":"2003","journal-title":"Neurotoxicol. Teratol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1113\/jphysiol.2012.235119","article-title":"The developmental stages of synaptic plasticity","volume":"592","author":"Lohmann","year":"2014","journal-title":"J. Physiol. (Lond)."},{"key":"B31","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1016\/S0306-4522(98)00106-7","article-title":"Endogenous serotonin inhibits epileptiform activity in rat hippocampal CA1 neurons via 5-hydroxytryptamine1A receptor activation","volume":"86","author":"Lu","year":"1998","journal-title":"Neuroscience"},{"key":"B32","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/S0741-8329(00)00133-6","article-title":"Regional differences in cell loss associated with binge-like alcohol exposure during the first two trimesters equivalent in the rat","volume":"23","author":"Maier","year":"2001","journal-title":"Alcohol"},{"key":"B33","doi-asserted-by":"publisher","first-page":"8027","DOI":"10.1523\/JNEUROSCI.2434-05.2005","article-title":"Developmentally regulated actions of alcohol on hippocampal glutamatergic transmission","volume":"25","author":"Mameli","year":"2005","journal-title":"J. Neurosci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1016\/S0006-8993(97)00297-7","article-title":"Serotonin depletion during synaptogenesis leads to decreased synaptic density and learning deficits in the adult rat: a possible model of neurodevelopmental disorders with cognitive deficits","volume":"760","author":"Mazer","year":"1997","journal-title":"Brain Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1111\/j.1471-4159.2007.04448.x","article-title":"Plasticity of 5-HT 1A receptor-mediated signaling during early postnatal brain development","volume":"101","author":"Mehta","year":"2007","journal-title":"J. Neurochem."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1106","DOI":"10.1038\/mp.2012.128","article-title":"Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation","volume":"18","author":"Migliarini","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"B37","doi-asserted-by":"publisher","first-page":"e66","DOI":"10.1038\/tp.2011.58","article-title":"Serotonin 1A receptor-mediated signaling through ERK and PKCalpha is essential for normal synaptogenesis in neonatal mouse hippocampus","volume":"2","author":"Mogha","year":"2012","journal-title":"Transl. Psychiatry"},{"key":"B38","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1615\/CritRevNeurobiol.v18.i1-2.30","article-title":"Role of giant depolarizing potentials in shaping synaptic currents in the developing hippocampus","volume":"18","author":"Mohajerani","year":"2006","journal-title":"Crit. Rev. Neurobiol."},{"key":"B39","doi-asserted-by":"publisher","DOI":"10.3791\/51839","article-title":"Construction of vapor chambers used to expose mice to alcohol during the equivalent of all three trimesters of human development","author":"Morton","year":"2014","journal-title":"J. Vis. Exp."},{"key":"B40","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1523\/ENEURO.0079-15.2015","article-title":"Electrophysiological assessment of serotonin and GABA neuron function in the dorsal raphe during the third trimester equivalent developmental period in mice","author":"Morton","year":"2015","journal-title":"eNeuro"},{"key":"B41","first-page":"97","article-title":"Advances in Diagnosis and treatment of fetal alcohol spectrum disorders: from animal models to human studies","volume":"37","author":"Murawski","year":"2015","journal-title":"Alcohol Res."},{"key":"B42","doi-asserted-by":"publisher","first-page":"e2782","DOI":"10.1371\/journal.pone.0002782","article-title":"Modulation of serotonin transporter function during fetal development causes dilated heart cardiomyopathy and lifelong behavioral abnormalities","volume":"3","author":"Noorlander","year":"2008","journal-title":"PLoS ONE"},{"key":"B43","doi-asserted-by":"publisher","first-page":"10734","DOI":"10.1073\/pnas.95.18.10734","article-title":"Increased anxiety of mice lacking the serotonin1A receptor","volume":"95","author":"Parks","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B44","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1016\/j.devbrainres.2005.03.006","article-title":"Ontogeny of 5-HT1A receptor expression in the developing hippocampus","volume":"157","author":"Patel","year":"2005","journal-title":"Brain Res. Dev. Brain Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/sj.bjp.0701807","article-title":"Effect of the selective 5-HT1A receptor antagonist WAY 100635 on the inhibition of e.p.s.ps produced by 5-HT in the CA1 region of rat hippocampal slices","volume":"124","author":"Pugliese","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"14476","DOI":"10.1073\/pnas.95.24.14476","article-title":"Serotonin receptor 1A knockout: an animal model of anxiety-related disorder","volume":"95","author":"Ramboz","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1263","DOI":"10.1002\/hipo.20852","article-title":"A unified framework for the functional organization of the medial temporal lobes and the phenomenology of episodic memory","volume":"20","author":"Ranganath","year":"2010","journal-title":"Hippocampus"},{"key":"B48","doi-asserted-by":"publisher","first-page":"4809","DOI":"10.1523\/JNEUROSCI.1498-13.2014","article-title":"Dorsal raphe serotonin neurons in mice: immature hyperexcitability transitions to adult state during first three postnatal weeks suggesting sensitive period for environmental perturbation","volume":"34","author":"Rood","year":"2014","journal-title":"J. Neurosci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1111\/acer.12939","article-title":"Worldwide prevalence of fetal alcohol spectrum disorders: a systematic literature review including meta-analysis","volume":"40","author":"Roozen","year":"2016","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B50","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/S0006-8993(96)01044-X","article-title":"Effects of serotonin on induced epileptiform activity in CA1 pyramidal neurons of genetically epilepsy prone rats","volume":"743","author":"Salgado-Commissariat","year":"1996","journal-title":"Brain Res."},{"key":"B51","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1097\/01.ALC.0000128228.08472.39","article-title":"Prenatal alcohol exposure causes long-term serotonin neuron deficit in mice","volume":"28","author":"Sari","year":"2004","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B52","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1016\/0014-4886(85)90008-1","article-title":"Prenatal exposure to ethanol retards the development of kindling in adult rats","volume":"89","author":"Savage","year":"1985","journal-title":"Exp. Neurol."},{"key":"B53","doi-asserted-by":"publisher","first-page":"897","DOI":"10.1016\/j.neuropharm.2006.02.005","article-title":"Opposing effects of AMPA and 5-HT1A receptor blockade on passive avoidance and object recognition performance: correlation with AMPA receptor subunit expression in rat hippocampus","volume":"50","author":"Schiapparelli","year":"2006","journal-title":"Neuropharmacology"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1111","DOI":"10.1016\/j.psyneuen.2008.05.001","article-title":"Effects of prenatal ethanol exposure on regulation of basal hypothalamic-pituitary-adrenal activity and hippocampal 5-HT1A receptor mRNA levels in female rats across the estrous cycle","volume":"33","author":"Sliwowska","year":"2008","journal-title":"Psychoneuroendocrinology"},{"key":"B55","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1111\/acer.12224","article-title":"Prenatal alcohol exposure results in long-term serotonin neuron deficits in female rats: modulatory role of ovarian steroids","volume":"38","author":"Sliwowska","year":"2014","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B56","doi-asserted-by":"crossref","first-page":"8153","DOI":"10.1523\/JNEUROSCI.18-20-08153.1998","article-title":"Neurotransmitter activation of inwardly rectifying potassium current in dissociated hippocampal CA3 neurons: interactions among multiple receptors","volume":"18","author":"Sodickson","year":"1998","journal-title":"J. Neurosci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/0741-8329(88)90084-5","article-title":"Chronic maternal ethanol consumption results in decreased serotonergic 5-HT1 sites in cerebral cortical regions from offspring","volume":"5","author":"Tajuddin","year":"1988","journal-title":"Alcohol"},{"key":"B58","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.eplepsyres.2007.05.010","article-title":"Serotonin but not zonisamide inhibits theophylline-induced epileptiform activity in guinea pig hippocampal CA3 neurons","volume":"76","author":"Thone","year":"2007","journal-title":"Epilepsy Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1007\/s00221-002-1259-6","article-title":"Comparison of the effects of 5-HT1A and 5-HT4 receptor activation on field potentials and epileptiform activity in rat hippocampus","volume":"147","author":"Tokarski","year":"2002","journal-title":"Exp. Brain Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"268","DOI":"10.1002\/jnr.20247","article-title":"5-HT1A, 5-HT2, and GABAB receptors interact to modulate neurotransmitter release probability in layer 2\/3 somatosensory rat cortex as evaluated by the paired pulse protocol","volume":"78","author":"Torres-Escalante","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"B61","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1016\/j.biopsych.2009.08.013","article-title":"Early-life blockade of 5-HT(1A) receptors alters adult anxiety behavior and benzodiazepine sensitivity","volume":"67","author":"Vinkers","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"B62","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1016\/0165-3806(85)90155-5","article-title":"Effects of alcohol exposure during different periods of development: changes in hippocampal mossy fibers","volume":"349","author":"West","year":"1985","journal-title":"Brain Res."},{"key":"B63","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1126\/science.7466371","article-title":"Prenatal exposure to ethanol alters the organization of hippocampal mossy fibers in rats","volume":"211","author":"West","year":"1981","journal-title":"Science"},{"key":"B64","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/S0165-3806(96)00175-7","article-title":"5-HT1a receptors mediate the neurotrophic effect of serotonin on developing dentate granule cells","volume":"98","author":"Yan","year":"1997","journal-title":"Brain Res. Dev. Brain Res."},{"key":"B65","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1097\/01.ALC.0000150636.19677.6F","article-title":"Fetal alcohol exposure reduces serotonin innervation and compromises development of the forebrain along the serotonergic pathway","volume":"29","author":"Zhou","year":"2005","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"B66","doi-asserted-by":"publisher","first-page":"6776","DOI":"10.1523\/JNEUROSCI.5405-09.2010","article-title":"Low concentrations of alcohol inhibit BDNF-dependent GABAergic plasticity via L-type Ca2+ channel inhibition in developing CA3 hippocampal pyramidal neurons","volume":"30","author":"Zucca","year":"2010","journal-title":"J. Neurosci."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"deposited":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T06:46:34Z","timestamp":1568011594000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/Article\/10.3389\/fnins.2016.00266\/abstract"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,8]]},"references-count":66,"URL":"https:\/\/doi.org\/10.3389\/fnins.2016.00266","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,8]]}}}