{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,13]],"date-time":"2026-03-13T01:22:01Z","timestamp":1773364921641,"version":"3.50.1"},"reference-count":91,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["EY022358"],"award-info":[{"award-number":["EY022358"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2016.00494","type":"journal-article","created":{"date-parts":[[2016,11,3]],"date-time":"2016-11-03T08:04:43Z","timestamp":1478160283000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":38,"title":["Early Cytoskeletal Protein Modifications Precede Overt Structural Degeneration in the DBA\/2J Mouse Model of Glaucoma"],"prefix":"10.3389","volume":"10","author":[{"given":"Gina N.","family":"Wilson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew A.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise M.","family":"Inman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine M.","family":"Dengler-Crish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel D.","family":"Crish","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2016,11,3]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1083\/jcb.200303138","article-title":"Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments","volume":"161","author":"Ackerley","year":"2003","journal-title":"J. Cell Biol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1111\/j.1365-2990.2012.01308.x","article-title":"Axon pathology in age-related neurodegenerative disorders","volume":"39","author":"Adalbert","year":"2012","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"2910","DOI":"10.1073\/pnas.040577797","article-title":"Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5","volume":"97","author":"Ahlijanian","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U.S.A"},{"key":"B4","doi-asserted-by":"publisher","first-page":"152","DOI":"10.1016\/j.preteyeres.2011.11.002","article-title":"The molecular basis of retinal ganglion cell death in glaucoma","volume":"31","author":"Almasieh","year":"2012","journal-title":"Prog. Retin. Eye Res."},{"key":"B5","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.brainres.2008.09.044","article-title":"Elevated pressure induced astrocyte damage in the optic nerve","volume":"1244","author":"Balaratnasingam","year":"2008","journal-title":"Brain Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1002\/cne.22516","article-title":"Early microglia activation in a mouse model of chronic glaucoma","volume":"519","author":"Bosco","year":"2011","journal-title":"J. Comp. Neurol."},{"key":"B7","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1007\/BF00293315","article-title":"A sequence of cytoskeleton changes related to the formation of neurofibrillary tangles and neuropil threads","volume":"87","author":"Braak","year":"1994","journal-title":"Acta Neuropathol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"2735","DOI":"10.1523\/JNEUROSCI.4443-07.2008","article-title":"Progressive ganglion cell degeneration precedes neuronal loss in a mouse model of glaucoma","volume":"28","author":"Buckingham","year":"2008","journal-title":"J. Neurosci."},{"key":"B9","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/S0165-0173(00)00019-9","article-title":"Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work","volume":"33","author":"Bu\u00e9e","year":"2000","journal-title":"Brain Res. Rev."},{"key":"B10","doi-asserted-by":"publisher","first-page":"3654","DOI":"10.1167\/iovs.10-7106","article-title":"Quantification of deficits in spatial visual function of mouse models for glaucoma","volume":"52","author":"Burroughs","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1038\/nrneurol.2014.228","article-title":"Disturbed mitochondrial dynamics and neurodegenerative disorders","volume":"11","author":"Burt\u00e9","year":"2014","journal-title":"Nat. Rev. Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"5785","DOI":"10.1523\/jneurosci.3986-15.2016","article-title":"Tau accumulation, altered phosphorylation, and missorting promote neurodegeneration in glaucoma","volume":"36","author":"Chiasseu","year":"2016","journal-title":"J. Neurosci."},{"key":"B13","doi-asserted-by":"publisher","first-page":"737","DOI":"10.1007\/s00401-011-0807-1","article-title":"The optic nerve head is the site of axonal transport disruption, axonal cytoskeleton damage and putative axonal regeneration failure in a rat model of glaucoma","volume":"121","author":"Chidlow","year":"2011","journal-title":"Acta Neuropathol."},{"key":"B14","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.coph.2012.09.008","article-title":"Oxidative stress and mitochondrial dysfunction in glaucoma","volume":"13","author":"Chrysostomou","year":"2013","journal-title":"Curr. Opin. Pharmacol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"889","DOI":"10.1038\/nrn1788","article-title":"Axon degeneration mechanisms: commonality amid diversity","volume":"6","author":"Coleman","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"B16","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1002\/bies.10355","article-title":"Chronic activation of ERK and neurodegenerative diseases","volume":"25","author":"Colucci-D'Amato","year":"2003","journal-title":"Bioessays"},{"key":"B17","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.tins.2007.02.004","article-title":"Neuronal death: where does the end begin?","volume":"30","author":"Conforti","year":"2007","journal-title":"Trends Neurosci."},{"key":"B18","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1016\/j.exer.2015.11.016","article-title":"Early astrocyte redistribution in the optic nerve precedes axonopathy in the DBA\/2J mouse model of glaucoma","volume":"150","author":"Cooper","year":"2016","journal-title":"Exp. Eye Res"},{"key":"B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.neuroscience.2010.12.036","article-title":"Neurodegeneration in glaucoma: progression and calcium-dependent intracellular mechanisms","volume":"176","author":"Crish","year":"2011","journal-title":"Neuroscience"},{"key":"B20","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.neuroscience.2012.10.069","article-title":"Failure of axonal transport induces a spatially coincident increase in astrocyte BDNF prior to synapse loss in a central target","volume":"229","author":"Crish","year":"2013","journal-title":"Neuroscience"},{"key":"B21","doi-asserted-by":"publisher","first-page":"5196","DOI":"10.1073\/pnas.0913141107","article-title":"Distal axonopathy with structural persistence in glaucomatous neurodegeneration","volume":"107","author":"Crish","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B22","doi-asserted-by":"publisher","first-page":"3186","DOI":"10.1096\/fj.08-109181","article-title":"Phosphorylation of tau regulates its axonal transport by controlling its binding to kinesin","volume":"22","author":"Cuchillo-Ibanez","year":"2008","journal-title":"FASEB J."},{"key":"B23","doi-asserted-by":"publisher","first-page":"290","DOI":"10.3389\/fnins.2014.00290","article-title":"Anterograde transport blockade precedes deficits in retrograde transport in the visual projection of the DBA\/2J mouse model of glaucoma","volume":"8","author":"Dengler-Crish","year":"2014","journal-title":"Front. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1126\/science.1152993","article-title":"Differential regulation of dynein and kinesin motor proteins by tau","volume":"319","author":"Dixit","year":"2008","journal-title":"Science"},{"key":"B25","doi-asserted-by":"publisher","first-page":"727","DOI":"10.1083\/jcb.141.3.727","article-title":"Absence of the mid-sized neurofilament subunit decreases axonal calibers, levels of light neurofilament (NF-L), and neurofilament content","volume":"141","author":"Elder","year":"1998a","journal-title":"J. Cell Biol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1083\/jcb.143.1.195","article-title":"Requirement of heavy neurofilament subunit in the development of axons with large calibers","volume":"143","author":"Elder","year":"1998b","journal-title":"J. Cell Biol."},{"key":"B27","doi-asserted-by":"publisher","first-page":"397","DOI":"10.1146\/annurev.bb.17.060188.002145","article-title":"Cellular mechanics as an indicator of cytoskeletal structure and function","volume":"17","author":"Elson","year":"1988","journal-title":"Annu. Rev. Biophys. Biophys. Chem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.expneurol.2003.10.004","article-title":"Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man","volume":"185","author":"Fischer","year":"2004","journal-title":"Exp. Neurol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1002\/msj.20246","article-title":"Axonal damage in multiple sclerosis","volume":"78","author":"Haines","year":"2011","journal-title":"Mt. Sinai J. Med."},{"key":"B30","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1186\/s12974-016-0499-5","article-title":"Virus-mediated EpoR76E gene therapy preserves vision in a glaucoma model by modulating neuroinflammation and decreasing oxidative stress","volume":"13","author":"Hines-Beard","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"B31","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/1471-2156-8-45","article-title":"Absence of glaucoma in DBA\/2J mice homozygous for wild-type versions of Gpnmb and Tyrp1","volume":"8","author":"Howell","year":"2007","journal-title":"BMC Genet."},{"key":"B32","doi-asserted-by":"publisher","first-page":"1429","DOI":"10.1172\/JCI44646","article-title":"Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma","volume":"121","author":"Howell","year":"2011","journal-title":"J. Clin. Invest."},{"key":"B33","doi-asserted-by":"publisher","first-page":"3049","DOI":"10.1167\/iovs.09-4364","article-title":"Calpain activation in experimental glaucoma","volume":"51","author":"Huang","year":"2010","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"2879","DOI":"10.1167\/iovs.10-5929","article-title":"Distortion of axonal cytoskeleton: an early sign of glaucomatous damage","volume":"52","author":"Huang","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"e65389","DOI":"10.1371\/journal.pone.0065389","article-title":"\u03b1-Lipoic acid antioxidant treatment limits glaucoma-related retinal ganglion cell death and dysfunction.pdf","volume":"8","author":"Inman","year":"2013","journal-title":"PLoS ONE"},{"key":"B36","doi-asserted-by":"publisher","first-page":"986","DOI":"10.1167\/iovs.05-0925","article-title":"Quantitative correlation of optic nerve pathology with ocular pressure and corneal thickness in the DBA\/2 mouse model of glaucoma","volume":"47","author":"Inman","year":"2006","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/nrneurol.2015.225","article-title":"Tau and neurodegenerative disease: the story so far","volume":"12","author":"Iqbal","year":"2016","journal-title":"Nat. Rev. Neurol."},{"key":"B38","first-page":"2647","article-title":"Induction of amyloid-\u03b2(1-42) in the retina and optic nerve head of chronic ocular hypertensive monkeys. Mol","volume":"18","author":"Ito","year":"2012","journal-title":"Vis."},{"key":"B39","first-page":"951","article-title":"Essential iris atrophy, pigment dispersion, and glaucoma in DBA\/2J mice","volume":"39","author":"John","year":"1998","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"5721","DOI":"10.1242\/jcs.01558","article-title":"Tau phosphorylation in neuronal cell function and dysfunction","volume":"117","author":"Johnson","year":"2004","journal-title":"J. Cell Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1007\/s00401-015-1506-0","article-title":"SNTF immunostaining reveals previously undetected axonal pathology in traumatic brain injury","volume":"131","author":"Johnson","year":"2016","journal-title":"Acta Neuropathol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/S0079-6603(08)60823-5","article-title":"Neurofilaments in Health and Disease","volume":"61","author":"Julien","year":"1998","journal-title":"Prog. Nucleic Acid Res. Mol. Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.molbrainres.2005.08.009","article-title":"The high and middle molecular weight neurofilament subunits regulate the association of neurofilaments with kinesin: Inhibition by phosphorylation of the high molecular weight subunit","volume":"141","author":"Jung","year":"2005","journal-title":"Mol. Brain Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1002\/(SICI)1097-0169(1999)42:3230::AID-CM63.0.CO;2-A","article-title":"Regulation of neurofilament axonal transport by phosphorylation in optic axons in situ","volume":"42","author":"Jung","year":"1999","journal-title":"Cell Motil. Cytoskeleton"},{"key":"B45","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1016\/j.molbrainres.2003.10.008","article-title":"Neurofilament subunits undergo more rapid translocation within retinas than in optic axons","volume":"122","author":"Jung","year":"2004","journal-title":"Mol. Brain Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1001\/jamaophthalmol.2014.100","article-title":"A prospective study of folate, vitamin B6, and vitamin B12 intake in relation to exfoliation glaucoma or suspected exfoliation glaucoma","volume":"132","author":"Kang","year":"2014","journal-title":"JAMA Ophthalmol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/S0361-9230(00)00370-1","article-title":"Molecular mechanism of neurodegeneration induced by Alzheimer's \u03b2-amyloid protein: channel formation and disruption of calcium homeostasis","volume":"53","author":"Kawahara","year":"2000","journal-title":"Brain Res. Bull."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e1839","DOI":"10.1038\/cddis.2015.180","article-title":"DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma","volume":"6","author":"Kim","year":"2015","journal-title":"Cell Death Dis."},{"key":"B49","doi-asserted-by":"publisher","first-page":"8843","DOI":"10.1523\/JNEUROSCI.2868-05.2005","article-title":"Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease","volume":"25","author":"Kitazawa","year":"2005","journal-title":"J. Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1007\/s12035-008-8018-z","article-title":"Dendritic spine loss and synaptic alterations in Alzheimer's disease","volume":"37","author":"Knobloch","year":"2008","journal-title":"Mol. Neurobiol."},{"key":"B51","first-page":"24374","article-title":"Microtubule-associated protein tau: abnormal phosphorylation of a non-paired helical filament pool in Alzheimer disease. J. Biol","volume":"268","author":"K\u00f6pke","year":"1993","journal-title":"Chem."},{"key":"B52","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/35012636","article-title":"Neurotoxicity induces cleavage of p35 to p25 by calpain","volume":"405","author":"Lee","year":"2000","journal-title":"Nature"},{"key":"B53","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00418-013-1101-1","article-title":"Review on intermediate filaments of the nervous system and their pathological alterations","volume":"140","author":"L\u00e9pinoux-Chambaud","year":"2013","journal-title":"Histochem. Cell Biol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1146\/annurev.genom.6.080604.162209","article-title":"Complex genetics of glaucoma susceptibility","volume":"6","author":"Libby","year":"2005","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"B55","doi-asserted-by":"publisher","first-page":"110502","DOI":"10.1117\/1.JBO.17.11.110502","article-title":"Effect of axonal micro-tubules on the morphology of retinal nerve fibers studied by second-harmonic generation","volume":"17","author":"Lim","year":"2012","journal-title":"J. Biomed. Opt."},{"key":"B56","doi-asserted-by":"publisher","first-page":"497802","DOI":"10.1155\/2014\/497802","article-title":"Oxidative stress and metabolic syndrome: cause or consequence of Alzheimer's disease?","volume":"2014","author":"Luque-Contreras","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B57","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1016\/j.nicl.2014.02.005","article-title":"In vivo axonal transport deficits in a mouse model of fronto-temporal dementia","volume":"4","author":"Majid","year":"2014","journal-title":"NeuroImage. Clin."},{"key":"B58","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1016\/j.neuint.2010.12.023","article-title":"Post-translational modifications of tau protein: implications for Alzheimer's disease","volume":"58","author":"Martin","year":"2011a","journal-title":"Neurochem. Int."},{"key":"B59","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/j.neuint.2011.05.010","article-title":"Tau phosphorylation and neuronal apoptosis induced by the blockade of PP2A preferentially involve GSK3\u03b2","volume":"59","author":"Martin","year":"2011b","journal-title":"Neurochem. Int."},{"key":"B60","doi-asserted-by":"publisher","first-page":"s1140","DOI":"10.2741\/1172","article-title":"Glaucoma: ocular Alzheimer's disease?","volume":"8","author":"McKinnon","year":"2003","journal-title":"Front. Biosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"816","DOI":"10.1016\/j.exer.2008.12.002","article-title":"Mouse models of retinal ganglion cell death and glaucoma","volume":"88","author":"McKinnon","year":"2009","journal-title":"Exp. Eye Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"12776","DOI":"10.1523\/JNEUROSCI.3463-09.2009","article-title":"Axonal transport defects in neurodegenerative diseases","volume":"29","author":"Morfini","year":"2009","journal-title":"J. Neurosci."},{"key":"B63","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1016\/j.brainresbull.2016.06.009","article-title":"Conventional kinesin: biochemical heterogeneity and functional implications in health and disease","volume":"126","author":"Morfini","year":"2016","journal-title":"Brain Res. Bull."},{"key":"B64","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1111\/j.1601-183X.2007.00376.x","article-title":"Glycogen synthase kinase-3b, or a link between amyloid and tau pathology?","volume":"7","author":"Muyllaert","year":"2008","journal-title":"Genes, Brain Behav."},{"key":"B65","doi-asserted-by":"publisher","first-page":"3527","DOI":"10.1128\/MCB.22.10.3527-3536.2002","article-title":"Tyrosine phosphorylation regulates alpha ii spectrin cleavage by calpain","volume":"22","author":"Nicolas","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1083\/jcb.126.4.1031","article-title":"Phosphorylation on carboxyl terminus domains of neurofilament proteins in retinal ganglion cell neurons in vivo: influences on regional neurofilament accumulation, interneurofilament spacing, and axon caliber","volume":"126","author":"Nixon","year":"1994","journal-title":"J. Cell Biol."},{"key":"B67","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1186\/1742-2094-11-76","article-title":"FGF-2 released from degenerating neurons exerts microglial-induced neuroprotection via FGFR3-ERK signaling pathway","volume":"11","author":"Noda","year":"2014","journal-title":"J. Neuroinflammation"},{"key":"B68","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1097\/00132578-200307000-00009","article-title":"Reduction of intraocular pressure and glaucoma progression","volume":"4","author":"Parrish","year":"2003","journal-title":"Evid. Based Eye Care"},{"key":"B69","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.expneurol.2008.06.008","article-title":"Phosphorylation and compactness of neurofilaments in multiple sclerosis: indicators of axonal pathology","volume":"213","author":"Petzold","year":"2008","journal-title":"Exp. Neurol."},{"key":"B70","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S1350-9462(98)00014-7","article-title":"Neuronal death in glaucoma","volume":"18","author":"Quigley","year":"1999","journal-title":"Prog. Retin. Eye Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1007\/s00401-004-0952-x","article-title":"Axonal transport defects: a common theme in neurodegenerative diseases","volume":"109","author":"Roy","year":"2005","journal-title":"Acta Neuropathol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1186\/1471-2202-7-66","article-title":"Progressive ganglion cell loss and optic nerve degeneration in DBA\/2J mice is variable and asymmetric","volume":"7","author":"Schlamp","year":"2006","journal-title":"BMC Neurosci."},{"key":"B73","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-3-642-60915-2_10","article-title":"Neurofibrillary degeneration in hypophysiotrophic nuclei of the aging human hypothalamus","volume-title":"Neuroendocrinology: Retrospect and Perspectives","author":"Schultz","year":"1997"},{"key":"B74","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1111\/j.1460-9568.2008.06165.x","article-title":"Regulation of neurofilament dynamics by phosphorylation","volume":"27","author":"Shea","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/j.neuron.2013.01.036","article-title":"Transglutaminase and polyamination of tubulin: posttranslational modification for stabilizing axonal microtubules","volume":"78","author":"Song","year":"2013","journal-title":"Neuron"},{"key":"B76","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1167\/iovs.10-5856","article-title":"Retinal ganglion cell loss in a rat ocular hypertension model is sectorial and involves early optic nerve axon loss","volume":"52","author":"Soto","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B77","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1126\/science.1105681","article-title":"Axonopathy and transport deficits early in the pathogenesis of Alzheimer's disease","volume":"307","author":"Stokin","year":"2005","journal-title":"Science"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/j.1750-3639.2010.00417.x","article-title":"Reduction in the motoneuron inhibitory\/excitatory synaptic ratio in an early-symptomatic mouse model of amyotrophic lateral sclerosis","volume":"21","author":"Sunico","year":"2011","journal-title":"Brain Pathol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/S0361-9230(03)00083-2","article-title":"Alpha-fodrin is cleaved by caspase-3 in a chronic ocular hypertensive (COH) rat model of glaucoma","volume":"62","author":"Tahzib","year":"2004","journal-title":"Brain Res. Bull."},{"key":"B80","doi-asserted-by":"publisher","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"B81","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1016\/j.expneurol.2007.06.018","article-title":"Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans","volume":"208","author":"Uryu","year":"2007","journal-title":"Exp. Neurol."},{"key":"B82","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1016\/j.exer.2009.02.005","article-title":"Immunoregulation of retinal ganglion cell fate in glaucoma","volume":"88","author":"Wax","year":"2009","journal-title":"Exp. Eye Res."},{"key":"B83","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.ceb.2007.02.001","article-title":"The JNK signal transduction pathway","volume":"19","author":"Weston","year":"2007","journal-title":"Curr. Opin. Cell Biol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1186\/s12974-015-0399-0","article-title":"Early pro-inflammatory cytokine elevations in the DBA\/2J mouse model of glaucoma","volume":"12","author":"Wilson","year":"2015","journal-title":"J. Neuroinflammation"},{"key":"B85","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1016\/j.bpj.2013.12.047","article-title":"Axonal transport: how high microtubule density can compensate for boundary effects in small-caliber axons","volume":"106","author":"Wortman","year":"2014","journal-title":"Biophys. J."},{"key":"B86","doi-asserted-by":"publisher","first-page":"452","DOI":"10.1126\/science.1232251","article-title":"Actin, spectrin, and associated proteins form a periodic cytoskeletal structure in axons","volume":"339","author":"Xu","year":"2013","journal-title":"Science"},{"key":"B87","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1007\/s13670-012-0009-2","article-title":"Spectrin breakdown products (SBDPs) as potential biomarkers for neurodegenerative diseases","volume":"1","author":"Yan","year":"2012","journal-title":"Curr. Transl. Geriatr. Exp. Gerontol. Rep."},{"key":"B88","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1167\/iovs.16-19153","article-title":"Antioxidant treatment limits neuroinflammation in experimental glaucoma","volume":"57","author":"Yang","year":"2016","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"68","DOI":"10.1186\/s13024-015-0064-1","article-title":"Tau missorting and spastin-induced microtubule disruption in neurodegeneration: Alzheimer Disease and Hereditary Spastic Paraplegia","volume":"10","author":"Zempel","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"B90","doi-asserted-by":"publisher","first-page":"1431","DOI":"10.1096\/fj.05-5223com","article-title":"Peroxynitrite induces Alzheimer-like tau modifications and accumulation in rat brain and its underlying mechanisms","volume":"20","author":"Zhang","year":"2006","journal-title":"FASEB J."},{"key":"B91","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1002\/(SICI)1097-4652(199908)180:2<182::AID-JCP6>3.0.CO;2-X","article-title":"Oxidative stress affects cytoskeletal structure and cell-matrix interactions in cells from an ocular tissue: the trabecular meshwork","volume":"180","author":"Zhou","year":"1999","journal-title":"J. Cell. Physiol."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnins.2016.00494\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,24]],"date-time":"2017-06-24T22:42:52Z","timestamp":1498344172000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnins.2016.00494\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,3]]},"references-count":91,"URL":"https:\/\/doi.org\/10.3389\/fnins.2016.00494","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,3]]}}}