{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T05:24:24Z","timestamp":1772342664588,"version":"3.50.1"},"reference-count":63,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000890","name":"National Multiple Sclerosis Society","doi-asserted-by":"publisher","award":["RG 466-A-2"],"award-info":[{"award-number":["RG 466-A-2"]}],"id":[{"id":"10.13039\/100000890","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2017.00284","type":"journal-article","created":{"date-parts":[[2017,5,26]],"date-time":"2017-05-26T04:01:34Z","timestamp":1495771294000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":15,"title":["MRI Analysis of White Matter Myelin Water Content in Multiple Sclerosis: A Novel Approach Applied to Finding Correlates of Cortical Thinning"],"prefix":"10.3389","volume":"11","author":[{"given":"Michael","family":"Dayan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra M.","family":"Hurtado R\u00faa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Monohan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sneha","family":"Pandya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eve M.","family":"LoCastro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Vartanian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanh D.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashish","family":"Raj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan A.","family":"Gauthier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1965","published-online":{"date-parts":[[2017,5,26]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1007\/s00415-011-6147-1","article-title":"Basal ganglia, thalamus and neocortical atrophy predicting slowed cognitive processing in multiple sclerosis","volume":"259","author":"Batista","year":"2012","journal-title":"J. Neurol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1212","DOI":"10.1007\/s00415-006-0503-6","article-title":"Cortical atrophy is relevant in multiple sclerosis at clinical onset","volume":"254","author":"Calabrese","year":"2007","journal-title":"J. Neurol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1586\/ern.10.155","article-title":"Cortical pathology and cognitive impairment in multiple sclerosis","volume":"11","author":"Calabrese","year":"2011","journal-title":"Exp. Rev. Neurotherapeut."},{"key":"B4","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1212\/WNL.0b013e3181cbcd03","article-title":"Widespread cortical thinning characterizes patients with ms with mild cognitive impairment","volume":"74","author":"Calabrese","year":"2010","journal-title":"Neurology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.neuroimage.2008.04.173","article-title":"A voxel-based morphometry study of grey matter loss in ms patients with different clinical phenotypes","volume":"42","author":"Ceccarelli","year":"2008","journal-title":"Neuroimage"},{"key":"B6","first-page":"952","article-title":"Mean diffusivity and fractional anisotropy histograms of patients with multiple sclerosis","volume-title":"Am. J. Neuroradiol.","author":"Cercignani","year":"2001"},{"key":"B7","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1140\/epjb\/e2007-00343-8","article-title":"Kinetic exchange models for income and wealth distributions","volume":"60","author":"Chatterjee","year":"2007","journal-title":"Eur. Phys. J. B"},{"key":"B8","doi-asserted-by":"crossref","DOI":"10.1007\/978-0-387-72796-7_16","volume-title":"Estimating Income Distributions Using a Mixture of Gamma Densities","author":"Chotikapanich","year":"2008"},{"key":"B9","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1002\/nbm.3266","article-title":"Tractography of the optic radiation: a repeatability and reproducibility study","volume":"28","author":"Dayan","year":"2015","journal-title":"NMR Biomed."},{"key":"B10","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1002\/hbm.23082","article-title":"Profilometry: a new statistical framework for the characterization of white matter pathways, with application to multiple sclerosis","volume":"37","author":"Dayan","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"B11","doi-asserted-by":"publisher","first-page":"239","DOI":"10.11138\/FNeur\/2016.31.4.239","article-title":"Impact of cerebellar atrophy on cortical gray matter and cerebellar peduncles as assessed by voxel-based morphometry and high angular resolution diffusion imaging","volume":"31","author":"Dayan","year":"2017","journal-title":"Funct. Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1002\/mrm.1910400508","article-title":"Adiabatic water suppression using frequency selective excitation","volume":"40","author":"De Graaf","year":"1998","journal-title":"Magn. Reson. Med."},{"key":"B13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.2517-6161.1977.tb01600.x","article-title":"Maximum likelihood from incomplete data via the em algorithm","volume":"39","author":"Dempster","year":"1977","journal-title":"J. R. Stat. Soc."},{"key":"B14","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.nicl.2016.11.020","article-title":"MRI FLAIR lesion segmentation in multiple sclerosis: does automated segmentation hold up with manual annotation?","volume":"13","author":"Egger","year":"2017","journal-title":"Neuroimage"},{"key":"B15","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1002\/1531-8249(200003)47:3<391::AID-ANA20>3.0.CO;2-J","article-title":"Quantitative pathological evidence for axonal loss in normal appearing white matter in multiple sclerosis","volume":"47","author":"Evangelou","year":"2000","journal-title":"Ann. Neurol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1002\/ana.21436","article-title":"Gray matter atrophy in multiple sclerosis: a longitudinal study","volume":"64","author":"Fisher","year":"2008","journal-title":"Ann. Neurol."},{"key":"B17","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1002\/1522-2586(200006)11:6<586::AID-JMRI3>3.0.CO;2-V","article-title":"Magnetization transfer and multicomponent t2 relaxation measurements with histopathologic correlation in an experimental model of ms","volume":"11","author":"Gareau","year":"2000","journal-title":"J. Magn. Reson. Imaging"},{"key":"B18","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1016\/S1474-4422(08)70191-1","article-title":"Grey matter pathology in multiple sclerosis","volume":"7","author":"Geurts","year":"2008","journal-title":"Lancet Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1016\/j.neuroimage.2009.06.060","article-title":"Accurate and robust brain image alignment using boundary-based registration","volume":"48","author":"Greve","year":"2009","journal-title":"Neuroimage"},{"key":"B20","doi-asserted-by":"publisher","first-page":"58S","DOI":"10.1177\/1051228405282242","article-title":"Magnetization transfer imaging in multiple sclerosis","volume":"15","author":"Horsfield","year":"2005","journal-title":"J. Neuroimaging"},{"key":"B21","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.1002\/mrm.24564","article-title":"Motion and flow insensitive adiabatic t2-preparation module for cardiac mr imaging at 3 tesla","volume":"70","author":"Jenista","year":"2013","journal-title":"Magn. Reson. Med."},{"key":"B22","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1016\/S0140-6736(07)61194-5","article-title":"Effect of early versus delayed interferon beta-1b treatment on disability after a first clinical event suggestive of multiple sclerosis: a 3-year follow-up analysis of the benefit study","volume":"370","author":"Kappos","year":"2007","journal-title":"Lancet"},{"key":"B23","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1002\/mrm.1910140306","article-title":"Relaxometry of brain: why white matter appears bright in MRI","volume":"14","author":"Koenig","year":"1990","journal-title":"Magn. Reson. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1002\/mrm.21966","article-title":"Myelin water imaging: implementation and development at 3.0t and comparison to 1.5t measurements","volume":"62","author":"Kolind","year":"2009","journal-title":"Magn. Reson. Med."},{"key":"B25","doi-asserted-by":"publisher","first-page":"796","DOI":"10.1002\/mrm.21527","article-title":"High-resolution myelin water measurements in rat spinal cord","volume":"59","author":"Kozlowski","year":"2008","journal-title":"Magn. Reson. Med."},{"key":"B26","first-page":"702","article-title":"Modeling the relationship among gray matter atrophy, abnormalities in connecting white matter, and cognitive performance in early multiple sclerosis","volume-title":"Am. J. Neuroradiol.","author":"Kuceyeski","year":"2015"},{"key":"B27","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1002\/mrm.24170","article-title":"Bayesian algorithm using spatial priors for multiexponential t2 relaxometry from multiecho spin echo MRI","volume":"68","author":"Kumar","year":"2012","journal-title":"Magn. Reson. Med."},{"key":"B28","doi-asserted-by":"publisher","first-page":"2705","DOI":"10.1093\/brain\/awh641","article-title":"Cortical demyelination and diffuse white matter injury in multiple sclerosis","volume":"128","author":"Kutzelnigg","year":"2005","journal-title":"Brain"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1575","DOI":"10.1016\/j.neuroimage.2007.12.008","article-title":"Myelin water imaging of multiple sclerosis at 7 T: correlations with histopathology","volume":"40","author":"Laule","year":"2008","journal-title":"Neuroimage"},{"key":"B30","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1177\/1352458506070928","article-title":"Myelin water imaging in multiple sclerosis: quantitative correlations with histopathology","volume":"12","author":"Laule","year":"2006","journal-title":"Multiple Sclerosis"},{"key":"B31","doi-asserted-by":"publisher","first-page":"1579","DOI":"10.1007\/s00415-007-0595-7","article-title":"Long t2 water in multiple sclerosis: what else can we learn from multi-echo t2 relaxation?","volume":"254","author":"Laule","year":"2007","journal-title":"J. Neurol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1177\/1352458510384008","article-title":"Pathological basis of diffusely abnormal white matter: insights from magnetic resonance imaging and histology","volume":"17","author":"Laule","year":"2011","journal-title":"Multiple Sclerosis"},{"key":"B33","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1007\/s00415-004-0306-6","article-title":"Water content and myelin water fraction in multiple sclerosis. a t2 relaxation study","volume":"251","author":"Laule","year":"2004","journal-title":"J. Neurol."},{"key":"B34","volume-title":"Introduction to Bivariate and Multivariate Analysis","author":"Lindeman","year":"1980"},{"key":"B35","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1016\/j.mri.2005.12.037","article-title":"Insights into brain microstructure from the t-2 distribution","volume":"24","author":"MacKay","year":"2006","journal-title":"Magn. Reson. Imaging"},{"key":"B36","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1002\/mrm.1910310614","article-title":"In vivo visualization of myelin water in brain by magnetic resonance","volume":"31","author":"MacKay","year":"1994","journal-title":"Magn. Reson. Med."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.neuroimage.2008.12.071","article-title":"Multiexponential t2 and magnetization transfer mri of demyelination and remyelination in murine spinal cord","volume":"45","author":"McCreary","year":"2009","journal-title":"Neuroimage"},{"key":"B38","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/S1474-4422(08)70200-X","article-title":"Comparison of subcutaneous interferon beta-1a with glatiramer acetate in patients with relapsing multiple sclerosis (the rebif vs glatiramer acetate in relapsing ms disease [regard] study): a multicentre, randomised, parallel, open-label trial","volume":"7","author":"Mikol","year":"2008","journal-title":"Lancet Neurol."},{"key":"B39","first-page":"1802","article-title":"Dirty-appearing white matter in multiple sclerosis: preliminary observations of myelin phospholipid and axonal loss","volume-title":"J. Neurol.","author":"Moore","year":"2008"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1506","DOI":"10.1212\/WNL.55.10.1506","article-title":"A pathology-MRI study of the short-t2 component in formalin-fixed multiple sclerosis brain","volume":"55","author":"Moore","year":"2000","journal-title":"Neurology"},{"key":"B41","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.nicl.2012.11.009","article-title":"Regional cortical thickness in relapsing remitting multiple sclerosis: a multi-center study","volume":"2","author":"Narayana","year":"2013","journal-title":"Neuroimage"},{"key":"B42","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1002\/mrm.24128","article-title":"T2 prep three-dimensional spiral imaging with efficient whole brain coverage for myelin water quantification at 1.5 tesla","volume":"67","author":"Nguyen","year":"2012","journal-title":"Magn. Reson. Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1002\/ana.1123","article-title":"Transected neurites, apoptotic neurons, and reduced inflammation in cortical multiple sclerosis lesions","volume":"50","author":"Peterson","year":"2001","journal-title":"Ann. Neurol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"1243","DOI":"10.1111\/j.1471-4159.2010.06831.x","article-title":"Axon-oligodendrocyte interactions during developmental myelination, demyelination and repair","volume":"114","author":"Piaton","year":"2010","journal-title":"J. Neurochem."},{"key":"B45","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1056\/NEJMoa044397","article-title":"A randomized, placebo-controlled trial of natalizumab for relapsing multiple sclerosis","volume":"354","author":"Polman","year":"2006","journal-title":"N. Engl. J. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisions to the mcdonald criteria","volume":"69","author":"Polman","year":"2011","journal-title":"Ann. Neurol."},{"key":"B47","doi-asserted-by":"publisher","first-page":"840","DOI":"10.1002\/ana.20703","article-title":"Diagnostic criteria for multiple sclerosis: 2005 revisions to the \u201cmcdonald criteria.\u201d","volume":"58","author":"Polman","year":"2005","journal-title":"Ann. Neurol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"e98391","DOI":"10.1371\/journal.pone.0098391","article-title":"Multi-compartment t2 relaxometry using a spatially constrained multi-gaussian model","volume":"9","author":"Raj","year":"2014","journal-title":"PLoS ONE"},{"key":"B49","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.jns.2008.12.034","article-title":"Extent of cerebellum, subcortical and cortical atrophy in patients with ms. A case-control study","volume":"282","author":"Ramasamy","year":"2009","journal-title":"J. Neurol. Sci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"1098","DOI":"10.1177\/1352458511404916","article-title":"Grey matter volume in a large cohort of ms patients: relation to MRI parameters and disability","volume":"17","author":"Roosendaal","year":"2011","journal-title":"Multiple Sclerosis J."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1526","DOI":"10.1212\/01.wnl.0000184471.83948.e0","article-title":"Diffusion MRI in multiple sclerosis","volume":"65","author":"Rovaris","year":"2005","journal-title":"Neurology"},{"key":"B52","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1177\/1352458511406575","article-title":"Imaging the tip of the iceberg: visualization of cortical lesions in multiple sclerosis","volume":"17","author":"Seewann","year":"2011","journal-title":"Multiple Sclerosis J."},{"key":"B53","doi-asserted-by":"publisher","first-page":"601","DOI":"10.1001\/archneurol.2009.57","article-title":"Diffusely abnormal white matter in chronic multiple sclerosis: imaging and histopathologic analysis","volume":"66","author":"Seewann","year":"2009","journal-title":"Arch. Neurol."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1175\/1520-0450(2003)042<1031:RSDEOG>2.0.CO;2","article-title":"Raindrop size distributions: exponential or gammadoes the difference matter?","volume":"42","author":"Smith","year":"2003","journal-title":"J. Appl. Meteorol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"832","DOI":"10.1148\/radiol.14132708","article-title":"What explains gray matter atrophy in long-standing multiple sclerosis?","volume":"272","author":"Steenwijk","year":"2014","journal-title":"Radiology"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1796","DOI":"10.1002\/hbm.22738","article-title":"Unraveling the relationship between regional gray matter atrophy and pathology in connected white matter tracts in long-standing multiple sclerosis","volume":"36","author":"Steenwijk","year":"2015","journal-title":"Hum. Brain Mapp."},{"key":"B57","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S1474-4422(08)70293-X","article-title":"Biomarkers in amyotrophic lateral sclerosis","volume":"8","author":"Turner","year":"2009","journal-title":"Lancet Neurol."},{"key":"B58","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1002\/mrm.1910360420","article-title":"Quantitative volumetric magnetization transfer analysis in multiple sclerosis: estimation of macroscopic and microscopic disease burden","volume":"36","author":"Van Buchem","year":"1996","journal-title":"Magn. Reson. Med."},{"key":"B59","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1097\/01.jnen.0000190067.20935.42","article-title":"Grey matter pathology in multiple sclerosis","volume":"64","author":"Vercellino","year":"2005","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1002\/mrm.1910370107","article-title":"In vivo measurement of t2 distributions and water contents in normal human brain","volume":"37","author":"Whittall","year":"1997","journal-title":"Magn. Reson. Med."},{"key":"B61","doi-asserted-by":"publisher","first-page":"127","DOI":"10.1016\/j.csda.2013.09.001","article-title":"Test for homogeneity in gamma mixture models using likelihood ratio","volume":"70","author":"Wong","year":"2014","journal-title":"Comput. Stat. Data Anal."},{"key":"B62","doi-asserted-by":"publisher","first-page":"3851","DOI":"10.1002\/hyp.5985","article-title":"Rainfall frequency analysis using a mixed gamma distribution: evaluation of the global warming effect on daily rainfall","volume":"19","author":"Yoo","year":"2005","journal-title":"Hydrol. Process."},{"key":"B63","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1109\/42.906424","article-title":"Segmentation of brain mr images through a hidden markov random field model and the expectation-maximization algorithm","volume":"20","author":"Zhang","year":"2001","journal-title":"IEEE Trans. Med. Imaging"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnins.2017.00284\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T10:37:38Z","timestamp":1719225458000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnins.2017.00284\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,26]]},"references-count":63,"alternative-id":["10.3389\/fnins.2017.00284"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2017.00284","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,26]]},"article-number":"284"}}