{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T15:06:34Z","timestamp":1785942394517,"version":"3.56.0"},"reference-count":92,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CRC 1052\/2 (Obesity Mechanisms)"],"award-info":[{"award-number":["CRC 1052\/2 (Obesity Mechanisms)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2017.00293","type":"journal-article","created":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T03:56:11Z","timestamp":1495598171000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":78,"title":["Cannabinoid Receptor Signaling in Central Regulation of Feeding Behavior: A Mini-Review"],"prefix":"10.3389","volume":"11","author":[{"given":"Marco","family":"Koch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,5,24]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"400","DOI":"10.3109\/15622975.2011.602720","article-title":"World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for the pharmacological treatment of eating disorders","volume":"12","author":"Aigner","year":"2011","journal-title":"World J. Biol. Psychiatry"},{"key":"B2","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1093\/nutrit\/nuv002","article-title":"Food reward system: current perspectives and future research needs","volume":"73","author":"Alonso-Alonso","year":"2015","journal-title":"Nutr. Rev."},{"key":"B3","doi-asserted-by":"publisher","first-page":"9625","DOI":"10.1073\/pnas.1307389110","article-title":"Orexin neurons use endocannabinoids to break obesity-induced inhibition","volume":"110","author":"Alpar","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B4","doi-asserted-by":"publisher","first-page":"R59","DOI":"10.1530\/JME-16-0182","article-title":"Glial cells and energy balance","volume":"58","author":"Argente-Arizon","year":"2017","journal-title":"J. Mol. Endocrinol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1007\/s00401-016-1595-4","article-title":"High-fat diet-induced brain region-specific phenotypic spectrum of CNS resident microglia","volume":"132","author":"Baufeld","year":"2016","journal-title":"Acta Neuropathol."},{"key":"B6","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1038\/nn.2494","article-title":"Bimodal control of stimulated food intake by the endocannabinoid system","volume":"13","author":"Bellocchio","year":"2010","journal-title":"Nat. Neurosci."},{"key":"B7","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/nn.3053","article-title":"Mitochondrial CB(1) receptors regulate neuronal energy metabolism","volume":"15","author":"Benard","year":"2012","journal-title":"Nat. Neurosci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.molmet.2013.08.001","article-title":"Astroglial CB1 cannabinoid receptors regulate leptin signaling in mouse brain astrocytes","volume":"2","author":"Bosier","year":"2013","journal-title":"Mol. Metab."},{"key":"B9","doi-asserted-by":"publisher","first-page":"5","DOI":"10.12688\/f1000research.8245.1","article-title":"Cannabinoid receptor type-1: breaking the dogmas","volume":"2016","author":"Busquets Garcia","year":"2016","journal-title":"F1000Res"},{"key":"B10","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1038\/nn.4495","article-title":"A molecular census of arcuate hypothalamus and median eminence cell types","volume":"20","author":"Campbell","year":"2017","journal-title":"Nat. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"4136","DOI":"10.1210\/en.2012-1405","article-title":"Hypothalamic CB1 cannabinoid receptors regulate energy balance in mice","volume":"153","author":"Cardinal","year":"2012","journal-title":"Endocrinology"},{"key":"B12","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1016\/j.neuron.2012.09.020","article-title":"Endocannabinoid signaling and synaptic function","volume":"76","author":"Castillo","year":"2012","journal-title":"Neuron"},{"key":"B13","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1016\/j.cell.2015.01.033","article-title":"Sensory detection of food rapidly modulates arcuate feeding circuits","volume":"160","author":"Chen","year":"2015","journal-title":"Cell"},{"key":"B14","doi-asserted-by":"publisher","first-page":"PL113","DOI":"10.1016\/S0024-3205(98)00322-1","article-title":"Appetite suppression and weight loss after the cannabinoid antagonist SR 141716","volume":"63","author":"Colombo","year":"1998","journal-title":"Life Sci."},{"key":"B15","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1172\/JCI17725","article-title":"The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis","volume":"112","author":"Cota","year":"2003","journal-title":"J. Clin. Invest."},{"key":"B16","doi-asserted-by":"publisher","first-page":"E2229","DOI":"10.1073\/pnas.1219485110","article-title":"Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons","volume":"110","author":"Cristino","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1946","DOI":"10.1126\/science.1470919","article-title":"Isolation and structure of a brain constituent that binds to the cannabinoid receptor","volume":"258","author":"Devane","year":"1992","journal-title":"Science"},{"key":"B18","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1038\/35071088","article-title":"Leptin-regulated endocannabinoids are involved in maintaining food intake","volume":"410","author":"Di Marzo","year":"2001","journal-title":"Nature"},{"key":"B19","doi-asserted-by":"publisher","first-page":"S18","DOI":"10.1038\/ijo.2009.67","article-title":"The endocannabinoid system as a link between homoeostatic and hedonic pathways involved in energy balance regulation","volume":"33","author":"Di Marzo","year":"2009","journal-title":"Int. J. Obes."},{"key":"B20","doi-asserted-by":"publisher","first-page":"675","DOI":"10.1038\/nrd3739","article-title":"Limitations in anti-obesity drug development: the critical role of hunger-promoting neurons","volume":"11","author":"Dietrich","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"B21","doi-asserted-by":"publisher","first-page":"7369","DOI":"10.1523\/JNEUROSCI.5455-09.2010","article-title":"The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice","volume":"30","author":"Dodd","year":"2010","journal-title":"J. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.neuropharm.2013.03.007","article-title":"Central functional response to the novel peptide cannabinoid, hemopressin","volume":"71","author":"Dodd","year":"2013","journal-title":"Neuropharmacology"},{"key":"B23","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1111\/j.1365-2826.2008.01683.x","article-title":"Dysregulation of the endocannabinoid system in obesity","volume":"20","author":"Engeli","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"B24","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1038\/nn.4442","article-title":"A rapidly acting glutamatergic ARC\u2013>PVH satiety circuit postsynaptically regulated by alpha-MSH","volume":"20","author":"Fenselau","year":"2017","journal-title":"Nat. Neurosci."},{"key":"B25","doi-asserted-by":"publisher","first-page":"1217","DOI":"10.1016\/j.celrep.2016.10.004","article-title":"Alpha\/beta-hydrolase domain 6 in the ventromedial hypothalamus controls energy metabolism flexibility","volume":"17","author":"Fisette","year":"2016","journal-title":"Cell Rep."},{"key":"B26","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1038\/nature01921","article-title":"Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha","volume":"425","author":"Fu","year":"2003","journal-title":"Nature"},{"key":"B27","doi-asserted-by":"publisher","first-page":"8096","DOI":"10.1523\/JNEUROSCI.0036-10.2010","article-title":"The fat-induced satiety factor oleoylethanolamide suppresses feeding through central release of oxytocin","volume":"30","author":"Gaetani","year":"2010","journal-title":"J. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"R845","DOI":"10.1016\/j.cub.2016.07.069","article-title":"Feeding behavior: hypocretin\/orexin neurons act between food seeking and eating","volume":"26","author":"Gao","year":"2016","journal-title":"Curr. Biol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1186\/1475-2891-13-17","article-title":"Peroxisome proliferator-activated receptors and their ligands: nutritional and clinical implications\u2013a review","volume":"13","author":"Grygiel-Gorniak","year":"2014","journal-title":"Nutr. J."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1016\/j.cell.2012.01.037","article-title":"Acute cannabinoids impair working memory through astroglial CB1 receptor modulation of hippocampal LTD","volume":"148","author":"Han","year":"2012","journal-title":"Cell"},{"key":"B31","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.cmet.2016.12.020","article-title":"(S)Pot on mitochondria: cannabinoids disrupt cellular respiration to limit neuronal activity","volume":"25","author":"Harkany","year":"2017","journal-title":"Cell Metab."},{"key":"B32","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1038\/nature20127","article-title":"A cannabinoid link between mitochondria and memory","volume":"539","author":"Hebert-Chatelain","year":"2016","journal-title":"Nature"},{"key":"B33","doi-asserted-by":"publisher","first-page":"495","DOI":"10.1016\/j.molmet.2014.03.007","article-title":"Cannabinoid control of brain bioenergetics: exploring the subcellular localization of the CB1 receptor","volume":"3","author":"Hebert-Chatelain","year":"2014","journal-title":"Mol. Metab."},{"key":"B34","doi-asserted-by":"publisher","first-page":"20588","DOI":"10.1073\/pnas.0706980105","article-title":"Hemopressin is an inverse agonist of CB1 cannabinoid receptors","volume":"104","author":"Heimann","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B35","doi-asserted-by":"publisher","first-page":"9746","DOI":"10.1523\/JNEUROSCI.2769-05.2005","article-title":"Differential regulation of synaptic inputs by constitutively released endocannabinoids and exogenous cannabinoids","volume":"25","author":"Hentges","year":"2005","journal-title":"J. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1932","DOI":"10.1073\/pnas.87.5.1932","article-title":"Cannabinoid receptor localization in brain","volume":"87","author":"Herkenham","year":"1990","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B37","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1172\/JCI19376","article-title":"Endocannabinoids and the regulation of body fat: the smoke is clearing","volume":"112","author":"Horvath","year":"2003","journal-title":"J. Clin. Invest."},{"key":"B38","doi-asserted-by":"publisher","first-page":"750 e714","DOI":"10.1016\/j.cell.2016.10.004","article-title":"Crystal structure of the human cannabinoid receptor CB1","volume":"167","author":"Hua","year":"2016","journal-title":"Cell"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1151","DOI":"10.1038\/sj.bjp.0704379","article-title":"Anandamide administration into the ventromedial hypothalamus stimulates appetite in rats","volume":"134","author":"Jamshidi","year":"2001","journal-title":"Br. J. Pharmacol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"908","DOI":"10.1038\/nn.3725","article-title":"Leptin signaling in astrocytes regulates hypothalamic neuronal circuits and feeding","volume":"17","author":"Kim","year":"2014","journal-title":"Nat. Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1038\/mp.2014.30","article-title":"Molecular and cellular regulation of hypothalamic melanocortin neurons controlling food intake and energy metabolism","volume":"19","author":"Koch","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"B42","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1038\/nature14260","article-title":"Hypothalamic POMC neurons promote cannabinoid-induced feeding","volume":"519","author":"Koch","year":"2015","journal-title":"Nature"},{"key":"B43","doi-asserted-by":"publisher","first-page":"e1797","DOI":"10.1371\/journal.pone.0001797","article-title":"The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system","volume":"3","author":"Kola","year":"2008","journal-title":"PLoS ONE"},{"key":"B44","doi-asserted-by":"publisher","first-page":"1663","DOI":"10.1016\/j.cell.2016.12.001","article-title":"Harvesting benefits from cannabinoids","volume":"167","author":"Kruger","year":"2016","journal-title":"Cell"},{"key":"B45","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.phrs.2016.04.020","article-title":"Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain","volume":"110","author":"Leishman","year":"","journal-title":"Pharmacol. Res."},{"key":"B46","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/j.bbalip.2016.03.003","article-title":"Lipidomics profile of a NAPE-PLD KO mouse provides evidence of a broader role of this enzyme in lipid metabolism in the brain","volume":"1861","author":"Leishman","year":"","journal-title":"Biochim. Biophys. Acta"},{"key":"B47","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.pharmthera.2014.06.007","article-title":"GPR55: from orphan to metabolic regulator?","volume":"145","author":"Liu","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"B48","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1124\/mol.104.006353","article-title":"The nuclear receptor peroxisome proliferator-activated receptor-alpha mediates the anti-inflammatory actions of palmitoylethanolamide","volume":"67","author":"Lo Verme","year":"2005","journal-title":"Mol. Pharmacol."},{"key":"B49","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1038\/nrn4036","article-title":"The endocannabinoid system in guarding against fear, anxiety and stress","volume":"16","author":"Lutz","year":"2015","journal-title":"Nat. Rev. Neurosci."},{"key":"B50","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1038\/346561a0","article-title":"Structure of a cannabinoid receptor and functional expression of the cloned cDNA","volume":"346","author":"Matsuda","year":"1990","journal-title":"Nature"},{"key":"B51","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1016\/j.tem.2015.07.007","article-title":"The endocannabinoid system: pivotal orchestrator of obesity and metabolic disease","volume":"26","author":"Mazier","year":"2015","journal-title":"Trends Endocrinol. Metab."},{"key":"B52","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1016\/j.neulet.2007.04.012","article-title":"The cannabinoid antagonist SR 141716A (Rimonabant) reduces the increase of extra-cellular dopamine release in the rat nucleus accumbens induced by a novel high palatable food","volume":"419","author":"Melis","year":"2007","journal-title":"Neurosci. Lett."},{"key":"B53","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1002\/glia.22773","article-title":"Rising stars: modulation of brain functions by astroglial type-1 cannabinoid receptors","volume":"63","author":"Metna-Laurent","year":"2015","journal-title":"Glia"},{"key":"B54","doi-asserted-by":"publisher","first-page":"4759","DOI":"10.1073\/pnas.1521304113","article-title":"Orexin-A represses satiety-inducing POMC neurons and contributes to obesity via stimulation of endocannabinoid signaling","volume":"113","author":"Morello","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B55","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/j.molmet.2017.01.004","article-title":"Cannabinoid type 1 receptor-containing axons innervate NPY\/AgRP neurons in the mouse arcuate nucleus","volume":"6","author":"Morozov","year":"2017","journal-title":"Mol. Metab."},{"key":"B56","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.molmet.2015.03.005","article-title":"Ghrelin","volume":"4","author":"Muller","year":"2015","journal-title":"Mol. Metab."},{"key":"B57","doi-asserted-by":"publisher","first-page":"6","DOI":"10.3389\/fnut.2016.00006","article-title":"Hedonics act in unison with the homeostatic system to unconsciously control body weight","volume":"3","author":"Munzberg","year":"2016","journal-title":"Front Nutr"},{"key":"B58","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/j.neuron.2010.08.043","article-title":"Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes","volume":"68","author":"Navarrete","year":"2010","journal-title":"Neuron"},{"key":"B59","doi-asserted-by":"publisher","first-page":"2977","DOI":"10.2337\/db08-0161","article-title":"Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats","volume":"57","author":"Nogueiras","year":"2008","journal-title":"Diabetes"},{"key":"B60","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.neuroscience.2015.05.002","article-title":"Astroglial type-1 cannabinoid receptor (CB1): a new player in the tripartite synapse","volume":"323","author":"Oliveira Da Cruz","year":"2016","journal-title":"Neuroscience"},{"key":"B61","doi-asserted-by":"publisher","first-page":"13669","DOI":"10.1074\/jbc.M115.646885","article-title":"Negative regulation of leptin-induced Reactive Oxygen Species (ROS) formation by cannabinoid CB1 receptor activation in hypothalamic neurons","volume":"290","author":"Palomba","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"3133","DOI":"10.1007\/s12010-015-1488-3","article-title":"Systemic mechanism of taste, flavour and palatability in brain","volume":"175","author":"Pandurangan","year":"2015","journal-title":"Appl. Biochem. Biotechnol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.brat.2014.07.007","article-title":"Hungry for reward: how can neuroscience inform the development of treatment for Anorexia Nervosa?","volume":"62","author":"Park","year":"2014","journal-title":"Behav. Res. Ther."},{"key":"B64","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1038\/nature14206","article-title":"Neuroscience: a cellular basis for the munchies","volume":"519","author":"Patel","year":"2015","journal-title":"Nature"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1360","DOI":"10.2174\/092986710790980050","article-title":"Receptors and channels targeted by synthetic cannabinoid receptor agonists and antagonists","volume":"17","author":"Pertwee","year":"2010","journal-title":"Curr. Med. Chem."},{"key":"B66","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1017\/S0029665113003649","article-title":"Elevating endocannabinoid levels: pharmacological strategies and potential therapeutic applications","volume":"73","author":"Pertwee","year":"2014","journal-title":"Proc. Nutr. Soc."},{"key":"B67","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1126\/science.1089459","article-title":"Rapid rewiring of arcuate nucleus feeding circuits by leptin","volume":"304","author":"Pinto","year":"2004","journal-title":"Science"},{"key":"B68","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1038\/nrn1247","article-title":"The molecular logic of endocannabinoid signalling","volume":"4","author":"Piomelli","year":"2003","journal-title":"Nat. Rev. Neurosci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1002\/mnfr.201500449","article-title":"G protein coupled receptor 18: a potential role for endocannabinoid signaling in metabolic dysfunction","volume":"60","author":"Rajaraman","year":"2016","journal-title":"Mol. Nutr. Food Res."},{"key":"B70","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s40262-015-0363-2","article-title":"Pharmacokinetics of cannabis in cancer cachexia-anorexia syndrome","volume":"55","author":"Reuter","year":"2016","journal-title":"Clin. Pharmacokinet."},{"key":"B71","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/nn.4462","article-title":"Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes","volume":"20","author":"Romanov","year":"2017","journal-title":"Nat. Neurosci."},{"key":"B72","doi-asserted-by":"publisher","first-page":"5899","DOI":"10.1021\/cr2002799","article-title":"Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathways","volume":"111","author":"Rouzer","year":"2011","journal-title":"Chem. Rev."},{"key":"B73","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.1748-1716.2011.02280.x","article-title":"The serine hydrolases MAGL, ABHD6 and ABHD12 as guardians of 2-arachidonoylglycerol signalling through cannabinoid receptors","volume":"204","author":"Savinainen","year":"2012","journal-title":"Acta Physiol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"1233","DOI":"10.1517\/13543784.14.10.1233","article-title":"The use of melanocortin antagonists in cachexia of chronic disease","volume":"14","author":"Scarlett","year":"2005","journal-title":"Expert Opin. Investig. Drugs"},{"key":"B75","doi-asserted-by":"publisher","first-page":"805","DOI":"10.1016\/j.cell.2015.02.028","article-title":"The hunger games","volume":"160","author":"Seeley","year":"2015","journal-title":"Cell"},{"key":"B76","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1038\/nature20613","article-title":"High-resolution crystal structure of the human CB1 cannabinoid receptor","volume":"540","author":"Shao","year":"2016","journal-title":"Nature"},{"key":"B77","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1016\/j.cmet.2013.03.001","article-title":"The endocannabinoid system in energy homeostasis and the etiopathology of metabolic disorders","volume":"17","author":"Silvestri","year":"2013","journal-title":"Cell Metab."},{"key":"B78","first-page":"179","article-title":"SR 141716, a CB1 cannabinoid receptor antagonist, selectively reduces sweet food intake in marmoset","volume":"9","author":"Simiand","year":"1998","journal-title":"Behav. Pharmacol."},{"key":"B79","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nn.3647","article-title":"The endocannabinoid system controls food intake via olfactory processes","volume":"17","author":"Soria-Gomez","year":"","journal-title":"Nat. Neurosci."},{"key":"B80","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.neuroscience.2014.01.005","article-title":"Cannabinoid type-1 receptors in the paraventricular nucleus of the hypothalamus inhibit stimulated food intake","author":"Soria-Gomez","year":"","journal-title":"Neuroscience"},{"key":"B81","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1016\/j.cmet.2012.07.002","article-title":"Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance","volume":"16","author":"Tam","year":"2012","journal-title":"Cell Metab."},{"key":"B82","doi-asserted-by":"publisher","first-page":"2581","DOI":"10.1093\/cercor\/bhs240","article-title":"Activation-dependent subcellular distribution patterns of CB1 cannabinoid receptors in the rat forebrain","volume":"23","author":"Thibault","year":"2013","journal-title":"Cereb. Cortex"},{"key":"B83","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.bbalip.2014.12.015","article-title":"Endocannabinoids and their oxygenation by cyclo-oxygenases, lipoxygenases and other oxygenases","volume":"1851","author":"Urquhart","year":"2015","journal-title":"Biochim. Biophys. Acta"},{"key":"B84","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1126\/science.1243985","article-title":"Pregnenolone can protect the brain from cannabis intoxication","volume":"343","author":"Vallee","year":"2014","journal-title":"Science"},{"key":"B85","doi-asserted-by":"publisher","first-page":"1079","DOI":"10.1038\/embor.2012.174","article-title":"Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis","volume":"13","author":"Varela","year":"2012","journal-title":"EMBO Rep."},{"key":"B86","doi-asserted-by":"publisher","first-page":"2207","DOI":"10.1111\/j.1460-9568.2009.06750.x","article-title":"Involvement of hypothalamic peptides in the anorectic action of the CB receptor antagonist rimonabant (SR 141716)","volume":"29","author":"Verty","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"B87","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1016\/j.tem.2012.11.004","article-title":"CNS insulin signaling in the control of energy homeostasis and glucose metabolism - from embryo to old age","volume":"24","author":"Vogt","year":"2013","journal-title":"Trends Endocrinol. Metab."},{"key":"B88","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.tics.2010.11.001","article-title":"Reward, dopamine and the control of food intake: implications for obesity","volume":"15","author":"Volkow","year":"2011","journal-title":"Trends Cogn. Sci."},{"key":"B89","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1038\/sj.bjp.0705667","article-title":"Cannabinoids and neuroinflammation","volume":"141","author":"Walter","year":"2004","journal-title":"Br. J. Pharmacol."},{"key":"B90","doi-asserted-by":"publisher","first-page":"2456","DOI":"10.1001\/jama.2015.6358","article-title":"Cannabinoids for medical use: a systematic review and meta-analysis","volume":"313","author":"Whiting","year":"2015","journal-title":"JAMA"},{"key":"B91","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s002130050953","article-title":"Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors","volume":"143","author":"Williams","year":"1999","journal-title":"Psychopharmacology"},{"key":"B92","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/nn.4372","article-title":"Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis","volume":"19","author":"Zhang","year":"2016","journal-title":"Nat. Neurosci."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnins.2017.00293\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,5,24]],"date-time":"2017-05-24T03:56:14Z","timestamp":1495598174000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnins.2017.00293\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,24]]},"references-count":92,"alternative-id":["10.3389\/fnins.2017.00293"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2017.00293","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,24]]},"article-number":"293"}}