{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:20:56Z","timestamp":1787026856210,"version":"build-2736575974"},"reference-count":40,"publisher":"Frontiers Media SA","funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["P41 EB015894"],"award-info":[{"award-number":["P41 EB015894"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["P30 NS076408"],"award-info":[{"award-number":["P30 NS076408"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR000114"],"award-info":[{"award-number":["UL1TR000114"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["KL2TR000113"],"award-info":[{"award-number":["KL2TR000113"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK099137"],"award-info":[{"award-number":["R01DK099137"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R56DK099137"],"award-info":[{"award-number":["R56DK099137"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2017.00529","type":"journal-article","created":{"date-parts":[[2017,9,25]],"date-time":"2017-09-25T00:21:45Z","timestamp":1506298905000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":32,"title":["Type 1 Diabetes and Impaired Awareness of Hypoglycemia Are Associated with Reduced Brain Gray Matter Volumes"],"prefix":"10.3389","volume":"11","author":[{"given":"Petr","family":"Bednarik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir A.","family":"Moheet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heidi","family":"Grohn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anjali F.","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn E.","family":"Eberly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth R.","family":"Seaquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Mangia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2017,9,25]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"A108","DOI":"10.13140\/RG.2.2.12109.23521","article-title":"Volume of hippocampus and other subcortical brain structures in subjects with type 1 diabetes. in Proceedings of the 75th Scientific Session of the American Diabetes Association (ADA). Boston, MA","volume":"64","author":"Bednarik","year":"2015","journal-title":"Diabetes"},{"key":"B2","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. B."},{"key":"B3","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.brainres.2009.05.032","article-title":"Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes mellitus","volume":"1280","author":"Bruehl","year":"2009","journal-title":"Brain Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"724","DOI":"10.1016\/j.neuroimage.2004.06.018","article-title":"A unified approach for morphometric and functional data analysis in young, old, and demented adults using automated atlas-based head size normalization: reliability and validation against manual measurement of total intracranial volume","volume":"23","author":"Buckner","year":"2004","journal-title":"Neuroimage"},{"key":"B5","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1016\/S0896-6273(02)00830-9","article-title":"The human hippocampus and spatial and episodic memory","volume":"35","author":"Burgess","year":"2002","journal-title":"Neuron"},{"key":"B6","doi-asserted-by":"publisher","first-page":"517","DOI":"10.2337\/diacare.18.4.517","article-title":"Reduced awareness of hypoglycemia in adults with IDDM. A prospective study of hypoglycemic frequency and associated symptoms","volume":"18","author":"Clarke","year":"1995","journal-title":"Diabetes Care"},{"key":"B7","doi-asserted-by":"publisher","first-page":"3592","DOI":"10.2337\/diabetes.54.12.3592","article-title":"Mechanisms of hypoglycemia-associated autonomic failure and its component syndromes in diabetes","volume":"54","author":"Cryer","year":"2005","journal-title":"Diabetes"},{"key":"B8","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1002\/dmrr.2507","article-title":"Diabetes, dysglycemia and cognitive dysfunction","volume":"30","author":"Cukierman-Yaffe","year":"2014","journal-title":"Diabetes Metab. Res. Rev."},{"key":"B9","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.2337\/diab.43.12.1426","article-title":"Reversal of hypoglycemia unawareness, but not defective glucose counterregulation, in IDDM","volume":"43","author":"Dagogo-Jack","year":"1994","journal-title":"Diabetes"},{"key":"B10","doi-asserted-by":"publisher","first-page":"1604","DOI":"10.1007\/s00125-003-1235-0","article-title":"Type 2 diabetes and atrophy of medial temporal lobe structures on brain MRI","volume":"46","author":"den Heijer","year":"2003","journal-title":"Diabetologia"},{"key":"B11","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"Neuroimage"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1265","DOI":"10.1007\/BF00399801","article-title":"Long-term recovery from unawareness, deficient counterregulation and lack of cognitive dysfunction during hypoglycaemia, following institution of rational, intensive insulin therapy in IDDM","volume":"37","author":"Fanelli","year":"1994","journal-title":"Diabetologia"},{"key":"B13","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0896-6273(02)00569-X","article-title":"Whole brain segmentation: automated labeling of neuroanatomical structures in the human brain","volume":"33","author":"Fischl","year":"2002","journal-title":"Neuron"},{"key":"B14","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1111\/j.1464-5491.2007.02084.x","article-title":"Severe hypoglycaemia in insulin-treated Type 2 diabetes","volume":"24","author":"Geddes","year":"2007","journal-title":"Diabet. Med"},{"key":"B15","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1111\/j.1464-5491.2008.02413.x","article-title":"Prevalence of impaired awareness of hypoglycaemia in adults with Type 1 diabetes","volume":"25","author":"Geddes","year":"2008","journal-title":"Diabet. Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.neuroimage.2013.04.127","article-title":"The minimal preprocessing pipelines for the Human Connectome Project","volume":"80","author":"Glasser","year":"2013","journal-title":"Neuroimage"},{"key":"B17","doi-asserted-by":"publisher","first-page":"697","DOI":"10.2337\/diacare.17.7.697","article-title":"Frequency of severe hypoglycemia in patients with type I diabetes with impaired awareness of hypoglycemia","volume":"17","author":"Gold","year":"1994","journal-title":"Diabetes Care"},{"key":"B18","doi-asserted-by":"publisher","first-page":"236","DOI":"10.2337\/db09-1117","article-title":"Hippocampal volumes in youth with type 1 diabetes","volume":"59","author":"Hershey","year":"2010","journal-title":"Diabetes"},{"key":"B19","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1016\/j.jdiacomp.2013.07.001","article-title":"Frontal gray matter atrophy in middle aged adults with type 1 diabetes is independent of cardiovascular risk factors and diabetes complications","volume":"27","author":"Hughes","year":"2013","journal-title":"J. Diabetes Complications"},{"key":"B20","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1210\/er.2007-0034","article-title":"Cognitive dysfunction and diabetes mellitus","volume":"29","author":"Kodl","year":"2008","journal-title":"Endocr. Rev."},{"key":"B21","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1093\/brain\/awt162","article-title":"The role of the posterior cingulate cortex in cognition and disease","volume":"137","author":"Leech","year":"2014","journal-title":"Brain"},{"key":"B22","doi-asserted-by":"publisher","first-page":"4063","DOI":"10.2337\/dc13-1004","article-title":"Restoration of self-awareness of hypoglycemia in adults with long-standing type 1 diabetes: hyperinsulinemic-hypoglycemic clamp substudy results from the HypoCOMPaSS trial","volume":"36","author":"Leelarathna","year":"2013","journal-title":"Diabetes Care"},{"key":"B23","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1111\/j.1464-5491.2005.01716.x","article-title":"Hippocampal volume and cognitive performance in long-standing Type 1 diabetic patients without macrovascular complications","volume":"23","author":"Lobnig","year":"2006","journal-title":"Diabet. Med."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2084","DOI":"10.1038\/jcbfm.2012.117","article-title":"Hypoglycemia-induced increases in thalamic cerebral blood flow are blunted in subjects with type 1 diabetes and hypoglycemia unawareness","volume":"32","author":"Mangia","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B25","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1046\/j.1464-5491.2001.00620.x","article-title":"Symptoms of hypoglycaemia in people with diabetes","volume":"18","author":"McAulay","year":"2001","journal-title":"Diabet. Med."},{"key":"B26","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1001\/archinte.1922.00110120086003","article-title":"Psychologic tests applied to diabetic patients","volume":"30","author":"Miles","year":"1922","journal-title":"Arch. Intern. Med."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.jdiacomp.2015.08.004","article-title":"Naltrexone for treatment of impaired awareness of hypoglycemia in type 1 diabetes: a randomized clinical trial","volume":"29","author":"Moheet","year":"","journal-title":"J. Diabetes Complicatons"},{"key":"B28","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1111\/nyas.12807","article-title":"Impact of diabetes on cognitive function and brain structure","volume":"1353","author":"Moheet","year":"","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"326","DOI":"10.2337\/diabetes.55.02.06.db05-0520","article-title":"Effects of type 1 diabetes on gray matter density as measured by voxel-based morphometry","volume":"55","author":"Musen","year":"2006","journal-title":"Diabetes"},{"key":"B30","doi-asserted-by":"publisher","first-page":"586","DOI":"10.1097\/01.wco.0000247609.36482.ae","article-title":"Cognition and medial frontal cortex in health and disease","volume":"19","author":"Nachev","year":"2006","journal-title":"Curr. Opin. Neurol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"1248","DOI":"10.1016\/S0140-6736(00)04405-6","article-title":"Activity of angiotensin-converting enzyme and risk of severe hypoglycaemia in type 1 diabetes mellitus","volume":"357","author":"Pedersen-Bjergaard","year":"2001","journal-title":"Lancet"},{"key":"B32","doi-asserted-by":"publisher","first-page":"11","DOI":"10.1136\/jnnp.20.1.11","article-title":"Loss of recent memory after bilateral hippocampal lesions","volume":"20","author":"Scoville","year":"1957","journal-title":"J. Neurol. Neurosurg. Psychiatr."},{"key":"B33","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1146\/annurev.neuro.27.070203.144130","article-title":"The medial temporal lobe","volume":"27","author":"Squire","year":"2004","journal-title":"Annu. Rev. Neurosci."},{"key":"B34","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.2337\/dc17-S003","article-title":"Standards of Medical Care in Diabetes-2017: Summary of Revisions","volume":"40","year":"2017","journal-title":"Diabetes Care"},{"key":"B35","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1038\/jcbfm.2014.32","article-title":"Changes in human brain glutamate concentration during hypoglycemia: insights into cerebral adaptations in hypoglycemia-associated autonomic failure in type 1 diabetes","volume":"34","author":"Terpstra","year":"2014","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B36","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1111\/j.1749-6632.2010.05820.x","article-title":"Neuroendocrine responses to hypoglycemia","volume":"1212","author":"Tesfaye","year":"2010","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"2539","DOI":"10.2337\/dc06-1637","article-title":"Brain imaging in patients with diabetes: a systematic review","volume":"29","author":"van Harten","year":"2006","journal-title":"Diabetes Care"},{"key":"B38","doi-asserted-by":"publisher","first-page":"1763","DOI":"10.1007\/s00125-007-0714-0","article-title":"Cognitive performance in type 1 diabetes patients is associated with cerebral white matter volume","volume":"50","author":"Wessels","year":"2007","journal-title":"Diabetologia"},{"key":"B39","doi-asserted-by":"publisher","first-page":"2474","DOI":"10.1007\/s00125-006-0283-7","article-title":"Voxel-based morphometry demonstrates reduced grey matter density on brain MRI in patients with diabetic retinopathy","volume":"49","author":"Wessels","year":"2006","journal-title":"Diabetologia"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1047","DOI":"10.2337\/diacare.27.5.1047","article-title":"Global prevalence of diabetes: estimates for the year 2000 and projections for 2030","volume":"27","author":"Wild","year":"2004","journal-title":"Diabetes Care"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnins.2017.00529\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T02:24:28Z","timestamp":1719455068000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnins.2017.00529\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9,25]]},"references-count":40,"alternative-id":["10.3389\/fnins.2017.00529"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2017.00529","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,9,25]]},"article-number":"529"}}