{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:49:55Z","timestamp":1790768995266,"version":"4.1.0"},"reference-count":75,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T00:00:00Z","timestamp":1517788800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007557","name":"California Institute of Regenerative Medicine","doi-asserted-by":"publisher","award":["EDUC2-08391"],"award-info":[{"award-number":["EDUC2-08391"]}],"id":[{"id":"10.13039\/100007557","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NIH R01 NS074408"],"award-info":[{"award-number":["NIH R01 NS074408"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["RO1 NS100529"],"award-info":[{"award-number":["RO1 NS100529"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2017.00736","type":"journal-article","created":{"date-parts":[[2018,2,5]],"date-time":"2018-02-05T04:29:53Z","timestamp":1517804993000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Altered Expression of Matrix Metalloproteinases and Their Endogenous Inhibitors in a Human Isogenic Stem Cell Model of Huntington's Disease"],"prefix":"10.3389","volume":"11","author":[{"given":"Swati","family":"Naphade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Embusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuruwitage Lakshika","family":"Madushani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen L.","family":"Ring","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa M.","family":"Ellerby","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,2,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"e159","DOI":"10.1161\/01.STR.0000127420.10990.76","article-title":"Measurement of gelatinase B (MMP-9) in the cerebrospinal fluid of patients with vascular dementia and alzheimer disease","volume":"35","author":"Adair","year":"2004","journal-title":"Stroke"},{"key":"B2","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1016\/j.stem.2012.04.026","article-title":"Genetic correction of Huntington's disease phenotypes in induced pluripotent stem cells","volume":"11","author":"An","year":"2012","journal-title":"Cell Stem Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"e332","DOI":"10.1038\/cddis.2012.54","article-title":"Tissue inhibitor of metalloproteinases-1 protects human neurons from staurosporine and HIV-1-induced apoptosis: mechanisms and relevance to HIV-1-associated dementia","volume":"3","author":"Ashutosh","year":"2012","journal-title":"Cell Death Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"15935","DOI":"10.1074\/jbc.M112.341156","article-title":"Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure","volume":"287","author":"Batra","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B5","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1111\/j.1582-4934.2010.01011.x","article-title":"Early defect of transforming growth factor beta1 formation in Huntington's disease","volume":"15","author":"Battaglia","year":"2011","journal-title":"J. Cell. Mol. Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"6653","DOI":"10.1021\/jm100669j","article-title":"Orally active MMP-1 sparing alpha-tetrahydropyranyl and alpha-piperidinyl sulfone matrix metalloproteinase (MMP) inhibitors with efficacy in cancer, arthritis, and cardiovascular disease","volume":"53","author":"Becker","year":"2010","journal-title":"J. Med. Chem."},{"key":"B7","doi-asserted-by":"publisher","first-page":"707","DOI":"10.1016\/j.jmb.2003.12.033","article-title":"Crystal structure of the catalytic domain of human matrix metalloproteinase 10","volume":"336","author":"Bertini","year":"2004","journal-title":"J. Mol. Biol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"1869","DOI":"10.1084\/jem.20080178","article-title":"A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease","volume":"205","author":"Bjorkqvist","year":"2008","journal-title":"J. Exp. Med."},{"key":"B9","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.bbamcr.2010.01.003","article-title":"The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity","volume":"1803","author":"Brew","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"B10","doi-asserted-by":"publisher","first-page":"620581","DOI":"10.1155\/2015\/620581","article-title":"Friends or foes: matrix metalloproteinases and their multifaceted roles in neurodegenerative diseases","volume":"2015","author":"Brkic","year":"2015","journal-title":"Mediators Inflamm."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1097\/NEN.0b013e3181c22569","article-title":"Increased matrix metalloproteinase 9 activity in mild cognitive impairment","volume":"68","author":"Bruno","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"B12","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1111\/j.1471-4159.2008.05399.x","article-title":"A novel intracellular role of matrix metalloproteinase-3 during apoptosis of dopaminergic cells","volume":"106","author":"Choi","year":"2008","journal-title":"J. Neurochem."},{"key":"B13","first-page":"1011","article-title":"A diverse role of MMP-2 and MMP-9 in the onset of alzheimer disease and cancer","volume":"1","author":"Chowdhury","year":"2016","journal-title":"Austin Neurol. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"74","DOI":"10.1016\/j.neuroscience.2016.03.031","article-title":"Enhanced immune response to MMP3 stimulation in microglia expressing mutant huntingtin","volume":"325","author":"Connolly","year":"2016","journal-title":"Neuroscience"},{"key":"B15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1002\/jnr.10836","article-title":"The TIMPs tango with MMPs and more in the central nervous system","volume":"75","author":"Crocker","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"B16","doi-asserted-by":"publisher","first-page":"51","DOI":"10.1016\/j.jns.2010.04.005","article-title":"MMP-2 and MMP-9 are elevated in spinal cord and skin in a mouse model of ALS","volume":"294","author":"Fang","year":"2010","journal-title":"J. Neurol. Sci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1674","DOI":"10.1038\/jcbfm.2008.59","article-title":"Tissue inhibitor of metalloproteinases protect blood-brain barrier disruption in focal cerebral ischemia","volume":"28","author":"Fujimoto","year":"2008","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B18","doi-asserted-by":"publisher","first-page":"20211","DOI":"10.1074\/jbc.M401267200","article-title":"Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain\/caspase fragments in the nucleus","volume":"279","author":"Gafni","year":"2004","journal-title":"J. Biol. Chem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1002\/jnr.10835","article-title":"Tissue inhibitor of metalloproteinase (TIMP)-1: the TIMPed balance of matrix metalloproteinases in the central nervous system","volume":"74","author":"Gardner","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"B20","doi-asserted-by":"publisher","first-page":"3530","DOI":"10.1002\/stem.2189","article-title":"TIMP3 Attenuates the loss of neural stem cells, mature neurons and neurocognitive dysfunction in traumatic brain injury","volume":"33","author":"Gibb","year":"2015","journal-title":"Stem Cells"},{"key":"B21","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/1471-2407-12-26","article-title":"TGF-beta1 modulates the homeostasis between MMPs and MMP inhibitors through p38 MAPK and ERK1\/2 in highly invasive breast cancer cells","volume":"12","author":"Gomes","year":"2012","journal-title":"BMC Cancer"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1179","DOI":"10.1016\/j.cell.2006.04.026","article-title":"Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin","volume":"125","author":"Graham","year":"2006","journal-title":"Cell"},{"key":"B23","doi-asserted-by":"publisher","first-page":"10304","DOI":"10.1074\/jbc.M212334200","article-title":"The comparative role of activator protein 1 and smad factors in the regulation of Timp-1 and MMP-1 gene expression by transforming growth factor-beta 1","volume":"278","author":"Hall","year":"2003","journal-title":"J. Biol. Chem."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e73777","DOI":"10.1371\/journal.pone.0073777","article-title":"Association studies of MMP-9 in Parkinson's disease and amyotrophic lateral sclerosis","volume":"8","author":"He","year":"2013","journal-title":"PLoS ONE"},{"key":"B25","doi-asserted-by":"publisher","first-page":"15078","DOI":"10.1074\/jbc.M114.610931","article-title":"Sequential amyloid-beta degradation by the matrix metalloproteases MMP-2 and MMP-9","volume":"290","author":"Hernandez-Guillamon","year":"2015","journal-title":"J. Biol. Chem."},{"key":"B26","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.neuroscience.2012.06.019","article-title":"Intranuclear matrix metalloproteinases promote DNA damage and apoptosis induced by oxygen-glucose deprivation in neurons","volume":"220","author":"Hill","year":"2012","journal-title":"Neuroscience"},{"key":"B27","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.tibs.2004.04.001","article-title":"MT1-MMP: an enzyme with multidimensional regulation","volume":"29","author":"Itoh","year":"2004","journal-title":"Trends Biochem. Sci."},{"key":"B28","doi-asserted-by":"publisher","first-page":"82","DOI":"10.1002\/neu.20205","article-title":"Tissue inhibitor of metalloproteinase-2(TIMP-2)-deficient mice display motor deficits","volume":"66","author":"Jaworski","year":"2006","journal-title":"J. Neurobiol."},{"key":"B29","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1016\/j.celrep.2016.04.011","article-title":"Human iPSC-derived immature astroglia promote oligodendrogenesis by increasing TIMP-1 secretion","volume":"15","author":"Jiang","year":"2016","journal-title":"Cell Rep."},{"key":"B30","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.neuron.2013.12.009","article-title":"Neuronal matrix metalloproteinase-9 is a determinant of selective neurodegeneration","volume":"81","author":"Kaplan","year":"2014","journal-title":"Neuron"},{"key":"B31","doi-asserted-by":"publisher","first-page":"28","DOI":"10.4103\/0973-1482.157337","article-title":"Seesaw of matrix metalloproteinases (MMPs)","volume":"12","author":"Kapoor","year":"2016","journal-title":"J. Cancer Res. Ther."},{"key":"B32","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1111\/j.1471-4159.2010.07082.x","article-title":"Role of matrix metalloproteinase-3 in neurodegeneration","volume":"116","author":"Kim","year":"2011","journal-title":"J. Neurochem."},{"key":"B33","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.neulet.2009.10.084","article-title":"The neuroprotective role of tissue inhibitor of metalloproteinase-2 in MPP+- or 6-OHDA-treated SK-N-BE(2)C and SH-SY5Y human neuroblastoma cells","volume":"468","author":"Kim","year":"2010","journal-title":"Neurosci. Lett."},{"key":"B34","doi-asserted-by":"publisher","first-page":"3701","DOI":"10.1523\/JNEUROSCI.4346-04.2005","article-title":"Matrix metalloproteinase-3: a novel signaling proteinase from apoptotic neuronal cells that activates microglia","volume":"25","author":"Kim","year":"2005","journal-title":"J. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"6927328","DOI":"10.1155\/2016\/6927328","article-title":"Oxidative DNA damage mediated by intranuclear MMP activity Is associated with neuronal apoptosis in ischemic stroke","volume":"2016","author":"Kimura-Ohba","year":"2016","journal-title":"Oxid. Med. Cell. Longev."},{"key":"B36","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1002\/j.1460-2075.1995.tb07052.x","article-title":"TGF-beta superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity","volume":"14","author":"Krieglstein","year":"1995","journal-title":"EMBO J."},{"key":"B37","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1016\/0306-4522(94)90583-5","article-title":"Transforming growth factor-beta promotes survival of midbrain dopaminergic neurons and protects them against N-methyl-4-phenylpyridinium ion toxicity","volume":"63","author":"Krieglstein","year":"1994","journal-title":"Neuroscience"},{"key":"B38","doi-asserted-by":"publisher","first-page":"338","DOI":"10.12965\/jer.130049","article-title":"Aging, exercise, and extracellular matrix in the heart","volume":"9","author":"Kwak","year":"2013","journal-title":"J. Exerc. Rehabil."},{"key":"B39","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1186\/1742-2094-11-116","article-title":"The anti-inflammatory role of tissue inhibitor of metalloproteinase-2 in lipopolysaccharide-stimulated microglia","volume":"11","author":"Lee","year":"2014","journal-title":"J. Neuroinflam."},{"key":"B40","first-page":"133","article-title":"Cell cycle-dependent localization of tissue inhibitor of metalloproteinases-1 immunoreactivity in cultured human gingival fibroblasts","volume":"58","author":"Li","year":"1995","journal-title":"Nagoya J. Med. Sci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1021\/bi901994d","article-title":"Degradation of soluble and fibrillar amyloid beta-protein by matrix metalloproteinase (MT1-MMP) in vitro","volume":"49","author":"Liao","year":"2010","journal-title":"Biochemistry"},{"key":"B42","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1046\/j.1471-4159.1996.67010251.x","article-title":"Matrix metalloproteinases in the neocortex and spinal cord of amyotrophic lateral sclerosis patients","volume":"67","author":"Lim","year":"1996","journal-title":"J. Neurochem."},{"key":"B43","doi-asserted-by":"publisher","first-page":"779","DOI":"10.3233\/JAD-2011-101974","article-title":"Investigation of matrix metalloproteinases, MMP-2 and MMP-9, in plasma reveals a decrease of MMP-2 in Alzheimer's disease","volume":"26","author":"Lim","year":"2011","journal-title":"J. Alzheimers. Dis."},{"key":"B44","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/S0022-510X(02)00398-2","article-title":"Tissue inhibitors of matrix metalloproteinases are elevated in cerebrospinal fluid of neurodegenerative diseases","volume":"207","author":"Lorenzl","year":"","journal-title":"J. Neurol. Sci."},{"key":"B45","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1006\/exnr.2002.8019","article-title":"Expression of MMP-2, MMP-9, and MMP-1 and their endogenous counterregulators TIMP-1 and TIMP-2 in postmortem brain tissue of parkinson's disease","volume":"178","author":"Lorenzl","year":"2002","journal-title":"Exp. Neurol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/S0197-0186(03)00004-4","article-title":"Increased plasma levels of matrix metalloproteinase-9 in patients with Alzheimer's disease","volume":"43","author":"Lorenzl","year":"","journal-title":"Neurochem. Int."},{"key":"B47","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1038\/sj.gt.3302894","article-title":"Neuroprotective effect of adenoviral-mediated gene transfer of TIMP-1 and\u22122 in ischemic brain injury","volume":"14","author":"Magnoni","year":"2007","journal-title":"Gene. Ther."},{"key":"B48","doi-asserted-by":"publisher","first-page":"1696","DOI":"10.2741\/1915","article-title":"Matrix metalloproteinases (MMPs) in health and disease: an overview","volume":"11","author":"Malemud","year":"2006","journal-title":"Front. Biosci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1023\/A:1012493808790","article-title":"Tissue inhibitors of metalloproteinases and programmed cell death: conundrums, controversies and potential implications","volume":"6","author":"Mannello","year":"2001","journal-title":"Apoptosis"},{"key":"B50","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1007\/s10495-005-6058-7","article-title":"Multiple roles of matrix metalloproteinases during apoptosis","volume":"10","author":"Mannello","year":"2005","journal-title":"Apoptosis"},{"key":"B51","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.proghi.2011.12.002","article-title":"Nuclear localization of matrix metalloproteinases","volume":"47","author":"Mannello","year":"2012","journal-title":"Prog. Histochem. Cytochem."},{"key":"B52","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1523\/JNEUROSCI.21-06-01830.2001","article-title":"Tissue-specific proteolysis of Huntingtin (htt) in human brain: evidence of enhanced levels of N- and C-terminal htt fragments in Huntington's disease striatum","volume":"21","author":"Mende-Mueller","year":"2001","journal-title":"J. Neurosci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1016\/j.neuron.2010.06.021","article-title":"Matrix metalloproteinases are modifiers of huntingtin proteolysis and toxicity in Huntington's disease","volume":"67","author":"Miller","year":"2010","journal-title":"Neuron"},{"key":"B54","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1124\/jpet.109.154724","article-title":"Matrix metalloprotease-9 inhibition improves amyloid beta-mediated cognitive impairment and neurotoxicity in mice","volume":"331","author":"Mizoguchi","year":"2009","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B55","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.ajpath.2011.09.008","article-title":"An alternate perspective on the roles of TIMPs and MMPs in pathology","volume":"180","author":"Moore","year":"2012","journal-title":"Am. J. Pathol."},{"key":"B56","doi-asserted-by":"publisher","first-page":"6247","DOI":"10.1523\/JNEUROSCI.5474-10.2011","article-title":"Astrocytic tissue inhibitor of metalloproteinase-1 (TIMP-1) promotes oligodendrocyte differentiation and enhances CNS myelination","volume":"31","author":"Moore","year":"2011","journal-title":"J. Neurosci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"273","DOI":"10.3233\/JAD-13064","article-title":"The role of matrix metalloproteinases and tissue inhibitors of metalloproteinases in the pathophysiology of neurodegeneration: a literature study","volume":"37","author":"Mroczko","year":"2013","journal-title":"J. Alzheimers. Dis."},{"key":"B58","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1038\/cr.1998.18","article-title":"Cell surface activation of progelatinase A (proMMP-2) and cell migration","volume":"8","author":"Nagase","year":"1998","journal-title":"Cell Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","article-title":"Structure and function of matrix metalloproteinases and TIMPs","volume":"69","author":"Nagase","year":"2006","journal-title":"Cardiovasc. Res."},{"key":"B60","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.1016\/0896-6273(94)90062-0","article-title":"TGF beta 2 and TGF beta 3 are potent survival factors for midbrain dopaminergic neurons","volume":"13","author":"Poulsen","year":"1994","journal-title":"Neuron"},{"key":"B61","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1016\/j.matbio.2007.07.001","article-title":"Control of matrix metalloproteinase catalytic activity","volume":"26","author":"Ra","year":"2007","journal-title":"Matrix. Biol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1023","DOI":"10.1016\/j.stemcr.2015.11.005","article-title":"Genomic analysis reveals disruption of striatal neuronal development and therapeutic targets in human huntington's disease neural stem cells","volume":"5","author":"Ring","year":"2015","journal-title":"Stem Cell Reports"},{"key":"B63","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1016\/S1044-7431(03)00081-2","article-title":"Transforming growth factor beta1 overexpression in the nigrostriatal system increases the dopaminergic deficit of MPTP mice","volume":"23","author":"Sanchez-Capelo","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1390","DOI":"10.2353\/ajpath.2006.060005","article-title":"Matrix metalloproteinase 3 is present in the cell nucleus and is involved in apoptosis","volume":"169","author":"Si-Tayeb","year":"2006","journal-title":"Am. J. Pathol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"re6","DOI":"10.1126\/scisignal.127re6","article-title":"Tissue inhibitors of metalloproteinases in cell signaling: metalloproteinase-independent biological activities","volume":"1","author":"Stetler-Stevenson","year":"2008","journal-title":"Sci. Signal."},{"key":"B66","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1016\/S1044-7431(02)00024-6","article-title":"Tissue inhibitor of metalloproteinase 1 inhibits excitotoxic cell death in neurons","volume":"22","author":"Tan","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"1935","DOI":"10.1089\/neu.2009.0959","article-title":"Neuroprotective effects of overexpressing tissue inhibitor of metalloproteinase TIMP-1","volume":"26","author":"Tejima","year":"2009","journal-title":"J. Neurotrauma."},{"key":"B68","doi-asserted-by":"publisher","first-page":"4584","DOI":"10.1523\/JNEUROSCI.2952-16.2017","article-title":"Deficiency in neuronal TGF-beta signaling leads to nigrostriatal degeneration and activation of TGF-beta signaling protects against MPTP neurotoxicity in mice","volume":"37","author":"Tesseur","year":"2017","journal-title":"J. Neurosci."},{"key":"B69","doi-asserted-by":"publisher","first-page":"904","DOI":"10.1038\/nrd4390","article-title":"Is there new hope for therapeutic matrix metalloproteinase inhibition?","volume":"13","author":"Vandenbroucke","year":"2014","journal-title":"Nat. Rev. Drug Discov."},{"key":"B70","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1016\/j.expneurol.2008.11.022","article-title":"TIMP-3 and MMP-3 contribute to delayed inflammation and hippocampal neuronal death following global ischemia","volume":"216","author":"Walker","year":"2009","journal-title":"Exp. Neurol."},{"key":"B71","doi-asserted-by":"publisher","first-page":"2738","DOI":"10.1093\/hmg\/ddn175","article-title":"Accumulation of N-terminal mutant huntingtin in mouse and monkey models implicated as a pathogenic mechanism in Huntington's disease","volume":"17","author":"Wang","year":"2008","journal-title":"Hum. Mol. Genet."},{"key":"B72","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3233\/JAD-150759","article-title":"Matrix Metalloproteinase in blood-brain barrier breakdown in dementia","volume":"49","author":"Weekman","year":"2016","journal-title":"J. Alzheimers Dis."},{"key":"B73","doi-asserted-by":"crossref","first-page":"7862","DOI":"10.1523\/JNEUROSCI.22-18-07862.2002","article-title":"Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease","volume":"22","author":"Wellington","year":"2002","journal-title":"J. Neurosci."},{"key":"B74","doi-asserted-by":"publisher","first-page":"19831","DOI":"10.1074\/jbc.M001475200","article-title":"Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells","volume":"275","author":"Wellington","year":"2000","journal-title":"J. Biol. Chem."},{"key":"B75","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1242\/jcs.111.9.1147","article-title":"Cell cycle-associated accumulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) in the nuclei of human gingival fibroblasts","author":"Zhao","year":"1998","journal-title":"J. Cell. Sci."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnins.2017.00736\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,13]],"date-time":"2022-08-13T22:17:33Z","timestamp":1660429053000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnins.2017.00736\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,5]]},"references-count":75,"alternative-id":["10.3389\/fnins.2017.00736"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2017.00736","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,5]]},"article-number":"736"}}