{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:47:03Z","timestamp":1790488023413,"version":"4.1.0"},"reference-count":48,"publisher":"Frontiers Media SA","content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2018.00124","type":"journal-article","created":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T04:36:46Z","timestamp":1519879006000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":25,"title":["Tau Depletion in APP Transgenic Mice Attenuates Task-Related Hyperactivation of the Hippocampus and Differentially Influences Locomotor Activity and Spatial Memory"],"prefix":"10.3389","volume":"12","author":[{"given":"Misato","family":"Yoshikawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiyuki","family":"Soeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Michikawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osborne F. X.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Takashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,3,1]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1567","DOI":"10.1038\/nn.2433","article-title":"Amyloid-\u03b2 as positive endogenous regulator of release probability at hippocampal synapses","volume":"12","author":"Abramov","year":"2009","journal-title":"Nat. Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.neuron.2012.03.023","article-title":"Report reduction of hippocampal hyperactivity improves cognition in amnestic mild cognitive impairment","volume":"74","author":"Bakker","year":"2012","journal-title":"Neuron"},{"key":"B3","doi-asserted-by":"publisher","first-page":"338r","DOI":"10.1126\/scitranslmed.aaf2362","article-title":"Tau and A\u03b2 imaging, CSF measures, and cognition in Alzheimer's disease","volume":"8","author":"Brier","year":"2016","journal-title":"Sci. Transl. Med."},{"key":"B4","doi-asserted-by":"publisher","first-page":"8740","DOI":"10.1073\/pnas.1206171109","article-title":"Critical role of soluble amyloid-\u03b2 for early hippocampal hyperactivity in a mouse model of Alzheimer's disease","volume":"109","author":"Busche","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B5","doi-asserted-by":"publisher","first-page":"20150429","DOI":"10.1098\/rstb.2015.0429","article-title":"Impairments of neural circuit function in Alzheimer's disease","volume":"371","author":"Busche","year":"2016","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci"},{"key":"B6","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1016\/j.arr.2013.03.002","article-title":"The intersection of amyloid \u03b2 and tau in glutamatergic synaptic dysfunction and collapse in Alzheimer's disease","volume":"12","author":"Crimins","year":"2013","journal-title":"Ageing Res. Rev."},{"key":"B7","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1242\/jcs.114.6.1179","article-title":"Inhibition of neuronal maturation in primary hippocampal neurons from tau deficient mice","volume":"114","author":"Dawson","year":"2001","journal-title":"J. Cell Sci."},{"key":"B8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0166-4328(96)00163-5","article-title":"Response learning of rats in a Morris water maze: involvement of the medical prefrontal cortex","volume":"85","author":"de Bruin","year":"1997","journal-title":"Behav. Brain Res."},{"key":"B9","doi-asserted-by":"publisher","first-page":"404","DOI":"10.1212\/01.wnl.0000171450.97464.49","article-title":"Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD","volume":"65","author":"Dickerson","year":"2005","journal-title":"Neurology"},{"key":"B10","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1038\/nrn.2017.74","article-title":"Prefrontal-hippocampal interactions in episodic memory","volume":"18","author":"Eichenbaum","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1038\/nn.3806","article-title":"Neural compensation in older people with brain amyloid-\u03b2 deposition","volume":"17","author":"Elman","year":"2014","journal-title":"Nat. Neurosci"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1038\/npp.2010.32","article-title":"Rosiglitazone rescues memory impairment in Alzheimer's transgenic mice: mechanisms involving a reduced amyloid and tau pathology","volume":"35","author":"Escribano","year":"2010","journal-title":"Neuropsychopharmacology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"11157","DOI":"10.1523\/JNEUROSCI.2884-10.2010","article-title":"A noncompetitive BACE1 inhibitor TAK-070 ameliorates A\u03b2 pathology and behavioural deficits in a mouse model of Alzheimer's disease","volume":"6","author":"Fukumoto","year":"2010","journal-title":"J. Neurosci."},{"key":"B14","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1073\/pnas.0509695103","article-title":"Reversal of Alzheimer's-like pathology and behavior in human APP transgenic mice by mutation of Asp664","volume":"103","author":"Galvan","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B15","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1016\/S0140-6736(08)61075-2","article-title":"Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial","volume":"372","author":"Holmes","year":"2008","journal-title":"Lancet"},{"key":"B16","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1016\/j.cell.2010.06.036","article-title":"Dendritic function of tau mediates amyloid- b toxicity in Alzheimer's disease mouse models","volume":"142","author":"Ittner","year":"2010","journal-title":"Cell"},{"key":"B17","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"Jack","year":"2013","journal-title":"Lancet Neurol."},{"key":"B18","first-page":"979","article-title":"A\u03b2 peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease","volume-title":"Nature","author":"Janus","year":"2000"},{"key":"B19","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/S0896-6273(03)00124-7","article-title":"APP processing and synaptic function","volume":"37","author":"Kamenetz","year":"2003","journal-title":"Neuron"},{"key":"B20","doi-asserted-by":"publisher","first-page":"20130144","DOI":"10.1098\/rstb.2013.0144","article-title":"Microtubule-associated protein tau is essential for long-term depression in the hippocampus","volume":"369","author":"Kimura","year":"2013","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"5143","DOI":"10.1038\/sj.emboj.7601917","article-title":"Hyperphosphorylated tau in parahippocampal cortex impairs place learning in aged mice expressing wild-type human tau","volume":"26","author":"Kimura","year":"2007","journal-title":"EMBO J."},{"key":"B22","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.ebiom.2017.05.012","article-title":"Local somatodendritic translation and hyperphosphorylation of tau protein triggered by AMPA and NMDA receptor stimulation","volume":"20","author":"Kobayashi","year":"2017","journal-title":"EBioMedicine"},{"key":"B23","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/S0149-7634(01)00041-0","article-title":"The neurobiological basis of spontaneous alternation","volume":"26","author":"Lalonde","year":"2002","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B24","doi-asserted-by":"publisher","first-page":"e22978","DOI":"10.7554\/eLife.22978","article-title":"Hippocampal activation is associated with longitudinal amyloid accumulation and cognitive decline","volume":"6","author":"Leal","year":"2017","journal-title":"Elife"},{"key":"B25","doi-asserted-by":"publisher","first-page":"3192","DOI":"10.1523\/JNEUROSCI.3769-16.2017","article-title":"Tau and \u03b2-Amyloid are associated with medial temporal lobe structure, function, and memory encoding in normal aging","volume":"37","author":"Marks","year":"2017","journal-title":"J. Neurosci."},{"key":"B26","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1073\/pnas.0706818105","article-title":"Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation","volume":"105","author":"Miller","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1813","DOI":"10.1093\/cercor\/bhr255","article-title":"A\u03b2 deposition in aging is associated with increases in brain activation during successful memory encoding","volume":"22","author":"Mormino","year":"2012","journal-title":"Cereb. Cortex"},{"key":"B28","doi-asserted-by":"crossref","first-page":"4050","DOI":"10.1523\/JNEUROSCI.20-11-04050.2000","article-title":"High-level neuronal expression of A\u03b21\u221242 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation","volume":"20","author":"Mucke","year":"2000","journal-title":"J. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","first-page":"800","DOI":"10.1038\/nn.4018","article-title":"Three dimensions of the amyloid hypothesis: time, space and 'wingmen'","volume":"18","author":"Musiek","year":"2015","journal-title":"Nat. Neurosci"},{"key":"B30","doi-asserted-by":"publisher","first-page":"e10943","DOI":"10.1371\/journal.pone.0010943","article-title":"Lowering \u03b2-amyloid levels rescues learning and memory in a down syndrome mouse model","volume":"6","author":"Netzer","year":"2010","journal-title":"PLoS ONE"},{"key":"B31","doi-asserted-by":"publisher","first-page":"5191","DOI":"10.1073\/pnas.90.11.5191","article-title":"Release of amyloid beta-protein precursor derivatives by electrical depolarization of rat hippocampal slices","volume":"90","author":"Nitsch","year":"1993","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B32","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/j.neuron.2007.07.025","article-title":"Aberrant excitatory neuronal activity and compensatory remodeling of inhibitory hippocampal circuits in mouse models of Alzheimer's disease","volume":"55","author":"Palop","year":"2007","journal-title":"Neuron"},{"key":"B33","doi-asserted-by":"publisher","first-page":"9572","DOI":"10.1073\/pnas.1133381100","article-title":"Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits","volume":"100","author":"Palop","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B34","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/nn.2583","article-title":"Amyloid-\u03b2 induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks","volume":"13","author":"Palop","year":"2010","journal-title":"Nat. Neurosci."},{"key":"B35","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1523\/JNEUROSCI.4152-10.2011","article-title":"Amyloid-\u03b2\/Fyn-induced synaptic, network, and cognitive impairments depend on tau levels in multiple mouse models of Alzheimer's disease","volume":"31","author":"Roberson","year":"2011","journal-title":"J. Neurosci."},{"key":"B36","doi-asserted-by":"publisher","first-page":"750","DOI":"10.1126\/science.1141736","article-title":"Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model","volume":"316","author":"Roberson","year":"2007","journal-title":"Science"},{"key":"B37","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1038\/22124","article-title":"Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse","volume":"400","author":"Schenk","year":"1999","journal-title":"Nature"},{"key":"B38","doi-asserted-by":"publisher","first-page":"426","DOI":"10.1002\/cmmi.1469","article-title":"Evaluation of manganese uptake and toxicity in mouse brain during continuous MnCl2 administration using osmotic pumps","volume":"7","author":"Sep\u00falveda","year":"2012","journal-title":"Contrast Media Mol. Imaging"},{"key":"B39","doi-asserted-by":"publisher","first-page":"1688","DOI":"10.1523\/JNEUROSCI.2610-10.2011","article-title":"Tau protein is required for amyloid-induced impairment of hippocampal long-term potentiation","volume":"31","author":"Shipton","year":"2011","journal-title":"J. Neurosci."},{"key":"B40","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1093\/schbul\/sbn056","article-title":"Manganense-enhanced MRI: an exceptional tool in translational neuroimaging","volume":"34","author":"Silva","year":"2008","journal-title":"Schizophr. Bull."},{"key":"B41","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1136\/jnnp.74.1.44","article-title":"fMRI studies of associative encoding in young and elderly controls and mild Alzheimer's disease","volume":"74","author":"Sperling","year":"2003","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B42","doi-asserted-by":"publisher","first-page":"a006296","DOI":"10.1101\/cshperspect.a006296","article-title":"The genetics of Alzheimer disease","volume":"2","author":"Tanzi","year":"2012","journal-title":"Cold Spring Harb. Perspect. Med."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2093","DOI":"10.1093\/cercor\/bht060","article-title":"The GABAergic septohippocampal pathway is directly involved in internal processes related to operant reward learning","volume":"24","author":"Vega-Flores","year":"2014","journal-title":"Cereb. Cortex"},{"key":"B44","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1038\/416535a","article-title":"Naturally secreted oligomers of amyloid beta protein potently inhibit hippocampal long-term potentiation in vivo","volume":"416","author":"Walsh","year":"2002","journal-title":"Nature"},{"key":"B45","doi-asserted-by":"publisher","first-page":"e59586","DOI":"10.1371\/journal.pone.0059586","article-title":"Neuroinflammation and neuronal loss precede A\u03b2 plaque deposition in the hAPP-J20 mouse model of Alzheimer's disease","volume":"8","author":"Wright","year":"2013","journal-title":"PLoS ONE"},{"key":"B46","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/nn.4328","article-title":"Neuronal activity enhances tau propagation and tau pathology in vivo","volume":"19","author":"Wu","year":"2016","journal-title":"Nat. Neurosci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1002\/hipo.20808","article-title":"Pattern separation deficits associated with increased hippocampal CA3 and dentate gyrus activity in nondemented older adults","volume":"21","author":"Yassa","year":"2011","journal-title":"Hippocampus"},{"key":"B48","doi-asserted-by":"publisher","first-page":"817","DOI":"10.2174\/1567205013666160129095508","article-title":"Increased epileptiform EEG activity and decreased seizure threshold in arctic APP transgenic mouse model of Alzheimer's disease","volume":"13","author":"Ziyatdinova","year":"2016","journal-title":"Curr. Alzheimer Res."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnins.2018.00124\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T01:52:44Z","timestamp":1660528364000},"score":1,"resource":{"primary":{"URL":"http:\/\/journal.frontiersin.org\/article\/10.3389\/fnins.2018.00124\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,1]]},"references-count":48,"alternative-id":["10.3389\/fnins.2018.00124"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2018.00124","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,1]]},"article-number":"124"}}