{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T11:32:55Z","timestamp":1780054375119,"version":"3.54.0"},"reference-count":68,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T00:00:00Z","timestamp":1541376000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2018.00807","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T04:32:10Z","timestamp":1541392330000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":36,"title":["Whole-Brain Monosynaptic Afferent Projections to the Cholecystokinin Neurons of the Suprachiasmatic Nucleus"],"prefix":"10.3389","volume":"12","author":[{"given":"Xiang-Shan","family":"Yuan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao-Hua","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Min","family":"Qu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Xi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,11,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1080\/23328940.2017.1413155","article-title":"Role of the median preoptic nucleus in the autonomic response to heat-exposure","volume":"5","author":"Abbott","year":"2018","journal-title":"Temperature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/S0006-8993(01)02890-6","article-title":"Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections","volume":"916","author":"Abrahamson","year":"2001","journal-title":"Brain Res."},{"key":"B3","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/j.tins.2005.01.003","article-title":"Orchestrating time: arrangements of the brain circadian clock","volume":"28","author":"Antle","year":"2005","journal-title":"Trends Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1038\/nature11270","article-title":"Deconstruction of a neural circuit for hunger","volume":"488","author":"Atasoy","year":"2012","journal-title":"Nature"},{"key":"B5","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0074-7696(08)60567-7","article-title":"Neurosecretion","volume":"19","author":"Bargmann","year":"1966","journal-title":"Int. Rev. Cytol."},{"key":"B6","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0024-3205(92)90169-P","article-title":"Unexpected regulation of hypothalamic neuropeptide Y by food deprivation and refeeding in the Zucker rat","volume":"50","author":"Beck","year":"1992","journal-title":"Life Sci."},{"key":"B7","first-page":"R1164","article-title":"Response of tissues of the rat to anisosmolality in-vivo","volume":"264","author":"Bedford","year":"1993","journal-title":"Am. J. Physiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"379","DOI":"10.1126\/science.1195262","article-title":"Temperature as a universal resetting cue for mammalian circadian oscillators","volume":"330","author":"Buhr","year":"2010","journal-title":"Science"},{"key":"B9","doi-asserted-by":"publisher","first-page":"3325","DOI":"10.1210\/jc.2009-2590","article-title":"Human phase response curves to three days of daily melatonin: 0.5 mg versus 3.0 mg","volume":"95","author":"Burgess","year":"2010","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"B10","doi-asserted-by":"publisher","first-page":"R714","DOI":"10.1152\/ajpregu.00355.2002","article-title":"Exercise elicits phase shifts and acute alterations of melatonin that vary with circadian phase","volume":"284","author":"Buxton","year":"2003","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"202","DOI":"10.3389\/fnmol.2018.00202","article-title":"Anterior paraventricular thalamus to nucleus accumbens projection is involved in feeding behavior in a novel environment","volume":"11","author":"Cheng","year":"2018","journal-title":"Front. Mol. Neurosci."},{"key":"B12","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1469-7793.1997.149bl.x","article-title":"Neurones in the supraoptic nucleus of the rat are regulated by a projection from the suprachiasmatic nucleus","volume":"502","author":"Cui","year":"1997","journal-title":"J. Physiol."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2950","DOI":"10.1101\/gad.183500","article-title":"Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus","volume":"14","author":"Damiola","year":"2000","journal-title":"Genes Dev."},{"key":"B14","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.neuron.2005.12.021","article-title":"Leptin directly activates SF1 neurons in the VMH, and this action by leptin is required for normal body-weight homeostasis","volume":"49","author":"Dhillon","year":"2006","journal-title":"Neuron"},{"key":"B15","doi-asserted-by":"publisher","first-page":"e13214","DOI":"10.7554\/eLife.13214","article-title":"Cell type-specific long-range connections of basal forebrain circuit","volume":"5","author":"Do","year":"2016","journal-title":"Elife"},{"key":"B16","doi-asserted-by":"publisher","first-page":"1665","DOI":"10.1111\/j.1460-9568.2009.06972.x","article-title":"Peripheral oscillators: the driving force for food-anticipatory activity","volume":"30","author":"Escobar","year":"2009","journal-title":"Eur. J. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"6047","DOI":"10.1073\/pnas.1523629113","article-title":"Architecture of retinal projections to the central circadian pacemaker","volume":"113","author":"Fernandez","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B18","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1210\/en.2007-0008","article-title":"Food restriction alters neuronal morphology in the hypothalamic ventromedial nucleus of male rats","volume":"149","author":"Flanagan-Cato","year":"2008","journal-title":"Endocrinology"},{"key":"B19","doi-asserted-by":"publisher","first-page":"179S","DOI":"10.1111\/j.1469-445X.2000.tb00022.x","article-title":"Diurnal rhythms in neurohypophysial function","author":"Forsling","year":"2000","journal-title":"Exp. Physiol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/3-540-27789-7","article-title":"Neuronal input pathways to the brain's biological clock and their functional significance","volume":"182","author":"Hannibal","year":"2006","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1111\/j.1460-9568.2010.07385.x","article-title":"Cholecystokinin (CCK)-expressing neurons in the suprachiasmatic nucleus: innervation, light responsiveness and entrainment in CCK-deficient mice","volume":"32","author":"Hannibal","year":"2010","journal-title":"Eur. J. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"73","DOI":"10.3389\/fnbeh.2014.00073","article-title":"Contributions of the paraventricular thalamic nucleus in the regulation of stress, motivation, and mood","volume":"8","author":"Hsu","year":"2014","journal-title":"Front. Behav. Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"98","DOI":"10.3389\/fnana.2016.00098","article-title":"Whole-brain monosynaptic afferent inputs to basal forebrain cholinergic system","volume":"10","author":"Hu","year":"2016","journal-title":"Front. Neuroanat."},{"key":"B24","doi-asserted-by":"publisher","first-page":"2200","DOI":"10.1210\/en.2016-1640","article-title":"High-sugar, but not high-fat, food activates supraoptic nucleus neurons in the male rat","volume":"158","author":"Hume","year":"2017","journal-title":"Endocrinology"},{"key":"B25","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1113\/JP273020","article-title":"Caloric restriction selectively reduces the GABAergic phenotype of mouse hypothalamic proopiomelanocortin neurons","volume":"595","author":"Jarvie","year":"2017","journal-title":"J. Physiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"458","DOI":"10.1177\/0748730406293854","article-title":"SCN outputs and the hypothalamic balance of life","volume":"21","author":"Kalsbeek","year":"2006","journal-title":"J. Biol. Rhythms"},{"key":"B27","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1016\/S0079-6123(02)39020-4","article-title":"Modulation of synaptic transmission by oxytocin and vasopressin in the supraoptic nucleus","volume":"139","author":"Kombian","year":"2002","journal-title":"Prog. Brain Res."},{"key":"B28","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1080\/17450398709428267","article-title":"Electrophysiological characteristic of the ventromedial hypothalamic nucleus and lateral hypothalamic area in normally fed and 24 hour food deprived conscious sheep","volume":"37","author":"Kosta","year":"1987","journal-title":"Arch. Tierernahr."},{"key":"B29","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/S0306-4522(01)00551-6","article-title":"CNS inputs to the suprachiasmatic nucleus of the rat","volume":"110","author":"Krout","year":"2002","journal-title":"Neuroscience"},{"key":"B30","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0006-8993(91)90768-Q","article-title":"Vasopressin release within the supraoptic and paraventricular nuclei of the rat brain: osmotic stimulation via microdialysis","volume":"558","author":"Landgraf","year":"1991","journal-title":"Brain Res."},{"key":"B31","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1016\/j.cell.2015.07.014","article-title":"Intact-brain analyses reveal distinct information carried by SNc dopamine subcircuits","volume":"162","author":"Lerner","year":"2015","journal-title":"Cell"},{"key":"B32","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1177\/0748730409350876","article-title":"Circadian trafficking of calbindin-ir in fibers of SCN neurons","volume":"24","author":"LeSauter","year":"2009","journal-title":"J. Biol. Rhythms"},{"key":"B33","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/S0306-4522(01)00604-2","article-title":"Calbindin-D(28K) cells selectively contact intra-SCN neurons","volume":"111","author":"LeSauter","year":"2002","journal-title":"Neuroscience"},{"key":"B34","doi-asserted-by":"publisher","first-page":"R803","DOI":"10.1152\/ajpregu.00682.2007","article-title":"Characterization of mice lacking the gene for cholecystokinin","volume":"294","author":"Lo","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1126\/science.aar4983","article-title":"Regulation of feeding by somatostatin neurons in the tuberal nucleus","volume":"361","author":"Luo","year":"","journal-title":"Science"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1576","DOI":"10.1038\/s41467-018-03889-3","article-title":"Nucleus accumbens controls wakefulness by a subpopulation of neurons expressing dopamine D1 receptors","volume":"9","author":"Luo","year":"","journal-title":"Nat. Commun."},{"key":"B37","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/0006-8993(91)91748-P","article-title":"Melatonin directly resets the rat suprachiasmatic circadian clock in vitro","volume":"565","author":"McArthur","year":"1991","journal-title":"Brain Res."},{"key":"B38","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/bs.pbr.2017.07.006","article-title":"Paraventricular thalamus: gateway to feeding, appetitive motivation, and drug addiction","volume":"235","author":"Millan","year":"2017","journal-title":"Prog. Brain Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1321","DOI":"10.1111\/j.1532-5415.2000.tb02608.x","article-title":"Nocturnal polyuria in older people: pathophysiology and clinical implications","volume":"48","author":"Miller","year":"2000","journal-title":"J. Am. Geriatr. Soc."},{"key":"B40","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0361-9230(94)90231-3","article-title":"Not only osmotic stress but also repeated restraint stress causes structural plasticity in the supraoptic nucleus of the rat hypothalamus","volume":"33","author":"Miyata","year":"1994","journal-title":"Brain Res. Bull."},{"key":"B41","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1002\/(SICI)1096-9861(19971222)389:3<508::AID-CNE11>3.0.CO;2-H","article-title":"Organization of neural inputs to the suprachiasmatic nucleus in the rat","volume":"389","author":"Moga","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"B42","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1111\/j.1464-410X.2004.05003.x","article-title":"Antidiuretic hormone in elderly male patients with severe nocturia: a circadian study","volume":"94","author":"Moon","year":"2004","journal-title":"BJU Int."},{"key":"B43","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1007\/s00441-002-0575-2","article-title":"Suprachiasmatic nucleus organization","volume":"309","author":"Moore","year":"2002","journal-title":"Cell Tissue Res."},{"key":"B44","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.expneurol.2012.06.026","article-title":"Neuroanatomy of the extended circadian rhythm system","volume":"243","author":"Morin","year":"2013","journal-title":"Exp. Neurol."},{"key":"B45","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.mce.2011.09.003","article-title":"Circadian system, sleep and endocrinology","volume":"349","author":"Morris","year":"2012","journal-title":"Mol. Cell. Endocrinol."},{"key":"B46","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/nature11705","article-title":"Central nervous system control of metabolism","volume":"491","author":"Myers","year":"2012","journal-title":"Nature"},{"key":"B47","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1292\/jvms.66.1297","article-title":"Involvement of thalamic paraventricular nucleus in the anticipatory reaction under food restriction in the rat","volume":"66","author":"Nakahara","year":"2004","journal-title":"J. Vet. Med. Sci."},{"key":"B48","doi-asserted-by":"publisher","first-page":"2387","DOI":"10.1038\/npp.2017.150","article-title":"Paraventricular thalamic control of food intake and reward: role of glucagon-like peptide-1 receptor signaling","volume":"42","author":"Ong","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"B49","volume-title":"The mouse brain in stereotaxic coordinates.","author":"Paxinos","year":"2001"},{"key":"B50","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1002\/cne.902110107","article-title":"The afferent connections of the suprachiasmatic nucleus of the golden hamster with emphasis on the retinohypothalamic projection","volume":"211","author":"Pickard","year":"1982","journal-title":"J. Comp. Neurol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1016\/j.neuron.2014.07.002","article-title":"A whole-brain atlas of inputs to serotonergic neurons of the dorsal and median raphe nuclei","volume":"83","author":"Pollak Dorocic","year":"2014","journal-title":"Neuron"},{"key":"B52","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.jchemneu.2009.03.005","article-title":"Neurochemistry of the paraventricular nucleus of the hypothalamus: implications for cardiovascular regulation","volume":"38","author":"Pyner","year":"2009","journal-title":"J. Chem. Neuroanat."},{"key":"B53","doi-asserted-by":"publisher","first-page":"3483","DOI":"10.1210\/en.2011-1044","article-title":"Transcriptomic analysis of the osmotic and reproductive remodeling of the female rat supraoptic nucleus","volume":"152","author":"Qiu","year":"2011","journal-title":"Endocrinology"},{"key":"B54","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1111\/j.1365-2826.2011.02249.x","article-title":"Enhanced expression of heme oxygenase-1 and carbon monoxide excitatory effects in oxytocin and vasopressin neurones during water deprivation","volume":"24","author":"Reis","year":"2012","journal-title":"J. Neuroendocrinol."},{"key":"B55","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0196-9781(88)90013-7","article-title":"Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus","volume":"9","author":"Sahu","year":"1988","journal-title":"Peptides"},{"key":"B56","doi-asserted-by":"publisher","first-page":"1356","DOI":"10.1038\/nn1550","article-title":"Topographic mapping of VMH \u2013> arcuate nucleus microcircuits and their reorganization by fasting","volume":"8","author":"Sternson","year":"2005","journal-title":"Nat. Neurosci."},{"key":"B57","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1007\/s12264-018-0216-8","article-title":"Whole-brain mapping of direct inputs to and axonal projections from gabaergic neurons in the parafacial zone","volume":"34","author":"Su","year":"2018","journal-title":"Neurosci. Bull."},{"key":"B58","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.cell.2016.08.028","article-title":"Warm-sensitive neurons that control body temperature","volume":"167","author":"Tan","year":"2016","journal-title":"Cell"},{"key":"B59","doi-asserted-by":"publisher","first-page":"995","DOI":"10.1016\/j.neuron.2011.07.026","article-title":"A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex","volume":"71","author":"Taniguchi","year":"2011","journal-title":"Neuron"},{"key":"B60","doi-asserted-by":"publisher","first-page":"S64","DOI":"10.1038\/508S64a","article-title":"Neuroscience: dissecting appetite","volume":"508","author":"Trivedi","year":"2014","journal-title":"Nature"},{"key":"B61","doi-asserted-by":"publisher","first-page":"U467","DOI":"10.1038\/nn.2503","article-title":"Central clock excites vasopressin neurons by waking osmosensory afferents during late sleep","volume":"13","author":"Trudel","year":"2010","journal-title":"Nat. Neurosci."},{"key":"B62","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1111\/j.1365-2826.2012.02298.x","article-title":"Circadian modulation of osmoregulated firing in rat supraoptic nucleus neurones","volume":"24","author":"Trudel","year":"2012","journal-title":"J. Neuroendocrinol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1016\/j.neuron.2007.01.033","article-title":"Monosynaptic restriction of transsynaptic tracing from single, genetically targeted neurons","volume":"53","author":"Wickersham","year":"2007","journal-title":"Neuron"},{"key":"B64","doi-asserted-by":"publisher","first-page":"e29055","DOI":"10.7554\/eLife.29055","article-title":"Striatal adenosine A2A receptor neurons control active-period sleep via parvalbumin neurons in external globus pallidus","volume":"6","author":"Yuan","year":"2017","journal-title":"Elife"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1341","DOI":"10.1038\/nn.4372","article-title":"Hypothalamic arcuate nucleus tyrosine hydroxylase neurons play orexigenic role in energy homeostasis","volume":"19","author":"Zhang","year":"2016","journal-title":"Nat. Neurosci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1126\/science.aam7100","article-title":"Rapid binge-like eating and body weight gain driven by zona incerta GABA neuron activation","volume":"356","author":"Zhang","year":"2017","journal-title":"Science"},{"key":"B67","doi-asserted-by":"publisher","first-page":"e16231","DOI":"10.1038\/lsa.2016.231","article-title":"Red light at intensities above 10 lx alters sleep\u2013wake behavior in mice","volume":"6","author":"Zhang","year":"2017","journal-title":"Light Sci. Appl."},{"key":"B68","doi-asserted-by":"publisher","first-page":"2042","DOI":"10.1073\/pnas.1616255114","article-title":"A hypothalamic circuit that controls body temperature","volume":"114","author":"Zhao","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2018.00807\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T04:32:14Z","timestamp":1541392334000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2018.00807\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,5]]},"references-count":68,"alternative-id":["10.3389\/fnins.2018.00807"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2018.00807","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,5]]},"article-number":"807"}}