{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T19:16:54Z","timestamp":1784575014519,"version":"3.55.0"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2018.00889","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T09:12:43Z","timestamp":1543482763000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["Decreased Intrinsic Functional Connectivity of the Salience Network in Drug-Na\u00efve Patients With Obsessive-Compulsive Disorder"],"prefix":"10.3389","volume":"12","author":[{"given":"Yun-Hui","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su-Fang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gui-Dong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Hua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Chong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang-Tang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Ping","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.neuron.2010.02.005","article-title":"Functional-anatomic fractionation of the brain\u2019s default network.","volume":"65","author":"Andrewshanna","year":"2010","journal-title":"Neuron"},{"key":"B2","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1192\/bjp.bp.113.137380","article-title":"Default mode network subsystem alterations in obsessive-compulsive disorder.","volume":"205","author":"Beucke","year":"2014","journal-title":"Br. J. Psychiatry"},{"key":"B3","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1038\/nrn3475","article-title":"Power failure: why small sample size undermines the reliability of neuroscience.","volume":"14","author":"Button","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"B4","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1159\/000325223","article-title":"Functional neuroimaging in obsessive-compulsive disorder.","volume":"64","author":"Del Casale","year":"2011","journal-title":"Neuropsychobiology"},{"key":"B5","doi-asserted-by":"publisher","first-page":"7900","DOI":"10.1073\/pnas.1602413113","article-title":"Cluster failure: why fMRI inferences for spatial extent have inflated false-positive rates.","volume":"113","author":"Eklund","year":"2016","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B6","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.jad.2017.07.041","article-title":"Altered connectivity within and between the default mode, central executive, and salience networks in obsessive-compulsive disorder.","volume":"223","author":"Fan","year":"","journal-title":"J. Affect. Disord."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.nicl.2017.04.002","article-title":"Resting-state functional connectivity between right anterior insula and right orbital frontal cortex correlate with insight level in obsessive-compulsive disorder.","volume":"15","author":"Fan","year":"","journal-title":"Neuroimage Clin."},{"key":"B8","doi-asserted-by":"publisher","first-page":"100","DOI":"10.1016\/j.biopsycho.2015.09.004","article-title":"Resting-state connectivity of the amygdala predicts response to cognitive behavioral therapy in obsessive compulsive disorder.","volume":"111","author":"Gottlich","year":"2015","journal-title":"Biol. Psychol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.pnpbp.2013.10.021","article-title":"Abnormal default-mode network homogeneity in first-episode, drug-naive schizophrenia at rest.","volume":"49","author":"Guo","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B10","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/j.neubiorev.2018.01.016","article-title":"Frontoparietal areas link impairments of large-scale intrinsic brain networks with aberrant fronto-striatal interactions in OCD: a meta-analysis of resting-state functional connectivity.","volume":"87","author":"G\u00fcrsel","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B11","doi-asserted-by":"publisher","first-page":"263","DOI":"10.3389\/fnagi.2017.00127","article-title":"Disrupted intrinsic connectivity among default, dorsal attention, and frontoparietal control networks in individuals with chronic traumatic brain injury.","volume":"22","author":"Han","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"B12","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1016\/j.biopsych.2012.10.006","article-title":"Brain corticostriatal systems and the major clinical symptom dimensions of obsessive-compulsive disorder.","volume":"73","author":"Harrison","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"B13","doi-asserted-by":"publisher","first-page":"1189","DOI":"10.1001\/archgenpsychiatry.2009.152","article-title":"Altered corticostriatal functional connectivity in obsessive-compulsive disorder.","volume":"66","author":"Harrison","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.drugalcdep.2013.01.021","article-title":"Resting-state activity in the left executive control network is associated with behavioral approach and is increased in substance dependence.","volume":"129","author":"Krmpotich","year":"2013","journal-title":"Drug Alcohol Depend."},{"key":"B15","doi-asserted-by":"publisher","first-page":"327","DOI":"10.3233\/JAD-160730","article-title":"The effects of gene mutations on default mode network in familial Alzheimer\u2019s disease.","volume":"56","author":"Li","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"B16","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2015.00026","article-title":"Aberrant functional connectivity in the default mode and central executive networks in subjects with schizophrenia-a whole-brain resting-state ICA study.","volume":"6","author":"Littow","year":"2015","journal-title":"Front. Psychiatry"},{"key":"B17","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.biopsycho.2015.09.005","article-title":"Abnormal degree centrality of functional hubs associated with negative coping in older Chinese adults who lost their only child.","volume":"112","author":"Liu","year":"2015","journal-title":"Biol. Psychol."},{"key":"B18","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.tics.2011.08.003","article-title":"Large-scale brain networks and psychopathology: a unifying triple network model.","volume":"15","author":"Menon","year":"2011","journal-title":"Trends Cogn. Sci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1007\/s00429-010-0262-0","article-title":"Saliency, switching, attention and control: a network model of insula function.","volume":"214","author":"Menon","year":"2010","journal-title":"Brain Struct. Funct."},{"key":"B20","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1016\/j.neubiorev.2007.09.005","article-title":"Integrating evidence from neuroimaging and neuropsychological studies of obsessive-compulsive disorder: the orbitofronto-striatal model revisited.","volume":"32","author":"Menzies","year":"2008","journal-title":"Neurosci. Biobehav. Rev."},{"key":"B21","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.neuroimage.2017.01.015","article-title":"Global signal regression acts as a temporal downweighting process in resting-state fMRI.","volume":"152","author":"Nalci","year":"2017","journal-title":"Neuroimage"},{"key":"B22","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1503\/jpn.100176","article-title":"Does the salience network play a cardinal role in psychosis? An emerging hypothesis of insular dysfunction.","volume":"37","author":"Palaniyappan","year":"2011","journal-title":"J. Psychiatry Neurosci."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2852","DOI":"10.1002\/hbm.22371","article-title":"Reduced functional connectivity within the limbic cortico-striato-thalamo-cortical loop in unmedicated adults with obsessive-compulsive disorder.","volume":"35","author":"Posner","year":"2014","journal-title":"Hum. Brain Mapp."},{"key":"B24","doi-asserted-by":"publisher","first-page":"678","DOI":"10.1002\/hbm.23408","article-title":"Increased functional connectivity between the default mode and salience networks in unmedicated adults with obsessive-compulsive disorder.","volume":"38","author":"Posner","year":"2016","journal-title":"Hum. Brain Mapp."},{"key":"B25","doi-asserted-by":"publisher","first-page":"2142","DOI":"10.1016\/j.neuroimage.2011.10.018","article-title":"Spurious but systematic correlations in functional connectivity MRI networks arise from subject motion.","volume":"59","author":"Power","year":"2012","journal-title":"Neuroimage"},{"key":"B26","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/mp.2008.94","article-title":"The epidemiology of obsessive-compulsive disorder in the national comorbidity survey replication.","volume":"15","author":"Ruscio","year":"2010","journal-title":"Mol. Psychiatry"},{"key":"B27","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.biopsych.2013.09.002","article-title":"The effects of pharmacological treatment on functional brain connectome in obsessive-compulsive disorder.","volume":"75","author":"Shin","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"B28","doi-asserted-by":"publisher","first-page":"12569","DOI":"10.1073\/pnas.0800005105","article-title":"A critical role for the right fronto-insular cortex in switching between central-executive and default-mode networks.","volume":"105","author":"Sridharan","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0036356","article-title":"Resting-state functional connectivity between fronto-parietal and default mode networks in obsessive-compulsive disorder.","volume":"7","author":"Stern","year":"2012","journal-title":"PLoS One"},{"key":"B30","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1093\/brain\/awn267","article-title":"The major symptom dimensions of obsessive-compulsive disorder are mediated by partially distinct neural systems.","volume":"132","author":"van den Heuvel","year":"2009","journal-title":"Brain"},{"key":"B31","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx194","article-title":"Altered functional connectivity of the default mode network in patients with schizo-obsessive comorbidity: a comparison between schizophrenia and obsessive-compulsive disorder.","author":"Wang","year":"2018","journal-title":"Schizophr. Bull."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0068910","article-title":"BrainNet viewer: a network visualization tool for human brain connectomics.","volume":"8","author":"Xia","year":"2013","journal-title":"PLoS One"},{"key":"B33","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1007\/s12021-016-9299-4","article-title":"DPABI: data processing & analysis for (resting-state) brain imaging.","volume":"14","author":"Yan","year":"2016","journal-title":"Neuroinformatics"},{"key":"B34","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/j.jad.2015.07.048","article-title":"Regional homogeneity of spontaneous brain activity in adult patients with obsessive-compulsive disorder before and after cognitive behavioural therapy.","volume":"188","author":"Yang","year":"2015","journal-title":"J. Affect. Disord."},{"key":"B35","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1503\/jpn.100006","article-title":"Abnormal small-world architecture of top-down control networks in obsessive-compulsive disorder.","volume":"36","author":"Zhang","year":"2011","journal-title":"J. Psychiatry Neurosci."},{"key":"B36","doi-asserted-by":"publisher","DOI":"10.1186\/s12888-016-0806-9","article-title":"Altered intrinsic insular activity predicts symptom severity in unmedicated obsessive-compulsive disorder patients: a resting state functional magnetic resonance imaging study.","volume":"16","author":"Zhu","year":"2016","journal-title":"BMC Psychiatry"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2018.00889\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T09:12:45Z","timestamp":1543482765000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2018.00889\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,28]]},"references-count":36,"alternative-id":["10.3389\/fnins.2018.00889"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2018.00889","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,28]]},"article-number":"889"}}