{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T03:19:51Z","timestamp":1791429591944,"version":"4.3.3"},"reference-count":88,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2019.00059","type":"journal-article","created":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T23:41:43Z","timestamp":1549323703000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":29,"title":["The anx\/anx Mouse \u2013 A Valuable Resource in Anorexia Nervosa Research"],"prefix":"10.3389","volume":"13","author":[{"given":"Ida A. K.","family":"Nilsson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,2,5]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"846","DOI":"10.1038\/nature07181","article-title":"UCP2 mediates ghrelin\u2019s action on NPY\/AgRP neurons by lowering free radicals.","volume":"454","author":"Andrews","year":"2008","journal-title":"Nature"},{"key":"B2","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.1097\/00004647-200110000-00001","article-title":"An energy budget for signaling in the grey matter of the brain.","volume":"21","author":"Attwell","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B3","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1530\/JOE-16-0383","article-title":"Reduced metabolism in the hypothalamus of the anorectic anx\/anx mouse.","volume":"233","author":"Bergstrom","year":"2017","journal-title":"J. Endocrinol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"7130","DOI":"10.1523\/JNEUROSCI.19-16-07130.1999","article-title":"Changes in neuropeptide Y receptors and pro-opiomelanocortin in the anorexia (anx\/anx) mouse hypothalamus.","volume":"19","author":"Broberger","year":"1999","journal-title":"J. Neurosci."},{"key":"B5","doi-asserted-by":"publisher","first-page":"15043","DOI":"10.1073\/pnas.95.25.15043","article-title":"The neuropeptide Y\/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice.","volume":"95","author":"Broberger","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B6","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1002\/(SICI)1096-9861(19971013)387:1<124::AID-CNE10>3.0.CO;2-U","article-title":"Hypothalamic neurohistochemistry of the murine anorexia (anx\/anx) mutation: altered processing of neuropeptide Y in the arcuate nucleus.","volume":"387","author":"Broberger","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1001\/archpsyc.63.3.305","article-title":"Prevalence, heritability, and prospective risk factors for anorexia nervosa.","volume":"63","author":"Bulik","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"B8","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1006\/exnr.1996.0180","article-title":"Evidence for physiological down-regulation of brain oxidative phosphorylation in Alzheimer\u2019s disease.","volume":"142","author":"Chandrasekaran","year":"1996","journal-title":"Exp. Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/0196-9781(85)90128-7","article-title":"Anatomy and physiology of the neuroendocrine arcuate nucleus.","author":"Chronwall","year":"1985","journal-title":"Peptides"},{"key":"B10","doi-asserted-by":"publisher","first-page":"S63","DOI":"10.1038\/sj.ijo.0801913","article-title":"The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis.","author":"Cone","year":"2001","journal-title":"Int. J. Obes. Relat. Metab. Disord."},{"key":"B11","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1016\/j.nut.2010.07.021","article-title":"Brain fuel metabolism, aging, and Alzheimer\u2019s disease.","volume":"27","author":"Cunnane","year":"2011","journal-title":"Nutrition"},{"key":"B12","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1111\/j.1365-2362.2004.01415.x","article-title":"Chemical-physical properties of lipoproteins in anorexia nervosa.","volume":"34","author":"Curatola","year":"2004","journal-title":"Eur. J. Clin. Invest."},{"key":"B13","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.psyneuen.2006.11.003","article-title":"Family trios analysis of common polymorphisms in the obestatin\/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: association with subtype, body-mass index, severity and age of onset.","volume":"32","author":"Dardennes","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"B14","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.nut.2011.02.001","article-title":"What can anorexia nervosa teach us about appetite regulation?","volume":"27","author":"DeBoer","year":"2011","journal-title":"Nutrition"},{"key":"B15","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1093\/brain\/awp058","article-title":"Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease.","author":"Distelmaier","year":"2009","journal-title":"Brain"},{"key":"B16","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1176\/appi.ajp.2017.16121402","article-title":"Significant locus and metabolic genetic correlations revealed in genome-wide association study of anorexia nervosa.","volume":"174","author":"Duncan","year":"2017","journal-title":"Am. J. Psychiatry"},{"key":"B17","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1038\/sj.emboj.7601748","article-title":"Human CIA30 is involved in the early assembly of mitochondrial complex I and mutations in its gene cause disease.","volume":"26","author":"Dunning","year":"2007","journal-title":"EMBO J."},{"key":"B18","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1097\/MCO.0b013e32831cef61","article-title":"Inflammatory burden and amino acid metabolism in cancer cachexia.","volume":"12","author":"Durham","year":"2009","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"key":"B19","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.peptides.2015.06.011","article-title":"Hypothalamic inflammation and food intake regulation during chronic illness.","volume":"77","author":"Dwarkasing","year":"2016","journal-title":"Peptides"},{"key":"B20","doi-asserted-by":"publisher","first-page":"518","DOI":"10.1016\/j.cmet.2012.01.023","article-title":"Saturated fatty acid and TLR signaling link beta cell dysfunction and islet inflammation.","volume":"15","author":"Eguchi","year":"2012","journal-title":"Cell Metab."},{"key":"B21","doi-asserted-by":"publisher","first-page":"3217","DOI":"10.1111\/j.1460-9568.2005.04513.x","article-title":"Alterations of arcuate nucleus neuropeptidergic development in contactin-deficient mice: comparison with anorexia and food-deprived mice.","volume":"22","author":"Fetissov","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"B22","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S0006-3223(98)00292-3","article-title":"Leptin, neuropeptide Y, and peptide YY in long-term recovered eating disorder patients.","volume":"46","author":"Gendall","year":"1999","journal-title":"Biol. Psychiatry"},{"key":"B23","doi-asserted-by":"publisher","first-page":"2389","DOI":"10.1001\/jama.2010.1706","article-title":"Mitochondrial dysfunction in autism.","volume":"304","author":"Giulivi","year":"2010","journal-title":"JAMA"},{"key":"B24","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.cmet.2016.09.002","article-title":"The assembly pathway of mitochondrial respiratory chain complex I.","volume":"25","author":"Guerrero-Castillo","year":"2017","journal-title":"Cell Metab."},{"key":"B25","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.cbpa.2011.03.026","article-title":"AMPK and ACCchange with fasting and physiological condition in euthermic and hibernating golden-mantled ground squirrels (Callospermophilus lateralis).","volume":"159","author":"Healy","year":"2011","journal-title":"Comp. Biochem. Physiol. A Mol. Integr. Physiol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"321","DOI":"10.1038\/mp.2016.126","article-title":"Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index.","volume":"22","author":"Hinney","year":"2017","journal-title":"Mol. Psychiatry"},{"key":"B27","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1016\/j.tem.2008.10.003","article-title":"Fuel utilization by hypothalamic neurons: roles for ROS.","volume":"20","author":"Horvath","year":"2009","journal-title":"Trends Endocrinol. Metab."},{"key":"B28","first-page":"88","article-title":"Prevalence of anorexia nervosa and bulimia among young diabetic women.","volume":"46","author":"Hudson","year":"1985","journal-title":"J. Clin. Psychiatry"},{"key":"B29","doi-asserted-by":"publisher","first-page":"1331","DOI":"10.1210\/en.2002-221033","article-title":"Hypothalamic proopiomelanocortin neurons are glucose responsive and express K(ATP) channels.","volume":"144","author":"Ibrahim","year":"2003","journal-title":"Endocrinology"},{"key":"B30","doi-asserted-by":"publisher","first-page":"855","DOI":"10.1006\/bbrc.1996.1112","article-title":"A novel gene iba1 in the major histocompatibility complex class III region encoding an EF hand protein expressed in a monocytic lineage.","volume":"224","author":"Imai","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B31","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/S0006-8993(98)00049-3","article-title":"Neuropeptide Y mRNA and serotonin innervation in the arcuate nucleus of anorexia mutant mice.","volume":"790","author":"Jahng","year":"1998","journal-title":"Brain Res."},{"key":"B32","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1007\/s00415-006-0229-5","article-title":"31P-MRS of skeletal muscle is not a sensitive diagnostic test for mitochondrial myopathy.","volume":"254","author":"Jeppesen","year":"2007","journal-title":"J. Neurol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1016\/S0169-328X(00)00228-X","article-title":"Hypothalamic CART and serum leptin levels are reduced in the anorectic (anx\/anx) mouse.","volume":"84","author":"Johansen","year":"2000","journal-title":"Brain Res. Mol. Brain Res."},{"key":"B34","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.ejphar.2003.08.104","article-title":"Approaches to anorexia in rodents: focus on the anx\/anx mouse.","volume":"480","author":"Johansen","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2737","DOI":"10.1097\/00001756-200108280-00029","article-title":"Altered dopaminergic transmission in the anorexic anx\/anx mouse striatum.","volume":"12","author":"Johansen","year":"2001","journal-title":"Neuroreport"},{"key":"B36","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1530\/JOE-14-0527","article-title":"Myeloid SIRT1 regulates macrophage infiltration and insulin sensitivity in mice fed a high-fat diet.","volume":"224","author":"Ka","year":"2015","journal-title":"J. Endocrinol."},{"key":"B37","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.physbeh.2007.11.037","article-title":"Neurobiology of anorexia and bulimia nervosa.","volume":"94","author":"Kaye","year":"2008","journal-title":"Physiol. Behav."},{"key":"B38","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.physbeh.2005.04.013","article-title":"Serotonin alterations in anorexia and bulimia nervosa: new insights from imaging studies.","volume":"85","author":"Kaye","year":"2005","journal-title":"Physiol. Behav."},{"key":"B39","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1016\/S0893-133X(99)00053-6","article-title":"Altered dopamine activity after recovery from restricting-type anorexia nervosa.","volume":"21","author":"Kaye","year":"1999","journal-title":"Neuropsychopharmacology"},{"key":"B40","doi-asserted-by":"publisher","first-page":"1259","DOI":"10.1176\/appi.ajp.2007.06081388","article-title":"Epidemiology and course of anorexia nervosa in the community.","volume":"164","author":"Keski-Rahkonen","year":"2007","journal-title":"Am. J. Psychiatry"},{"key":"B41","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1242\/dmm.027433","article-title":"The tyrosine kinase receptor Tyro3 enhances lifespan and neuropeptide Y (Npy) neuron survival in the mouse anorexia (anx) mutation.","volume":"10","author":"Kim","year":"2017","journal-title":"Dis. Model. Mech."},{"key":"B42","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1016\/S0304-3940(01)01684-6","article-title":"Increases in cell proliferation and apoptosis in dentate gyrus of anorexia (anx\/anx) mice.","volume":"302","author":"Kim","year":"2001","journal-title":"Neurosci. Lett."},{"key":"B43","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/S0306-4522(01)00463-8","article-title":"Expression of the neuropeptide Y Y1 receptor in the CNS of rat and of wild-type and Y1 receptor knock-out mice. Focus on immunohistochemical localization.","volume":"111","author":"Kopp","year":"2002","journal-title":"Neuroscience"},{"key":"B44","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1016\/j.molbrainres.2005.06.003","article-title":"Gene expression profiling reveals an inflammatory process in the anx\/anx mutant mice.","volume":"139","author":"Lachuer","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"key":"B45","doi-asserted-by":"publisher","first-page":"E418","DOI":"10.1152\/ajpendo.00081.2015","article-title":"Glucose intolerance and pancreatic beta-cell dysfunction in the anorectic anx\/anx mouse.","volume":"309","author":"Lindfors","year":"2015","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"B46","doi-asserted-by":"publisher","first-page":"18108","DOI":"10.1073\/pnas.1114863108","article-title":"Hypothalamic mitochondrial dysfunction associated with anorexia in the anx\/anx mouse.","volume":"108","author":"Lindfors","year":"2011","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B47","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1093\/emboj\/18.4.833","article-title":"Alternative sulfonylurea receptor expression defines metabolic sensitivity of K-ATP channels in dopaminergic midbrain neurons.","volume":"18","author":"Liss","year":"1999","journal-title":"EMBO J."},{"key":"B48","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1093\/oxfordjournals.jhered.a109987","article-title":"Anorexia, a recessive mutation causing starvation in preweanling mice.","volume":"75","author":"Maltais","year":"1984","journal-title":"J. Hered."},{"key":"B49","doi-asserted-by":"publisher","first-page":"678","DOI":"10.2337\/diacare.24.4.678","article-title":"Disordered eating, body mass, and glycemic control in adolescents with type 1 diabetes.","volume":"24","author":"Meltzer","year":"2001","journal-title":"Diabetes Care"},{"key":"B50","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1152\/physiolgenomics.90255.2008","article-title":"Hypothalamus transcriptome profile suggests an anorexia-cachexia syndrome in the anx\/anx mouse model.","volume":"35","author":"Mercader","year":"","journal-title":"Physiol. Genom."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1234","DOI":"10.1093\/hmg\/ddn013","article-title":"Association of NTRK3 and its interaction with NGF suggest an altered cross-regulation of the neurotrophin signaling pathway in eating disorders.","volume":"17","author":"Mercader","year":"","journal-title":"Hum. Mol. Genet."},{"key":"B52","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1038\/87455","article-title":"ATP-sensitive K+ channels in the hypothalamus are essential for the maintenance of glucose homeostasis.","volume":"4","author":"Miki","year":"2001","journal-title":"Nat. Neurosci."},{"key":"B53","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.ymgme.2013.07.007","article-title":"Diagnosis of mitochondrial myopathies.","volume":"110","author":"Milone","year":"2013","journal-title":"Mol. Genet. Metab."},{"key":"B54","doi-asserted-by":"publisher","first-page":"1057","DOI":"10.1016\/j.psyneuen.2006.06.006","article-title":"Plasma agouti-related protein levels in women with anorexia nervosa.","volume":"31","author":"Moriya","year":"2006","journal-title":"Psychoneuroendocrinology"},{"key":"B55","doi-asserted-by":"crossref","first-page":"65","DOI":"10.2174\/1568006043481284","article-title":"Microglia: neuroprotective and neurotrophic cells in the central nervous system.","volume":"4","author":"Nakajima","year":"2004","journal-title":"Curr. Drug Targets Cardiovasc. Haematol. Disord."},{"key":"B56","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1002\/cne.21599","article-title":"Aberrant agouti-related protein system in the hypothalamus of the anx\/anx mouse is associated with activation of microglia.","volume":"507","author":"Nilsson","year":"2008","journal-title":"J. Comp. Neurol."},{"key":"B57","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/B978-0-12-410473-0.00002-7","article-title":"Anorexia and hypothalamic degeneration.","volume":"92","author":"Nilsson","year":"2013","journal-title":"Vitam. Horm."},{"key":"B58","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1002\/glia.21075","article-title":"Evidence of hypothalamic degeneration in the anorectic anx\/anx mouse.","volume":"59","author":"Nilsson","year":"2011","journal-title":"Glia"},{"key":"B59","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1176\/appi.ajp.2013.11111745","article-title":"Altered insula response to sweet taste processing after recovery from anorexia and bulimia nervosa.","volume":"170","author":"Oberndorfer","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"B60","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1192\/bjp.bp.108.054742","article-title":"Excess mortality, causes of death and prognostic factors in anorexia nervosa.","volume":"194","author":"Papadopoulos","year":"2009","journal-title":"Br. J. Psychiatry"},{"key":"B61","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1038\/ijo.2011.160","article-title":"Does dieting make you fat? A twin study.","volume":"36","author":"Pietilainen","year":"2012","journal-title":"Int. J. Obes."},{"key":"B62","first-page":"277","article-title":"L-dopa, growth hormone and adipokinesis in the lean and the obese.","volume":"12","author":"Pinter","year":"1975","journal-title":"Int. J. Clin. Pharmacol. Biopharm."},{"key":"B63","doi-asserted-by":"publisher","first-page":"10996","DOI":"10.1073\/pnas.1006214107","article-title":"Complex I deficiency due to loss of Ndufs4 in the brain results in progressive encephalopathy resembling Leigh syndrome.","volume":"107","author":"Quintana","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B64","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s00429-009-0231-7","article-title":"Microglia-associated granule cell death in the normal adult dentate gyrus.","volume":"214","author":"Ribak","year":"2009","journal-title":"Brain Struct. Funct."},{"key":"B65","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1038\/sj.mp.4001281","article-title":"Met66 in the brain-derived neurotrophic factor (BDNF) precursor is associated with anorexia nervosa restrictive type.","volume":"8","author":"Ribases","year":"2003","journal-title":"Mol. Psychiatry"},{"key":"B66","doi-asserted-by":"publisher","first-page":"851","DOI":"10.1038\/sj.mp.4001670","article-title":"Contribution of NTRK2 to the genetic susceptibility to anorexia nervosa, harm avoidance and minimum body mass index.","volume":"10","author":"Ribases","year":"2005","journal-title":"Mol. Psychiatry"},{"key":"B67","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1002\/erv.2553","article-title":"The science behind the academy for eating disorders\u2019 nine truths about eating disorders.","volume":"25","author":"Schaumberg","year":"2017","journal-title":"Eur. Eat. Disord. Rev."},{"key":"B68","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1038\/nrendo.2016.175","article-title":"The endocrine manifestations of anorexia nervosa: mechanisms and management.","volume":"13","author":"Schorr","year":"2017","journal-title":"Nat. Rev. Endocrinol."},{"key":"B69","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/0166-2236(95)94495-Q","article-title":"Selective neuronal vulnerability in the hippocampus\u2013a role for gene expression?","volume":"18","author":"Schreiber","year":"1995","journal-title":"Trends Neurosci."},{"key":"B70","doi-asserted-by":"publisher","first-page":"978","DOI":"10.1177\/153537020122601103","article-title":"Brain pathways controlling food intake and body weight.","volume":"226","author":"Schwartz","year":"2001","journal-title":"Exp. Biol. Med."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1000840","article-title":"Action potential energy efficiency varies among neuron types in vertebrates and invertebrates.","volume":"6","author":"Sengupta","year":"2010","journal-title":"PLoS Comput. Biol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1016\/S0031-9384(03)00103-3","article-title":"Animal models in the investigation of anorexia.","volume":"79","author":"Siegfried","year":"2003","journal-title":"Physiol. Behav."},{"key":"B73","doi-asserted-by":"publisher","first-page":"342","DOI":"10.1038\/35072063","article-title":"The genetics and pathology of oxidative phosphorylation.","volume":"2","author":"Smeitink","year":"2001","journal-title":"Nat. Rev. Genet."},{"key":"B74","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/0169-328X(94)90287-9","article-title":"Drastic and selective hyperinnervation of central serotonergic neurons in a lethal neurodevelopmental mouse mutant, Anorexia (anx).","volume":"25","author":"Son","year":"1994","journal-title":"Brain Res. Mol. Brain Res."},{"key":"B75","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1179\/016164105X49463","article-title":"Role of microglia in the central nervous system\u2019s immune response.","volume":"27","author":"Streit","year":"2005","journal-title":"Neurol. Res."},{"key":"B76","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1111\/epi.12731","article-title":"Cerebral glucose hypometabolism is associated with mitochondrial dysfunction in patients with intractable epilepsy and cortical dysplasia.","volume":"55","author":"Tenney","year":"2014","journal-title":"Epilepsia"},{"key":"B77","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1093\/hmg\/ddh071","article-title":"Differences in assembly or stability of complex I and other mitochondrial OXPHOS complexes in inherited complex I deficiency.","volume":"13","author":"Ugalde","year":"","journal-title":"Hum. Mol. Genet."},{"key":"B78","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1093\/hmg\/ddh262","article-title":"Human mitochondrial complex I assembles through the combination of evolutionary conserved modules: a framework to interpret complex I deficiencies.","volume":"13","author":"Ugalde","year":"","journal-title":"Hum. Mol. Genet."},{"key":"B79","doi-asserted-by":"publisher","first-page":"815","DOI":"10.1016\/j.neuroscience.2006.09.059","article-title":"Pharmacological and molecular characterization of ATP-sensitive K(+) conductances in CART and NPY\/AgRP expressing neurons of the hypothalamic arcuate nucleus.","volume":"144","author":"van den Top","year":"2007","journal-title":"Neuroscience"},{"key":"B80","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/S0079-6123(06)53008-0","article-title":"Integration of metabolic stimuli in the hypothalamic arcuate nucleus.","volume":"153","author":"van den Top","year":"2006","journal-title":"Prog. Brain Res."},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106463","article-title":"Altered mitochondrial function and oxidative stress in leukocytes of anorexia nervosa patients.","volume":"9","author":"Victor","year":"2014","journal-title":"PLoS One"},{"key":"B82","doi-asserted-by":"publisher","first-page":"5317","DOI":"10.1111\/j.1742-4658.2005.04928.x","article-title":"Human mitochondrial complex I assembly is mediated by NDUFAF1.","volume":"272","author":"Vogel","year":"2005","journal-title":"FEBS J."},{"key":"B83","doi-asserted-by":"publisher","first-page":"615","DOI":"10.1101\/gad.408407","article-title":"Cytosolic signaling protein Ecsit also localizes to mitochondria where it interacts with chaperone NDUFAF1 and functions in complex I assembly.","volume":"21","author":"Vogel","year":"2007","journal-title":"Genes Dev."},{"key":"B84","doi-asserted-by":"publisher","first-page":"202","DOI":"10.1016\/j.bbrc.2006.09.029","article-title":"Respiratory chain dysfunction in skeletal muscle does not cause insulin resistance.","volume":"350","author":"Wredenberg","year":"2006","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B85","doi-asserted-by":"publisher","first-page":"9218","DOI":"10.1523\/JNEUROSCI.2449-08.2008","article-title":"Ablation of neurons expressing agouti-related protein activates fos and gliosis in postsynaptic target regions.","volume":"28","author":"Wu","year":"2008","journal-title":"J. Neurosci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"3155","DOI":"10.1073\/pnas.1120501109","article-title":"Ablation of neurons expressing agouti-related protein, but not melanin concentrating hormone, in leptin-deficient mice restores metabolic functions and fertility.","volume":"109","author":"Wu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B87","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/j.jpsychires.2014.04.005","article-title":"The role of leptin, melanocortin, and neurotrophin system genes on body weight in anorexia nervosa and bulimia nervosa.","volume":"55","author":"Yilmaz","year":"2014","journal-title":"J. Psychiatr. Res."},{"key":"B88","doi-asserted-by":"publisher","first-page":"11738","DOI":"10.1073\/pnas.91.24.11738","article-title":"Localization of neuropeptide Y Y1 receptors in the rat nervous system with special reference to somatic receptors on small dorsal root ganglion neurons.","volume":"91","author":"Zhang","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.00059\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,4]],"date-time":"2019-02-04T23:41:46Z","timestamp":1549323706000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.00059\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,5]]},"references-count":88,"alternative-id":["10.3389\/fnins.2019.00059"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2019.00059","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,5]]},"article-number":"59"}}