{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T23:54:01Z","timestamp":1785542041451,"version":"3.56.0"},"reference-count":49,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T00:00:00Z","timestamp":1549497600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006599","name":"Focused Ultrasound Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006599","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2019.00066","type":"journal-article","created":{"date-parts":[[2019,2,7]],"date-time":"2019-02-07T04:30:38Z","timestamp":1549513838000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":26,"title":["MR-Guided Focused Ultrasound Versus Radiofrequency Capsulotomy for Treatment-Refractory Obsessive-Compulsive Disorder: A Cost-Effectiveness Threshold Analysis"],"prefix":"10.3389","volume":"13","author":[{"given":"Kevin K.","family":"Kumar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahendra T.","family":"Bhati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinod K.","family":"Ravikumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pejman","family":"Ghanouni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherman C.","family":"Stein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey H.","family":"Halpern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,2,7]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1016\/S0140-6736(09)60240-3","article-title":"Obsessive-compulsive disorder.","volume":"374","author":"Abramowitz","year":"2009","journal-title":"Lancet"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-244X-11-125","article-title":"Internet-based cognitive behavior therapy for obsessive compulsive disorder: a pilot study.","volume":"11","author":"Andersson","year":"2011","journal-title":"BMC Psychiatry"},{"key":"B3","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1136\/jnnp-2017-317082","article-title":"Charting the road forward in psychiatric neurosurgery: proceedings of the 2016 American Society for Stereotactic and Functional Neurosurgery workshop on neuromodulation for psychiatric disorders.","volume":"89","author":"Bari","year":"2018","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B4","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.jad.2006.12.007","article-title":"Factors associated with major depressive disorder occurring after the onset of obsessive-compulsive disorder.","volume":"102","author":"Besiroglu","year":"2007","journal-title":"J. Affect. Disord."},{"key":"B5","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3171\/2015.1.JNS14681","article-title":"Dorsal anterior cingulotomy and anterior capsulotomy for severe, refractory obsessive-compulsive disorder: a systematic review of observational studies.","volume":"124","author":"Brown","year":"2016","journal-title":"J. Neurosurg."},{"key":"B6","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1176\/ps.50.3.412","article-title":"Quality-of-life changes among patients with obsessive-compulsive disorder in a partial hospitalization program.","volume":"50","author":"Bystritsky","year":"1999","journal-title":"Psychiatr. Serv."},{"key":"B7","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-015-0306-5","article-title":"Psychometric properties of the incontinence utility index among patients with idiopathic overactive bladder: data from two multicenter, double-blind, randomized. Phase 3, placebo-controlled clinical trials.","volume":"13","author":"Castejon","year":"2015","journal-title":"Health Qual. Life Outcomes"},{"key":"B8","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1002\/ana.25126","article-title":"A prospective trial of magnetic resonance guided focused ultrasound thalamotomy for essential tremor: results at the 2-year follow-up.","volume":"83","author":"Chang","year":"2017","journal-title":"Ann. Neurol."},{"key":"B9","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1159\/000070837","article-title":"Anterior capsulotomy for treatment of refractory obsessive-compulsive disorder: results in a young and an old patient.","volume":"79","author":"Christensen","year":"2002","journal-title":"Stereotact. Funct. Neurosurg."},{"key":"B10","doi-asserted-by":"publisher","first-page":"198","DOI":"10.1016\/j.jad.2010.02.127","article-title":"Long-term follow-up of patients with obsessive-compulsive disorder treated by anterior capsulotomy: a neuropsychological study.","volume":"126","author":"Csigo","year":"2010","journal-title":"J. Affect. Disord."},{"key":"B11","doi-asserted-by":"publisher","first-page":"1292","DOI":"10.1227\/01.NEU.0000159882.11635.EA","article-title":"Prophylaxis for deep venous thrombosis in craniotomy patients: a decision analysis.","volume":"56","author":"Danish","year":"2005","journal-title":"Neurosurgery"},{"key":"B12","doi-asserted-by":"publisher","first-page":"1208","DOI":"10.1136\/jnnp-2012-303826","article-title":"Bilateral stereotactic anterior capsulotomy for obsessive-compulsive disorder: long-term follow-up.","volume":"84","author":"D\u2019Astous","year":"2013","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B13","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1016\/S0149-2918(97)80140-3","article-title":"Pharmacoeconomic applications of meta-analysis for single groups using antifungal onychomycosis lacquers as an example.","volume":"19","author":"Einarson","year":"1997","journal-title":"Clin. Ther."},{"key":"B14","doi-asserted-by":"publisher","first-page":"518","DOI":"10.4088\/JCP.v68n0405","article-title":"Duloxetine treatment for role functioning improvement in generalized anxiety disorder: three independent studies.","volume":"68","author":"Endicott","year":"2007","journal-title":"J. Clin. Psychiatry"},{"key":"B15","doi-asserted-by":"publisher","first-page":"685","DOI":"10.4088\/JCP.12m07789","article-title":"Treatment response, symptom remission, and wellness in obsessive-compulsive disorder.","volume":"74","author":"Farris","year":"2013","journal-title":"J. Clin. Psychiatry"},{"key":"B16","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780195108248.001.0001","author":"Gold","year":"1996","journal-title":"Cost-Effectiveness in Health and Medicine."},{"key":"B17","doi-asserted-by":"publisher","first-page":"1012","DOI":"10.1001\/archpsyc.1989.01810110054008","article-title":"The yale-brown obsessive compulsive scale. II. Validity.","volume":"46","author":"Goodman","year":"1989","journal-title":"Arch. Gen. Psychiatry"},{"key":"B18","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1111\/j.1475-6773.2008.00872.x","article-title":"Decision-analytic modeling to assist decision making in organizational innovation: the case of shared care in hearing aid provision.","author":"Grutters","year":"2008","journal-title":"Health Serv. Res."},{"key":"B19","doi-asserted-by":"publisher","first-page":"784","DOI":"10.4088\/JCP.09m05911blu","article-title":"Quality of life outcomes in patients with obsessive-compulsive disorder: relationship to treatment response and symptom relapse.","volume":"71","author":"Hollander","year":"2010","journal-title":"J. Clin. Psychiatry"},{"key":"B20","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.clineuro.2009.11.006","article-title":"Unilateral deep brain stimulation of the nucleus accumbens in patients with treatment-resistant obsessive-compulsive disorder: outcomes after one year.","volume":"112","author":"Huff","year":"2010","journal-title":"Clin. Neurol. Neurosurg."},{"key":"B21","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1002\/da.20506","article-title":"Quality of life and functional impairment in obsessive-compulsive disorder: a comparison of patients with and without comorbidity, patients in remission, and healthy controls.","volume":"26","author":"Huppert","year":"2009","journal-title":"Depress. Anxiety"},{"key":"B22","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1038\/mp.2014.154","article-title":"Bilateral thermal capsulotomy with MR-guided focused ultrasound for patients with treatment-refractory obsessive-compulsive disorder: a proof-of-concept study.","volume":"20","author":"Jung","year":"2015","journal-title":"Mol. Psychiatry"},{"key":"B23","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/mpr.167","article-title":"The US National Comorbidity Survey Replication (NCS-R): design and field procedures.","volume":"13","author":"Kessler","year":"2004","journal-title":"Int. J. Methods Psychiatr. Res."},{"key":"B24","doi-asserted-by":"publisher","first-page":"4037","DOI":"10.1200\/JCO.2001.19.20.4037","article-title":"Neurobehavioral status and health-related quality of life in newly diagnosed high-grade glioma patients.","volume":"19","author":"Klein","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1055\/s-0032-1328689","article-title":"Interdisciplinary GoR level III guidelines for the diagnosis, therapy and follow-up care of breast cancer: short version \u2013 AWMF registry No.: 032-045OL AWMF-Register-Nummer: 032-045OL \u2013 kurzversion 3.0, Juli 2012.","volume":"73","author":"Kreienberg","year":"2013","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-319318","article-title":"Comparative effectiveness of neuroablation and deep brain stimulation for treatment-resistant obsessive-compulsive disorder: a meta-analytic study.","author":"Kumar","year":"2019","journal-title":"J. Neurol. Neurosurg. Psychiatry."},{"key":"B27","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1016\/S1474-4422(13)70048-6","article-title":"MR-guided focused ultrasound thalamotomy for essential tremor: a proof-of-concept study.","volume":"12","author":"Lipsman","year":"2013","journal-title":"Lancet Neurol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1016\/j.jocn.2007.07.086","article-title":"Stereotactic treatment of refractory obsessive compulsive disorder by bilateral capsulotomy with 3 years follow-up.","volume":"15","author":"Liu","year":"2008","journal-title":"J. Clin. Neurosci."},{"key":"B29","doi-asserted-by":"publisher","DOI":"10.3171\/2017.11.FOCUS17628","article-title":"A meta-analysis of outcomes and complications of magnetic resonance-guided focused ultrasound in the treatment of essential tremor.","volume":"44","author":"Mohammed","year":"2018","journal-title":"Neurosurg. Focus"},{"key":"B30","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1097\/00005650-199901000-00005","article-title":"Health utilities in Alzheimer\u2019s disease: a cross-sectional study of patients and caregivers.","volume":"37","author":"Neumann","year":"1999","journal-title":"Med. Care"},{"key":"B31","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1002\/da.20298","article-title":"Quality of life in obsessive-compulsive disorder: an evaluation of impairment and a preliminary analysis of the ameliorating effects of treatment.","volume":"25","author":"Norberg","year":"2008","journal-title":"Depress. Anxiety"},{"key":"B32","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1207\/S15324826AN0802_3","article-title":"Executive and cognitive functions in patients with extreme obsessive-compulsive disorder treated by capsulotomy.","volume":"8","author":"Nyman","year":"2001","journal-title":"Appl. Neuropsychol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1159\/000075110","article-title":"Bilateral anterior capsulotomy for refractory obsessive-compulsive disorders.","volume":"81","author":"Oliver","year":"2003","journal-title":"Stereotact. Funct. Neurosurg."},{"key":"B34","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1136\/jnnp-2012-302550","article-title":"Deep brain stimulation for obsessive-compulsive disorders: long-term analysis of quality of life.","volume":"85","author":"Ooms","year":"2014","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"B35","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.biopsych.2017.11.034","article-title":"Gamma ventral capsulotomy in intractable obsessive-compulsive disorder.","volume":"84","author":"Rasmussen","year":"2018","journal-title":"Biol. Psychiatry"},{"key":"B36","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1002\/mds.26997","article-title":"Cost-effectiveness of focused ultrasound, radiosurgery, and DBS for essential tremor.","volume":"32","author":"Ravikumar","year":"2017","journal-title":"Mov. Disord."},{"key":"B37","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1097\/JCP.0b013e3181dbfb53","article-title":"Long-term follow-up study of patients with serotonin reuptake inhibitor-nonresponsive obsessive-compulsive disorder.","volume":"30","author":"Reddy","year":"2010","journal-title":"J. Clin. Psychopharmacol."},{"key":"B38","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1176\/appi.neuropsych.20.4.450","article-title":"Long-term follow-up study of patients with refractory obsessive-compulsive disorder.","volume":"20","author":"Ross","year":"2008","journal-title":"J. Neuropsychiatry Clin. Neurosci."},{"key":"B39","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1001\/archpsyc.65.8.914","article-title":"Capsulotomy for obsessive-compulsive disorder: long-term follow-up of 25 patients.","volume":"65","author":"Ruck","year":"2008","journal-title":"Arch. Gen. Psychiatry"},{"key":"B40","doi-asserted-by":"publisher","first-page":"941","DOI":"10.1016\/j.brat.2010.05.026","article-title":"Challenges using motivational interviewing as an adjunct to exposure therapy for obsessive-compulsive disorder.","volume":"48","author":"Simpson","year":"2010","journal-title":"Behav. Res. Ther."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1133","DOI":"10.4088\/JCP.v67n0717","article-title":"A randomized clinical trial of cognitive-behavioral group therapy and sertraline in the treatment of obsessive-compulsive disorder.","volume":"67","author":"Sousa","year":"2006","journal-title":"J. Clin. Psychiatry"},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.1002\/9781118341544","author":"Sox","year":"2013","journal-title":"Medical Decision Making"},{"key":"B43","doi-asserted-by":"publisher","first-page":"178","DOI":"10.1016\/j.ajp.2011.05.008","article-title":"Quality of life in patients with obsessive compulsive disorder: a longitudinal study from India.","volume":"4","author":"Srivastava","year":"2011","journal-title":"Asian J. Psychiatr."},{"key":"B44","doi-asserted-by":"publisher","first-page":"2008","DOI":"10.1001\/jama.283.15.2008","article-title":"Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group.","volume":"283","author":"Stroup","year":"2000","journal-title":"JAMA"},{"key":"B45","doi-asserted-by":"publisher","first-page":"1559","DOI":"10.1002\/sim.1187","article-title":"How should meta-regression analyses be undertaken and interpreted?","volume":"21","author":"Thompson","year":"2002","journal-title":"Stat. Med."},{"key":"B46","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1159\/000070785","article-title":"Cognitive-behavioral group therapy in obsessive-compulsive disorder: a randomized clinical trial.","volume":"72","author":"Volpato Cordioli","year":"2003","journal-title":"Psychother. Psychosom."},{"key":"B47","doi-asserted-by":"publisher","first-page":"1253","DOI":"10.1001\/jama.1996.03540150055031","article-title":"Recommendations of the panel on cost-effectiveness in health and medicine.","volume":"276","author":"Weinstein","year":"1996","journal-title":"JAMA"},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3171\/2017.6.FOCUS17250","article-title":"History of psychosurgery at Sainte-Anne Hospital, Paris, France, through translational interactions between psychiatrists and neurosurgeons.","volume":"43","author":"Zanello","year":"2017","journal-title":"Neurosurg. Focus"},{"key":"B49","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1016\/j.clineuro.2014.01.009","article-title":"Long-term follow-up of bilateral anterior capsulotomy in patients with refractory obsessive-compulsive disorder.","volume":"119","author":"Zhan","year":"2014","journal-title":"Clin. Neurol. Neurosurg."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.00066\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T16:08:35Z","timestamp":1720973315000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.00066\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,7]]},"references-count":49,"alternative-id":["10.3389\/fnins.2019.00066"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2019.00066","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,7]]},"article-number":"66"}}