{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:55:57Z","timestamp":1790034957700,"version":"4.0.1"},"reference-count":43,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T00:00:00Z","timestamp":1557446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC 31671082"],"award-info":[{"award-number":["NSFC 31671082"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["NSFC31371117"],"award-info":[{"award-number":["NSFC31371117"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Basic Research Program of China","doi-asserted-by":"publisher","award":["2013CB329504"],"award-info":[{"award-number":["2013CB329504"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2019.00477","type":"journal-article","created":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T12:24:34Z","timestamp":1557491074000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":9,"title":["Chronic Unilateral Hearing Loss Disrupts Neural Tuning to Sound-Source Azimuth in the Rat Primary Auditory Cortex"],"prefix":"10.3389","volume":"13","author":[{"given":"Xiuwen","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiping","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"B1","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1152\/jn.1996.75.3.1206","article-title":"Cortical synthesis of azimuth-sensitive single-unit responses with nonmonotonic level tuning: a thalamocortical comparison in the cat.","volume":"75","author":"Barone","year":"1996","journal-title":"J. Neurophysiol."},{"key":"B2","doi-asserted-by":"publisher","first-page":"14127","DOI":"10.1523\/JNEUROSCI.2061-09.2009","article-title":"The synaptic representation of sound source location in auditory cortex.","volume":"29","author":"Chadderton","year":"2009","journal-title":"J. Neurosci."},{"key":"B3","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1152\/jn.1995.74.3.961","article-title":"Comparison of noise and tone azimuth tuning of neurons in cat primary auditory cortex and medical geniculate body.","volume":"74","author":"Clarey","year":"1995","journal-title":"J. Neurophysiol."},{"key":"B4","doi-asserted-by":"publisher","first-page":"10214","DOI":"10.1523\/JNEUROSCI.0226-16.2016","article-title":"Conductive hearing loss has long-lasting structural and molecular effects on presynaptic and postsynaptic structures of auditory nerve synapses in the cochlear nucleus.","volume":"36","author":"Clarkson","year":"2016","journal-title":"J. Neurosci."},{"key":"B5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/cne.10412","article-title":"Redefining the tonotopic core of rat auditory cortex: physiological evidence for a posterior field.","volume":"453","author":"Doron","year":"2002","journal-title":"J. Comp. Neurol."},{"key":"B6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0378-5955(91)90144-X","article-title":"Neonatal conductive hearing loss does not compromise brainstem auditory function and structure in rhesus monkeys.","volume":"54","author":"Doyle","year":"1991","journal-title":"Hear. Res."},{"key":"B7","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1152\/jn.1998.80.4.2133","article-title":"Azimuth coding in primary auditory cortex of the cat. I. spike synchrony versus spike count representations.","volume":"80","author":"Eggermont","year":"1998","journal-title":"J. Neurophysiol."},{"key":"B8","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.neuroscience.2006.07.039","article-title":"Unilateral cochlear ablation before hearing onset disrupts the maintenance of dorsal nucleus of the lateral lemniscus projection patterns in the rat inferior colliculus.","volume":"143","author":"Franklin","year":"2006","journal-title":"Neuroscience"},{"key":"B9","doi-asserted-by":"crossref","first-page":"6939","DOI":"10.1523\/JNEUROSCI.20-18-06939.2000","article-title":"Plasticity in the development of afferent patterns in the inferior colliculus of the rat after unilateral cochlear ablation.","volume":"20","author":"Gabriele","year":"2000","journal-title":"J. Neurosci."},{"key":"B10","doi-asserted-by":"publisher","first-page":"1320","DOI":"10.1111\/ejn.13943","article-title":"Nonuniform impacts of forward suppression on neural responses to preferred stimuli and nonpreferred stimuli in the rat auditory cortex.","volume":"47","author":"Gao","year":"2018","journal-title":"Eur. J. Neurosci."},{"key":"B11","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1044\/jslhr.4303.631","article-title":"Effects of otitis media with effusion on hearing in the first 3 years of life.","volume":"43","author":"Gravel","year":"2000","journal-title":"J. Speech Lang. Hear. Res."},{"key":"B12","doi-asserted-by":"crossref","first-page":"508","DOI":"10.3109\/00206098009070082","article-title":"Horizontal sound localization skills of unilaterally hearing-impaired children.","volume":"19","author":"Humes","year":"1980","journal-title":"Audiology"},{"key":"B13","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.heares.2007.12.007","article-title":"Consequences of unilateral hearing loss: cortical adjustment to unilateral deprivation.","volume":"237","author":"Hutson","year":"2008","journal-title":"Hear. Res."},{"key":"B14","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1152\/jn.1990.63.6.1448","article-title":"Single-unit selectivity to azimuthal direction and sound pressure level of noise bursts in cat high-frequency primary auditory cortex.","volume":"63","author":"Imig","year":"1990","journal-title":"J. Neurophysiol."},{"key":"B15","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1152\/jn.1984.52.5.819","article-title":"Role of cat primary auditory cortex for sound-localization behavior.","volume":"52","author":"Jenkins","year":"1984","journal-title":"J. Neurophysiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2144","DOI":"10.1111\/ejn.12975","article-title":"Environmental enrichment rescues the degraded auditory temporal resolution of cortical neurons induced by early noise exposure.","volume":"42","author":"Jiang","year":"2015","journal-title":"Eur. J. Neurosci."},{"key":"B17","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1152\/jn.1988.59.6.1756","article-title":"Organization of auditory cortex in the albino rat: binaural response properties.","volume":"59","author":"Kelly","year":"1988","journal-title":"J. Neurophysiol."},{"key":"B18","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.heares.2007.01.001","article-title":"Physiological and behavioral studies of spatial coding in the auditory cortex.","volume":"229","author":"King","year":"2007","journal-title":"Hear. Res."},{"key":"B19","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/cne.903530303","article-title":"Development of ectopic projections from the ventral cochlear nucleus to the superior olivary complex induced by neonatal ablation of the contralateral cochlea.","volume":"353","author":"Kitzes","year":"1995","journal-title":"J. Comp. Neurol."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2013.00093","article-title":"Unilateral hearing during development: hemispheric specificity in plastic reorganizations.","volume":"7","author":"Kral","year":"","journal-title":"Front. Syst. Neurosci."},{"key":"B21","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1093\/brain\/aws305","article-title":"Single-sided deafness leads to unilateral aural preference within an early sensitive period.","author":"Kral","year":"","journal-title":"Brain"},{"key":"B22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0142341","article-title":"Chronic conductive hearing loss leads to cochlear degeneration.","volume":"10","author":"Liberman","year":"2015","journal-title":"PLoS One"},{"key":"B23","doi-asserted-by":"publisher","first-page":"50","DOI":"10.1016\/j.ijdevneu.2015.11.004","article-title":"Encoding of sound envelope transients in the auditory cortex of juvenile rats and adult rats.","volume":"48","author":"Lu","year":"2016","journal-title":"Int. J. Dev. Neurosci."},{"key":"B24","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1152\/jn.00720.2006","article-title":"Sound localization during homotopic and heterotopic bilateral cooling deactivation of primary and nonprimary auditory cortical areas in the cat.","volume":"97","author":"Malhotra","year":"2007","journal-title":"J. Neurophysiol."},{"key":"B25","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1152\/jn.1997.78.2.767","article-title":"Response properties of neurons in the inferior colliculus of the monaurally deafened ferret to acoustic stimulation of the intact ear.","volume":"78","author":"McAlpine","year":"1997","journal-title":"J. Neurophysiol."},{"key":"B26","doi-asserted-by":"crossref","first-page":"8649","DOI":"10.1523\/JNEUROSCI.23-25-08649.2003","article-title":"Representation of auditory space by cortical neurons in awake cats.","volume":"23","author":"Mickey","year":"2003","journal-title":"J. Neurosci."},{"key":"B27","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1523\/JNEUROSCI.09-04-01213.1989","article-title":"Auditory brain stem of the ferret: some effects of rearing with a unilateral ear plug on the cochlea, cochlear nucleus, and projections to the inferior colliculus.","volume":"9","author":"Moore","year":"1989","journal-title":"J. Neurosci."},{"key":"B28","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3547","article-title":"Brief hearing loss disrupts binaural integration during two early critical periods of auditory cortex development.","volume":"4","author":"Polley","year":"2013","journal-title":"Nat. Comm."},{"key":"B29","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1016\/j.neuron.2010.02.019","article-title":"Monaural deprivation disrupts development of binaural selectivity in auditory midbrain and cortex.","volume":"65","author":"Popescu","year":"2010","journal-title":"Neuron"},{"key":"B30","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1152\/jn.1990.64.3.872","article-title":"Azimuthal sensitivity of neurons in primary auditory cortex of cats. I. types of sensitivity and the effects of variations in stimulus parameters.","volume":"64","author":"Rajan","year":"1990","journal-title":"J. Neurophysiol."},{"key":"B31","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1152\/jn.1994.71.6.2194","article-title":"Effects of ear plugging on single-unit azimuth sensitivity in cat primary auditory cortex. II. azimuth tuning dependent upon binaural stimulation.","volume":"71","author":"Samson","year":"1994","journal-title":"J. Neurophysiol."},{"key":"B32","doi-asserted-by":"crossref","first-page":"4234","DOI":"10.1152\/jn.00401.2005","article-title":"Responses of ventral cochlear nucleus neurons to contralateral sound after conductive hearing loss.","volume":"94","author":"Sumner","year":"2005","journal-title":"J. Neurophysiol."},{"key":"B33","doi-asserted-by":"publisher","first-page":"1762","DOI":"10.1093\/cercor\/bhv351","article-title":"Monaural congenital deafness affects aural dominance and degrades binaural processing.","volume":"26","author":"Tillein","year":"2016","journal-title":"Cereb. Cortex"},{"key":"B34","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1093\/cercor\/bhp222","article-title":"Cortical representation of interaural time difference in congenital deafness.","volume":"20","author":"Tillein","year":"2010","journal-title":"Cereb. Cortex"},{"key":"B35","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1097\/00005537-199909000-00001","article-title":"Conductive hearing loss results in a decrease in central auditory system activity in the young gerbil.","volume":"109","author":"Tucci","year":"1999","journal-title":"Laryngoscope"},{"key":"B36","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1016\/j.neuroscience.2011.10.021","article-title":"Monaural conductive hearing loss alters the expression of the GluA3 AMPA and glycine receptor alpha1 subunits in bushy and fusiform cells of the cochlear nucleus.","volume":"199","author":"Wang","year":"2011","journal-title":"Neuroscience"},{"key":"B37","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1016\/j.neuroscience.2009.07.049","article-title":"Cochlear nucleus neurons redistribute synaptic AMPA and glycine receptors in response to monaural conductive hearing loss.","volume":"163","author":"Whiting","year":"2009","journal-title":"Neuroscience"},{"key":"B38","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0378-5955(94)90179-1","article-title":"Binaural processing after corrected congenital unilateral conductive hearing loss.","volume":"74","author":"Wilmington","year":"1994","journal-title":"Hear. Res."},{"key":"B39","doi-asserted-by":"crossref","first-page":"3323","DOI":"10.1152\/jn.00392.2006","article-title":"Effects of stimulus azimuth and intensity on the single-neuron activity in the auditory cortex of the alert macaque monkey.","volume":"96","author":"Woods","year":"2006","journal-title":"J. Neurophysiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"9417","DOI":"10.1523\/JNEUROSCI.1992-07.2007","article-title":"Conductive hearing loss disrupts synaptic and spike adaptation in developing auditory cortex.","volume":"27","author":"Xu","year":"2007","journal-title":"J. Neurosci."},{"key":"B41","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1152\/jn.00219.2013","article-title":"Rat primary auditory cortex is tuned exclusively to the contralateral hemifield.","volume":"110","author":"Yao","year":"2013","journal-title":"J. Neurophysiol."},{"key":"B42","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.33891","article-title":"Developmental deprivation-induced perceptual and cortical processing deficits in awake-behaving animals.","volume":"7","author":"Yao","year":"2018","journal-title":"eLife"},{"key":"B43","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1152\/jn.00166.2003","article-title":"Binaural interaction revisited in the cat primary auditory cortex.","volume":"91","author":"Zhang","year":"2004","journal-title":"J. Neurophysiol."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.00477\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,10]],"date-time":"2019-05-10T12:24:40Z","timestamp":1557491080000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.00477\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,10]]},"references-count":43,"alternative-id":["10.3389\/fnins.2019.00477"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2019.00477","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,10]]},"article-number":"477"}}