{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:28:40Z","timestamp":1789939720828,"version":"4.0.1"},"reference-count":36,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T00:00:00Z","timestamp":1557878400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2019.00479","type":"journal-article","created":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T14:16:21Z","timestamp":1557929781000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":7,"title":["A Novel Role of VEGFC in Cerebral Ischemia With Lung Injury"],"prefix":"10.3389","volume":"13","author":[{"given":"Mu-Dong","family":"Wen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed","family":"Al-Hawwas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi-Qin","family":"Dan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-An","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Ming","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Mei","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu-Lin","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun-Hui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,5,15]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"657","DOI":"10.1128\/mmbr.67.4.657-685.2003","article-title":"RNA interference: biology, mechanism, and applications.","volume":"67","author":"Agrawal","year":"2003","journal-title":"Microbiol. Mol. Biol. Rev."},{"key":"B2","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/s1535-6108(02)00051-x","article-title":"Molecular mechanisms of lymphangiogenesis in health and disease.","volume":"1","author":"Alitalo","year":"2002","journal-title":"Cancer Cell"},{"key":"B3","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1007\/s12975-012-0213-6","article-title":"Vascular endothelial growth factors A and C are induced in the SVZ following neonatal hypoxia-ischemia and exert different effects on neonatal glial progenitors.","volume":"4","author":"Bain","year":"2013","journal-title":"Transl. Stroke Res."},{"key":"B4","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1016\/j.neuroscience.2015.01.025","article-title":"Ischemic tolerance is associated with VEGF-C and VEGFR-3 signaling in the mouse hippocampus.","volume":"290","author":"Bhuiyan","year":"2015","journal-title":"Neuroscience"},{"key":"B5","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1097\/CCM.0000000000001101","article-title":"Neurogenic pulmonary edema.","volume":"43","author":"Busl","year":"2015","journal-title":"Crit. Care Med."},{"key":"B6","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1111\/ajt.13564","article-title":"Ischemia-reperfusion injury enhances lymphatic endothelial vegfr3 and rejection in cardiac allografts.","volume":"16","author":"Dashkevich","year":"2016","journal-title":"Am. J. Transplant."},{"key":"B7","doi-asserted-by":"publisher","first-page":"1261","DOI":"10.1111\/cas.12504","article-title":"Tumor necrosis factor-alpha promotes the lymphangiogenesis of gallbladder carcinoma through nuclear factor-kappaB-mediated upregulation of vascular endothelial growth factor-C.","volume":"105","author":"Du","year":"2014","journal-title":"Cancer Sci."},{"key":"B8","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1196\/annals.1413.017","article-title":"Lymphatics in lung disease.","volume":"1131","author":"El-Chemaly","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"B9","first-page":"740","article-title":"The study of interfering of endogenous VEGF-C genes and the protein expression gastric cancer cell with siRNA technique.","volume":"44","author":"Guo","year":"2013","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban"},{"key":"B10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.mad.2006.11.021","article-title":"Protein microarray technology.","volume":"128","author":"Hall","year":"2007","journal-title":"Mech. Ageing Dev."},{"key":"B11","article-title":"Oxidative and inflammatory biomarkers of ischemia and reperfusion injuries.","volume":"62","author":"Halladin","year":"2015","journal-title":"Dan Med. J."},{"key":"B12","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1159\/000350199","article-title":"Stroke-associated pneumonia: major advances and obstacles.","volume":"35","author":"Hannawi","year":"2013","journal-title":"Cerebrovasc. Dis."},{"key":"B13","doi-asserted-by":"publisher","first-page":"975","DOI":"10.1161\/01.str.0000063373.70993.cd","article-title":"Nosocomial pneumonia after acute stroke: implications for neurological intensive care medicine.","volume":"34","author":"Hilker","year":"2003","journal-title":"Stroke"},{"key":"B14","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.expneurol.2008.11.007","article-title":"Therapeutic application of gene silencing MMP-9 in a middle cerebral artery occlusion-induced focal ischemia rat model.","volume":"216","author":"Hu","year":"2009","journal-title":"Exp. Neurol."},{"key":"B15","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1164\/rccm.200508-1291oc","article-title":"Pulmonary vascular endothelial growth factor-C in development and lung injury in preterm infants.","volume":"174","author":"Janer","year":"2006","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"B16","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1161\/01.str.29.2.447","article-title":"Medical and neurological complications of ischemic stroke: experience from the RANTTAS trial. RANTTAS investigators.","volume":"29","author":"Johnston","year":"1998","journal-title":"Stroke"},{"key":"B17","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1002\/j.1460-2075.1996.tb00359.x","article-title":"A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.","volume":"15","author":"Joukov","year":"1996","journal-title":"EMBO J."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186977","article-title":"Reduced expression of IQGAP2 and higher expression of IQGAP3 correlates with poor prognosis in cancers.","volume":"12","author":"Kumar","year":"2017","journal-title":"PLoS One"},{"key":"B19","doi-asserted-by":"publisher","first-page":"340","DOI":"10.1038\/nn1646","article-title":"VEGF-C is a trophic factor for neural progenitors in the vertebrate embryonic brain.","volume":"9","author":"Le Bras","year":"2006","journal-title":"Nat. Neurosci."},{"key":"B20","doi-asserted-by":"publisher","DOI":"10.1097\/md.0000000000006667","article-title":"Efficacy and safety of desmoteplase in acute ischemic stroke patients: a systematic review and meta-analysis.","volume":"96","author":"Li","year":"2017","journal-title":"Medicine"},{"key":"B21","doi-asserted-by":"publisher","first-page":"H1141","DOI":"10.1152\/ajpheart.00451.2015","article-title":"Chloride intracellular channel 4 is required for maturation of the cerebral collateral circulation.","volume":"309","author":"Lucitti","year":"2015","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/nm.1960","article-title":"Macrophages regulate salt-dependent volume and blood pressure by a vascular endothelial growth factor-C-dependent buffering mechanism.","volume":"15","author":"Machnik","year":"2009","journal-title":"Nat. Med."},{"key":"B23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/429101a","article-title":"Protein arrays: proteomics in multiplex.","volume":"429","author":"Melton","year":"2004","journal-title":"Nature"},{"key":"B24","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1038\/nbt0302-225","article-title":"A perspective on protein microarrays.","volume":"20","author":"Mitchell","year":"2002","journal-title":"Nat. Biotechnol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1177\/0022034516681762","article-title":"Role of hyperplasia of gingival lymphatics in periodontal inflammation.","volume":"96","author":"Papadakou","year":"2017","journal-title":"J. Dent. Res."},{"key":"B26","doi-asserted-by":"publisher","first-page":"542","DOI":"10.1016\/j.pcad.2017.04.005","article-title":"Neuroprotection in the treatment of acute ischemic stroke.","volume":"59","author":"Patel","year":"2017","journal-title":"Prog. Cardiovasc. Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1177\/0885066613491919","article-title":"The prevalence and impact of mortality of the acute respiratory distress syndrome on admissions of patients with ischemic stroke in the United States.","volume":"29","author":"Rincon","year":"2014","journal-title":"J. Intensive Care Med."},{"key":"B28","first-page":"147","article-title":"Neurogenic pulmonary oedema.","volume":"150","author":"Sedy","year":"2011","journal-title":"Cas. Lek. Cesk"},{"key":"B29","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1007\/s00401-008-0423-x","article-title":"Differential regulation of vascular endothelial growth factor-C and its receptor in the rat hippocampus following transient forebrain ischemia.","volume":"116","author":"Shin","year":"2008","journal-title":"Acta Neuropathol."},{"key":"B30","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0083523","article-title":"Differentiation and migration of bone marrow mesenchymal stem cells transplanted through the spleen in rats with portal hypertension.","volume":"8","author":"Sun","year":"2013","journal-title":"PLoS One"},{"key":"B31","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1038\/nature07083","article-title":"Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation.","volume":"454","author":"Tammela","year":"2008","journal-title":"Nature"},{"key":"B32","first-page":"1878","article-title":"PC4 induces lymphangiogenesis dependent VEGF-C\/VEGF-D\/VEGFR-3 axis activation in lung adenocarcinoma.","volume":"5","author":"Tao","year":"2015","journal-title":"Am. J. Cancer Res."},{"key":"B33","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1038\/sj.jcbfm.9600073","article-title":"Metabolic crisis without brain ischemia is common after traumatic brain injury: a combined microdialysis and positron emission tomography study.","volume":"25","author":"Vespa","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1590\/1414-431X20154738","article-title":"Promoting inflammatory lymphangiogenesis by vascular endothelial growth factor-C (VEGF-C) aggravated intestinal inflammation in mice with experimental acute colitis.","volume":"49","author":"Wang","year":"2016","journal-title":"Braz. J. Med. Biol. Res."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1038\/nbt739","article-title":"siRNA-mediated gene silencing in vitro and in vivo.","volume":"20","author":"Xia","year":"2002","journal-title":"Nat. Biotechnol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1493","DOI":"10.1007\/s13277-013-0674-6","article-title":"RNAi-mediated gene silencing of vascular endothelial growth factor-C inhibits tumor lymphangiogenesis and growth of gastric cancer in vivo in mice.","volume":"34","author":"Yao","year":"2013","journal-title":"Tumour Biol."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.00479\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T13:36:38Z","timestamp":1558532198000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.00479\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,15]]},"references-count":36,"alternative-id":["10.3389\/fnins.2019.00479"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2019.00479","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,15]]},"article-number":"479"}}