{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T16:38:34Z","timestamp":1791909514960,"version":"4.3.4"},"reference-count":84,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T00:00:00Z","timestamp":1559606400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2019.00569","type":"journal-article","created":{"date-parts":[[2019,6,4]],"date-time":"2019-06-04T04:26:45Z","timestamp":1559622405000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":71,"title":["Neurogenesis in Neurodegenerative Diseases: Role of MFG-E8"],"prefix":"10.3389","volume":"13","author":[{"given":"Cletus","family":"Cheyuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monowar","family":"Aziz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,6,4]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1523\/jneurosci.22-03-00629.2002","article-title":"Neurogenesis in adult subventricular zone.","volume":"22","author":"Alvarez-Buylla","year":"2002","journal-title":"J. Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"H896","DOI":"10.1152\/ajpheart.00154.2017","article-title":"Vascular niche contribution to age-associated neural stem cell dysfunction.","volume":"313","author":"Apple","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"B3","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1007\/s10495-011-0630-0","article-title":"Review: milk fat globule-EGF factor 8 expression, function and plausible signal transduction in resolving inflammation.","volume":"16","author":"Aziz","year":"2011","journal-title":"Apoptosis"},{"key":"B4","doi-asserted-by":"publisher","first-page":"609","DOI":"10.1007\/s10495-008-0201-1","article-title":"Prolactin induces MFG-E8 production in macrophages via transcription factor C\/EBPbeta-dependent pathway.","volume":"13","author":"Aziz","year":"2008","journal-title":"Apoptosis"},{"key":"B5","doi-asserted-by":"publisher","first-page":"7832","DOI":"10.1074\/jbc.M807458200","article-title":"mTORC1 activation regulates beta-cell mass and proliferation by modulation of cyclin D2 synthesis and stability.","volume":"284","author":"Balcazar","year":"2009","journal-title":"J. Biol. Chem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"e8","DOI":"10.1016\/j.celrep.2018.11.088","article-title":"Increasing neural stem cell division asymmetry and quiescence are predicted to contribute to the age-related decline in neurogenesis.","volume":"25","author":"Bast","year":"2018","journal-title":"Cell Rep."},{"key":"B7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/jcp.21237","article-title":"Cell-matrix adhesion.","volume":"213","author":"Berrier","year":"2007","journal-title":"J. Cell Physiol."},{"key":"B8","doi-asserted-by":"crossref","first-page":"921","DOI":"10.2353\/ajpath.2007.060664","article-title":"Evidence of a role for lactadherin in Alzheimer\u2019s disease.","volume":"170","author":"Boddaert","year":"2007","journal-title":"Am. J. Pathol."},{"key":"B9","doi-asserted-by":"crossref","first-page":"111508","DOI":"10.18632\/oncotarget.22851","article-title":"Hypoxia-inducible factor-1\u03b1 regulates microglial functions affecting neuronal survival in the acute phase of ischemic stroke in mice.","volume":"8","author":"Bok","year":"2017","journal-title":"Oncotarget"},{"key":"B10","doi-asserted-by":"publisher","first-page":"2375","DOI":"10.1002\/j.1460-2075.1991.tb07776.x","article-title":"Characterization of the integrin alpha 8 subunit: a new integrin beta 1-associated subunit, which is prominently expressed on axons and on cells in contact with basal laminae in chick embryos.","volume":"10","author":"Bossy","year":"1991","journal-title":"EMBO J."},{"key":"B11","first-page":"3673","article-title":"Milk fat globule-EGF factor 8\/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium.","volume":"117","author":"Bu","year":"2007","journal-title":"J. Clin. Invest."},{"key":"B12","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1002\/aur.180","article-title":"Absence of preference for social novelty and increased grooming in integrin \u03b23 knockout mice: initial studies and future directions.","volume":"4","author":"Carter","year":"2011","journal-title":"Autism Res."},{"key":"B13","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122833","article-title":"Milk fat globule-EGF factor VIII attenuates CNS injury by promoting neural stem cell proliferation and migration after cerebral ischemia.","volume":"10","author":"Cheyuo","year":"2015","journal-title":"PLoS One"},{"key":"B14","doi-asserted-by":"publisher","first-page":"890","DOI":"10.1016\/j.neuropharm.2011.09.018","article-title":"Recombinant human MFG-E8 attenuates cerebral ischemic injury: its role in anti-inflammation and anti-apoptosis.","volume":"62","author":"Cheyuo","year":"2012","journal-title":"Neuropharmacology"},{"key":"B15","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1146\/annurev-cellbio-101512-122326","article-title":"Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles.","volume":"30","author":"Colombo","year":"2014","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"5157","DOI":"10.1021\/pr8004887","article-title":"Characterization and comprehensive proteome profiling of exosomes secreted by hepatocytes.","volume":"7","author":"Conde-Vancells","year":"2008","journal-title":"J. Proteome Res."},{"key":"B17","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.scr.2013.02.008","article-title":"Quiescent neural stem cells exit dormancy upon alteration of GABAAR signaling following radiation damage.","volume":"11","author":"Daynac","year":"2013","journal-title":"Stem Cell Res."},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2018.4377","article-title":"Prognosis and neuropathologic correlation of clinical subtypes of parkinson disease.","author":"De Pablo-Fern\u00e1ndez","year":"2019","journal-title":"JAMA Neurol."},{"key":"B19","doi-asserted-by":"publisher","first-page":"1176","DOI":"10.1172\/JCI65167","article-title":"MFGE8 inhibits inflammasome-induced IL-1\u03b2 production and limits postischemic cerebral injury.","volume":"123","author":"Deroide","year":"2013","journal-title":"J. Clin. Invest."},{"key":"B20","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1038\/nm.2009","article-title":"An integrin alpha(v)beta(3)-c-Src oncogenic unit promotes anchorage-independence and tumor progression.","volume":"15","author":"Desgrosellier","year":"2009","journal-title":"Nat. Med."},{"key":"B21","doi-asserted-by":"publisher","first-page":"703","DOI":"10.1016\/s0092-8674(00)80783-7","article-title":"Subventricular zone astrocytes are neural stem cells in the adult mammalian brain.","volume":"97","author":"Doetsch","year":"1999","journal-title":"Cell"},{"key":"B22","doi-asserted-by":"publisher","first-page":"209","DOI":"10.3109\/00365511003663648","article-title":"Biodistribution of 99mTc-HYNIC-lactadherin in mice\u2013a potential tracer for visualizing apoptosis in vivo.","volume":"70","author":"Falborg","year":"2010","journal-title":"Scand. J. Clin. Lab. Invest."},{"key":"B23","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1038\/nn.2553","article-title":"OSVZ progenitors of human and ferret neocortex are epithelial-like and expand by integrin signaling.","volume":"13","author":"Fietz","year":"2010","journal-title":"Nat. Neurosci."},{"key":"B24","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1002\/jnr.20778","article-title":"Regulation of human neural precursor cells by laminin and integrins.","volume":"83","author":"Flanagan","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"B25","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1007\/s11481-008-9118-2","article-title":"MFG-E8 regulates microglial phagocytosis of apoptotic neurons.","volume":"3","author":"Fuller","year":"2008","journal-title":"J. Neuroimmune Pharmacol."},{"key":"B26","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0939-5","article-title":"Recombinant milk fat globule-EGF factor-8 reduces apoptosis via integrin \u03b23\/FAK\/PI3K\/AKT signaling pathway in rats after traumatic brain injury.","volume":"9","author":"Gao","year":"2018","journal-title":"Cell Death"},{"key":"B27","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1002\/(sici)1097-4695(199808)36:2<234::aid-neu10>3.0.co;2-e","article-title":"Architecture and cell types of the adult subventricular zone: in search of the stem cells.","volume":"36","author":"Garc\u00eda-Verdugo","year":"1998","journal-title":"J. Neurobiol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/gbb.12130","article-title":"Not all water mazes are created equal: cyclin D2 knockout mice with constitutively suppressed adult hippocampal neurogenesis do show specific spatial learning deficits.","volume":"13","author":"Garthe","year":"2014","journal-title":"Genes Brain Behav."},{"key":"B29","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1038\/nrm1739","article-title":"The cell biology of neurogenesis.","volume":"6","author":"G\u00f6tz","year":"2005","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1675","DOI":"10.1089\/scd.2017.0182","article-title":"Positive modulation of AMPA receptors promotes survival and proliferation of neural stem\/progenitor cells from the adult rat spinal cord.","volume":"12","author":"Hachem","year":"2017","journal-title":"Stem Cells Dev."},{"key":"B31","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/417182a","article-title":"Identification of a factor that links apoptotic cells to phagocytes.","volume":"417","author":"Hanayama","year":"2002","journal-title":"Nature"},{"key":"B32","doi-asserted-by":"publisher","first-page":"1147","DOI":"10.1126\/science.1094359","article-title":"Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice.","volume":"304","author":"Hanayama","year":"2004","journal-title":"Science"},{"key":"B33","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: progress and problems on the road to therapeutics.","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"B34","doi-asserted-by":"publisher","first-page":"3196","DOI":"10.1073\/pnas.0308600100","article-title":"Neurons arise in the basal neuroepithelium of the early mammalian telencephalon: a major site of neurogenesis.","volume":"101","author":"Haubensak","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B35","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1189\/jlb.3a0416-184rr","article-title":"MFG-E8-derived peptide attenuates adhesion and migration of immune cells to endothelial cells.","volume":"5","author":"Hirano","year":"2017","journal-title":"J. Leukoc. Biol."},{"key":"B36","doi-asserted-by":"publisher","first-page":"726","DOI":"10.1038\/nn1265","article-title":"Dopamine depletion impairs precursor cell proliferation in parkinson disease.","volume":"7","author":"H\u00f6glinger","year":"2004","journal-title":"Nat. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1002\/ajmg.b.32429","article-title":"Adult neurogenesis and neurodegenerative diseases: a systems biology perspective.","volume":"1","author":"Horgusluoglu","year":"2017","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"B38","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1016\/j.scr.2013.12.009","article-title":"Perlecan is required for FGF-2 signaling in the neural stem cell niche.","volume":"12","author":"Kerever","year":"2014","journal-title":"Stem Cell Res."},{"key":"B39","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1038\/nm.3450","article-title":"Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids.","volume":"20","author":"Khalifeh-Soltani","year":"2014","journal-title":"Nat. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1016\/j.nbd.2012.11.010","article-title":"MFGE8 does not orchestrate clearance of apoptotic neurons in a mouse model of Parkinson\u2019s disease.","volume":"51","author":"Kinugawa","year":"2013","journal-title":"Neurobiol. Dis."},{"key":"B41","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1111\/j.1460-9568.2011.07933.x","article-title":"Fluoxetine rescues impaired hippocampal neurogenesis in a transgenic A53T synuclein mouse model.","volume":"35","author":"Kohl","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1083\/jcb.200404181","article-title":"The critical role of cyclin D2 in adult neurogenesis.","volume":"167","author":"Kowalczyk","year":"2004","journal-title":"J. Cell Biol."},{"key":"B43","doi-asserted-by":"publisher","first-page":"2271","DOI":"10.1084\/jem.20092401","article-title":"Engulfment of cerebral apoptotic bodies controls the course of prion disease in a mouse strain-dependent manner.","volume":"207","author":"Kranich","year":"2010","journal-title":"J. Exp. Med."},{"key":"B44","doi-asserted-by":"publisher","first-page":"826","DOI":"10.2174\/156652409789105543","article-title":"Prion protein misfolding.","volume":"9","author":"Kupfer","year":"2009","journal-title":"Curr. Mol. Med."},{"key":"B45","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2015.00093","article-title":"DISC1-mediated dysregulation of adult hippocampal neurogenesis in rats.","volume":"9","author":"Lee","year":"2015","journal-title":"Front. Syst. Neurosci."},{"key":"B46","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1517\/14728222.2013.829455","article-title":"Identification of MFG-E8 as a novel therapeutic target for diseases.","volume":"17","author":"Li","year":"2013","journal-title":"Expert Opin. Ther. Targets"},{"key":"B47","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.expneurol.2015.04.016","article-title":"MFGE8\/Integrin \u03b23 pathway alleviates apoptosis and inflammation in early brain injury after subarachnoid hemorrhage in rats.","volume":"272","author":"Liu","year":"2015","journal-title":"Exp. Neurol."},{"key":"B48","doi-asserted-by":"publisher","first-page":"E3536","DOI":"10.1073\/pnas.1703920114","article-title":"Intranasal MSC-derived A1-exosomes ease inflammation, and prevent abnormal neurogenesis and memory dysfunction after status epilepticus.","volume":"4","author":"Long","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B49","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1242\/dev.01551","article-title":"Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death.","volume":"132","author":"McCarty","year":"2005","journal-title":"Development"},{"key":"B50","doi-asserted-by":"publisher","first-page":"7667","DOI":"10.1128\/mcb.22.21.7667-7677.2002","article-title":"Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins.","volume":"22","author":"McCarty","year":"2002","journal-title":"Mol. Cell Biol."},{"key":"B51","doi-asserted-by":"publisher","first-page":"5983","DOI":"10.4049\/jimmunol.0802994","article-title":"Immature dendritic cell-derived exosomes rescue septic animals via milk fat globule epidermal growth factor-factor VIII [corrected].","volume":"183","author":"Miksa","year":"2009","journal-title":"J. Immunol."},{"key":"B52","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-6-85","article-title":"Adult hippocampal neurogenesis and its role in Alzheimer\u2019s disease.","volume":"6","author":"Mu","year":"2011","journal-title":"Mol. Neurodegener."},{"key":"B53","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1038\/35055553","article-title":"Neurons derived from radial glial cells establish radial units in neocortex.","volume":"409","author":"Noctor","year":"2001","journal-title":"Nature"},{"key":"B54","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1038\/ncb3045","article-title":"Direct cell-cell contact with the vascular niche maintains quiescent neural stem cells.","volume":"16","author":"Ottone","year":"2014","journal-title":"Nat. Cell Biol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"11564","DOI":"10.1523\/jneurosci.3796-05.2005","article-title":"Abnormalities of neurogenesis in the R6\/2 mouse model of Huntington\u2019s disease are attributable to the in vivo microenvironment.","volume":"25","author":"Phillips","year":"2005","journal-title":"J. Neurosci."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1186\/2191-219X-3-15","article-title":"Pharmacokinetics of the phosphatidylserine tracers 99mTc-lactadherin and 99mTc-annexin V in pigs.","volume":"3","author":"Poulsen","year":"2013","journal-title":"EJNMMI Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"1083","DOI":"10.1002\/mds.25075","article-title":"The incidence and prevalence of Huntington\u2019s disease: a systematic review and meta-analysis.","volume":"27","author":"Pringsheim","year":"2012","journal-title":"Mov. Disord."},{"key":"B58","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.scr.2010.09.005","article-title":"Stem cell integrins: implications for ex-vivo culture and cellular therapies.","volume":"6","author":"Prowse","year":"2011","journal-title":"Stem Cell Res."},{"key":"B59","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1016\/j.jconrel.2018.08.035","article-title":"Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson\u2019s disease.","volume":"287","author":"Qu","year":"2018","journal-title":"J. Control. Release"},{"key":"B60","doi-asserted-by":"publisher","first-page":"7694","DOI":"10.1523\/JNEUROSCI.5537-08.2009","article-title":"Regulation of radial glial survival by signals from the meninges.","volume":"29","author":"Radakovits","year":"2009","journal-title":"J. Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"514","DOI":"10.1038\/sj.mp.4001791","article-title":"Neural stem cell proliferation is decreased in schizophrenia, but not in depression.","volume":"11","author":"Reif","year":"2006","journal-title":"Mol. Psychiatry"},{"key":"B62","doi-asserted-by":"publisher","first-page":"240","DOI":"10.4161\/pri.29021","article-title":"Prion diseases and adult neurogenesis: how do prions counteract the brain\u2019s endogenous repair machinery?","volume":"8","author":"Rela\u00f1o-Gin\u00e9s","year":"2014","journal-title":"Prion"},{"key":"B63","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1038\/embor.2013.49","article-title":"Mechanosensitivity and compositional dynamics of cell-matrix adhesions.","volume":"14","author":"Schiller","year":"2013","journal-title":"EMBO Rep."},{"key":"B64","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1007\/s00401-010-0711-0","article-title":"The synaptic pathology of alpha-synuclein aggregation in dementia with lewy bodies, Parkinson\u2019s disease and Parkinson\u2019s disease dementia.","volume":"120","author":"Schulz-Schaeffer","year":"2010","journal-title":"Acta Neuropathol."},{"key":"B65","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.1242\/jcs.114.14.2553","article-title":"Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways.","volume":"114","author":"Schwartz","year":"2001","journal-title":"J. Cell Sci."},{"key":"B66","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1038\/nm1233","article-title":"Lactadherin promotes VEGF-dependent neovascularization.","volume":"11","author":"Silvestre","year":"2005","journal-title":"Nat. Med."},{"key":"B67","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1242\/dev.101907","article-title":"Integrin \u03b1v\u03b23 and thyroid hormones promote expansion of progenitors in embryonic neocortex.","volume":"141","author":"Stenzel","year":"2014","journal-title":"Development"},{"key":"B68","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.biochi.2006.10.014","article-title":"Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies.","volume":"89","author":"Subra","year":"2007","journal-title":"Biochimie"},{"key":"B69","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1016\/j.stem.2009.10.003","article-title":"Imbalance between GABAergic and glutamatergic transmission impairs adult neurogenesis in an animal model of Alzheimer\u2019s disease.","volume":"5","author":"Sun","year":"2009","journal-title":"Cell Stem Cell"},{"key":"B70","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1038\/nrn3707","article-title":"Growth and folding of the mammalian cerebral cortex: from molecules to malformations.","volume":"15","author":"Sun","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"B71","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.stem.2008.07.025","article-title":"A specialized vascular niche for adult neural stem cells.","volume":"3","author":"Tavazoie","year":"2008","journal-title":"Cell Stem Cell"},{"key":"B72","doi-asserted-by":"publisher","first-page":"3032","DOI":"10.1161\/strokeaha.107.488445","article-title":"Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke.","volume":"38","author":"Thored","year":"2007","journal-title":"Stroke"},{"key":"B73","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.biomaterials.2017.10.012","article-title":"Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy.","volume":"150","author":"Tian","year":"2018","journal-title":"Biomaterials"},{"key":"B74","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1111\/dgd.12135","article-title":"Asymmetric inheritance of Cyclin D2 maintains proliferative neural stem\/progenitor cells: a critical event in brain development and evolution.","volume":"56","author":"Tsunekawa","year":"2014","journal-title":"Dev. Growth Differ."},{"key":"B75","doi-asserted-by":"publisher","first-page":"3550","DOI":"10.4161\/cc.21500","article-title":"How to keep proliferative neural stem\/progenitor cells: a critical role of asymmetric inheritance of cyclin D2.","volume":"11","author":"Tsunekawa","year":"2012","journal-title":"Cell Cycle"},{"key":"B76","doi-asserted-by":"publisher","first-page":"1981","DOI":"10.1016\/j.ajpath.2014.03.017","article-title":"MFG-E8 regulates angiogenesis in cutaneous wound healing.","volume":"184","author":"Uchiyama","year":"2014","journal-title":"Am. J. Pathol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"273","DOI":"10.1016\/j.ebiom.2018.11.026","article-title":"Neural stem cell derived extracellular vesicles: attributes and prospects for treating neurodegenerative disorders.","volume":"38","author":"Vogel","year":"2018","journal-title":"EBioMedicine"},{"key":"B78","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1111\/j.1474-9726.2012.00813.x","article-title":"MFG-E8 activates proliferation of vascular smooth muscle cells via integrin signaling.","volume":"11","author":"Wang","year":"2012","journal-title":"Aging Cell"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a021287","article-title":"Adult neurogenesis in neurodegenerative diseases.","volume":"7","author":"Winner","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"B80","doi-asserted-by":"publisher","first-page":"700","DOI":"10.1182\/blood-2012-07-440644","article-title":"Structural framework of c-Src activation by integrin \u03b23.","volume":"121","author":"Xiao","year":"2013","journal-title":"Blood"},{"key":"B81","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-1094-3","article-title":"Milk fat globule epidermal growth factor-factor 8-derived peptide attenuates organ injury and improves survival in sepsis.","volume":"19","author":"Yang","year":"2015","journal-title":"Crit. Care"},{"key":"B82","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1038\/s41591-019-0348-z","article-title":"Biomarkers for Alzheimer\u2019s disease beyond amyloid and tau.","volume":"25","author":"Zetterberg","year":"2019","journal-title":"Nat. Med."},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1177\/1010428317707881","article-title":"MFG-E8 overexpression promotes colorectal cancer progression via AKT\/MMPs signalling.","volume":"39","author":"Zhao","year":"2017","journal-title":"Tumour Biol."},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.08.005","article-title":"Autocrine Mfge8 signaling prevents developmental exhaustion of the adult neural stem cell pool.","volume":"23","author":"Zhou","year":"2018","journal-title":"Cell Stem Cell"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.00569\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T04:06:29Z","timestamp":1663560389000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.00569\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,4]]},"references-count":84,"alternative-id":["10.3389\/fnins.2019.00569"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2019.00569","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,4]]},"article-number":"569"}}