{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T07:10:25Z","timestamp":1788851425948,"version":"build-2803163510"},"reference-count":129,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T00:00:00Z","timestamp":1560211200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20160101004JC"],"award-info":[{"award-number":["20160101004JC"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["20160414045GH"],"award-info":[{"award-number":["20160414045GH"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2019.00586","type":"journal-article","created":{"date-parts":[[2019,6,11]],"date-time":"2019-06-11T01:16:45Z","timestamp":1560215805000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":108,"title":["Neuroprotection by Therapeutic Hypothermia"],"prefix":"10.3389","volume":"13","author":[{"given":"Ying-Jian","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi-Yuan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Yu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,6,11]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1159\/000345645","article-title":"Evaluation of the therapeutic benefit of delayed administration of erythropoietin following early hypoxic-ischemic injury in rodents.","volume":"34","author":"Alexander","year":"2012","journal-title":"Dev. Neurosci."},{"key":"B2","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1016\/0003-4975(93)90014-9","article-title":"Effects of pH on brain energetics after hypothermic circulatory arrest.","volume":"55","author":"Aoki","year":"1993","journal-title":"Ann. Thorac. Surg."},{"key":"B3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.5152\/tpa.2015.2167","article-title":"Comparison of selective head cooling therapy and whole body cooling therapy in newborns with hypoxic ischemic encephalopathy: short term results.","volume":"50","author":"Atici","year":"2015","journal-title":"Turk. Pediatr. Ars."},{"key":"B4","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-8-17","article-title":"The TOBY study. Whole body hypothermia for the treatment of perinatal asphyxial encephalopathy: a randomised controlled trial.","volume":"8","author":"Azzopardi","year":"2008","journal-title":"BMC Pediatr."},{"key":"B5","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1203\/PDR.0b013e3181d4ff4d","article-title":"Phenobarbital augments hypothermic neuroprotection.","volume":"67","author":"Barks","year":"2010","journal-title":"Pediatr. Res."},{"key":"B6","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1089\/ther.2014.0002","article-title":"The effects of local and general hypothermia on temperature profiles of the central nervous system following spinal cord injury in rats.","volume":"4","author":"Bazley","year":"2014","journal-title":"Ther. Hypothermia Temp. Manag."},{"key":"B7","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1113\/jphysiol.2006.119602","article-title":"The effect of cerebral hypothermia on white and grey matter injury induced by severe hypoxia in preterm fetal sheep.","volume":"578","author":"Bennet","year":"2007","journal-title":"J. Physiol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1159\/000351011","article-title":"Docosahexaenoic acid augments hypothermic neuroprotection in a neonatal rat asphyxia model.","volume":"104","author":"Berman","year":"2013","journal-title":"Neonatology"},{"key":"B9","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1016\/S0021-9258(19)41781-X","article-title":"The synthesis of neurotensin.","volume":"250","author":"Carraway","year":"1975","journal-title":"J. Biol. Chem."},{"key":"B10","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1111\/ped.12747","article-title":"Comparison of selective head cooling versus whole-body cooling.","volume":"58","author":"Celik","year":"2016","journal-title":"Pediatr. Int."},{"key":"B11","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1016\/j.nbd.2011.04.010","article-title":"The RNA-binding protein RBM3 is involved in hypothermia induced neuroprotection.","volume":"43","author":"Chip","year":"2011","journal-title":"Neurobiol. Dis."},{"key":"B12","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1056\/NEJM200102223440803","article-title":"Lack of effect of induction of hypothermia after acute brain injury.","volume":"344","author":"Clifton","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"2906","DOI":"10.1073\/pnas.2628027100","article-title":"Hypothermia rescues hippocampal CA1 neurons and attenuates down-regulation of the AMPA receptor GluR2 subunit after forebrain ischemia.","volume":"100","author":"Colbourne","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B14","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1006\/bbrc.1997.7059","article-title":"Increased transcript level of RBM3, a member of the glycine-rich RNA-binding protein family, in human cells in response to cold stress.","volume":"236","author":"Danno","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B15","first-page":"954","article-title":"Sedation after cardiac arrest and during therapeutic hypothermia.","volume":"80","author":"Dell\u2019Anna","year":"2014","journal-title":"Minerva Anestesiol."},{"key":"B16","doi-asserted-by":"publisher","first-page":"2307","DOI":"10.1093\/hmg\/4.12.2307","article-title":"RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain.","volume":"4","author":"Derry","year":"1995","journal-title":"Hum. Mol. Genet."},{"key":"B17","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1097\/00000542-199701000-00007","article-title":"Changes in cerebrospinal fluid pressure and lactate concentrations during thoracoabdominal aortic aneurysm surgery.","volume":"86","author":"Drenger","year":"1997","journal-title":"Anesthesiology"},{"key":"B18","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.19-01-00503.1999","article-title":"Identification of the receptor subtype involved in the analgesic effect of neurotensin.","volume":"19","author":"Dubuc","year":"1999","journal-title":"J. Neurosci."},{"key":"B19","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1097\/00002826-200109000-00002","article-title":"Acute spinal cord injury, part I: pathophysiologic mechanisms.","volume":"24","author":"Dumont","year":"2001","journal-title":"Clin. Neuropharmacol."},{"key":"B20","doi-asserted-by":"publisher","first-page":"532","DOI":"10.2143\/AC.69.5.3044880","article-title":"Osborn wave in patients with ST-elevation myocardial infarction undergoing mild therapeutic hypothermia after cardiac arrest.","volume":"69","author":"Dzieciol","year":"2014","journal-title":"Acta Cardiol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1007\/978-0-387-89520-8_5","article-title":"The role of FasL and Fas in health and disease.","volume":"647","author":"Ehrenschwender","year":"2009","journal-title":"Adv. Exp. Med. Biol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/pr.2012.138","article-title":"Effects of combination therapy using hypothermia and erythropoietin in a rat model of neonatal hypoxia-ischemia.","volume":"73","author":"Fang","year":"2013","journal-title":"Pediatr. Res."},{"key":"B23","doi-asserted-by":"publisher","first-page":"C392","DOI":"10.1152\/ajpcell.00098.2011","article-title":"Enhanced survival of skeletal muscle myoblasts in response to overexpression of cold shock protein RBM3.","volume":"301","author":"Ferry","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B24","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00196","article-title":"The combination of human urinary kallidinogenase and mild hypothermia protects adult rats against hypoxic-ischemic encephalopathy-induced injury by promoting angiogenesis and regeneration.","volume":"10","author":"Gao","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"B25","doi-asserted-by":"publisher","DOI":"10.1038\/srep07091","article-title":"Combination of mild hypothermia with neuroprotectants has greater neuroprotective effects during oxygen-glucose deprivation and reoxygenation-mediated neuronal injury.","volume":"4","author":"Gao","year":"2014","journal-title":"Sci. Rep."},{"key":"B26","first-page":"239","article-title":"Effect of combination therapy using hypothermia and granulocyte colony-stimulating factor in a rat transient middle cerebral artery occlusion model.","volume":"18","author":"Ghahari","year":"2014","journal-title":"Iran. Biomed. J."},{"key":"B27","doi-asserted-by":"publisher","first-page":"1704","DOI":"10.1046\/j.1471-4159.1995.65041704.x","article-title":"Glutamate release and free radical production following brain injury: effects of posttraumatic hypothermia.","volume":"65","author":"Globus","year":"1995","journal-title":"J. Neurochem."},{"key":"B28","doi-asserted-by":"publisher","first-page":"E105","DOI":"10.1097\/CCM.0b013e31827c0b1f","article-title":"Effects of pretreatment hypothermia during resuscitated porcine hemorrhagic shock.","volume":"41","author":"Gr\u00f6ger","year":"2013","journal-title":"Crit. Care Med."},{"key":"B29","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1016\/j.expneurol.2015.02.029","article-title":"Pharmacologically induced hypothermia attenuates traumatic brain injury in neonatal rats.","volume":"267","author":"Gu","year":"2015","journal-title":"Exp. Neurol."},{"key":"B30","doi-asserted-by":"publisher","first-page":"720","DOI":"10.23736\/S0375-9393.18.12164-X","article-title":"Effect of therapeutic hypothermia on survival and neurological outcome in adults suffering cardiac arrest: a systematic review and meta-analysis.","volume":"84","author":"Hakim","year":"2018","journal-title":"Minerva Anestesiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1038\/nrm3270","article-title":"The unfolded protein response: controlling cell fate decisions under ER stress and beyond.","volume":"13","author":"Hetz","year":"2012","journal-title":"Nat. Rev. Mol. Cell. Biol."},{"key":"B32","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1111\/j.1399-6576.2007.01353.x","article-title":"Anti-inflammatory effects of sevoflurane and mild hypothermia in endotoxemic rats.","volume":"51","author":"Hofstetter","year":"2007","journal-title":"Acta Anaesthesiol. Scand."},{"key":"B33","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.surneu.2005.12.028","article-title":"Inflammation in stroke and focal cerebral ischemia.","volume":"66","author":"Huang","year":"2006","journal-title":"Surg. Neurol."},{"key":"B34","doi-asserted-by":"publisher","first-page":"1211","DOI":"10.1111\/j.1399-6576.2007.01419.x","article-title":"Induced mild hypothermia reduces mortality during acute inflammation in rats.","volume":"51","author":"Huet","year":"2007","journal-title":"Acta Anaesthesiol. Scand."},{"key":"B35","doi-asserted-by":"publisher","first-page":"2447","DOI":"10.1056\/NEJMoa0706930","article-title":"Hypothermia therapy after traumatic brain injury in children.","volume":"358","author":"Hutchison","year":"2008","journal-title":"N. Engl. J. Med."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1417","DOI":"10.1089\/neu.2013.3251","article-title":"Therapeutic effects of pharmacologically induced hypothermia against traumatic brain injury in mice.","volume":"31","author":"Hwan","year":"2014","journal-title":"J. Neurotrauma"},{"key":"B37","doi-asserted-by":"crossref","DOI":"10.12659\/MSM.883208","article-title":"Comparison of whole-body cooling and selective head cooling on changes in urinary 8-hydroxy-2-deoxyguanosine levels in patients with global brain ischemia undergoing mild hypothermia therapy.","volume":"18","author":"Ikeda","year":"2012","journal-title":"Med. Sci. Monit."},{"key":"B38","first-page":"199","article-title":"Hypothermia prevents biphasic glutamate release and corresponding neuronal degeneration after transient spinal cord ischemia in the rat.","volume":"19","author":"Ishikawa","year":"1999","journal-title":"Cell Mol. Neurobiol."},{"key":"B39","doi-asserted-by":"publisher","first-page":"692","DOI":"10.1001\/archpediatrics.2011.43","article-title":"Whole-body hypothermia for term and near-term newborns with hypoxic-ischemic encephalopathy: a randomized controlled trial.","volume":"165","author":"Jacobs","year":"2011","journal-title":"Arch. Pediatr. Adolesc. Med."},{"key":"B40","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/j.surg.2014.03.038","article-title":"Development of a novel neuroprotective strategy: combined treatment with hypothermia and valproic acid improves survival in hypoxic hippocampal cells.","volume":"156","author":"Jin","year":"2014","journal-title":"Surgery"},{"key":"B41","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1021\/acschemneuro.5b00056","article-title":"Translating drug-induced hibernation to therapeutic hypothermia.","volume":"6","author":"Jinka","year":"2015","journal-title":"ACS Chem. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.brainres.2012.05.001","article-title":"Mild hypothermia facilitates the expression of cold-inducible RNA-binding protein and heat shock protein 70.1 in mouse brain.","volume":"1466","author":"Kaneko","year":"2012","journal-title":"Brain Res."},{"key":"B43","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1177\/1941874413519802","article-title":"Therapeutic hypothermia for neuroprotection: history, mechanisms, risks, and clinical applications.","volume":"4","author":"Karnatovskaia","year":"2014","journal-title":"Neurohospitalist"},{"key":"B44","doi-asserted-by":"publisher","first-page":"806","DOI":"10.1097\/01.ccm.0000114998.00860.fd","article-title":"Neurotensin-induced hypothermia improves neurologic outcome after hypoxic-ischemia.","volume":"32","author":"Katz","year":"2004","journal-title":"Crit. Care Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.neuropharm.2004.10.008","article-title":"In vivo behavioral effects of stable, receptor-selective neurotensin[8\u201313] analogues that cross the blood\u2013brain barrier.","volume":"48","author":"Kokko","year":"2005","journal-title":"Neuropharmacology"},{"key":"B46","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1111\/j.1749-6632.2009.05358.x","article-title":"Neuroprotection by hypothermia plus alkalinization of dorsal root ganglia neurons through ischemia.","volume":"1199","author":"Kuffler","year":"2010","journal-title":"Ann. N. Y. Acad Sci."},{"key":"B47","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1016\/s0304-3940(96)13238-9","article-title":"Hypothermia suppresses nitric oxide elevation during reperfusion after focal cerebral ischemia in rats.","volume":"220","author":"Kumura","year":"1996","journal-title":"Neurosci. Lett."},{"key":"B48","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2016.00323","article-title":"Effects of cannabidiol and hypothermia on short-term brain damage in new-born piglets after acute hypoxia-ischemia.","volume":"10","author":"Lafuente","year":"2016","journal-title":"Front. Neurosci."},{"key":"B49","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1016\/j.bbrc.2015.07.066","article-title":"Cold-inducible RNA-binding protein, CIRP, inhibits DNA damage-induced apoptosis by regulating p53.","volume":"464","author":"Lee","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B50","doi-asserted-by":"publisher","first-page":"289","DOI":"10.3171\/jns.2005.103.2.0289","article-title":"Reduction in levels of matrix metalloproteinases and increased expression of tissue inhibitor of metalloproteinase-2 in response to mild hypothermia therapy in experimental stroke.","volume":"103","author":"Lee","year":"2005","journal-title":"J. Neurosurg."},{"key":"B51","doi-asserted-by":"publisher","first-page":"1907","DOI":"10.1161\/STROKEAHA.116.013061","article-title":"Improved therapeutic benefits by combining physical cooling with pharmacological hypothermia after severe stroke in rats.","volume":"47","author":"Lee","year":"2016","journal-title":"Stroke"},{"key":"B52","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.jns.2008.07.029","article-title":"Atorvastatin enhances hypothermia-induced neuroprotection after stroke.","volume":"275","author":"Lee","year":"2008","journal-title":"J. Neurol. Sci."},{"key":"B53","doi-asserted-by":"crossref","DOI":"10.5137\/1019-5149.JTN.19696-16.2","article-title":"Hypothermia therapy after traumatic brain injury: a systematic review and meta-analysis.","author":"Leng","year":"2017","journal-title":"Turk. Neurosurg."},{"key":"B54","doi-asserted-by":"publisher","first-page":"871","DOI":"10.1089\/neu.2000.17.871","article-title":"Free radical pathways in CNS injury.","volume":"17","author":"Lewen","year":"2000","journal-title":"J. Neurotrauma"},{"key":"B55","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.brainres.2011.12.053","article-title":"Cold-inducible RNA binding protein inhibits H2O2-induced apoptosis in rat cortical neurons.","volume":"1441","author":"Li","year":"2012","journal-title":"Brain Res."},{"key":"B56","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.brainres.2014.11.061","article-title":"Cloning, expression, and purification of cold inducible RNA-binding protein and its neuroprotective mechanism of action.","volume":"1597","author":"Liu","year":"2015","journal-title":"Brain Res."},{"key":"B57","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1179\/1743132815Y.0000000031","article-title":"Enhanced beneficial effects of mild hypothermia by phenothiazine drugs in stroke therapy.","volume":"37","author":"Liu","year":"2015","journal-title":"Neurol. Res."},{"key":"B58","doi-asserted-by":"publisher","first-page":"541","DOI":"10.1111\/j.1471-4159.2008.05411.x","article-title":"FasL shedding is reduced by hypothermia in experimental stroke.","volume":"106","author":"Liu","year":"2008","journal-title":"J. Neurochem."},{"key":"B59","doi-asserted-by":"publisher","first-page":"559","DOI":"10.1038\/pr.2012.7","article-title":"Bumetanide augments the neuroprotective efficacy of phenobarbital plus hypothermia in a neonatal hypoxia-ischemia model.","volume":"71","author":"Liu","year":"2012","journal-title":"Pediatr. Res."},{"key":"B60","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0170682","article-title":"Anesthesia-induced hypothermia attenuates early-phase blood-brain barrier disruption but not infarct volume following cerebral ischemia.","volume":"12","author":"Liu","year":"2017","journal-title":"PLoS One"},{"key":"B61","doi-asserted-by":"publisher","first-page":"1655","DOI":"10.4103\/1673-5374.217338","article-title":"Effect of erythropoietin combined with hypothermia on serum tau protein levels and neurodevelopmental outcome in neonates with hypoxic-ischemic encephalopathy.","volume":"12","author":"Lv","year":"2017","journal-title":"Neural Regen. Res."},{"key":"B62","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1002\/ana.20547","article-title":"Xenon and hypothermia combine to provide neuroprotection from neonatal asphyxia.","volume":"58","author":"Ma","year":"2005","journal-title":"Ann. Neurol."},{"key":"B63","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1089\/neu.2013.3197","article-title":"Prolonged mild therapeutic hypothermia versus fever control with tight hemodynamic monitoring and slow rewarming in patients with severe traumatic brain injury: a randomized controlled trial.","volume":"32","author":"Maekawa","year":"2015","journal-title":"J. Neurotrauma"},{"key":"B64","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.jneumeth.2011.01.033","article-title":"Electrochemical detection of endogenous glutamate release from rat spinal cord organotypic slices as a real-time method to monitor excitotoxicity.","volume":"197","author":"Mazzone","year":"2011","journal-title":"J. Neurosci. Methods"},{"key":"B65","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1097\/ta.0b013e3182826edd","article-title":"Induced hypothermia does not impair coagulation system in a swine multiple trauma model.","volume":"74","author":"Mohr","year":"2013","journal-title":"J. Trauma Acute Care Surg."},{"key":"B66","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jocn.2005.07.005","article-title":"Inflammation following stroke.","volume":"13","author":"Nilupul Perera","year":"2006","journal-title":"J. Clin. Neurosci."},{"key":"B67","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1083\/jcb.137.4.899","article-title":"A glycine-rich RNA-binding protein mediating cold-inducible suppression of mammalian cell growth.","volume":"137","author":"Nishiyama","year":"1997","journal-title":"J. Cell Biol."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1143","DOI":"10.1038\/jcbfm.2010.208","article-title":"Combinational therapy using hypothermia and the immunophilin ligand FK506 to target altered pial arteriolar reactivity, axonal damage, and blood-brain barrier dysfunction after traumatic brain injury in rat.","volume":"31","author":"Oda","year":"2011","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B69","doi-asserted-by":"publisher","first-page":"e1149","DOI":"10.1097\/CCM.0000000000002690","article-title":"Valproic acid combined with postcardiac arrest hypothermic-targeted temperature management prevents delayed seizures and improves survival in a rat cardiac arrest model.","volume":"45","author":"Oh","year":"2017","journal-title":"Crit. Care Med."},{"key":"B70","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1016\/j.braindev.2005.01.004","article-title":"Prolonged hypothermia protects neonatal rat brain against hypoxic-ischemia by reducing both apoptosis and necrosis.","volume":"27","author":"Ohmura","year":"2005","journal-title":"Brain Dev."},{"key":"B71","doi-asserted-by":"publisher","first-page":"E1551","DOI":"10.1097\/BRS.0b013e31826ff7f1","article-title":"Neuroprotective effects of hypothermia after spinal cord injury in rats: comparative study between epidural hypothermia and systemic hypothermia.","volume":"37","author":"Ok","year":"2012","journal-title":"Spine"},{"key":"B72","doi-asserted-by":"publisher","first-page":"754","DOI":"10.1089\/0897715041269641","article-title":"The role of excitotoxicity in secondary mechanisms of spinal cord injury: a review with an emphasis on the implications for white matter degeneration.","volume":"21","author":"Park","year":"2004","journal-title":"J. Neurotrauma"},{"key":"B73","doi-asserted-by":"publisher","first-page":"32520","DOI":"10.1074\/jbc.274.45.32520","article-title":"Involvement of DNA-dependent protein kinase in UV-induced replication arrest.","volume":"274","author":"Park","year":"1999","journal-title":"J. Biol. Chem."},{"key":"B74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120893","article-title":"Hypothermia augments neuroprotective activity of mesenchymal stem cells for neonatal hypoxic-ischemic encephalopathy.","volume":"10","author":"Park","year":"2015","journal-title":"PLoS One"},{"key":"B75","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1210\/er.2009-0040","article-title":"Thyronamines\u2013past, present, and future.","volume":"32","author":"Piehl","year":"2011","journal-title":"Endocr. Rev."},{"key":"B76","doi-asserted-by":"publisher","first-page":"15318","DOI":"10.1073\/pnas.261323298","article-title":"BID mediates neuronal cell death after oxygen\/ glucose deprivation and focal cerebral ischemia.","volume":"98","author":"Plesnila","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2011.292","article-title":"Improved neuroprotection with melatonin-augmented hypothermia vs hypothermia alone in a perinatal asphyxia model: a randomized study.","volume":"96","author":"Powell","year":"2011","journal-title":"Pediatr. Res."},{"key":"B78","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1093\/brain\/aws285","article-title":"Melatonin augments hypothermic neuroprotection in a perinatal asphyxia model.","volume":"136","author":"Robertson","year":"2013","journal-title":"Brain"},{"key":"B79","doi-asserted-by":"publisher","first-page":"2925","DOI":"10.1093\/brain\/awy220","article-title":"Neuroprotective exendin-4 enhances hypothermia therapy in a model of hypoxic-ischaemic encephalopathy.","volume":"141","author":"Rocha-Ferreira","year":"2018","journal-title":"Brain"},{"key":"B80","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2147\/HP.S132462","article-title":"Neuroprotection via RNA-binding protein RBM3 expression is regulated by hypothermia but not by hypoxia in human SK-N-SH neurons.","volume":"5","author":"Rosenthal","year":"2017","journal-title":"Hypoxia"},{"key":"B81","doi-asserted-by":"publisher","first-page":"1001","DOI":"10.1542\/peds.2005-0328","article-title":"Mild hypothermia and the distribution of cerebral lesions in neonates with hypoxic-ischemic encephalopathy.","volume":"116","author":"Rutherford","year":"2005","journal-title":"Pediatrics"},{"key":"B82","doi-asserted-by":"publisher","first-page":"50015","DOI":"10.1074\/jbc.M209258200","article-title":"Comprehensive expression analysis of time-dependent genetic responses in yeast cells to low temperature.","volume":"277","author":"Sahara","year":"2002","journal-title":"J. Biol. Chem."},{"key":"B83","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/j.jocn.2009.05.016","article-title":"Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats.","volume":"17","author":"Sahin","year":"2010","journal-title":"J. Clin. Neurosci."},{"key":"B84","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.2174\/138161207781368756","article-title":"Cooling the injured brain: how does moderate hypothermia influence the pathophysiology of traumatic brain injury.","volume":"13","author":"Sahuquillo","year":"2007","journal-title":"Curr. Pharm. Des."},{"key":"B85","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.bbamcr.2006.02.007","article-title":"Cirp protects against tumor necrosis factor-\u03b1-induced apoptosis via activation of extracellular signal-regulated kinase.","volume":"1763","author":"Sakurai","year":"2006","journal-title":"Biochim. Biophys. Acta"},{"key":"B86","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1055\/s-0028-1103154","article-title":"Pulmonary dysfunction and therapeutic hypothermia in asphyxiated newborns: whole body versus selective head cooling.","volume":"26","author":"Sarkar","year":"","journal-title":"Am. J. Perinatol."},{"key":"B87","doi-asserted-by":"publisher","first-page":"558","DOI":"10.1038\/jp.2009.37","article-title":"Effects of therapeutic hypothermia on multiorgan dysfunction in asphyxiated newborns: whole-body cooling versus selective head cooling.","volume":"29","author":"Sarkar","year":"","journal-title":"J. Perinatol."},{"key":"B88","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/j.pathophys.2003.09.001","article-title":"Hypothermia and stroke: the pathophysiological background.","volume":"10","author":"Schaller","year":"2003","journal-title":"Pathophysiology"},{"key":"B89","author":"Schwab","year":"1998","journal-title":"Moderate Hypothermia in the Treatment of Patients with Severe Middle Cerebral Artery Infarction."},{"key":"B90","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.bbamcr.2010.11.024","article-title":"BH3-only proteins: orchestrators of apoptosis.","volume":"1813","author":"Shamas-Din","year":"2011","journal-title":"Biochim. Biophys. Acta"},{"key":"B91","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1056\/NEJMcps050929","article-title":"Whole-body hypothermia for neonates with hypoxic-ischemic encephalopathy.","volume":"353","author":"Shankaran","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"B92","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.bbr.2011.06.014","article-title":"The role of NTS2 in the development of tolerance to NT69L in mouse models for hypothermia and thermal analgesia.","volume":"224","author":"Smith","year":"2011","journal-title":"Behav. Brain Res."},{"key":"B93","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1242\/jeb.079160","article-title":"Is cold acclimation of benefit to hibernating rodents?","volume":"216","author":"Stuart","year":"2013","journal-title":"J. Exp. Biol."},{"key":"B94","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.neuint.2019.03.006","article-title":"Therapeutic hypothermia protects photoreceptors through activating Cirbp pathway.","volume":"126","author":"Sun","year":"2019","journal-title":"Neurochem. Int."},{"key":"B95","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s12017-012-8167-0","article-title":"C5a receptor (CD88) inhibition improves hypothermia-induced neuroprotection in an in vitro ischemic model.","volume":"14","author":"Thundyil","year":"2012","journal-title":"Neuromol. Med."},{"key":"B96","doi-asserted-by":"publisher","first-page":"2393","DOI":"10.1089\/neu.2012.2374","article-title":"Combination of temperature-sensitive stem cells and mild hypothermia: a new potential therapy for severe traumatic brain injury.","volume":"29","author":"Tu","year":"2012","journal-title":"J. Neurotrauma"},{"key":"B97","doi-asserted-by":"publisher","first-page":"931","DOI":"10.4103\/1673-5374.184491","article-title":"Neuroprotective effects of bloodletting at jing points combined with mild induced hypothermia in acute severe traumatic brain injury.","volume":"11","author":"Tu","year":"2016","journal-title":"Neural Regen. Res."},{"key":"B98","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/s0167-0115(00)00183-x","article-title":"Neurotensin: peptide for the next millennium.","volume":"93","author":"Tyler-McMahon","year":"","journal-title":"Regul. Pept."},{"key":"B99","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/s0014-2999(99)00877-8","article-title":"Highly potent neurotensin analog that causes hypothermia and antinociception.","volume":"390","author":"Tyler-McMahon","year":"","journal-title":"Eur. J. Pharmacol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"638","DOI":"10.1016\/j.tice.2017.09.004","article-title":"Enhanced neuroprotective effect of mild-hypothermia with VPA against ethanol-mediated neuronal injury.","volume":"49","author":"Vishwakarma","year":"2017","journal-title":"Tissue Cell"},{"key":"B101","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1159\/000059387","article-title":"Anti-inflammatory cytokines: expression and action in the brain.","volume":"9","author":"Vitkovic","year":"2001","journal-title":"Neuroimmunomodulation"},{"key":"B102","doi-asserted-by":"publisher","first-page":"2189","DOI":"10.4103\/1673-5374.147952","article-title":"Mild hypothermia combined with a scaffold of NgR-silenced neural stem cells\/Schwann cells to treat spinal cord injury.","volume":"9","author":"Wang","year":"2014","journal-title":"Neural Regen. Res."},{"key":"B103","doi-asserted-by":"publisher","first-page":"1745","DOI":"10.4103\/1673-5374.143417","article-title":"Mild hypothermia combined with neural stem cell transplantation for hypoxic-ischemic encephalopathy: neuroprotective effects of combined therapy.","volume":"9","author":"Wang","year":"2014","journal-title":"Neural Regen. Res."},{"key":"B104","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.3892\/mmr.2014.2905","article-title":"Effects of hypothermia combined with neural stem cell transplantation on recovery of neurological function in rats with spinal cord injury.","volume":"11","author":"Wang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"B105","doi-asserted-by":"publisher","first-page":"272","DOI":"10.3171\/jns.2004.100.2.0272","article-title":"Rapid and selective cerebral hypothermia achieved using a cooling helmet.","volume":"100","author":"Wang","year":"2004","journal-title":"J. Neurosurg."},{"key":"B106","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s00701-006-0747-z","article-title":"Cold as a therapeutic agent.","volume":"148","author":"Wang","year":"2006","journal-title":"Acta Neurochir."},{"key":"B107","first-page":"246","article-title":"Effect of mild hypothermia on glucose metabolism and glycerol of brain tissue in patients with severe traumatic brain injury.","volume":"10","author":"Wang","year":"2007","journal-title":"Chin. J. Traumatol."},{"key":"B108","doi-asserted-by":"publisher","DOI":"10.1038\/srep01388","article-title":"Anesthesia-induced hypothermia mediates decreased ARC gene and protein expression through ERK\/MAPK inactivation.","volume":"3","author":"Whittington","year":"2013","journal-title":"Sci. Rep."},{"key":"B109","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1089\/ther.2014.0014","article-title":"Mild therapeutic hypothermia does not reduce thrombin-induced brain injury.","volume":"4","author":"Wowk","year":"2014","journal-title":"Ther. Hypothermia Temp. Manag."},{"key":"B110","doi-asserted-by":"publisher","first-page":"891","DOI":"10.3892\/etm.2017.4044","article-title":"Emulsified isoflurane combined with therapeutic hypothermia improves survival and neurological outcomes in a rat model of cardiac arrest.","volume":"13","author":"Wu","year":"2017","journal-title":"Exp. Ther. Med."},{"key":"B111","doi-asserted-by":"publisher","first-page":"2140","DOI":"10.1016\/j.jpedsurg.2013.02.065","article-title":"The protective effect of cold-inducible rna-binding protein (CIRP) on testicular torsion\/detorsion: an experimental study in mice.","volume":"48","author":"Xia","year":"2013","journal-title":"J. Pediatr. Surg."},{"key":"B112","doi-asserted-by":"publisher","first-page":"1279","DOI":"10.4103\/1673-5374.162761","article-title":"Dantrolene enhances the protective effect of hypothermia on cerebral cortex neurons.","volume":"10","author":"Xu","year":"2015","journal-title":"Neural Regen. Res."},{"key":"B113","doi-asserted-by":"publisher","first-page":"1238","DOI":"10.1016\/s0891-5849(99)00158-6","article-title":"Effects of ischemia and H2O2 on the cold stress protein CIRP expression in rat neuronal cells.","volume":"27","author":"Xue","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"B114","doi-asserted-by":"publisher","DOI":"10.1038\/srep41738","article-title":"RNA-binding protein RBM3 prevents NO-induced apoptosis in human neuroblastoma cells by modulating p38 signaling and miR-143.","volume":"7","author":"Yang","year":"2017","journal-title":"Sci. Rep."},{"key":"B115","doi-asserted-by":"publisher","first-page":"971","DOI":"10.1097\/00004647-200208000-00008","article-title":"Elevated intracranial IL-18 in humans and mice after traumatic brain injury and evidence of neuroprotective effects of IL-18-binding protein after experimental closed head injury.","volume":"22","author":"Yatsiv","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B116","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1097\/00004647-200201000-00004","article-title":"Mild hypothermia attenuates cytochrome c release but does not alter Bcl-2 expression or caspase activation after experimental stroke.","volume":"22","author":"Yenari","year":"2002","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"B117","first-page":"4293","article-title":"Cellular levels of thioredoxin associated with drug sensitivity to cisplatin, mitomycin c, doxorubicin, and etoposide.","volume":"55","author":"Yokomizo","year":"1995","journal-title":"Cancer Res."},{"key":"B118","doi-asserted-by":"publisher","first-page":"3108","DOI":"10.1080\/14767058.2017.1365123","article-title":"Therapeutic hypothermia in infants with hypoxic-ischemic encephalopathy and reversible persistent pulmonary hypertension: short-term hospital outcomes.","volume":"31","author":"Yum","year":"2018","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"B119","doi-asserted-by":"publisher","first-page":"578","DOI":"10.14336\/AD.2017.0817","article-title":"Synergistically induced hypothermia and enhanced neuroprotection by pharmacological and physical approaches in stroke.","volume":"9","author":"Zhang","year":"2018","journal-title":"Aging Dis."},{"key":"B120","doi-asserted-by":"publisher","first-page":"507","DOI":"10.14336\/AD.2017.0628","article-title":"Effects of therapeutic hypothermia combined with other neuroprotective strategies on ischemic stroke: review of evidence.","volume":"9","author":"Zhang","year":"2018","journal-title":"Aging Dis."},{"key":"B121","doi-asserted-by":"publisher","first-page":"371","DOI":"10.2174\/1871527311312030010","article-title":"Drug-induced hypothermia in stroke models: does it always protect?","volume":"12","author":"Zhang","year":"2013","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"B122","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.4103\/1673-5374.238617","article-title":"Combination of mild therapeutic hypothermia and adipose-derived stem cells for ischemic brain injury.","volume":"13","author":"Zhao","year":"2018","journal-title":"Neural Regen. Res."},{"key":"B123","doi-asserted-by":"publisher","first-page":"22235","DOI":"10.18632\/oncotarget.14755","article-title":"RNA binding motif protein 3: a potential biomarker in cancer and therapeutic target in neuroprotection.","volume":"8","author":"Zhou","year":"2017","journal-title":"Oncotarget"},{"key":"B124","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.brainres.2003.10.013","article-title":"Post-ischemic hypothermia-induced tissue protection and diminished apoptosis after neonatal cerebral hypoxia-ischemia.","volume":"996","author":"Zhu","year":"2004","journal-title":"Brain Res."},{"key":"B125","doi-asserted-by":"publisher","first-page":"361","DOI":"10.1016\/j.expneurol.2005.01.022","article-title":"Post-ischemic modest hypothermia (35 degrees C) combined with intravenous magnesium is more effective at reducing CA1 neuronal death than either treatment used alone following global cerebral ischemia in rats.","volume":"193","author":"Zhu","year":"2005","journal-title":"Exp. Neurol."},{"key":"B126","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1159\/000369007","article-title":"Additive neuroprotection of a 20-hete inhibitor with delayed therapeutic hypothermia after hypoxia-ischemia in neonatal piglets.","volume":"37","author":"Zhu","year":"2015","journal-title":"Dev. Neurosci."},{"key":"B127","doi-asserted-by":"publisher","first-page":"3839","DOI":"10.1007\/s00018-016-2253-7","article-title":"Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold.","volume":"73","author":"Zhu","year":"","journal-title":"Cell. Mol. Life Sci."},{"key":"B128","doi-asserted-by":"publisher","first-page":"624","DOI":"10.1096\/fj.15-274639","article-title":"Cold-inducible RBM3 inhibits PERK phosphorylation through cooperation with NF90 to protect cells from endoplasmic reticulum stress.","volume":"30","author":"Zhu","year":"","journal-title":"FASEB J."},{"key":"B129","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1007\/s12031-017-0964-3","article-title":"Cold-inducible protein RBM3 Protects UV irradiation-induced apoptosis in neuroblastoma cells by affecting p38 and JNK pathways and Bcl2 family proteins.","volume":"63","author":"Zhuang","year":"2017","journal-title":"J. Mol. Neurosci."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.00586\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T03:13:44Z","timestamp":1663643624000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.00586\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6,11]]},"references-count":129,"alternative-id":["10.3389\/fnins.2019.00586"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2019.00586","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,11]]},"article-number":"586"}}