{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T19:51:41Z","timestamp":1792612301776,"version":"4.5.0"},"reference-count":214,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T00:00:00Z","timestamp":1566950400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS056224"],"award-info":[{"award-number":["R01NS056224"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2019.00862","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T06:18:45Z","timestamp":1566973125000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":201,"title":["Neuronal Sigma-1 Receptors: Signaling Functions and Protective Roles in Neurodegenerative Diseases"],"prefix":"10.3389","volume":"13","author":[{"given":"Daniel A.","family":"Ryskamp","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Svetlana","family":"Korban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Zhemkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Kraskovskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilya","family":"Bezprozvanny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,8,28]]},"reference":[{"key":"B1","first-page":"517","article-title":"Amelioration of the haloperidol-induced memory impairment and brain oxidative stress by cinnarizine.","volume":"11","author":"Abdel-Salam","year":"2012","journal-title":"EXCLI J."},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20170898","article-title":"Sigmar1 regulates endoplasmic reticulum stress-induced C\/EBP-homologous protein expression in cardiomyocytes.","volume":"37","author":"Alam","year":"2017","journal-title":"Biosci. Rep."},{"key":"B3","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.brainresbull.2011.03.019","article-title":"Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats.","volume":"85","author":"Allahtavakoli","year":"2011","journal-title":"Brain Res. Bull."},{"key":"B4","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1002\/ana.22534","article-title":"A mutation in sigma-1 receptor causes juvenile amyotrophic lateral sclerosis.","volume":"70","author":"Al-Saif","year":"2011","journal-title":"Ann. Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1111\/j.1471-4159.2009.06000.x","article-title":"Anti-amnesic properties of (\u00b1)-PPCC, a novel sigma receptor ligand, on cognitive dysfunction induced by selective cholinergic lesion in rats.","volume":"109","author":"Antonini","year":"2009","journal-title":"J. Neurochem."},{"key":"B6","doi-asserted-by":"publisher","first-page":"399","DOI":"10.1016\/s0896-6273(02)00677-3","article-title":"The sigma receptor as a ligand-regulated auxiliary potassium channel subunit.","volume":"34","author":"Aydar","year":"2002","journal-title":"Neuron"},{"key":"B7","doi-asserted-by":"publisher","first-page":"32353","DOI":"10.1074\/jbc.M114.603506","article-title":"A direct interaction between the sigma-1 receptor and the hERG voltage-gated K+ channel revealed by atomic force microscopy and homogeneous time-resolved fluorescence (HTRF(R)).","volume":"289","author":"Balasuriya","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B8","doi-asserted-by":"publisher","first-page":"37021","DOI":"10.1074\/jbc.M112.382077","article-title":"The sigma-1 receptor binds to the Nav1.5 voltage-gated Na+ channel with 4-fold symmetry.","volume":"287","author":"Balasuriya","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B9","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1016\/j.neuron.2015.10.038","article-title":"RAN translation in huntington disease.","volume":"88","author":"Banez-Coronel","year":"2015","journal-title":"Neuron"},{"key":"B10","doi-asserted-by":"publisher","first-page":"875","DOI":"10.1093\/brain\/awv008","article-title":"Dysfunction in endoplasmic reticulum-mitochondria crosstalk underlies SIGMAR1 loss of function mediated motor neuron degeneration.","volume":"138","author":"Bernard-Marissal","year":"2015","journal-title":"Brain"},{"key":"B11","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.spjpm.2016.03.003","article-title":"Sigma-1 receptor as a potential pharmacological target for the treatment of neuropathology.","volume":"2","author":"Bolshakova","year":"2016","journal-title":"St. Petersburg Polytech. Univ. J.: Phys. Math."},{"key":"B12","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s10517-017-3968-7","article-title":"Neuroprotective effect of sigma1-receptors on the cell model of huntington\u2019s disease.","volume":"164","author":"Bol\u2019shakova","year":"2017","journal-title":"Bull. Exp. Biol. Med."},{"key":"B13","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/j.conb.2007.04.009","article-title":"Do thin spines learn to be mushroom spines that remember?","volume":"17","author":"Bourne","year":"2007","journal-title":"Curr Opin Neurobiol"},{"key":"B14","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1042\/BJ20150934","article-title":"Cocaine inhibits store-operated Ca2+ entry in brain microvascular endothelial cells: critical role for sigma-1 receptors.","volume":"473","author":"Brailoiu","year":"2016","journal-title":"Biochem. J."},{"key":"B15","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1016\/j.neuron.2006.01.020","article-title":"M1 receptors play a central role in modulating AD-like pathology in transgenic mice.","volume":"49","author":"Caccamo","year":"2006","journal-title":"Neuron"},{"key":"B16","doi-asserted-by":"publisher","first-page":"6266","DOI":"10.1021\/bi300010w","article-title":"Membrane protein structure determination using crystallography and lipidic mesophases: recent advances and successes.","volume":"51","author":"Caffrey","year":"2012","journal-title":"Biochemistry"},{"key":"B17","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1016\/j.bpj.2009.12.4293","article-title":"Demonstration of a direct interaction between sigma-1 receptors and acid-sensing ion channels.","volume":"98","author":"Carnally","year":"2010","journal-title":"Biophys. J."},{"key":"B18","doi-asserted-by":"publisher","first-page":"3532","DOI":"10.1021\/bi061727o","article-title":"Characterization of the cocaine binding site on the sigma-1 receptor.","volume":"46","author":"Chen","year":"2007","journal-title":"Biochemistry"},{"key":"B19","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1021\/bi301517u","article-title":"Photoaffinity labeling of the sigma-1 receptor with N-[3-(4-nitrophenyl) propyl]-N-dodecylamine: evidence of receptor dimers.","volume":"52","author":"Chu","year":"2013","journal-title":"Biochemistry"},{"key":"B20","doi-asserted-by":"publisher","first-page":"2801","DOI":"10.1111\/j.1476-5381.1995.tb15929.x","article-title":"Blockade by sigma site ligands of high voltage-activated Ca2+ channels in rat and mouse cultured hippocampal pyramidal neurones.","volume":"116","author":"Church","year":"1995","journal-title":"Br. J. Pharmacol."},{"key":"B21","doi-asserted-by":"publisher","first-page":"27947","DOI":"10.1074\/jbc.M111.226738","article-title":"Sig1R protein regulates hERG channel expression through a post-translational mechanism in leukemic cells.","volume":"286","author":"Crottes","year":"2011","journal-title":"J. Biol. Chem."},{"key":"B22","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1016\/S1474-4422(11)70233-2","article-title":"Mermai, pridopidine for the treatment of motor function in patients with huntington\u2019s disease (MermaiHD): a phase 3, randomised, double-blind, placebo-controlled trial.","volume":"10","author":"De Yebenes","year":"2011","journal-title":"Lancet Neurol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s41380-018-0092-7","article-title":"Cocaine engages a non-canonical, dopamine-independent, mechanism that controls neuronal excitability in the nucleus accumbens.","volume":"2018","author":"Delint-Ramirez","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"B24","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1007\/s10571-015-0244-0","article-title":"Sigma-1 receptor modulates neuroinflammation after traumatic brain injury.","volume":"36","author":"Dong","year":"2016","journal-title":"Cell. Mol. Neurobiol."},{"key":"B25","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.ejphar.2009.11.025","article-title":"The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties.","volume":"628","author":"Dyhring","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.nbd.2019.05.009","article-title":"Pridopidine protects neurons from mutant-huntingtin toxicity via the sigma-1 receptor.","volume":"129","author":"Eddings","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"B27","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1097\/WNF.0b013e31821c31d8","article-title":"Regional cerebral glucose metabolism after pridopidine (ACR16) treatment in patients with huntington disease.","volume":"34","author":"Esmaeilzadeh","year":"2011","journal-title":"Clin. Neuropharmacol."},{"key":"B28","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.neulet.2012.04.046","article-title":"Association between a variant of the sigma-1 receptor gene and Alzheimer\u2019s disease.","volume":"517","author":"Feh\u00e9r","year":"2012","journal-title":"Neurosci. Lett."},{"key":"B29","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1159\/000440864","article-title":"AF710B, a novel M1\/sigma1 agonist with therapeutic efficacy in animal models of alzheimer\u2019s disease.","volume":"16","author":"Fisher","year":"2016","journal-title":"Neurodegener. Dis."},{"key":"B30","doi-asserted-by":"publisher","first-page":"1998","DOI":"10.1093\/brain\/awu107","article-title":"Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism.","volume":"137","author":"Francardo","year":"2014","journal-title":"Brain"},{"key":"B31","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1007\/s13311-018-00699-9","article-title":"Pridopidine induces functional neurorestoration via the sigma-1 receptor in a mouse model of parkinson\u2019s disease.","volume":"16","author":"Francardo","year":"2019","journal-title":"Neurotherapeutics"},{"key":"B32","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1002\/syn.21549","article-title":"Sigma-1 receptor chaperones regulate the secretion of brain-derived neurotrophic factor.","volume":"66","author":"Fujimoto","year":"2012","journal-title":"Synapse"},{"key":"B33","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049384","article-title":"Sigma-1 receptor agonists directly inhibit Nav1.2\/1.4 channels.","volume":"7","author":"Gao","year":"2012","journal-title":"PLoS One"},{"key":"B34","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.95665","article-title":"Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 huntington disease mice.","volume":"2","author":"Garcia-Miralles","year":"2017","journal-title":"JCI Insight."},{"key":"B35","doi-asserted-by":"publisher","first-page":"3975","DOI":"10.1093\/hmg\/ddw238","article-title":"Pridopidine activates neuroprotective pathways impaired in huntington disease.","volume":"25","author":"Geva","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"B36","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s12640-017-9838-2","article-title":"Sigma-1 receptor agonists induce oxidative stress in mitochondria and enhance complex i activity in physiological condition but protect against pathological oxidative stress.","volume":"35","author":"Goguadze","year":"2019","journal-title":"Neurotox. Res."},{"key":"B37","first-page":"212","article-title":"Regulation of [3H]dopamine release from rat striatal slices by sigma receptor ligands.","volume":"271","author":"Gonzalez-Alvear","year":"1994","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B38","doi-asserted-by":"publisher","first-page":"3741","DOI":"10.1093\/hmg\/ddw220","article-title":"Loss-of-function mutations in the SIGMAR1 gene cause distal hereditary motor neuropathy by impairing ER-mitochondria tethering and Ca2+ signalling.","volume":"25","author":"Gregianin","year":"2016","journal-title":"Hum. Mol. Genet."},{"key":"B39","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1016\/j.yjmcc.2009.03.001","article-title":"Mitochondrial calcium transport in the heart: physiological and pathological roles.","volume":"46","author":"Griffiths","year":"2009","journal-title":"J. Mol. Cell Cardiol."},{"key":"B40","doi-asserted-by":"publisher","first-page":"20333","DOI":"10.1074\/jbc.M113.537993","article-title":"The oligomeric states of the purified sigma-1 receptor are stabilized by ligands.","volume":"289","author":"Gromek","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s00702-013-1002-4","article-title":"The dopaminergic stabilizer pridopidine increases neuronal activity of pyramidal neurons in the prefrontal cortex.","volume":"120","author":"Gronier","year":"2013","journal-title":"J. Neural. Transm."},{"key":"B42","doi-asserted-by":"publisher","first-page":"1757","DOI":"10.1523\/jneurosci.06-06-01757.1986","article-title":"Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine.","volume":"6","author":"Gundlach","year":"1986","journal-title":"J. Neurosci."},{"key":"B43","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1124\/mol.112.083840","article-title":"SKF83959 is a potent allosteric modulator of sigma-1 receptor.","volume":"83","author":"Guo","year":"2013","journal-title":"Mol. Pharmacol."},{"key":"B44","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1038\/4789","article-title":"Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.","volume":"5","author":"Guo","year":"1999","journal-title":"Nat. Med."},{"key":"B45","doi-asserted-by":"publisher","first-page":"7749","DOI":"10.1167\/iovs.11-8169","article-title":"Late-onset inner retinal dysfunction in mice lacking sigma receptor 1 (sigmaR1).","volume":"52","author":"Ha","year":"2011","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B46","first-page":"2860","article-title":"Diabetes accelerates retinal ganglion cell dysfunction in mice lacking sigma receptor 1.","volume":"18","author":"Ha","year":"2012","journal-title":"Mol. Vis."},{"key":"B47","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1016\/j.jalz.2017.11.009","article-title":"AF710B, an M1\/sigma-1 receptor agonist with long-lasting disease-modifying properties in a transgenic rat model of Alzheimer\u2019s disease.","volume":"14","author":"Hall","year":"2018","journal-title":"Alzheimers Dement"},{"key":"B48","doi-asserted-by":"publisher","first-page":"8072","DOI":"10.1073\/pnas.93.15.8072","article-title":"Purification, molecular cloning, and expression of the mammalian sigma1-binding site.","volume":"93","author":"Hanner","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B49","doi-asserted-by":"publisher","first-page":"1129","DOI":"10.1111\/j.1471-4159.2009.06181.x","article-title":"The amyloid hypothesis for Alzheimer\u2019s disease: a critical reappraisal.","volume":"110","author":"Hardy","year":"2009","journal-title":"J. Neurochem."},{"key":"B50","doi-asserted-by":"publisher","first-page":"43156","DOI":"10.1074\/jbc.M112.380444","article-title":"The lifetime of UDP-galactose:ceramide galactosyltransferase is controlled by a distinct endoplasmic reticulum-associated degradation (ERAD) regulated by sigma-1 receptor chaperones.","volume":"287","author":"Hayashi","year":"2012","journal-title":"J. Biol. Chem."},{"key":"B51","first-page":"788","article-title":"Ca(2+) signaling via sigma(1)-receptors: novel regulatory mechanism affecting intracellular Ca(2+) concentration.","volume":"293","author":"Hayashi","year":"2000","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B52","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1073\/pnas.021413698","article-title":"Regulating ankyrin dynamics: roles of sigma-1 receptors.","volume":"98","author":"Hayashi","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B53","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1124\/jpet.103.051284","article-title":"Sigma-1 receptors (sigma(1) binding sites) form raft-like microdomains and target lipid droplets on the endoplasmic reticulum: roles in endoplasmic reticulum lipid compartmentalization and export.","volume":"306","author":"Hayashi","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B54","doi-asserted-by":"publisher","first-page":"14949","DOI":"10.1073\/pnas.0402890101","article-title":"Sigma-1 receptors at galactosylceramide-enriched lipid microdomains regulate oligodendrocyte differentiation.","volume":"101","author":"Hayashi","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B55","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1016\/j.lfs.2005.05.009","article-title":"The potential role of sigma-1 receptors in lipid transport and lipid raft reconstitution in the brain: implication for drug abuse.","volume":"77","author":"Hayashi","year":"2005","journal-title":"Life Sci."},{"key":"B56","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/j.cell.2007.08.036","article-title":"Sigma-1 receptor chaperones at the ER-mitochondrion interface regulate Ca(2+) signaling and cell survival.","volume":"131","author":"Hayashi","year":"2007","journal-title":"Cell"},{"key":"B57","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1038\/nature15257","article-title":"Labelling, and optical erasure of synaptic memory traces in the motor cortex.","volume":"525","author":"Hayashi-Takagi","year":"2015","journal-title":"Nature"},{"key":"B58","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1124\/jpet.108.143974","article-title":"sigma-1 receptor modulation of acid-sensing ion channel a (ASIC1a) and ASIC1a-induced Ca2+ influx in rat cortical neurons.","volume":"327","author":"Herrera","year":"2008","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B59","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1002\/hup.1106","article-title":"Cognition and depression: the effects of fluvoxamine, a sigma-1 receptor agonist, reconsidered.","volume":"25","author":"Hindmarch","year":"2010","journal-title":"Hum. Psychopharmacol."},{"key":"B60","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.neurobiolaging.2017.08.007","article-title":"Sigma-1 receptor knockout increases alpha-synuclein aggregation and phosphorylation with loss of dopaminergic neurons in substantia nigra.","volume":"59","author":"Hong","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"B61","doi-asserted-by":"publisher","first-page":"11250","DOI":"10.1074\/jbc.M116.774075","article-title":"The sigma-1 receptor modulates dopamine transporter conformation and cocaine binding and may thereby potentiate cocaine self-administration in rats.","volume":"292","author":"Hong","year":"2017","journal-title":"J. Biol. Chem."},{"key":"B62","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1212\/wnl.0000000000003212","article-title":"SIGMAR1 mutation associated with autosomal recessive Silver-like syndrome.","volume":"87","author":"Horga","year":"2016","journal-title":"Neurology"},{"key":"B63","doi-asserted-by":"publisher","first-page":"765","DOI":"10.2174\/156720511797633232","article-title":"Genetic polymorphisms in sigma-1 receptor and apolipoprotein E interact to influence the severity of Alzheimer\u2019s disease.","volume":"8","author":"Huang","year":"2011","journal-title":"Curr. Alzheimer Res."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1407","DOI":"10.1002\/mds.25362","article-title":"Study Group, a randomized, double-blind, placebo-controlled trial of pridopidine in huntington\u2019s disease.","volume":"28","author":"Huntington","year":"2013","journal-title":"Mov. Disord."},{"key":"B65","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.170","article-title":"Sigma-1 receptor agonist PRE084 is protective against mutant huntingtin-induced cell degeneration: involvement of calpastatin and the NF-kappaB pathway.","volume":"4","author":"Hyrskyluoto","year":"2013","journal-title":"Cell Death Dis."},{"key":"B66","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1042\/BJ20071619","article-title":"Huntington\u2019s disease: from pathology and genetics to potential therapies.","volume":"412","author":"Imarisio","year":"2008","journal-title":"Biochem. J."},{"key":"B67","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1451-2","article-title":"Targeting the sigma-1 receptor via pridopidine ameliorates central features of ALS pathology in a SOD1(G93A) model.","volume":"10","author":"Ionescu","year":"2019","journal-title":"Cell Death Dis."},{"key":"B68","first-page":"25","article-title":"The role of sigma-1 receptors in the pathophysiology of neuropsychiatric diseases.","volume":"3","author":"Ishikawa","year":"2009","journal-title":"J. Receptor. Ligand Channel Res."},{"key":"B69","doi-asserted-by":"publisher","first-page":"11111","DOI":"10.1074\/jbc.M114.548529","article-title":"Characterization of recombinant ELMOD (cell engulfment and motility domain) proteins as GTPase-activating proteins (GAPs) for ARF family GTPases.","volume":"289","author":"Ivanova","year":"2014","journal-title":"J. Biol. Chem."},{"key":"B70","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/0006-8993(93)91441-t","article-title":"Loss of sigma binding sites in the CA1 area of the anterior hippocampus in alzheimer\u2019s disease correlates with CA1 pyramidal cell loss.","volume":"623","author":"Jansen","year":"1993","journal-title":"Brain Res."},{"key":"B71","doi-asserted-by":"publisher","first-page":"C328","DOI":"10.1152\/ajpcell.00383.2010","article-title":"Antagonist action of progesterone at sigma-receptors in the modulation of voltage-gated sodium channels.","volume":"300","author":"Johannessen","year":"2011","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B72","doi-asserted-by":"publisher","first-page":"C1049","DOI":"10.1152\/ajpcell.00431.2008","article-title":"Voltage-gated sodium channel modulation by sigma-receptors in cardiac myocytes and heterologous systems.","volume":"296","author":"Johannessen","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"B73","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2016.319","article-title":"Transactivation of TrkB by Sigma-1 receptor mediates cocaine-induced changes in dendritic spine density and morphology in hippocampal and cortical neurons.","volume":"7","author":"Ka","year":"2016","journal-title":"Cell Death Dis."},{"key":"B74","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1006\/bbrc.1996.1842","article-title":"Cloning and functional expression of the human type 1 sigma receptor (hSigmaR1).","volume":"229","author":"Kekuda","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"B75","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/j.neulet.2008.05.055","article-title":"Chronic treatment with a selective ligand for the sigma-1 receptor chaperone, SA4503, up-regulates BDNF protein levels in the rat hippocampus.","volume":"440","author":"Kikuchi-Utsumi","year":"2008","journal-title":"Neurosci. Lett."},{"key":"B76","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1124\/mol.109.057083","article-title":"Sigma 1 receptor modulation of G-protein-coupled receptor signaling: potentiation of opioid transduction independent from receptor binding.","volume":"77","author":"Kim","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"B77","doi-asserted-by":"publisher","first-page":"e7","DOI":"10.1016\/j.neurobiolaging.2014.03.001","article-title":"Mutations in UBQLN2 and SIGMAR1 genes are rare in korean patients with amyotrophic lateral sclerosis.","volume":"35","author":"Kim","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"B78","doi-asserted-by":"publisher","first-page":"1205","DOI":"10.1016\/j.str.2009.08.002","article-title":"Secondary structure of huntingtin amino-terminal region.","volume":"17","author":"Kim","year":"2009","journal-title":"Structure"},{"key":"B79","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0075760","article-title":"Sigma-1 receptor enhances neurite elongation of cerebellar granule neurons via TrkB signaling.","volume":"8","author":"Kimura","year":"2013","journal-title":"PLoS One"},{"key":"B80","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.brainres.2012.02.070","article-title":"Sigma-1 receptor alters the kinetics of Kv1.3 voltage gated potassium channels but not the sensitivity to receptor ligands.","volume":"1452","author":"Kinoshita","year":"2012","journal-title":"Brain Res."},{"key":"B81","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1016\/j.cell.2012.12.004","article-title":"Dynamic interaction between sigma-1 receptor and Kv1.2 shapes neuronal and behavioral responses to cocaine.","volume":"152","author":"Kourrich","year":"2013","journal-title":"Cell"},{"key":"B82","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1016\/j.tins.2012.09.007","article-title":"The sigma-1 receptor: roles in neuronal plasticity and disease.","volume":"35","author":"Kourrich","year":"2012","journal-title":"Trends Neurosci."},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0259-3","article-title":"Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse.","volume":"13","author":"Kusko","year":"2018","journal-title":"Mol. Neurodegener."},{"key":"B84","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.70","article-title":"Blockade of Tau hyperphosphorylation and A\u03b2 1\u201342 generation by the aminotetrahydrofuran derivative ANAVEX2-73, a mixed muscarinic and \u03c3 1 receptor agonist, in a nontransgenic mouse model of Alzheimer\u2019s disease.","volume":"38","author":"Lahmy","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"B85","doi-asserted-by":"publisher","first-page":"2188","DOI":"10.1046\/j.1460-9568.2003.02950.x","article-title":"Generation and phenotypic analysis of sigma receptor type I (sigma 1) knockout mice.","volume":"18","author":"Langa","year":"2003","journal-title":"Eur. J. Neurosci."},{"key":"B86","doi-asserted-by":"publisher","first-page":"834","DOI":"10.1021\/ml2001505","article-title":"Homology model and docking-based virtual screening for ligands of the sigma1 receptor.","volume":"2","author":"Laurini","year":"2011","journal-title":"ACS Med. Chem. Lett."},{"key":"B87","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3753","article-title":"Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress.","volume":"4","author":"Leitman","year":"2013","journal-title":"Nat. Commun."},{"key":"B88","doi-asserted-by":"publisher","first-page":"1395","DOI":"10.1016\/j.bbabio.2009.06.009","article-title":"Mitochondrial calcium and the permeability transition in cell death.","volume":"1787","author":"Lemasters","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"B89","doi-asserted-by":"publisher","first-page":"2430","DOI":"10.1212\/WNL.0000000000001680","article-title":"A SIGMAR1 splice-site mutation causes distal hereditary motor neuropathy.","volume":"84","author":"Li","year":"2015","journal-title":"Neurology"},{"key":"B90","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1016\/s0896-6273(01)00194-5","article-title":"Activation of synaptic NMDA receptors induces membrane insertion of new AMPA receptors and LTP in cultured hippocampal neurons.","volume":"29","author":"Lu","year":"2001","journal-title":"Neuron"},{"key":"B91","doi-asserted-by":"publisher","first-page":"260","DOI":"10.1097\/WNF.0b013e3181ebb285","article-title":"Efficacy and safety of the dopaminergic stabilizer pridopidine (ACR16) in patients with huntington\u2019s disease.","volume":"33","author":"Lundin","year":"2010","journal-title":"Clin. Neuropharmacol."},{"key":"B92","doi-asserted-by":"publisher","first-page":"639","DOI":"10.1002\/ana.22274","article-title":"Sigma nonopioid intracellular receptor 1 mutations cause frontotemporal lobar degeneration-motor neuron disease.","volume":"68","author":"Luty","year":"2010","journal-title":"Ann. Neurol."},{"key":"B93","article-title":"safety and efficacy 31 week data of anavex 2-73 in a phase 2a study in mild-moderate alzheimer\u2019s disease patients.","volume":"12","author":"Macfarlane","year":"2016","journal-title":"Alzheimer\u2019s Dementia J. Alzheimer\u2019s Assoc."},{"key":"B94","doi-asserted-by":"publisher","first-page":"814","DOI":"10.1007\/s13311-012-0140-y","article-title":"Sigma-1R agonist improves motor function and motoneuron survival in ALS mice.","volume":"9","author":"Mancuso","year":"2012","journal-title":"Neurotherapeutics"},{"key":"B95","doi-asserted-by":"publisher","first-page":"578","DOI":"10.1124\/jpet.112.198168","article-title":"sigma-1 receptor at the mitochondrial-associated endoplasmic reticulum membrane is responsible for mitochondrial metabolic regulation.","volume":"343","author":"Marriott","year":"2012","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B96","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1113\/jphysiol.2006.116178","article-title":"The sigma-1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus.","volume":"578","author":"Martina","year":"2007","journal-title":"J. Physiol."},{"key":"B97","doi-asserted-by":"publisher","first-page":"432","DOI":"10.1159\/000101990","article-title":"Sigma receptor type 1 gene variation in a group of Polish patients with alzheimer\u2019s disease and mild cognitive impairment.","volume":"23","author":"Maruszak","year":"2007","journal-title":"Dement. Geriatr. Cogn. Disord."},{"key":"B98","doi-asserted-by":"publisher","first-page":"271","DOI":"10.1016\/0014-2999(96)00201-4","article-title":"Binding properties of SA4503, a novel and selective \u03c31 receptor agonist.","volume":"306","author":"Matsuno","year":"1996","journal-title":"Eur. J. Pharmacol"},{"key":"B99","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/164_2017_15","article-title":"Sigma-1 (sigma1) receptor in memory and neurodegenerative diseases.","volume":"244","author":"Maurice","year":"2017","journal-title":"Handb. Exp. Pharmacol."},{"key":"B100","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1016\/j.pbb.2006.07.009","article-title":"Neuro(active)steroids actions at the neuromodulatory sigma1 (sigma1) receptor: biochemical and physiological evidences, consequences in neuroprotection.","volume":"84","author":"Maurice","year":"","journal-title":"Pharmacol. Biochem. Behav."},{"key":"B101","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1124\/jpet.105.097394","article-title":"Interaction with sigma(1) protein, but not N-methyl-D-aspartate receptor, is involved in the pharmacological activity of donepezil.","volume":"317","author":"Maurice","year":"","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B102","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1016\/s0278-5846(96)00160-1","article-title":"Neuroprotective and anti-amnesic potentials of sigma (sigma) receptor ligands.","volume":"21","author":"Maurice","year":"1997","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B103","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.bbr.2017.11.010","article-title":"Amyloid toxicity is enhanced after pharmacological or genetic invalidation of the sigma1 receptor.","volume":"339","author":"Maurice","year":"2018","journal-title":"Behav. Brain Res."},{"key":"B104","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1016\/j.phrs.2019.04.026","article-title":"Neuroprotection in non-transgenic and transgenic mouse models of Alzheimer\u2019s disease by positive modulation of sigma1 receptors.","volume":"144","author":"Maurice","year":"2019","journal-title":"Pharmacol. Res."},{"key":"B105","doi-asserted-by":"publisher","DOI":"10.1038\/srep10689","article-title":"Subcellular localization of the sigma-1 receptor in retinal neurons - an electron microscopy study.","volume":"5","author":"Mavlyutov","year":"","journal-title":"Sci. Rep."},{"key":"B106","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.jphs.2014.12.013","article-title":"Role of the Sigma-1 receptor in Amyotrophic Lateral Sclerosis (ALS).","volume":"127","author":"Mavlyutov","year":"","journal-title":"J. Pharmacol. Sci."},{"key":"B107","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1016\/j.neuroscience.2010.02.022","article-title":"The sigma-1 receptor is enriched in postsynaptic sites of C-terminals in mouse motoneurons. an anatomical and behavioral study.","volume":"167","author":"Mavlyutov","year":"2010","journal-title":"Neuroscience"},{"key":"B108","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.neuroscience.2013.02.035","article-title":"Lack of sigma-1 receptor exacerbates ALS progression in mice.","volume":"240","author":"Mavlyutov","year":"2013","journal-title":"Neuroscience"},{"key":"B109","first-page":"1034","article-title":"Accelerated retinal ganglion cell death in mice deficient in the Sigma-1 receptor.","volume":"17","author":"Mavlyutov","year":"2011","journal-title":"Mol. Vis."},{"key":"B110","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s13238-017-0468-5","article-title":"APEX2- tagging of Sigma 1-receptor indicates subcellular protein topology with cytosolic N-terminus and ER luminal C-terminus.","volume":"9","author":"Mavylutov","year":"2018","journal-title":"Protein Cell"},{"key":"B111","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1016\/0922-4106(90)90004-h","article-title":"Haloperidol-sensitive (+)[3H]SKF-10,047 binding sites (sigma sites) exhibit unique distribution in rat brain subcellular fractions.","volume":"188","author":"McCann","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"B112","doi-asserted-by":"publisher","first-page":"980","DOI":"10.1016\/j.ajpath.2011.04.041","article-title":"Loss of muscarinic M1 receptor exacerbates alzheimer\u2019s disease\u2013like pathology and cognitive decline.","volume":"179","author":"Medeiros","year":"2011","journal-title":"Am. J. Pathol."},{"key":"B113","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1124\/jpet.109.160960","article-title":"Sigma-1 receptors regulate Bcl-2 expression by reactive oxygen species-dependent transcriptional regulation of nuclear factor KB.","volume":"332","author":"Meunier","year":"2010","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B114","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1111\/neup.12080","article-title":"Accumulation of the sigma-1 receptor is common to neuronal nuclear inclusions in various neurodegenerative diseases.","volume":"34","author":"Miki","year":"2014","journal-title":"Neuropathology"},{"key":"B115","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.nbd.2014.11.005","article-title":"Sigma-1 receptor is involved in degradation of intranuclear inclusions in a cellular model of Huntington\u2019s disease.","volume":"74","author":"Miki","year":"2015","journal-title":"Neurobiol. Dis."},{"key":"B116","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1111\/j.1600-0404.2005.00432.x","article-title":"Function of sigma1 receptors in parkinson\u2019s disease.","volume":"112","author":"Mishina","year":"2005","journal-title":"Acta Neurol. Scand."},{"key":"B117","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/s12149-007-0094-z","article-title":"Low density of sigma1 receptors in early Alzheimer\u2019s disease.","volume":"22","author":"Mishina","year":"2008","journal-title":"Ann. Nucl. Med."},{"key":"B118","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1042\/BJ20141321","article-title":"The sigma-1 receptors are present in monomeric and oligomeric forms in living cells in the presence and absence of ligands.","volume":"466","author":"Mishra","year":"2015","journal-title":"Biochem. J."},{"key":"B119","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1172\/JCI45691","article-title":"Energy deficit in huntington disease: why it matters.","volume":"121","author":"Mochel","year":"2011","journal-title":"J. Clin. Invest."},{"key":"B120","first-page":"123","article-title":"Montigny, In vivo electrophysiological evidence for a selective modulation of N-methyl-D-aspartate-induced neuronal activation in rat CA3 dorsal hippocampus by sigma ligands.","volume":"261","author":"Monnet","year":"1992","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B121","doi-asserted-by":"publisher","first-page":"441","DOI":"10.1016\/0014-2999(90)90186-a","article-title":"Montigny, N-methyl-D-aspartate-induced neuronal activation is selectively modulated by sigma receptors.","volume":"179","author":"Monnet","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"B122","doi-asserted-by":"publisher","first-page":"3774","DOI":"10.1073\/pnas.92.9.3774","article-title":"Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus.","volume":"92","author":"Monnet","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B123","doi-asserted-by":"publisher","first-page":"3545","DOI":"10.1523\/JNEUROSCI.4147-13.2014","article-title":"Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: sigma1-D1-H3 receptor complexes as key targets for reducing cocaine\u2019s effects.","volume":"34","author":"Moreno","year":"2014","journal-title":"J. Neurosci."},{"key":"B124","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0076941","article-title":"Sigma-1 receptor chaperone at the ER-mitochondrion interface mediates the mitochondrion-ER-nucleus signaling for cellular survival.","volume":"8","author":"Mori","year":"2013","journal-title":"PLoS One"},{"key":"B125","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0060863","article-title":"Stimulation of the sigma-1 receptor by DHEA enhances synaptic efficacy and neurogenesis in the hippocampal dentate gyrus of olfactory bulbectomized mice.","volume":"8","author":"Moriguchi","year":"2013","journal-title":"PLoS One"},{"key":"B126","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1111\/j.1471-4159.2011.07256.x","article-title":"Sigma-1 receptor stimulation by dehydroepiandrosterone ameliorates cognitive impairment through activation of CaM kinase II, protein kinase C and extracellular signal-regulated kinase in olfactory bulbectomized mice.","volume":"117","author":"Moriguchi","year":"2011","journal-title":"J. Neurochem."},{"key":"B127","doi-asserted-by":"publisher","first-page":"8196","DOI":"10.1073\/pnas.96.14.8196","article-title":"Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem.","volume":"96","author":"Morin-Surun","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B128","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.neulet.2015.02.004","article-title":"Live imaging reveals a new role for the sigma-1 (sigma1) receptor in allowing microglia to leave brain injuries.","volume":"591","author":"Moritz","year":"2015","journal-title":"Neurosci. Lett."},{"key":"B129","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1038\/319774a0","article-title":"Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist. AP5.","volume":"319","author":"Morris","year":"1986","journal-title":"Nature"},{"key":"B130","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.exer.2012.11.002","article-title":"Sigma-1 receptor stimulation attenuates calcium influx through activated L-type voltage gated calcium channels in purified retinal ganglion cells.","volume":"107","author":"Mueller","year":"2013","journal-title":"Exp. Eye Res."},{"key":"B131","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/s0197-0186(97)00105-8","article-title":"Activation of sigma1 receptor subtype leads to neuroprotection in the rat primary neuronal cultures.","volume":"32","author":"Nakazawa","year":"1998","journal-title":"Neurochem. Int."},{"key":"B132","doi-asserted-by":"publisher","DOI":"10.1186\/s12858-015-0040-y","article-title":"Sigma-1 receptor directly interacts with Rac1-GTPase in the brain mitochondria.","volume":"16","author":"Natsvlishvili","year":"2015","journal-title":"BMC Biochem."},{"key":"B133","doi-asserted-by":"publisher","first-page":"18676","DOI":"10.1073\/pnas.1008911107","article-title":"Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine.","volume":"107","author":"Navarro","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B134","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0061245","article-title":"Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers.","volume":"8","author":"Navarro","year":"2013","journal-title":"PLoS One"},{"key":"B135","doi-asserted-by":"publisher","first-page":"1230","DOI":"10.1172\/jci30447","article-title":"Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1.","volume":"117","author":"Nelson","year":"2007","journal-title":"J. Clin. Invest."},{"key":"B136","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1016\/j.pnpbp.2004.05.004","article-title":"The dopaminergic stabiliser ACR16 counteracts the behavioural primitivization induced by the NMDA receptor antagonist MK-801 in mice: implications for cognition.","volume":"28","author":"Nilsson","year":"2004","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"B137","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002558","article-title":"Potentiation of nerve growth factor-induced neurite outgrowth by fluvoxamine: role of sigma-1 receptors, IP3 receptors and cellular signaling pathways.","volume":"3","author":"Nishimura","year":"2008","journal-title":"PLoS One"},{"key":"B138","doi-asserted-by":"publisher","first-page":"174","DOI":"10.1016\/j.neulet.2013.12.005","article-title":"SA4503, a sigma-1 receptor agonist, suppresses motor neuron damage in in vitro and in vivo amyotrophic lateral sclerosis models.","volume":"559","author":"Ono","year":"2014","journal-title":"Neurosci. Lett."},{"key":"B139","doi-asserted-by":"publisher","first-page":"659","DOI":"10.1016\/j.febslet.2015.01.033","article-title":"Solution NMR studies reveal the location of the second transmembrane domain of the human sigma-1 receptor.","volume":"589","author":"Ortega-Roldan","year":"2015","journal-title":"FEBS Lett."},{"key":"B140","doi-asserted-by":"publisher","first-page":"21448","DOI":"10.1074\/jbc.M113.450379","article-title":"). Characterization of the human sigma-1 receptor chaperone domain structure and binding immunoglobulin protein (BiP) interactions.","volume":"288","author":"Ortega-Roldan","year":"2013","journal-title":"J. Biol. Chem."},{"key":"B141","doi-asserted-by":"publisher","first-page":"11325","DOI":"10.1523\/JNEUROSCI.0458-14.2014","article-title":"NMDA receptors are upregulated and trafficked to the plasma membrane after sigma-1 receptor activation in the rat hippocampus.","volume":"34","author":"Pabba","year":"2014","journal-title":"J. Neurosci."},{"key":"B142","doi-asserted-by":"publisher","first-page":"19646","DOI":"10.1074\/jbc.M802192200","article-title":"Juxtaposition of the steroid binding domain-like I and II regions constitutes a ligand binding site in the sigma-1 receptor.","volume":"283","author":"Pal","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B143","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1124\/mol.107.038307","article-title":"Identification of regions of the sigma-1 receptor ligand binding site using a novel photoprobe.","volume":"72","author":"Pal","year":"2007","journal-title":"Mol. Pharmacol."},{"key":"B144","doi-asserted-by":"publisher","first-page":"11166","DOI":"10.1158\/0008-5472.can-07-1771","article-title":"Sigma-1 receptors bind cholesterol and remodel lipid rafts in breast cancer cell lines.","volume":"67","author":"Palmer","year":"2007","journal-title":"Cancer Res."},{"key":"B145","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-17762-8","article-title":"Stim2-Eb3 association and morphology of dendritic spines in hippocampal neurons.","volume":"7","author":"Pchitskaya","year":"2017","journal-title":"Sci. Rep."},{"key":"B146","doi-asserted-by":"publisher","first-page":"218","DOI":"10.1016\/j.nbd.2013.10.010","article-title":"Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation.","volume":"62","author":"Peviani","year":"2014","journal-title":"Neurobiol. Dis."},{"key":"B147","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ejphar.2010.07.023","article-title":"In vivo pharmacology of the dopaminergic stabilizer pridopidine.","volume":"644","author":"Ponten","year":"2010","journal-title":"Eur. J. Pharmacol."},{"key":"B148","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-015-0034-7","article-title":"STIM2 protects hippocampal mushroom spines from amyloid synaptotoxicity.","volume":"10","author":"Popugaeva","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"B149","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/S1474-4422(18)30391-0","article-title":"Huntington\u2019s disease, and i. huntington study group, safety and efficacy of pridopidine in patients with Huntington\u2019s disease (PRIDE-HD): a phase 2, randomised, placebo-controlled, multicentre, dose-ranging study.","volume":"18","author":"Reilmann","year":"2019","journal-title":"Lancet Neurol."},{"key":"B150","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aax3130","article-title":"Modulation of the sigma-1 receptor-IRE1 pathway is beneficial in preclinical models of inflammation and sepsis.","volume":"11","author":"Rosen","year":"2019","journal-title":"Sci. Transl. Med."},{"key":"B151","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/0166-2236(87)90177-9","article-title":"Excitotoxity and the NMDA receptor.","volume":"10","author":"Rothman","year":"1987","journal-title":"Trends Neurosci."},{"key":"B152","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1007\/s00702-008-0038-3","article-title":"Effects of (-)-OSU6162 and ACR16 on motor activity in rats, indicating a unique mechanism of dopaminergic stabilization.","volume":"115","author":"Rung","year":"2008","journal-title":"J. Neural. Transm."},{"key":"B153","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045118","article-title":"Effects of the sigma-1 receptor agonist 1-(3,4-dimethoxyphenethyl)-4-(3-phenylpropyl)-piperazine dihydro-chloride on inflammation after stroke.","volume":"7","author":"Ruscher","year":"2012","journal-title":"PLoS One"},{"key":"B154","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1093\/brain\/awq367","article-title":"The sigma-1 receptor enhances brain plasticity and functional recovery after experimental stroke.","volume":"134","author":"Ruscher","year":"2011","journal-title":"Brain"},{"key":"B155","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.nbd.2016.10.006","article-title":"The sigma-1 receptor mediates the beneficial effects of pridopidine in a mouse model of Huntington disease.","volume":"97","author":"Ryskamp","year":"2017","journal-title":"Neurobiol. Dis."},{"key":"B156","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1016\/j.nbd.2018.12.022","article-title":"Pridopidine stabilizes mushroom spines in mouse models of Alzheimer\u2019s disease by acting on the sigma-1 receptor.","volume":"124","author":"Ryskamp","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"B157","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.bbr.2008.11.036","article-title":"Sigma-1 receptor knockout mice display a depressive-like phenotype.","volume":"198","author":"Sabino","year":"2009","journal-title":"Behav. Brain Res."},{"key":"B158","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1038\/mp.2012.3","article-title":"The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the sigma-1 receptor.","volume":"18","author":"Sahlholm","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"B159","doi-asserted-by":"publisher","first-page":"3443","DOI":"10.1007\/s00213-015-3997-8","article-title":"Waarde, Pridopidine selectively occupies sigma-1 rather than dopamine D2 receptors at behaviorally active doses.","volume":"232","author":"Sahlholm","year":"2015","journal-title":"Psychopharmacology"},{"key":"B160","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02087-x","article-title":"The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission.","volume":"8","author":"Sambo","year":"2017","journal-title":"Nat. Commun."},{"key":"B161","doi-asserted-by":"publisher","first-page":"1943","DOI":"10.1017\/S1461145714000029","article-title":"The calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.","volume":"17","author":"Sanchez-Blazquez","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"B162","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1097\/WNR.0000000000000162","article-title":"Antidepressant fluvoxamine reduces cerebral infarct volume and ameliorates sensorimotor dysfunction in experimental stroke.","volume":"25","author":"Sato","year":"2014","journal-title":"Neuroreport"},{"key":"B163","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1038\/s41594-018-0137-2","article-title":"Structural basis for sigma1 receptor ligand recognition.","volume":"25","author":"Schmidt","year":"2018","journal-title":"Nat. Struct. Mol. Biol."},{"key":"B164","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1038\/nature17391","article-title":"Crystal structure of the human sigma1 receptor.","volume":"532","author":"Schmidt","year":"2016","journal-title":"Nature"},{"key":"B165","doi-asserted-by":"publisher","first-page":"369","DOI":"10.3233\/JAD-132543","article-title":"Amyloid-beta peptides are generated in mitochondria-associated endoplasmic reticulum membranes.","volume":"43","author":"Schreiner","year":"2015","journal-title":"J. Alzheimers. Dis."},{"key":"B166","doi-asserted-by":"publisher","first-page":"1275","DOI":"10.1016\/j.euroneuro.2015.04.021","article-title":"Sex-related neurogenesis decrease in hippocampal dentate gyrus with depressive-like behaviors in sigma-1 receptor knockout mice.","volume":"25","author":"Sha","year":"2015","journal-title":"Eur. Neuropsychopharmacol."},{"key":"B167","doi-asserted-by":"publisher","first-page":"4154","DOI":"10.1167\/iovs.08-1824","article-title":"In vivo protection against retinal neurodegeneration by sigma receptor 1 ligand (+)-pentazocine.","volume":"49","author":"Smith","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B168","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00209","article-title":"Impairment and restoration of homeostatic plasticity in cultured cortical neurons from a mouse model of huntington disease.","volume":"13","author":"Smith-Dijak","year":"2019","journal-title":"Front. Cell. Neurosci."},{"key":"B169","doi-asserted-by":"publisher","first-page":"2540","DOI":"10.1111\/jcmm.12604","article-title":"Pridopidine, a dopamine stabilizer, improves motor performance and shows neuroprotective effects in huntington disease R6\/2 mouse model.","volume":"19","author":"Squitieri","year":"2015","journal-title":"J. Cell Mol. Med."},{"key":"B170","doi-asserted-by":"publisher","first-page":"65","DOI":"10.1083\/jcb.201506022","article-title":"Sigma1 receptors inhibit store-operated Ca2+ entry by attenuating coupling of STIM1 to Orai1.","volume":"213","author":"Srivats","year":"2016","journal-title":"J. Cell Biol."},{"key":"B171","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/j.tips.2016.01.003","article-title":"The sigma-1 receptor as a pluripotent modulator in living systems.","volume":"37","author":"Su","year":"2016","journal-title":"Trends Pharmacol. Sci."},{"key":"B172","first-page":"543","article-title":"Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand.","volume":"259","author":"Su","year":"1991","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"B173","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.neuron.2014.02.019","article-title":"Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice.","volume":"82","author":"Sun","year":"2014","journal-title":"Neuron"},{"key":"B174","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1159\/000086426","article-title":"Hippocampal spatial memory impairments caused by the familial Alzheimer\u2019s disease-linked presenilin 1 M146V mutation.","volume":"2","author":"Sun","year":"2005","journal-title":"Neurodegener. Dis."},{"key":"B175","article-title":"The actions of the dopamine stabilizer ACR16, but not (-)-OSU6162, in behavioral and neurochemical assays are not dependent on the presence of functional dopamine D2 receptors","author":"Svensson","year":"2009","journal-title":"Proceedings of the 39th Annual Meeting, Society for Neuroscience"},{"key":"B176","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.conb.2005.12.001","article-title":"Molecular mechanisms of dendritic spine morphogenesis.","volume":"16","author":"Tada","year":"2006","journal-title":"Curr. Opin. Neurobiol."},{"key":"B177","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1055\/s-2004-832679","article-title":"A perspective on the new mechanism of antidepressants: neuritogenesis through sigma-1 receptors.","volume":"37","author":"Takebayashi","year":"2004","journal-title":"Pharmacopsychiatry"},{"key":"B178","doi-asserted-by":"publisher","first-page":"1257","DOI":"10.1523\/JNEUROSCI.4411-08.2009","article-title":"Neuroprotective effects of inositol 1,4,5-trisphosphate receptor C-terminal fragment in a huntington\u2019s disease mouse model.","volume":"29","author":"Tang","year":"2009","journal-title":"J. Neurosci."},{"key":"B179","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/s0896-6273(03)00366-0","article-title":"Huntingtin and huntingtin-associated protein 1 influence neuronal calcium signaling mediated by inositol-(1,4,5) triphosphate receptor type 1.","volume":"39","author":"Tang","year":"2003","journal-title":"Neuron"},{"key":"B180","doi-asserted-by":"publisher","first-page":"4993","DOI":"10.1167\/iovs.08-1867","article-title":"Sigma-1 receptor regulation of voltage-gated calcium channels involves a direct interaction.","volume":"49","author":"Tchedre","year":"2008","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"B181","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1158\/0008-5472.CAN-16-1055","article-title":"Sigma1 targeting to suppress aberrant androgen receptor signaling in prostate cancer.","volume":"77","author":"Thomas","year":"2017","journal-title":"Cancer Res."},{"key":"B182","doi-asserted-by":"publisher","first-page":"E6562","DOI":"10.1073\/pnas.1518894112","article-title":"Sigma-1 receptor mediates cocaine-induced transcriptional regulation by recruiting chromatin-remodeling factors at the nuclear envelope.","volume":"112","author":"Tsai","year":"","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B183","doi-asserted-by":"publisher","first-page":"6742","DOI":"10.1073\/pnas.1422001112","article-title":"Sigma-1 receptor regulates Tau phosphorylation and axon extension by shaping p35 turnover via myristic acid.","volume":"112","author":"Tsai","year":"","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B184","doi-asserted-by":"publisher","first-page":"22468","DOI":"10.1073\/pnas.0909089106","article-title":"Sigma-1 receptors regulate hippocampal dendritic spine formation via a free radical-sensitive mechanism involving Rac1xGTP pathway.","volume":"106","author":"Tsai","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"B185","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1002\/syn.20984","article-title":"Insights into the Sigma-1 receptor chaperone\u2019s cellular functions: a microarray report.","volume":"66","author":"Tsai","year":"2012","journal-title":"Synapse"},{"key":"B186","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.cell.2006.06.059","article-title":"Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer\u2019s disease-linked mutations.","volume":"126","author":"Tu","year":"2006","journal-title":"Cell"},{"key":"B187","doi-asserted-by":"publisher","first-page":"1062","DOI":"10.1176\/appi.ajgp.13.12.1062","article-title":"A variant of the sigma receptor type-1 gene is a protective factor for Alzheimer disease.","volume":"13","author":"Uchida","year":"2005","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"B188","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1007\/s10048-015-0453-1","article-title":"In silico analysis of SIGMAR1 variant (rs4879809) segregating in a consanguineous Pakistani family showing amyotrophic lateral sclerosis without frontotemporal lobar dementia.","volume":"16","author":"Ullah","year":"2015","journal-title":"Neurogenetics"},{"key":"B189","doi-asserted-by":"publisher","first-page":"3304","DOI":"10.1161\/strokeaha.114.005835","article-title":"Stroke Recovery Study, Phase II trial of the Sigma-1 receptor agonist cutamesine (SA4503) for recovery enhancement after acute ischemic stroke.","volume":"45","author":"Urfer","year":"2014","journal-title":"Stroke"},{"key":"B190","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00223","article-title":"Allosteric modulators of sigma-1 receptor: a review.","volume":"10","author":"Vavers","year":"2019","journal-title":"Front. Pharmacol."},{"key":"B191","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/j.freeradbiomed.2015.04.009","article-title":"Sigma 1 receptor regulates the oxidative stress response in primary retinal Muller glial cells via NRF2 signaling and system xc(\u2212), the Na(+)-independent glutamate-cystine exchanger.","volume":"86","author":"Wang","year":"2015","journal-title":"Free Radic. Biol. Med."},{"key":"B192","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1111\/cns.12502","article-title":"Allosteric modulation of sigma-1 receptors elicits rapid antidepressant activity.","volume":"22","author":"Wang","year":"2016","journal-title":"CNS Neurosci. ther."},{"key":"B193","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.15252\/emmm.201606403","article-title":"Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS.","volume":"8","author":"Watanabe","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"B194","doi-asserted-by":"publisher","first-page":"285","DOI":"10.3233\/JHD-140108","article-title":"Co-administration of the dopaminergic stabilizer pridopidine and tetrabenazine in rats.","volume":"3","author":"Waters","year":"2014","journal-title":"J. Huntingtons Dis."},{"key":"B195","doi-asserted-by":"publisher","first-page":"1","DOI":"10.3233\/JHD-170267","article-title":"Pridopidine: overview of pharmacology and rationale for its use in Huntington\u2019s disease.","volume":"7","author":"Waters","year":"2018","journal-title":"J. Huntingtons Dis."},{"key":"B196","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4582135","article-title":"Loss of sigma-1 receptor chaperone promotes astrocytosis and enhances the Nrf2 antioxidant defense.","volume":"2017","author":"Weng","year":"","journal-title":"Oxid. Med. Cell Longev."},{"key":"B197","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-017-0380-6","article-title":"Roles of sigma-1 receptors on mitochondrial functions relevant to neurodegenerative diseases.","volume":"24","author":"Weng","year":"","journal-title":"J. Biomed. Sci."},{"key":"B198","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3233\/JHD-170266","article-title":"Inhibition of TRPC1-dependent store-operated calcium entry improves synaptic stability and motor performance in a mouse model of huntington\u2019s disease.","volume":"7","author":"Wu","year":"2018","journal-title":"J. Huntingtons Dis."},{"key":"B199","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1523\/JNEUROSCI.1038-15.2016","article-title":"Enhanced store-operated calcium entry leads to striatal synaptic loss in a huntington\u2019s disease mouse model.","volume":"36","author":"Wu","year":"2016","journal-title":"J. Neurosci."},{"key":"B200","doi-asserted-by":"publisher","first-page":"777","DOI":"10.1016\/j.chembiol.2011.04.012","article-title":"Neuronal store-operated calcium entry pathway as a novel therapeutic target for Huntington\u2019s disease treatment.","volume":"18","author":"Wu","year":"2011","journal-title":"Chem. Biol."},{"key":"B201","doi-asserted-by":"publisher","first-page":"28198","DOI":"10.1074\/jbc.M802099200","article-title":"Role of sigma-1 receptor C-terminal segment in inositol 1,4,5-trisphosphate receptor activation: constitutive enhancement of calcium signaling in MCF-7 tumor cells.","volume":"283","author":"Wu","year":"2008","journal-title":"J. Biol. Chem."},{"key":"B202","doi-asserted-by":"publisher","first-page":"14708","DOI":"10.1523\/JNEUROSCI.1637-10.2010","article-title":"BDNF overexpression in the forebrain rescues Huntington\u2019s disease phenotypes in YAC128 mice.","volume":"30","author":"Xie","year":"2010","journal-title":"J. Neurosci."},{"key":"B203","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1016\/s0014-5793(99)00084-8","article-title":"Amino acid residues in the transmembrane domain of the type 1 sigma receptor critical for ligand binding.","volume":"445","author":"Yamamoto","year":"1999","journal-title":"FEBS Lett."},{"key":"B204","doi-asserted-by":"publisher","first-page":"264","DOI":"10.1016\/j.neuropharm.2018.01.042","article-title":"Pharmacological profiling of sigma 1 receptor ligands by novel receptor homomer assays.","volume":"133","author":"Yano","year":"2018","journal-title":"Neuropharmacology"},{"key":"B205","doi-asserted-by":"publisher","first-page":"2538","DOI":"10.1182\/blood-2010-10-313593","article-title":"Cocaine-mediated induction of platelet-derived growth factor: implication for increased vascular permeability.","volume":"117","author":"Yao","year":"2011","journal-title":"Blood"},{"key":"B206","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.1016\/j.cell.2005.10.030","article-title":"In vitro analysis of huntingtin-mediated transcriptional repression reveals multiple transcription factor targets.","volume":"123","author":"Zhai","year":"2005","journal-title":"Cell"},{"key":"B207","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051910","article-title":"Methylphenidate enhances NMDA-receptor response in medial prefrontal cortex via sigma-1 receptor: a novel mechanism for methylphenidate action.","volume":"7","author":"Zhang","year":"2012","journal-title":"PLoS One"},{"key":"B208","doi-asserted-by":"publisher","first-page":"2867","DOI":"10.1152\/jn.2002.87.6.2867","article-title":"Sigma receptors inhibit high-voltage-activated calcium channels in rat sympathetic and parasympathetic neurons.","volume":"87","author":"Zhang","year":"2002","journal-title":"J. Neurophysiol."},{"key":"B209","doi-asserted-by":"publisher","first-page":"125","DOI":"10.1016\/j.neuropharm.2007.04.004","article-title":"Chronic SKF83959 induced less severe dyskinesia and attenuated L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson\u2019s disease.","volume":"53","author":"Zhang","year":"2007","journal-title":"Neuropharmacology"},{"key":"B210","doi-asserted-by":"publisher","first-page":"8566","DOI":"10.1523\/JNEUROSCI.1554-10.2010","article-title":"Role of presenilins in neuronal calcium homeostasis.","volume":"30","author":"Zhang","year":"2010","journal-title":"J. Neurosci."},{"key":"B211","doi-asserted-by":"publisher","first-page":"11837","DOI":"10.1523\/jneurosci.1188-16.2016","article-title":"Store-operated calcium channel complex in postsynaptic spines: a new therapeutic target for alzheimer\u2019s disease treatment.","volume":"36","author":"Zhang","year":"2016","journal-title":"J. Neurosci."},{"key":"B212","doi-asserted-by":"publisher","first-page":"13275","DOI":"10.1523\/JNEUROSCI.1034-15.2015","article-title":"Neuronal store-operated calcium entry and mushroom spine loss in amyloid precursor protein knock-in mouse model of alzheimer\u2019s disease.","volume":"35","author":"Zhang","year":"2015","journal-title":"J Neurosci"},{"key":"B213","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00302","article-title":"Sigma-1 receptor plays a negative modulation on n-type calcium channel.","volume":"8","author":"Zhang","year":"2017","journal-title":"Front. Pharmacol."},{"key":"B214","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1016\/j.neulet.2005.03.001","article-title":"The paradoxical effects of SKF83959, a novel dopamine D1-like receptor agonist, in the rat acoustic startle reflex paradigm.","volume":"382","author":"Zhang","year":"2005","journal-title":"Neurosci. Lett."}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.00862\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,23]],"date-time":"2019-09-23T19:45:13Z","timestamp":1569267913000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.00862\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,28]]},"references-count":214,"alternative-id":["10.3389\/fnins.2019.00862"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2019.00862","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,28]]},"article-number":"862"}}