{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:33:48Z","timestamp":1791862428132,"version":"4.3.4"},"reference-count":95,"publisher":"Frontiers Media SA","license":[{"start":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:00:00Z","timestamp":1566259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["frontiersin.org"],"crossmark-restriction":true},"short-container-title":["Front. Neurosci."],"DOI":"10.3389\/fnins.2019.00869","type":"journal-article","created":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T00:55:03Z","timestamp":1566262503000},"update-policy":"https:\/\/doi.org\/10.3389\/crossmark-policy","source":"Crossref","is-referenced-by-count":122,"title":["Roles of Neuropeptide Y in Neurodegenerative and Neuroimmune Diseases"],"prefix":"10.3389","volume":"13","author":[{"given":"Chunrong","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiujuan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kangding","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1965","published-online":{"date-parts":[[2019,8,20]]},"reference":[{"key":"B1","doi-asserted-by":"publisher","first-page":"1636","DOI":"10.1634\/stemcells.2008-56","article-title":"Neuropeptide Y promotes neurogenesis in murine subventricular zone.","volume":"26","author":"Agasse","year":"2008","journal-title":"Stem cells"},{"key":"B2","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.14803","article-title":"Neuronal Ca2+ -dependent activator protein 1 (NCDAP1) induces neuronal cell death by activating p53 pathway following traumatic brain injury.","author":"Arai","year":"2019","journal-title":"J. Neurochem."},{"key":"B3","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1007\/s11011-017-0173","article-title":"Ocimum basilicum improve chronic stress-induced neurodegenerative changes in mice hippocampus.","volume":"33","author":"Ayuob","year":"2018","journal-title":"Metab. Brain Dis."},{"key":"B4","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/s1474-4422(06)70381-7","article-title":"Effect of fetal neural transplants in patients with Huntington\u2019s disease 6 years after surgery: a long-term follow-up study.","volume":"5","author":"Bachoud-L\u00e9vi","year":"2006","journal-title":"Lancet Neurol."},{"key":"B5","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.npep.2016.11.008","article-title":"Central administration of neuropeptide Y differentially regulates monoamines and corticosterone in heat-exposed fed and fasted chicks.","volume":"62","author":"Bahry","year":"2017","journal-title":"Neuropeptides"},{"key":"B6","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1002\/ana.410200303","article-title":"Neuropeptide Y immunoreactivity is reduced in cerebral cortex in Alzheimer\u2019s disease.","volume":"20","author":"Beal","year":"1986","journal-title":"Ann. Neurol."},{"key":"B7","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1016\/j.it.2004.08.005","article-title":"More sympathy for autoimmunity with neuropeptide Y?","volume":"25","author":"Bedoui","year":"2004","journal-title":"Trends. Immunol."},{"key":"B8","doi-asserted-by":"publisher","first-page":"484","DOI":"10.1016\/j.jagp.2017.10.012","article-title":"Empathic accuracy deficits in patients with neurodegenerative disease: association with caregiver depression.","volume":"26","author":"Brown","year":"2018","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"B9","doi-asserted-by":"publisher","first-page":"1474","DOI":"10.15252\/embj.201695810","article-title":"Brain metabolism in health, aging, and neurodegeneration.","volume":"36","author":"Camandola","year":"2015","journal-title":"EMBO J."},{"key":"B10","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1111\/ceo.13176","article-title":"Impact of type 1 diabetes mellitus and sitagliptin treatment on the neuropeptide Y system of ratretina.","volume":"46","author":"Campos","year":"2018","journal-title":"Clin. Exp. Ophthalmol."},{"key":"B11","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1016\/s0169-328x(02)00555-7","article-title":"Increased neuropeptide Y mRNA expression in striatum in Parkinson\u2019s disease.","volume":"110","author":"Cannizzaro","year":"2003","journal-title":"Brain Res. Mol. Brain Res."},{"key":"B12","doi-asserted-by":"publisher","first-page":"234","DOI":"10.1016\/j.appet.2017.06.029","article-title":"Body weight loss, effective satiation and absence of homeostatic neuropeptide compensation in male Sprague Dawley rats schedule fed a protein crosslinked diet.","volume":"117","author":"Cassie","year":"2017","journal-title":"Appetite"},{"key":"B13","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1007\/s11095-012-0915-911","article-title":"Intranasal treatment of central nervous system dysfunction in humans.","volume":"30","author":"Chapman","year":"2013","journal-title":"Pharm. Res."},{"key":"B14","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00493","article-title":"neuropeptides exert neuroprotective effects in Alzheimer\u2019s disease.","volume":"11","author":"Chen","year":"2019","journal-title":"Front. Mol. Neurosci."},{"key":"B15","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2019.104490","article-title":"The adenosine A2A receptor antagonist SCH58261 reduces macrophage\/microglia activation and protects against experimental autoimmune encephalomyelitis in mice.","volume":"129","author":"Chen","year":"2019","journal-title":"Neurochem. Int."},{"key":"B16","doi-asserted-by":"publisher","first-page":"10192","DOI":"10.1523\/JNEUROSCI.3127-13.2014","article-title":"Single-cell imaging of bioenergetic responses to neuronal excitotoxicity and oxygen and glucose deprivation.","volume":"34","author":"Connolly","year":"2014","journal-title":"J. Neurosci."},{"key":"B17","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1159\/000323468","article-title":"Neuroprotective effect of neuropeptide Y against beta-amyloid 25-35 toxicity in SH-SY5Y neuroblastoma cells is associated with increased neurotrophin production.","volume":"8","author":"Croce","year":"2011","journal-title":"Neurodegener. Dis."},{"key":"B18","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1007\/s11010-013-1567-0","article-title":"NPY modulates miR-30a-5p and BDNF in opposite direction in an in vitro model of Alzheimer disease: a possible role in neuroprotection?","volume":"376","author":"Croce","year":"2013","journal-title":"Mol. Cell Biochem."},{"key":"B19","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1159\/000362724","article-title":"One hormone, two actions: anti- and pro-inflammatory effects of glucocorticoids.","volume":"22","author":"Cruz-Topete","year":"2015","journal-title":"Neuroimmunomodulation"},{"key":"B20","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1016\/0006-8993(85)90921-7","article-title":"Survival of basal ganglia neuropeptide Y-somatostatin neurones in Huntington\u2019s disease.","volume":"340","author":"Dawbarn","year":"1985","journal-title":"Brain Res."},{"key":"B21","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00485","article-title":"Peripheral oxidative stress biomarkers in spinocerebellar ataxia type 3\/Machado-Joseph disease.","volume":"8","author":"de Assis","year":"2017","journal-title":"Front. Neurol."},{"key":"B22","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1016\/j.expneurol.2012.09.004","article-title":"Neuropeptide Y and its role in CNS disease and repair.","volume":"238","author":"Decressac","year":"2012","journal-title":"Exp. Neurol."},{"key":"B23","doi-asserted-by":"publisher","first-page":"2125","DOI":"10.1016\/j.neurobiolaging.2011.06.018","article-title":"Neuroprotection by neuropeptide Y in cell and animal models of Parkinson\u2019s disease.","volume":"33","author":"Decressac","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"B24","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1002\/hipo.20765","article-title":"Exogenous neuropeptide Y promotes in vivo hippocampal neurogenesis.","volume":"21","author":"Decressac","year":"2011","journal-title":"Hippocampus"},{"key":"B25","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.expneurol.2010.07.022","article-title":"Neuropeptide Y modifies the disease course in the R6\/2 transgenic model of Huntington\u2019s disease.","volume":"226","author":"Decressac","year":"2010","journal-title":"Exp. Neurol."},{"key":"B26","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.neuroscience.2017.08.050","article-title":"Neuropeptide Y and its involvement in chronic pain.","volume":"387","author":"Diaz-delCastillo","year":"2018","journal-title":"Neuroscience"},{"key":"B27","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s00726-011-1185-7","article-title":"The intriguing mission of neuropeptide Y in the immune system.","volume":"45","author":"Dimitrijevic","year":"2013","journal-title":"Amino Acids"},{"key":"B28","doi-asserted-by":"publisher","first-page":"5451","DOI":"10.1093\/hmg\/ddv271","article-title":"Neuropeptide Y mitigates neuropathology and motor deficits in mouse models of Machado-Joseph disease.","volume":"24","author":"Duarte-Neves","year":"2015","journal-title":"Hum. Mol. Genet."},{"key":"B29","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1016\/j.cell.2018.12.004","article-title":"Small-molecule agonists of Ae. aegypti neuropeptide Y receptor block mosquito biting.","volume":"176","author":"Duvall","year":"2019","journal-title":"Cell"},{"key":"B30","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1111\/apha.12445","article-title":"The homeostatic role of neuropeptide Y in immune function and its impact on mood and behaviour.","volume":"213","author":"Farzi","year":"2015","journal-title":"Acta Physiol."},{"key":"B31","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1111\/j.1471-4159.2011.07541.x","article-title":"Neuropeptide Y inhibits interleukin-1 beta-induced microglia motility.","volume":"120","author":"Ferreira","year":"2012","journal-title":"J. Neurochem."},{"key":"B32","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-169","article-title":"Neuropeptide Y inhibits interleukin-1beta-induced phagocytosis by microglial cells.","volume":"8","author":"Ferreira","year":"2011","journal-title":"J. Neuroinflamm."},{"key":"B33","doi-asserted-by":"publisher","first-page":"41921","DOI":"10.1074\/jbc.M110.164020","article-title":"Neuropeptide Y modulation of interleukin-1{beta} (IL-1{beta})-induced nitric oxide production in microglia.","volume":"285","author":"Ferreira","year":"2010","journal-title":"J. Biol. Chem."},{"key":"B34","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.ygcen.2016.09.005","article-title":"Molecular characterization of neuropeptide Y (NPY) receptors (Y1, Y4 and Y6) and investigation of the tissue expression of their ligands (NPY, PYY and PP) in chickens.","volume":"240","author":"Gao","year":"2017","journal-title":"Gen. Comp. Endocrinol."},{"key":"B35","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1365-2893.2007.00908.x","article-title":"Cytokine mRNA expression in hepatitis C virus infection: TH1 predominance in patients with chronic hepatitis C and TH1-TH2 cytokine profile in subjects with self-limited disease.","volume":"15","author":"Gigi","year":"2008","journal-title":"J. Viral Hepat."},{"key":"B36","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.1111\/j.1460-9568.2012.08232.x","article-title":"Protective role of neuropeptide Y Y2 receptors in cell death and microglial response following methamphetamine injury.","volume":"36","author":"Gon\u00e7alves","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"B37","doi-asserted-by":"publisher","first-page":"3173","DOI":"10.1111\/j.1460-9568.2012.08232.x","article-title":"Protective role of neuropeptide Y Y(2) receptors in cell death and microglial response following methamphetamine injury.","volume":"36","author":"Goncalves","year":"2012","journal-title":"Eur. J. Neurosci."},{"key":"B38","doi-asserted-by":"publisher","first-page":"3158","DOI":"10.2174\/138161210793292465","article-title":"Neuropeptides as therapeutic approach to autoimmune diseases.","volume":"16","author":"Gonzalez-Rey","year":"2010","journal-title":"Curr. Pharm. Des."},{"key":"B39","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.1093\/brain\/awt084","article-title":"Defects in the striatal neuropeptide Y system in X-linked dystonia-parkinsonism.","volume":"136","author":"Goto","year":"2013","journal-title":"Brain"},{"key":"B40","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1083\/jcb.201709069","article-title":"Microglia in Alzheimer\u2019s disease.","volume":"217","author":"Hansen","year":"2018","journal-title":"J. Cell Biol."},{"key":"B41","doi-asserted-by":"publisher","first-page":"1031","DOI":"10.1016\/j.jocn.2007.09.016","article-title":"Increased levels of activated T-cells and reduced levels of CD4\/CD25+ cells in peripheral blood of Guillain-Barr\u00e9 syndrome patients compared to controls.","volume":"15","author":"Harness","year":"2008","journal-title":"J. Clin. Neurosci."},{"key":"B42","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1111\/j.1471-4159.2005.03057.x","article-title":"Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus.","volume":"93","author":"Howell","year":"2005","journal-title":"J. Neurochem."},{"key":"B43","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s12576-012-0208-9","article-title":"Differential control of efferent sympathetic activity revisited.","volume":"62","author":"Iriki","year":"2012","journal-title":"J. Physiol. Sci."},{"key":"B44","doi-asserted-by":"publisher","first-page":"947","DOI":"10.1016\/j.autrev.2013.02.006","article-title":"Effect of stress on brain inflammation and multiple sclerosis.","volume":"12","author":"Karagkouni","year":"2013","journal-title":"Autoimmun. Rev."},{"key":"B45","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/0304-3940(86)90174-6","article-title":"Striatal neuropeptide Y neurones are under the influence of the nigrostriatal dopaminergic pathway: immunohistochemical evidence.","volume":"1986","author":"Kerkerian","year":"1986","journal-title":"Neurosci. Lett."},{"key":"B46","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/0304-3940(95)11973-z","article-title":"Plasma neuropeptide Y is reduced in patients with Alzheimer\u2019s disease.","volume":"198","author":"Koide","year":"1995","journal-title":"Neurosci. Lett."},{"key":"B47","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.npep.2013.10.015","article-title":"Neuropeptides in epilepsy.","volume":"47","author":"Kovac","year":"2013","journal-title":"Neuropeptides"},{"key":"B48","doi-asserted-by":"publisher","first-page":"275","DOI":"10.14348\/molcells.2014.2374","article-title":"The role of macrophage polarization in infectious and inflammatory diseases.","volume":"37","author":"Labonte","year":"2014","journal-title":"Mol. Cells"},{"key":"B49","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1111\/ene.13439","article-title":"Alzheimer\u2019s disease.","volume":"25","author":"Lane","year":"2018","journal-title":"Eur. J. Neurol."},{"key":"B50","doi-asserted-by":"publisher","first-page":"525","DOI":"10.1007\/s00424-010-0809-801","article-title":"Glutamate receptors, neurotoxicity and neurodegeneration.","volume":"460","author":"Lau","year":"2010","journal-title":"Pflugers. Arch."},{"key":"B51","doi-asserted-by":"publisher","first-page":"352","DOI":"10.20471\/acc.2018.57.02.17","article-title":"Multiple Sclerosis: new aspects of immunopathogenesis.","volume":"57","author":"Lazibat","year":"2018","journal-title":"Acta Clin. Croat."},{"key":"B52","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1016\/j.cellsig.2015.03.016","article-title":"Neuropeptide Y receptor mediates activation of ERK1\/2 via transactivation of the IGF receptor.","volume":"27","author":"Lecat","year":"2015","journal-title":"Cell. Signal."},{"key":"B53","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1007\/s13770-018-0134-x","article-title":"Comparison of angiogenic activities of three neuropeptides, substance P, secretoneurin, and neuropeptide Y using myocardial infarction.","volume":"15","author":"Lee","year":"2018","journal-title":"Tissue Eng. Regen. Med."},{"key":"B54","doi-asserted-by":"publisher","first-page":"460","DOI":"10.1016\/j.coph.2008.05.001","article-title":"Neurotransmitters activate T-cells and elicit crucial functions via neurotransmitter receptors.","volume":"8","author":"Levite","year":"2008","journal-title":"Curr. Opin. Pharmacol."},{"key":"B55","doi-asserted-by":"publisher","first-page":"959","DOI":"10.4103\/1673-5374.133140","article-title":"Neuropeptide Y protects cerebral cortical neurons by regulating microglial immune function.","volume":"9","author":"Li","year":"2014","journal-title":"Neural Regen. Res."},{"key":"B56","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/260473","article-title":"IL-17 and IL-22 in cerebrospinal fluid and plasma are elevated inGuillain-Barr\u00e9 syndrome.","volume":"2012","author":"Li","year":"2012","journal-title":"Mediators Inflamm."},{"key":"B57","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1016\/0143-4179(94)90058-2","article-title":"Cerebrospinal fluid (CSF) neuropeptide Y- and somatostatin-like immunoreactivities in man.","volume":"27","author":"Maeda","year":"1994","journal-title":"Neuropeptides"},{"key":"B58","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1093\/brain\/awu352","article-title":"Transplantation of cerebellar neural stem cells improves motor coordination and neuropathology in Machado-Joseph disease mice.","volume":"138","author":"Mendon\u00e7a","year":"2015","journal-title":"Brain"},{"key":"B59","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1089\/hum.2018.157","article-title":"RNAi therapy for Machado-Joseph disease: long-term safety profile of lentiviral vectors encoding shRNAs targeting mutant ataxin-3.","volume":"30","author":"Nobrega","year":"2019","journal-title":"Hum. Gene Ther."},{"key":"B60","doi-asserted-by":"crossref","first-page":"91","DOI":"10.31887\/DCNS.2016.18.1\/pnopoulos","article-title":"Huntington disease: a single-gene degenerative disorder of the striatum.","volume":"18","author":"Nopoulos","year":"2016","journal-title":"Dialogues Clin. Neurosci."},{"key":"B61","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1001\/archneurol.2011.51","article-title":"TH1 and TH2 response to campylobacter jejuni antigen in Guillain-Barre syndrome.","volume":"68","author":"Nyati","year":"2011","journal-title":"Arch. Neurol."},{"key":"B62","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1016\/j.yebeh.2014.06.033","article-title":"Expression of neuropeptide Y1 receptors in the amygdala and hippocampus and anxiety-like behavior associated with Ammon\u2019s horn sclerosis following intrahippocampal kainate injection in C57BL\/6J mice.","author":"O\u2019Loughlin","year":"2014","journal-title":"Epilepsy Behav."},{"key":"B63","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12464","article-title":"Inflammatory process in Parkinson disease: neuroprotection by neuropeptide Y.","author":"Pain","year":"2019","journal-title":"Fundam. Clin. Pharmacol."},{"key":"B64","doi-asserted-by":"publisher","first-page":"1551","DOI":"10.1177\/0269881109348171","article-title":"Evidence from knockout mice that neuropeptide-Y Y2 and Y4 receptor signalling prevents long-term depression-like behaviour caused by immune challenge.","volume":"24","author":"Painsipp","year":"2010","journal-title":"J. Psychopharmacol."},{"key":"B65","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1111\/j.1601-183X.2008.00389.x","article-title":"Reduced anxiety-like and depression-related behavior in neuropeptide Y Y4 receptor knockout mice.","volume":"7","author":"Painsipp","year":"2008","journal-title":"Genes Brain Behav."},{"key":"B66","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.cyto.2016.11.014","article-title":"Cross-talk between innate cytokines and the pancreatic polypeptide family in acute pancreatitis.","volume":"90","author":"Pendharkar","year":"2017","journal-title":"Cytokine"},{"key":"B67","doi-asserted-by":"publisher","first-page":"8169","DOI":"10.1523\/jneurosci.17-21-08169.1997","article-title":"Inhibition of synaptic transmission by neuropeptide Y in rat hippocampal area CA1: modulation of presynaptic Ca2+ entry.","volume":"17","author":"Qian","year":"1997","journal-title":"J. Neurosic."},{"key":"B68","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1016\/j.neurobiolaging.2005.09.022","article-title":"Early neuropathology of somatostatin\/NPY GABAergic cells in the hippocampus of a PS1xAPP transgenic model of Alzheimer\u2019s disease.","volume":"27","author":"Ramos","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"B69","doi-asserted-by":"publisher","first-page":"1115","DOI":"10.1523\/JNEUROSCI.4220-08.2009","article-title":"europeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer\u2019s disease.","volume":"29","author":"Rose","year":"2009","journal-title":"J. Neurosci."},{"key":"B70","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19160","article-title":"Alteration in fluidity of cell plasma membrane in huntington disease revealed by spectral phasor analysis.","volume":"8","author":"Sameni","year":"2018","journal-title":"Sci. Rep."},{"key":"B71","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2013.160","article-title":"Neuropeptide Y receptors activation protects rat retinal neural cells against necrotic and apoptotic cell death induced by glutamate.","volume":"4","author":"Santos-Carvalho","year":"2013","journal-title":"Cell Death Dis."},{"key":"B72","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1007\/s12311-011-0326","article-title":"Body mass index is inversely correlated with the expanded CAG repeat length in SCA3\/MJD patients.","volume":"11","author":"Saute","year":"2012","journal-title":"Cerebellum"},{"key":"B73","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1016\/j.trim.2017.04.004","article-title":"Non-neuronal neuropeptide Y and its receptors during acute rejection of rat pulmonary allografts.","author":"Schmitz","year":"2017","journal-title":"Transpl. Immunol."},{"key":"B74","doi-asserted-by":"publisher","first-page":"319","DOI":"10.4142\/jvs.2018.19.3.319","article-title":"Microglial involvement in the development of olfactory dysfunction.","volume":"19","author":"Seo","year":"2018","journal-title":"J. Vet. Sci."},{"key":"B75","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.mehy.2006.01.021","article-title":"Any beneficial effects of mycobacteria on multiple sclerosis and experimental autoimmune encephalitis may include stimulation of the sympathetic nervous system.","volume":"67","author":"Shahabi","year":"2006","journal-title":"Med. Hypotheses"},{"key":"B76","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4286364","article-title":"Beneficial or harmful role of macrophages in Guillain-Barr\u00e9 syndrome and experimental autoimmune neuritis.","volume":"2018","author":"Shen","year":"2018","journal-title":"Mediators Inflamm."},{"key":"B77","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0057929","article-title":"Neuropeptide Y is produced by adipose tissue macrophages and regulates obesity-induced inflammation.","volume":"8","author":"Singer","year":"2013","journal-title":"PLoS One"},{"key":"B78","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s00213-012-2651-y","article-title":"Neuropeptide Y Y5 receptor antagonism attenuates cocaine-induced effects in mice.","volume":"222","author":"S\u00f8rensen","year":"2012","journal-title":"Psychopharmacology"},{"key":"B79","doi-asserted-by":"publisher","first-page":"647","DOI":"10.3233\/JAD-2011-110713","article-title":"Weight loss and rapid cognitive decline in community-dwelling patients with Alzheimer\u2019s disease.","volume":"28","author":"Soto","year":"2012","journal-title":"J. Alzheimers. Dis."},{"key":"B80","doi-asserted-by":"publisher","first-page":"1905","DOI":"10.1074\/jbc.M115.678185","article-title":"Systemic central nervous system (CNS)-targeted delivery of neuropeptide Y (NPY) reduces neurodegeneration and increases neural precursor cell proliferation in a mouse model of Alzheimer disease.","volume":"291","author":"Spencer","year":"2016","journal-title":"J. Biol. Chem."},{"key":"B81","doi-asserted-by":"publisher","first-page":"1635","DOI":"10.2174\/138161212799958639","article-title":"Sympathetic nervous system dysfunction in multiple sclerosis, linking neurodegeneration to a reduced response to therapy.","volume":"18","author":"Sternberg","year":"2012","journal-title":"Curr. Pharm. Des."},{"key":"B82","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1111\/j.1471-4159.2010.07154.x","article-title":"NPY promotes chemokinesis and neurogenesis in the rat subventricular zone.","volume":"116","author":"Thiriet","year":"2011","journal-title":"J. Neurochem."},{"key":"B83","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00178","article-title":"Neuropeptide Y in alcohol addiction and affective disorders.","volume":"8","author":"Thorsell","year":"2017","journal-title":"Front. Endocrinol."},{"key":"B84","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.omtn.2017.06.019","article-title":"Antisense oligonucleotide-mediated removal of the polyglutamine repeat in spinocerebellar ataxia type 3 mice.","volume":"8","author":"Toonen","year":"2017","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"B85","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1080\/17460441.2018.1428556","article-title":"Novel models for Parkinson\u2019s disease and their impact on future drug discovery.","volume":"13","author":"Trigo-Damas","year":"2018","journal-title":"Expert Opin. Drug Discov."},{"key":"B86","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.npep.2016.02.007","article-title":"Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation.","volume":"57","author":"Wagner","year":"2016","journal-title":"Neuropeptides"},{"key":"B87","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.2174\/156802607782341046","article-title":"NPY and receptors in immune and inflammatory diseases.","volume":"7","author":"Wheway","year":"2007","journal-title":"Curr. Top. Med. Chem."},{"key":"B88","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1111\/j.1745-7254.2005.00011.x","article-title":"Neuropeptide Y expression in mouse hippocampus and its role in neuronal excitotoxicity.","volume":"26","author":"Wu","year":"2005","journal-title":"Acta. Pharmacol. Sin."},{"key":"B89","doi-asserted-by":"publisher","first-page":"315","DOI":"10.2174\/157488906778773689","article-title":"Neuropeptide Y as an endogenous antiepileptic, neuroprotective and pro-neurogenic peptide.","volume":"1","author":"Xapelli","year":"2006","journal-title":"Recent Pat. CNS Drug Discov."},{"key":"B90","doi-asserted-by":"publisher","first-page":"2089","DOI":"10.1111\/j.1460-9568.2008.06172.x","article-title":"Interaction between neuropeptide Y (NPY) and brain-derived neurotrophic factor in NPY-mediated neuroprotection against excitotoxicity: a role for microglia.","volume":"27","author":"Xapelli","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"B91","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1159\/000486225","article-title":"A promising therapeutic target for metabolic diseases: neuropeptide Y receptors in humans.","volume":"45","author":"Yi","year":"2018","journal-title":"Cell Physiol. Biochem."},{"key":"B92","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.cytogfr.2013.05.005","article-title":"Th1\/Th2\/Th17\/Treg cytokines in Guillain-Barre syndrome and experimental autoimmune neuritis.","volume":"24","author":"Zhang","year":"2013","journal-title":"Cytokine Growth. Factor. Rev."},{"key":"B93","doi-asserted-by":"publisher","first-page":"1411","DOI":"10.1210\/en.2019-56","article-title":"Regulation of feeding-related behaviors by arcuate neuropeptide Y neurons.","volume":"160","author":"Zhang","year":"2019","journal-title":"Endocrinology"},{"key":"B94","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s12264-008-0130-6","article-title":"Neuropeptide Y promotes TGF-beta1 production in RAW264.7 cells by activating PI3K pathwayvia Y1 receptor.","volume":"24","author":"Zhou","year":"2008","journal-title":"Neurosci. Bull."},{"key":"B95","doi-asserted-by":"publisher","first-page":"1900","DOI":"10.1093\/brain\/awx113","article-title":"Loss of \u2018homeostatic\u2019 microglia and patterns of their activation in active multiple sclerosis.","volume":"140","author":"Zrzavy","year":"2017","journal-title":"Brain"}],"container-title":["Frontiers in Neuroscience"],"original-title":[],"link":[{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.00869\/full","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T20:46:03Z","timestamp":1610829963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.frontiersin.org\/article\/10.3389\/fnins.2019.00869\/full"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,20]]},"references-count":95,"alternative-id":["10.3389\/fnins.2019.00869"],"URL":"https:\/\/doi.org\/10.3389\/fnins.2019.00869","relation":{},"ISSN":["1662-453X"],"issn-type":[{"value":"1662-453X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,20]]},"article-number":"869"}}